Club Cell Protein 16 Attenuates CD16brightCD62dim Immunosuppressive Neutrophils in Damaged Tissue upon Posttraumatic Sepsis-Induced Lung Injury by Nils Becker, Philipp Störmann, Andrea Janicova, Kernt Köhler, Klemens Horst, Ildiko Rita Dunay, Claudia Neunaber, Ingo Marzi, Jan Tilmann Vollrath, Borna Relja

“…PMNL were characterized via expression of CD11b, CD16, CD45, CD62L, and Ly6G by flow cytometry in bone marrow (BM), blood, spleen, lung, liver, and bronchoalveolar and peritoneal lavage fluid (BALF and PL). …”
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Effects of exercise and exercise timing on energy intake and appetite control in Danish individuals with overweight or obesity with and without type 2 diabetes: a protocol for a ra... by Louise Groth Grunnet, Martin Bæk Blond, Jonas Salling Quist, Kristine Beaulieu, Graham Finlayson, Kristine Færch, Lea Jalking, Natja Poder Launbo, Marie Møller Jensen, Hanne Enghoff Pedersen, Marina Kjærgaard Gerstenberg

“…Fifteen minutes after the rest or exercise period, the participants will be presented with an ad libitum meal. Blood samples will be collected and subjective appetite will be assessed using Visual Analogue Scales in the fasted state before exercise/rest, immediately post-exercise/rest and at 15, 30, 45 and 60 min post-exercise/rest. …”
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A novel nomogram based on the patient’s clinical data and CT signs to predict poor outcomes in AIS patients by Jingyao Yang, Fangfang Deng, Qian Zhang, Zhuyin Zhang, Qinghua Luo, Yeyu Xiao

“…Results Multivariate logistic regression analysis showed that hyperdense middle cerebral artery sign (HMCAS) (OR 9.113; 95% CI [1.945–42.708]; P = 0.005), the Alberta Stroke Program Early Computed Tomography Score (ASPECTS) > 6 (OR 7.707; 95% CI [2.201–26.991]; P = 0.001), NIHSS score (OR 1.085; 95% CI [1.009–1.166]; P = 0.027), age (OR 1.077; 95% CI [1.020–1.138]; P = 0.008) and white blood cell count (WBC) (OR 1.200; 95% CI [1.008–1.428]; P = 0.040) were independent risk factors for early poor outcomes after mechanical thrombectomy. …”
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CHARACTERISTICS OF CYTOPROTECTIVE EFFECT ON THE GASTRIC MUCOSA OF CRYOPRESERVED PLACENTA EXTRACT UNDER WATER-IMMOBILIZATION STRESS by Illia Koshurba, Fedir Hladkykh, Mykola Chyzh

“…Along with psycho-emotional stressing experiences, the causes of formation of stress ulcers include major surgical interventions, thermal or mechanical injuries, severe blood loss, progressive syndrome of endogenous intoxication and more. …”
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Preoperative mapping techniques for brain tumor surgery: a systematic review by Augusto Leone, Augusto Leone, Francesco Carbone, Francesco Carbone, Uwe Spetzger, Peter Vajkoczy, Giovanni Raffa, Flavio Angileri, Antonino Germanó, Melina Engelhardt, Thomas Picht, Thomas Picht, Antonio Colamaria, Tizian Rosenstock, Tizian Rosenstock

“…Combining nTMS with tractography allows for preoperative assessment of short-term and long-term motor deficits, which may not be possible with fMRI. fMRI data interpretation requires careful consideration of co-activated, non-essential areas (potentially leading to false positives) and situations where neural activity and blood flow are uncoupled (potentially leading to false negatives). …”
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Role of Absorbable Polysaccharide Hemostatic Powder in the Prevention of Complications After Axillary Lymph Node Dissection in Breast Cancer Patients: A Multicenter Retrospective A... by Simona Parisi, Francesco Saverio Lucido, Francesca Fisone, Roberto Ruggiero, Salvatore Tolone, Francesco Iovino, Antonio Santoriello, Federico Maria Mongardini, Maddalena Paolicelli, Ludovico Docimo, Claudio Gambardella

“…Secondary endpoints included the presence of seroma at the ultrasound (US) follow-up, significant blood loss, hematoma, the duration of surgery, and postsurgical complications. …”
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Single‐cell sequencing reveals the features of adaptive immune responses in the liver of a mouse model of dengue fever by Yizhen Yuan, Qian Chen, Zhe Li, Fangzhou Cai, Dan Li, Wei Wang

