Evaluating the pharmacokinetics and safety of blonanserin tablets and Lonasen®: a randomized, open-label, two-period, two-sequence, self-crossover phase I clinical trial by Bo Qiu, Bo Qiu, Haojing Song, Haojing Song, Xue Sun, Xue Sun, Congyang Ding, Congyang Ding, Runxuan Du, Wanjun Bai, Wanjun Bai, Zhanjun Dong, Zhanjun Dong

“…Eligible healthy individuals received a single 4-mg dose of either the test or reference blonanserin tablet, followed by a wash out period of 14 days. Serial blood samples were collected for up to 72 h after administration during each period, and the plasma concentrations of blonanserin were determined using a validated method. …”
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Associations of PM2.5 with Chronic Obstructive Pulmonary Disease in Shipyard Workers: A Cohort Study by Nguyen Thanh Tung, Ching-Huang Lai, Chih-Hong Pan, Wei-Liang Chen, Chung-Ching Wang, Che-Wei Liang, Chi-Yu Chien, Kai-Jen Chuang, Huynh Nguyen Xuan Thao, Hoang Ba Dung, Tran Phan Chung Thuy, Hsiao-Chi Chuang

“…We conducted a cohort study with a follow-up of 4 years in 115 shipyard workers to investigate the incidence rate of chronic obstructive pulmonary disease (COPD), and to evaluate the effects of welding fume PM2.5 deposition on fractional exhaled nitric oxide (FeNO), lung function, and blood pressure using generalized estimating equation models. …”
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Activated CD27+PD-1+ CD8 T Cells and CD4 T Regulatory Cells Dominate the Tumor Microenvironment in Refractory Celiac Disease Type II by Tessa Dieckman, Mette Schreurs, Ciska Lindelauf, Ahmed Mahfouz, Caroline R. Meijer, Louise Pigeaud, Vincent van Unen, Gerd Bouma, Frits Koning

“…Methods: We applied mass cytometry on CD45+ duodenal cells derived from intestinal biopsies (n = 23) and blood samples (n = 20) from RCDII patients and controls. …”
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Myofascial trigger points therapy increases neck mobility and reduces headache pain in migraine patients – pilot study by Maciej Olesiejuk, Małgorzata Chalimoniuk, Tomasz Sacewicz

“…The application of IC-MTrPs therapy is of particular interest because it targets these trigger points, potentially normalizing muscle tone and improving local blood flow, which may alleviate pain and restore mobility. …”
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Association between renal mean perfusion pressure and prognosis in patients with sepsis-associated acute kidney injury: insights from the MIMIC IV database by Yipeng Fang, Aizhen Dou, Hui Xie, Yunfei Zhang, Weiwei Zhu, Yingjin Zhang, Caifeng Li, Yanchao Su, Ying Gao, Keliang Xie

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Cardiomeds, an mHealth App for Self-Management to Support Swiss Patients With Heart Failure: 2-Stage Mixed Methods Usability Study by Lisa Simioni, Elena Tessitore, Hamdi Hagberg, Aurélie Schneider-Paccot, Katherine Blondon, Liliane Gschwind, Philippe Meyer, Frederic Ehrler

“…This app includes an interactive medication list; daily self-monitoring of symptoms, weight, blood pressure, and heart rate; and educational information on HF delivered through various formats. …”
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Association between serum albumin and severe impairment of activities of daily living in patients with stroke: a cross-sectional study by Ranran Bi, Yupeng Shi, Manrong Li, Xiaochen Liu, Zhenchao Ma, Yiqing Huang, Bingyin Liang, Fang Cui

“…However, when serum albumin levels were greater than or equal to 38.0 g/L, the severe impairment of ADLs no longer decreased with rising serum albumin levels.ConclusionIn summary, an L-shaped connection with an approximate inflection point of 38.0 g/L was found between blood albumin levels and significant ADL impairment in stroke patients. …”
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Impaired Mitochondrial Bioenergetics Function in Pediatric Chronic Overlapping Pain Conditions with Functional Gastrointestinal Disorders by Gisela Chelimsky, Pippa Simpson, Liyun Zhang, Doug Bierer, Steve Komas, Balaraman Kalyanaraman, Thomas Chelimsky

“…We evaluated mitochondrial function in the white blood cells of these patients. Methods. This prospective Children’s Wisconsin IRB approved study recruited subjects aging 10–18 years from pediatric neurogastroenterology clinics and healthy comparison subjects (HC). …”
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Protective Effects of Gynostemma pentaphyllum Saponins on Liver Injury in Guinea Pigs of Hyperlipemia Based on Oxidative Stress by Tianyi DAI, Donglian LIU, Xingmin QIN, Chengling GAO, Jiayi LI, Hailing KUANG

“…The liver mass, liver to body ratio, and fasting blood glucose of guinea pigs were measured. The levels of SOD, MDA, CAT and GSH-px in the liver were detected. …”
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MicroRNA Expression in Cutaneous Lupus: A New Window to Understand Its Pathogenesis by Silvia Méndez-Flores, Janette Furuzawa-Carballeda, Gabriela Hernández-Molina, Gustavo Ramírez-Martinez, Nora E. Regino-Zamarripa, Blanca Ortiz-Quintero, Luis Jiménez-Alvarez, Alfredo Cruz-Lagunas, Joaquín Zúñiga

