Extracellular vesicles contribute to the beneficial effects of exercise training in APP/PS1 mice by Oliver K. Fuller, Emma D. McLennan, Casey L. Egan, Nimna Perera, Lauren V. Terry, Jae Pyun, Mariana de Mendonca, Guilherme Defante Telles, Benoit Smeuninx, Emma L. Burrows, Ghizal Siddiqui, Darren J. Creek, John W. Scott, Michael A. Pearen, Pamali Fonseka, Joseph A. Nicolazzo, Suresh Mathivanan, Anthony J. Hannan, Grant A. Ramm, Martin Whitham, Mark A. Febbraio

“…Next, we profiled extracellular vesicles (EVs) and examined whether they may play a role in the protective effects of VET via intranasal administration of EVs, purified from the blood of sedentary (sEV) and/or acutely exercised (eEV) donor wild-type mice into APP/PS1Tg mice. …”
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Unveiling immunogenic characteristics and neoantigens in endometrial cancer with POLE hotspot mutations for improved immunotherapy by Jian Huang, Shuangna Song, Yihua Yin, Yinyan He, Huimin Wang, Ye Gu, Laman He, Xintao Wang, Xiaocao Miao, Zhigang Zhang, Xueli Zhang, Yiran Li, Yiran Li

“…Consequently, by constructing human leukocyte antigen (HLA) tetramers and incubating them with patients’ peripheral blood mononuclear cells (PBMCs), T cells capable of recognizing the POLEP286R mutation were sorted for further transcriptomic, proteomic and T-cell receptor (TCR) sequencing analyses and for an organoid EC model.ResultsTumor- and immune-related pathways were shown to be activated in the POLEP286R mutant group. …”
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Transjugular Intrahepatic Portosystemic Shunt Placement for Portal Hypertension: Meta-Analysis of Safety and Efficacy of 8 mm vs. 10 mm Stents by Jiangtao Liu, Eric Paul Wehrenberg-Klee, Emily D. Bethea, Raul N. Uppot, Kei Yamada, Suvranu Ganguli

“…Controversy remains regarding the optimal stent diameter given that smaller stents may decrease the amount of shunted blood and decrease the risk of HE, but stent patency and/or clinical adequacy of portal decompression may also be affected. …”
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Fluid Resuscitation and Initial Management in Patients Presenting with Sepsis in the General Ward by Sung Won Chang, Juwhan Choi, Jee Youn Oh, Young Seok Lee, Kyung Hoon Min, Gyu Young Hur, Sung Yong Lee, Jae Jeong Shim, Jae Kyeom Sim

“…Low body weight and systolic blood pressure were associated with fluid resuscitation ≥30 mL/kg. …”
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Haptoglobin Gene Polymorphism among Sickle Cell Patients in West Cameroon: Hematological and Clinical Implications by Christian Bernard Kengne Fotsing, Constant Anatole Pieme, Prosper Cabral Biapa Nya, Jean Paul Chedjou, Samuel Ashusong, Gisele Njindam, Jocelyn Tony Nengom, Georges Teto, Carine Nguemeni, Wilfred Fon Mbacham, Donatien Gatsing

“…Haptoglobin genotype of 102 SCPs (SS) and 115 healthy individuals (60 AA and 55 AS) was determined by allele-specific polymerase chain reaction, and the complete blood count was determined using the AutoAnalyser. …”
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Development and external validation of a dynamic nomogram for predicting the risk of functional outcome after 90 days in patients with acute intracerebral hemorrhage by Shaojie Li, Hongjian Li, Jiani Chen, Baofang Wu, Jiayin Wang, Chaocan Hong, Changhu Yan, Weizhi Qiu, Yasong Li, Hongzhi Gao

“…Through variable screening, this study identified age, Glasgow Coma Scale (GCS), blood glucose, uric acid, hemoglobin, and hematoma location as independent predictors of poor prognosis in intracerebral hemorrhage. …”
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Antidiabetic Effect of Fenugreek Seed Powder Solution (Trigonella foenum-graecum L.) on Hyperlipidemia in Diabetic Patients by Genet Alem Geberemeskel, Yared Godefa Debebe, Nigisty Abraha Nguse

