Retinal Neuropathy in IGT Stage of OLETF Rats: Another Characteristic Change of Diabetic Retinopathy by Zhenhong Guo, Xiaoyue Sun, Juhong Yang, Jinlan Xie, Feifei Zhong, Xinran Li, Yi Zhang, Fei Han, Xiaoyun Yang, Shaohua Yang, Wei Zhou, Baocheng Chang

“…Inflammation and hypoxia may damage the blood retina barrier (BRB), leading to diabetic retinopathy.…”
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Assessment of relative energy deficiency in sport and malnutrition prevalence in female endurance runners by energy availability questionnaire, bioelectrical impedance analysis and... by Samantha Sharp, Roni Mashiach-Fransis, Nicola Keay, Adrian Slee

“…All participants answered the Energy Availability Questionnaire, and a scoring system was used to assess REDs risk. 56 from this group underwent anthropometric measurements using multifrequency BIA, and 20 subsequently underwent finger prick capillary blood test to evaluate oestrogen, progesterone, follicle-stimulating hormone, luteinising hormone, and testosterone levels 7 days before their predicted period. …”
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An observational, multigenerational platform for health systems and population health interventions to minimise intergenerational transmission of non-communicable diseases in India... by Vaman Khadilkar, Tarun Reddy Katapally, Jasmin Bhawra, Neha Kajale, Rubina Mandlik, Vivek Patwardhan, Demi Miriam, Dipali Ladkat, Chidvilas More, Ketan Gondhalekar, Anuradha Vaman Khadilkar

“…Clinical assessments include anthropometric measurements, blood samples for a wide range of NCD indicators, bone health and muscle function. …”
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Urolithin A increases the natural killer activity of PBMCs in patients with prostate cancer by Vladimir Rogovskii, Vladimir Rogovskii, Vladimir V. Murugin, Vladimir V. Murugin, Nikolay Vorobyev, Nikolay Vorobyev, Sergey Popov, Nikolay Sturov, Alexey Krasheninnikov, Alexander Morozov, Marina Prokhorova

“…BackgroundThe natural killer (NK) activity of peripheral blood mononuclear cells (PBMCs) is a crucial defense against the onset and spread of cancer. …”
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Serum-derived small extracellular vesicles as biomarkers for predicting pregnancy and delivery on assisted reproductive technology in patients with endometriosis by Ayako Muraoka, Akira Yokoi, Akira Yokoi, Akira Yokoi, Kosuke Yoshida, Kosuke Yoshida, Masami Kitagawa, Bayasula, Mayuko Murakami, Natsuki Miyake, Reina Sonehara, Tomoko Nakamura, Satoko Osuka, Hiroaki Kajiyama

“…Extracellular vesicles (EVs) exist in blood and it contains small non-coding RNAs (ncRNAs) that may reflect disease severity. …”
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MT2A promotes angiogenesis in chronically ischemic brains through a copper–mitochondria regulatory mechanism by Ni Mo, Chuyang Tai, Yang Yang, Cong Ling, Baoyu Zhang, Lei Wei, Cian Yao, Hui Wang, Chuan Chen

“…Moreover, significantly greater CD31 expression, less DLAT accumulation, more mitochondria, and fewer mitochondrial abnormalities were observed in the CPOMT2A+ group than in the CPO group, accompanied by significantly improved cerebral blood perfusion and cognitive function. Conclusion MT2A can promote angiogenesis in chronically ischemic brains by neutralizing excessive copper ions and rescuing CPO-induced mitochondrial dysfunction.…”
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Pre-immunotherapy alters stereotactic ablative radiotherapy-induced systemic T cell responses in early-stage NSCLC by Chao Liu, Yanjuan Chen, Xiaohui Li, Zhijie Bai, Meilin Jiang, Dongsheng Sheng, Wenxue Zou, Rui Huang, Qingyu Huang, Fuhao Wang, Jingyang Zhu, Huiru Sun, Bing Liu, Zongcheng Li, Bing Sun