“…Flow cytometry was used to detect T cells and macrophages in mouse liver and blood to verify the single‐cell sequencing results. …”
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Hemodiafiltration with endogenous reinfusion for uremic toxin removal in patients undergoing maintenance hemodialysis: a pilot study by Renhua Lu, Yan Fang, Wangshu Wu, Xiaojun Zeng, Tingting Liu, Yue Qian, Yuanyuan Xie, Yijun Zhou, Leyi Gu

“…Each subject underwent one HFR and one hemodiafiltration (HDF) treatment. Blood samples were collected before and after a single HFR or HDF treatment to test uremic toxin levels and to calculate clearance rate. …”
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Effect of Arthrospira platensis (Spirulina) as a dietary supplement during transition period in dairy buffaloes by Giuseppe De Rosa, Vittoria L. Barile, Carmela M.A. Barone, Claudia Lambiase, Francesco Serrapica, Giovanna De Matteis, Emanuela Rossi, Corrado Pacelli

“…Colostrum was collected within 6-8 hours post-calving, and its immunoglobulin content was immediately measured by an optical refractometer (Brix degrees). d-ROMs and BAP were measured on serum blood samples taken at group formation, at calving, 15 and 90 d after calving. …”
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Dietary tea tree (Melaleucae Aetheroleum) oil fortifies growth, biochemical, immune-antioxidant trait, gene function, tissue reaction, and Aeromonas sobria resistance in Nile tilap... by Mohamed Shaalan, Heba H. Mahboub, Ahmed Hosny Abdelgawad, Abdelwahab A. Abdelwarith, Elsayed M. Younis, Ahmed A. Elnegiry, Asmaa W. Basher, Walaa El-Houseiny, Sherif M. Shawky, Sahar H. Orabi, Simon J. Davies, Yasmina K. Mahmoud

“…Outcomes indicated an extensive elevation in growth metrics (final body weight, weight gain, SGR, feed intake and fish body protein). Similarly, the total blood protein, albumin, total globulin levels, Serum complement-3 levels, lysozyme activity, immunoglobulin M (IgM), nitric oxide, and phagocytic activity were significantly enhanced in all treatments, notably in the 2.0 mL TTO/kg fed groups compared to the control. …”
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Validating a clinically based MS-MLPA threshold through comparison with Sanger sequencing in glioblastoma patients by Halka Lhotska, Karolina Janeckova, Hana Cechova, Jaromir Macoun, Tatiana Aghova, Libuse Lizcova, Karla Svobodova, Lucie Hodanova, Dora Konecna, Jiri Soukup, Filip Kramar, David Netuka, Zuzana Zemanova

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Generation of Insulin-Producing Cells from Canine Adipose Tissue-Derived Mesenchymal Stem Cells by Takahiro Teshima, Keiji Okamoto, Kazuho Dairaku, Tomokazu Nagashima, Masaki Michishita, Ryohei Suzuki, Hirotaka Matsumoto, Hidekazu Koyama

“…Canine IPCs also showed gene expression typical for pancreatic beta cells and increased insulin secretion in response to glucose stimulation. The blood glucose levels in streptozotocin-induced diabetic mice were decreased after injection with the supernatant of canine IPCs, but the hyperglycemic states of diabetic mice were not improved after transplanting IPCs subcutaneously or intramesenterically. …”
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Elevations in D-dimer levels in patients with Plasmodium infections: a systematic review and meta-analysis by Suriyan Sukati, Kwuntida Uthaisar Kotepui, Frederick Ramirez Masangkay, Ching-Ping Tseng, Aongart Mahittikorn, Nsoh Godwin Anabire, Polrat Wilairatana, Kinley Wangdi, Hideyuki J Majima, Apiporn Thinkhamrop Suwannatrai, Wiyada Kwanhian Klangbud, Wanida Mala, Rujikorn Rattanatham, Manas Kotepui

“…Abstract D-dimer, a byproduct of cross-linked fibrin degradation, arises during the fibrinolysis process, breaking down blood clots in circulation. This systematic review and meta-analysis aimed to synthesize evidence of D-dimer alteration in people with malaria, including variations in disease severity. …”
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A Test-Retest Study of Single- and Multi-Delay pCASL for Choroid Plexus Perfusion Imaging in Healthy Subjects Aged 19 to 87 Years by Zixuan Liu, Qinyang Shou, Kay Jann, Chenyang Zhao, Danny JJ Wang, Xingfeng Shao