“…They were grouped into two groups: the treatment group (n=57) consumed 25 g Trigonella foenum-graecum seed powder solution orally twice a day for one month and the second group is the control (n=57) which receives metformin. Blood sample was collected from each participant by a medical technologist/technician before and after the study. …”
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Transcranial vibration stimulation at 40 Hz induced neural activity and promoted the coupling of global brain activity and cerebrospinal fluid flow by Linghan Kong, Wei Jin, Yue Jiang, Fuhua Yan, Jun Liu, Eric C. Leuthardt, Guang-Zhong Yang, Yuan Feng

“…Additionally, this study investigates alterations in the global blood-oxygen-level-dependent (gBOLD) signal and cerebrospinal fluid (CSF) inflow coupling, which serve as indicators of glymphatic system function. …”
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Effect of combined aerobic exercise and resistance training on postmenopausal women with type 2 diabetes: a systematic review and meta-analysis by Vitor Engracia Valenti, André dos Santos Chagas, Peter Chedraui, Ingrid Soares de Souza, Andrey Alves Porto, Isabel Cristina Esposito Sorpreso, Jose Maria Soares Júnior, Juliana Zangirolami-Raimundo, David M. Garner, Rodrigo Daminello Raimundo

“…The outcomes of interest were the blood glucose levels, insulin secretion, homeostasis model assessment-insulin resistance index (HOMA-IR) and glycated hemoglobin (HbA1c). …”
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Low Serum Magnesium Level Is Associated with Microalbuminuria in Chinese Diabetic Patients by Baihui Xu, Jichao Sun, Xinru Deng, Xiaolin Huang, Wanwan Sun, Yu Xu, Min Xu, Jieli Lu, Yufang Bi

“…After adjustment for age, sex, BMI, blood pressure, lipidaemic profile, HbA1c, eGFR, history of cardiovascular disease, HOMA-IR, antihypertensive and antidiabetic medication, and diabetes duration, we found that, compared with the subjects in tertile 3 of serum magnesium, those in tertile 1 had 1.85 times more likeliness to have microalbuminuria. …”
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Autologous precision-cut lung slice co-culture models for studying macrophage-driven fibrosis by So-Yi Chang, So-Yi Chang, Wen-Hsin Chang, Wen-Hsin Chang, David C. Yang, Qi-Sheng Hong, Qi-Sheng Hong, Ssu-Wei Hsu, Ssu-Wei Hsu, Reen Wu, Ching-Hsien Chen, Ching-Hsien Chen

“…To study macrophage recruitment, we employed an indirect co-culture model using transwells to approximate blood vessel function. Chemotactic studies revealed increased migration of autologous bone marrow-derived macrophages (BMDMs) toward and infiltration into CSE-injured PCLS. …”
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Predictors of Cardiovascular Autonomic Neuropathy Onset and Progression in a Cohort of Type 1 Diabetic Patients by M. Matta, A. Pavy-Le Traon, S. Perez-Lloret, C. Laporte, I. Berdugo, N. Nasr, H. Hanaire, J. M. Senard

“…Methods. 175 type 1 diabetic patients (mean age: 50 ± 11 years; female/male: 76/99) with positive bedside screening for CAN were included and underwent 2 standardized autonomic testings using 4 standardized tests (deep breathing, Valsalva maneuver, 30/15 ratio, and changes in blood pressure during standing), separated by 3 ± 1 years. …”
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Relation of left atrial overload indices with prognostic endpoints in heart failure and preserved ejection fraction by Shiro Hoshida, Koichi Tachibana, Yukinori Shinoda, Tomoko Minamisaka, Masahiro Seo, Masamichi Yano, Takaharu Hayashi, Akito Nakagawa, Yusuke Nakagawa, Shunsuke Tamaki, Takahisa Yamada, Yoshio Yasumura, Yohei Sotomi, Shungo Hikoso, Daisaku Nakatani, Yasushi Sakata, OCVC‐Heart Failure Investigators