“…We included 22 patients with subacute (SCLE) and 20 with discoid (DLE) lesions, and 19 healthy donors (HD). qRT-PCR for miRNA analysis, flow cytometry in peripheral blood, and skin immunohistochemistry were performed to determine the distribution of CD4 T cells and regulatory cells and their correlation with circulating miRNAs. …”
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Clinical Findings in Diabetes Mellitus Patients with COVID-19 by Ting Guo, Qinxue Shen, Xiaoli Ouyang, Wei Guo, Jinhua Li, Wenlong He, Bo Yu, Chenfang Wu, Zhiguo Zhou, Hong Luo, Hong Peng

“…In addition to timely systemic therapy, the control of blood glucose and proper diabetic therapy is essential to improve the prognosis of severe DM patients with COVID-19.…”
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Determination of HLA Tissue Type According to the Etiology of Patients with Chronic Renal Failure by Burcu KARAKUS TURAN, Fahri UCAR, Vural Taner YILMAZ, Yahya KILINC, Sule DARBAŞ ARAS, Huseyin KOCAK, Nurten SAYIN EKINCI, Bulent AYDINLI, Habibe Sema ARSLAN

“…Methods: Genomic DNA was obtained from peripheral blood samples of 1,079 patients with retrospective CKD and 1,111 healthy control individuals. …”
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Clinical Observation on Chronic Low Back Pain Treated by Sling and Tuina Exercise Therapy by Ning WANG, Yi DING, Qiangqiang XU, Jiapeng ZHANG, LI Li

“…The tuina treatment group was given pressing, rubbing, plucking and other manipulations to increase pain areas in lumbar muscles, improve lumbar blood circulation and relieve muscle tension and spasm. …”
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A retrospective multicenter study on the efficacy and safety of disitamab vedotin monotherapy versus combination with anti-PD-1 immunotherapy in advanced gastric cancer by Shuailei Dong, Chen Wei, Xueting Wang, Xinyi Yang, Wei Shen, Shuyi Li, Jiye Xu, Yijie Ma, Liangyu Bie, Wenyue Yu, Ning Li

“…Furthermore, the most common grade 3–5 treatment-related adverse events (TRAEs) included decreased white-blood-cell (WBC) count, decreased neutrophil count, and anemia. …”
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Correlation between Therapeutic Efficacy of CD34+ Cell Treatment and Directed In Vivo Angiogenesis in Patients with End-Stage Diffuse Coronary Artery Disease by Tien-Hung Huang, Cheuk-Kwan Sun, Yi-Ling Chen, Pei-Hsun Sung, Chi-Hsiang Chu, Mel S. Lee, Yuan-Ping Lin, Hon-Kan Yip, Fan-Yen Lee

“…This study was aimed at testing the association between the therapeutic efficacy of CD34+ cell treatment in patients with end-stage diffuse coronary artery disease as reflected in angiographic grading and results of directed in vivo angiogenesis assay (DIVAA) on their isolated peripheral blood mononuclear cell- (PBMC-) derived endothelial progenitor cells (EPCs). …”
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Is it Time to Recognize Political Anxiety as a Social Determinant of Health? by Brandon Ambrosino

“…In 2019, a psychiatrist at the University of Michigan gave an interview discussing how to avoid “political fatigue.”[2] Signs that political discussions are stressing you out might include high blood pressure, weight fluctuation, and sleep struggles. …”
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Quantitative Physiologic MRI Combined with Feature Engineering for Developing Machine Learning-Based Prediction Models to Distinguish Glioblastomas from Single Brain Metastases by Seyyed Ali Hosseini, Stijn Servaes, Brandon Hall, Sourav Bhaduri, Archith Rajan, Pedro Rosa-Neto, Steven Brem, Laurie A. Loevner, Suyash Mohan, Sanjeev Chawla

“…Median values of mean diffusivity (MD), fractional anisotropy, linear, planar and spheric anisotropic coefficients, and relative cerebral blood volume (rCBV) and maximum rCBV values were measured from CERs and immediate peritumor regions. …”
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Mannogalactoglucan from mushrooms protects pancreatic islets via restoring UPR and promotes insulin secretion in T1DM mice by Ting Liu, Si Chen, Yunhe Qu, Lujuan Zheng, Xiaoxuan Yang, Shuhan Men, Yuanning Wang, Hanrui Ma, Yifa Zhou, Yuying Fan

“…We demonstrated that AAMP-N lowered blood glucose and improved diabetes symptoms in T1DM mice. …”
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Exploring Mortality and Prognostic Factors of Heart Failure with In-Hospital and Emergency Patients by Electronic Medical Records: A Machine Learning Approach by Yu CS, Wu JL, Shih CM, Chiu KL, Chen YD, Chang TH

“…We aimed to investigate the relationship between morality and potential prognostic factors among in-patient and emergency patients with HF.Patients and Methods: A case series study: Data are collected from in-hospital and emergency care patients from 2014 to 2021, including their international classification of disease at admission, and laboratory data such as blood count, liver and renal functions, lipid profile, and other biochemistry from the hospital’s electrical medical records. …”
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Early precursor-derived pituitary gland tissue-resident macrophages play a pivotal role in modulating hormonal balance by Henna Lehtonen, Heli Jokela, Julian Hofmann, Lauriina Tola, Arfa Mehmood, Florent Ginhoux, Burkhard Becher, Melanie Greter, Gennady G. Yegutkin, Marko Salmi, Heidi Gerke, Pia Rantakari

“…The physical location of the pituitary gland at the base of the brain, though outside the protective blood-brain barrier, leads to an unexplored special immune environment. …”
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