“…This study systematically evaluated the test-retest reliability and quantification accuracy of cerebral blood flow (CBF) measurements, focusing on the ChP, using single-delay and multi-delay 3D gradient-and-spin echo (GRASE) pseudo-continuous ASL (pCASL) on 28 subjects (aged 19 to 87 years, 14 males/14 females) at 3.0 tesla. …”
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Lower Extremity Peripheral Arterial Disease Is an Independent Predictor of Coronary Heart Disease and Stroke Risks in Patients with Type 2 Diabetes Mellitus in China by Xiao-Hong Pang, Jue Han, Wan-Lan Ye, Xue Sun, Yue Ding, Wen-Juan Huang, Yi-Ming Zhao, Han-Yu Lou, Li-Zhen Shan, Ying-Xiu Kang, Xiao-Xiao Song, Song-Zhao Zhang, Wei Gu, Peng-Fei Shan

“…Age; duration of diabetes; systolic blood pressure; the hypertension rate; the use of hypertension drugs, ACEI /ARB, and statins; CHD risk; fatal CHD risk; stroke risk; and fatal stroke risk were significantly higher in the PAD group than in the non-PAD group (P<0.05 for all). …”
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Immune-checkpoint-inhibitor therapy directed against PD-L1 is tolerated in the heart without manifestation of cardiac inflammation in a preclinical reversible melanoma mouse model by Caroline Schoenherr, Caroline Schoenherr, Stefan Pietzsch, Stefan Pietzsch, Cristina Barca, Franziska E. Müller, Frauke S. Bahr, Martina Kasten, Andre Zeug, Sergej Erschow, Christine S. Falk, Evgeni Ponimaskin, James T. Thackeray, Denise Hilfiker-Kleiner, Denise Hilfiker-Kleiner, Melanie Ricke-Hoch

“…Although anti-PD-L1 treatment was associated with increased troponin I type 3 cardiac (TNNI3) blood levels, cardiac mRNA expression of macrophage markers and elevated cardiac levels of secreted inflammatory factors compared to Ctrl treatment, both groups showed a comparable density of inflammatory cells in the heart (using CXCR4-ligand 68Ga-Pentixafor in PET-CT and immunohistochemistry). …”
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Effects of Local Heating and Whole-Body Hyperthermia on Neuromuscular and Cognitive Function in Young and Old Healthy Adults by Junli Wang

“…Prolactin, interleukin-6, dopamine and cortisol concentrations were obtained via venous blood samples. The isometric torque of ankle plantar flexion muscles was assessed as the first study. …”
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Hyperleukocytosis in a neuroblastoma patient after treatment with natural killer T cells expressing a GD2-specific chimeric antigen receptor and IL-15 by Xin Xu, Shantan Reddy, Saleh Bhar, Frederic D Bushman, Amy N Courtney, Gabriel A Barragán, Gengwen Tian, Erica J Di Pierro, Leonid S Metelitsa, Antonino Montalbano, Hangjin Yu, Claudia Martinez Amador, Nisha Ghatwai, Michael S Wood, Deborah Schady, Aoife M Roche, David de la Cerda, Donald Williams Parsons, Andras Heczey

“…This patient was the first to be treated on dose level (DL) 5 and the first patient whose product was restimulated with K562-derived artificial antigen-presenting cells (aAPCs) instead of autologous peripheral blood mononuclear cells (PBMCs). 12 previously treated patients on DLs 1 through 4 did not experience significant toxicity. …”
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D-mannose alleviates chronic periodontitis in rats by regulating the functions of neutrophils by Xue Li, Xueting Chen, Qingyu Zhu, Pengye Zhang, Shunxue Nan, Lei Lv, Shengcai Qi

“…Additionally, neutrophils isolated from the peripheral blood of healthy rats were treated with LPS and D-mannose, and changes in the expression levels of myeloperoxidase (MPO), IL-1β, IL-6, IL-17, IL-10, and TET2 were observed via IF. …”
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Yoga programme for type-2 diabetes prevention (YOGA-DP) among high risk people in India: a multicentre feasibility randomised controlled trial protocol by Mark Hamer, Dorairaj Prabhakaran, Kavita Singh, Nikhil Tandon, Sanjay Kinra, Kaushik Chattopadhyay, Tess Harris, Pallavi Mishra, Sheila Margaret Greenfield, Sarah Anne Lewis, Nandi Krishnamurthy Manjunath, Rukamani Nair, Somnath Mukherjee, David Ross Harper

“…Physical activity and a healthy diet (healthy lifestyle) improve blood glucose levels in people at high risk of T2DM. …”
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