“…Methods and results We analysed 898 patients with HFpEF hospitalized for acute decompensated heart failure (men/women: 406/492). Blood tests and transthoracic echocardiography were performed before discharge. …”
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Metabolites and lipid species mediate the associations of adiposity in childhood and early adulthood with mammographic breast density in premenopausal women by Kayla R. Getz, Myung Sik Jeon, Lili Liu, Lei Liu, Haixiang Zhang, Chongliang Luo, Jingqin Luo, Adetunji T. Toriola

“…Louis, MO, and provided a fasting blood sample. Our comprehensive metabolomic and lipidomic profiling yielded complete data for 828 metabolites and 857 lipid species after imputation. …”
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Network pharmacology and multi-omics validation of the Jianpi-Yishen formula in the treatment of chronic kidney disease by Yuyan Li, Yueming Luo, Yilan Hu, Siting Li, Guandong Li, Wanyangchuan Zhang, Xiufen Gu, Jianting Wang, Shunmin Li, Hong Cheng

“…In vivo studies indicated that the JPYS formula could reduce blood urea nitrogen and serum creatinine in adenine-induced CKD rats. …”
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Protection of Fecal Microbiota Transplantation in a Mouse Model of Multiple Sclerosis by Kanglan Li, Shouchao Wei, Li Hu, Xiaojian Yin, Yingren Mai, Chunmei Jiang, Xiaoping Peng, Xingxing Cao, Zhongkai Huang, Haihong Zhou, Guoda Ma, Zhou Liu, Huiliang Li, Bin Zhao

“…We also found that FMT led to reduced activation of microglia and astrocytes and conferred protection on the blood-brain barrier (BBB), myelin, and axons in EAE. …”
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COVID-19 among staff and their family members of a healthcare research institution in Bangladesh between March 2020 and April 2021: a test-negative case–control study by Subhasish Das, Mustafa Mahfuz, Shah Mohammad Fahim, Tahmeed Ahmed, Shams E Arifeen, Md Ashraful Alam, Mustafizur Rahman, John D Clemens, S M Tafsir Hasan, Ishita Mostafa, Monira Sarmin, Shahana Parveen

“…Multivariable regression analysis showed that age more than 60 years (adjusted OR (aOR)=2.1, 95% CI 1.3 to 3.3; p<0.05), blood group AB (aOR=1.5, 95% CI 1.1 to 2; p<0.05), fever (aOR=3.1, 95% CI 2.6 to 3.7; p<0.05), cough (aOR=1.3, 95% CI 1.1 to 1.6; p<0.05) and anosmia (aOR=2.7, 95% CI 1.3 to 5.7; p<0.05) were significantly associated with higher odds of being COVID-19 positive when compared with participants who were tested negative.Conclusions The study findings suggest that older age, fever, cough and anosmia were associated with COVID-19 among the study participants.…”
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Guidelines for Stroke Critical Rehabilitation by PAN Yu, XIE Yuxiao, ZHANG Hao, LYU Zeping, XIE Qing, BAI Dingqun, WAN Chunxiao, JIANG Shan, HE Jing, LIU Shaxing, LI Chong, YANG Bing, LIU Weiming, YANG Guofa, ZHOU Hua, LI Xin, XIE Ruimou, NI Xueyi, MA Di

“…Stroke is a disease in which cerebral blood vessels are damaged by a variety of causes, producing focal or overall brain tissue damage. …”
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Changes in the intestinal microbiota induced by the postnatal environment and their association with hypertension by Patrizia Dardi, Camille Perella Coutinho, Sarah de Oliveira, Simone Aparecida Teixeira, Renaide Rodrigues Ferreira Gacek, Eduardo Purgatto, Marco Aurélio Ramirez Vinolo, Marcelo Nicolás Muscará, Luciana Venturini Rossoni

“…Moreover, decreased systolic blood pressure was observed in the SW group compared to the SS group in adulthood. …”
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The Predictive Value of Growth Differentiation Factor-15 in Recurrence of Atrial Fibrillation after Catheter Ablation by Ying Wei, Shuwang Liu, Haiyi Yu, Yuan Zhang, Wei Gao, Ming Cui, Lei Li

“…Clinical information about the patients was collected. Blood samples on the second morning of hospital admission and three months after RFCA were collected, and enzyme-linked immunosorbent assay (ELISA) was used to measure the concentration of GDF-15. …”
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