“…Methods We conducted single-cell RNA and T cell receptor (TCR) sequencing of T cells from peripheral blood of seven patients with early-stage NSCLC taken pre- and post-SABR without or with prior immunotherapy and chemotherapy (icSABR). …”
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The Clinical Value of the Combined Detection of Systemic Immune-Inflammation Index (SII), Systemic Inflammation Response Index (SIRI), and Prognostic Nutritional Index (PNI) in Ear... by Zheng J, Zheng L, Wang X, Mao X, Wang Q, Yang Y, Mo D

“…The pre-treatment SII, SIRI, and PNI was calculated from peripheral blood samples. Univariate and multivariate logistic regression analyses were utilized to verify independent risk factors for patients, and constructed the nomograms. …”
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CHI study: protocol for an observational cohort study on ageing and mental health in community-dwelling older adults by Lei Feng, Lieng Hsi Ling, Qiushi Feng, Rachael Zhi Yi Lee, Junhong Yu, Iris Rawtaer, Patrick Finbarr Allen, Zhiming Bao, Jeong Kyu Lee, Chin Tat Lim, Leng Leng Thang, Thet Naing, D Y Wang, Kai Zhen Yap, EH Kua, Rathi Mahendran

“…Assessments include basic sociodemographic, physical health and function (cardiac, oral and blood profiles and visual function), cognitive functioning, daily functioning, physical fitness, emotional state, free-flowing speech, sleep quality, social connectedness, caregiver burden, intergenerational communication, quality of life, life satisfaction, attitudes to ageing and gratitude and compassion. …”
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Platelet-derived extracellular vesicles induced through different activation pathways drive melanoma progression by functional and transcriptional changes by Zeynep Tavukcuoglu, Umar Butt, Alessandra V. S. Faria, Johannes Oesterreicher, Wolfgang Holnthoner, Saara Laitinen, Mari Palviainen, Pia R-M Siljander

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Impact of post-breeding administration of hCG and flunixin meglumine on luteal function and pregnancy rates in anestrous Nili-Ravi buffaloes by Ejaz Ahmad, Muhammad Muzammal Niaz, Muhammad Saleem Akhtar, Muhammad Rizwan Yousuf, Muhammad Zahid Tahir, Tanveer Ahmad

“…The size of the corpus luteum was measured by scanning ovaries through trans- rectal ultrasonog-raphy, and blood samples for serum progesterone assessment were collected on day 14 and day 20 post-TAI. …”
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Unraveling the Role of Oxygen Pulse Variability in Endurance Exercise Training in Individuals with COPD: A Novel Approach to Response of Oxygen Pulse and Quality of Life in Pulmona... by Huang SY, Hsieh PC, Huang KL, Yang MC, Jao LY, Tzeng IS, Lan CC, Wu YK

“…George’s Respiratory Questionnaire (SGRQ).Results: PR significantly improved exercise capacity (peak work rate and oxygen consumption), dyspnea score, and all domains of the SGRQ, maximum expiratory pressure, ventilatory equivalent, respiratory rate, and mean blood pressure at rest in both groups (p < 0.05). …”
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Early Electroacupuncture Extends the rtPA Time Window to 6 h in a Male Rat Model of Embolic Stroke via the ERK1/2-MMP9 Pathway by Xin-chang Zhang, Ya-hui Gu, Wen-tao Xu, Yang-yang Song, Ao Zhang, Zhi-hui Zhang, Si-yuan Jiang, Si-qi Chang, Guang-xia Ni

“…When administered at time points greater than 4.5 h after stroke onset, rtPA disrupts the blood-brain barrier (BBB), which leads to serious brain edema and hemorrhagic transformation. …”
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Effects of HIV exposure on anemia and vitamin D nutritional status in children aged 6–24 months: a hospital-based cross-sectional study by Huixia Li, Shan Yuan, Minghui Liao, Sanfeng Tan, Jianfei Zheng, Lijia Wan, Ying Tu, Min Yang, Jie Gao

“…Questionnaires about children’s characteristics and maternal gestational conditions were collected from children’s caregivers, and blood samples were collected from all children. Descriptive statistics, Chi-square test, non-parametric rank sum test, and logistic regression were used for analysis. …”
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An assessment of circulating biomarkers and germline genetic variants in predicting chemotherapy associated mucositis in Ewing sarcoma by Pawan Gulati, Vickyanne Carruthers, Claire Hutton, Chloe Cassidy, Edward B. Amankwatia, Séréna Pascual, Electra Florence, Tsegay G. Gebru, Andrea L. Jorgensen, Alastair Greystoke, Guy Makin, Martin G. McCabe, Daniel B. Hawcutt, Gareth J. Veal, David Jamieson

“…Here we investigated the role of circulating biomarkers and genetic factors in predicting mucositis severity in Ewing sarcoma. Methods: Blood samples were collected from 111 Ewing sarcoma patients during treatment. …”
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Oxygenation and intestinal perfusion and its association with perturbations of the early life gut microbiota composition of children with congenital heart disease by Hanna Renk, Hanna Renk, Hanna Renk, Ulrich Schoppmeier, Jennifer Müller, Vanessa Kuger, Felix Neunhoeffer, Christian Gille, Silke Peter, Silke Peter

“…We identified three distinct compositional microbial clusters, corresponding neonates differed significantly in intestinal blood flow and global gut perfusion.ConclusionEarly life differences in gut microbiota of CHD neonates versus HCs are possibly linked to oxygen levels. …”
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A meta-analysis of the value of indocyanine green fluorescence imaging in guiding surgical resection of primary and metastatic liver cancer by Dali Xiong, Jiaran Li, Li Li, Fuhao Xu, Tao Hu, He Zhu, Xiaohui Xu, Yawen Sun, Shuanghu Yuan

“…The results showed that indocyanine green fluorescence imaging significantly reduced intraoperative blood loss [Weighted mean difference (WMD), –88.75; 95 % CI, –128.48 to –49.02, p < 0.05], transfusion rate [Odds ratios (OR), 0.5; 95 % CI, 0.36–0.7, p < 0.05], hospital stay duration [WMD, –1.11; 95 % CI, –1.79 to –0.43, p < 0.05], and the overall complication rate [OR, 0.59; 95 % CI, 0.44–0.79, p < 0.05]. …”
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Transplacental and genotoxicity effects of thallium(I) during organogenesis in mice by Lucila Álvarez-Barrera, Rodrigo Aníbal Mateos-Nava, Keyla Nahomi Hernández-Córdova, Eduardo Lezama-Sánchez, Víctor Alan Alcántara-Mejía, Juan José Rodríguez-Mercado

“…The results revealed that the 9.25 mg/kg body weight dose produced maternal and fetal toxicity, and all of the treatment groups presented relatively high percentages of fetuses with external abnormalities, reduced bone ossification, and an increased percentage of liver cells with structural chromosomal aberrations (SCAs) and micronuclei (MNs) in blood cells. These results show that Tl(I) acetate administered during organogenesis produces abnormalities, including a delay in ossification and transplacental genotoxicity, in mouse fetuses. …”
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Sporothrix brasiliensis Gp70 is a cell wall protein required for adhesion, proper interaction with innate immune cells, and virulence by Leonardo Padró-Villegas, Manuela Gómez-Gaviria, Iván Martínez-Duncker, Luz A. López-Ramírez, José A. Martínez-Álvarez, Gustavo A. Niño-Vega, Héctor M. Mora-Montes

“…These phenotypical changes coincided with abnormal interaction with human peripheral blood mononuclear cells, where production of IL-1β, IL-17, and IL-22 was reduced and the strong dependence on cytokine stimulation via mannose receptor was lost. …”
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ApoB/ApoA-Ι is associated with major cardiovascular events and readmission risk of patients after percutaneous coronary intervention in one year by Jie Zhang, Mengyu Liu, Ju Gao, Xiaowen Tian, Yaru Song, Haibei Zhang, Peng Zhao

“…The ApoB/ApoA-I ratio serves as an independent risk factor for one-year MACEs in post-PCI patients and correlates closely with other blood lipid indicators. ApoB/ApoA-I demonstrates significant predictive value for the occurrence of MACEs within one year. …”
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