Is There a Nonlinear Relationship between Serum Uric Acid and Lipids in a Hypertensive Population with eGFR ≥30 ml/min/1.73 m2? Findings from the China Hypertension Registry Study... by Yu Yu, Xiao Huang, Minghui Li, Congcong Ding, Lihua Hu, Xiao Zhong, Wei Zhou, Tao Wang, Lingjuan Zhu, Huihui Bao, Xiaoshu Cheng

“…Evidence regarding the nonlinear relationship between serum uric acid (SUA) and blood lipids in Chinese population with hypertension is limited. …”
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Kaempferol protects against high-salt-induced hypertension and vascular endothelial injury by inhibiting ferroptosis through the ATF4/ACSL4 pathway by Qiuer Liang, Minghao Chen, Guangtian Chen, Pengli Xu, Lai Kwan Lam, Pengcheng Xie, Ting Xie, Wanqing Tu, Tianhao Liu, Xiaopeng Peng, Haoyao Yuan, Liguo Chen, Ya Xiao

“…Compared to ATF4+/−mice on a high-salt diet, ATF4+/−mice treated with Kae exhibited greater reductions in blood pressure and endothelial damage and more pronounced inhibition of ferroptosis. …”
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Lymphadenopathies: A Retrospective Study of Epidemiology, Characteristics, Diagnosis and Treatment Outcomes of Patients in a Tertiary Hospital in Mogadishu-Somalia by Kıratlı K, Bulut M, Ali MA, Aysin M, Ali AM, Mohamed Hirsi I, Bashir AM

“…It was determined that benign conditions, including tuberculosis were more common in pediatric group and younger adults (p< 0.001), and weight loss was a significant in terms of malignancy and tuberculosis (p< 0.001). White blood cell value (p< 0.001), erythrocyte sedimentation rate (p< 0.001), and C-reactive protein (p:0.001) revealed differences across the diagnostic groups.Conclusion: Almost two-thirds of patients were diagnosed with tuberculosis lymphadenitis. …”
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Sibling Species Composition and Susceptibility Status of Anopheles gambiae s.l. to Insecticides Used for Indoor Residual Spraying in Eastern Uganda by Julius Iga, Stephen Ochaya, Richard Echodu, Elizabeth A. Opiyo, Alex K. Musiime, Angella Nakamaanya, Geoffrey M. Malinga

“…Susceptibility tests were conducted on 2- to 5-day-old non-blood-fed adult female Anopheles that emerged using insecticide-impregnated papers with 0.1% bendiocarb and 0.25% pirimiphos-methyl following standard World Health Organization (WHO) insecticide susceptibility bioassays. …”
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Yiqi Juanshen decoction alleviates renal interstitial fibrosis by targeting the LOXL2/PI3K/AKT pathway to suppress EMT and inflammation by Kaiyue Tan, Jingwei Deng, Yi Liu, Yudi Zhang, Yu Xiong, Su Yuan, Jun Liu, Zhiwei Chen, Yuanyuan Liu, Wenfu Cao

“…YQJSD has been shown to effectively reduce serum creatinine and blood urea nitrogen levels, decrease extracellular matrix deposition, and down-regulate the expression of α-SMA, COL4α1, Fibronectin (FN). …”
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Association of pan-immune-inflammatory value with metabolic dysfunction-associated steatotic liver disease: findings from NHANES 2017–2020 by Lian-Zhen Huang, Ze-Bin Ni, Qi-Rong Yao, Wei-Feng Huang, Ji Li, Yan-Qing Wang, Jin-Yan Zhang

“…PIV was calculated based on blood count data. Weighted multivariable logistic regression was employed to calculate the odds ratio (OR) and 95% confidence interval (CI) to investigate the association of PIV and MASLD. …”
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Hubungan Kadar Profil Lipid dengan Kejadian Hipertensi pada Masyarakat Etnik Minangkabau di Kota Padang Tahun 2012 by Rahmat Feryadi, Delmi Sulastri, Husnil Kadri

“…Data was collected by interview to get respondent characteristics. Measurement of blood preasure waist and carried out by the WHO recommended and appointment value based on JNC VII. …”
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Study of pattern of lipid profile amongst type II diabetic patients of two major tribal populations of Tripura by Sagar Samrat Debbarma, Arunabha Dasgupta, Atanu Ghosh, Kanak Choudhury, Prithvijit Kole, Sonali Paul, Brainist Kalai, V. Saikumar

“…Also, 90 controls had lipid profile analysis performed along with blood sugar estimation. Results: In this study, 63 subjects were from the Tripuri population and the rest 27 were from the Reang community. …”
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Nutritional intake of micronutrient and macronutrient and type 2 diabetes: machine learning schemes by Mohammad Rashidmayvan, Amin Mansoori, Elahe Derakhshan-Nezhad, Davoud Tanbakuchi, Fatemeh Sangin, Maryam Mohammadi-Bajgiran, Malihehsadat Abedsaeidi, Sara Ghazizadeh, MohammadReza Mohammad Taghizadeh Sarabi, Ali Rezaee, Gordon Ferns, Habibollah Esmaily, Majid Ghayour-Mobarhan

“…Conclusion Machine learning models can identify T2D risk using questionnaires and blood samples. These have implications for electronic health records that can be explored further.…”
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Unlocking the Potential of Receptor-Based Approaches in Diabetes Treatment by Mohsina Patwekar, Faheem Patwekar, J. Pavan Kumar, P. Dharani Prasad, Nazia Malik, A. Venkata Badarinath, Prashanth Parupathi, Konatham Teja Kumar Reddy, Selvaraja Elumalai, Zainul Abedeen Ab Samad

“…Empagliflozin is a sodium-glucose co-transporter 2 (SGLT2) inhibitor with substantial promise in decreasing blood glucose levels, and providing cardiovascular and renal advantages. …”
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Alleviating effects and mechanisms of action of large-leaf yellow tea drinking on diabetes and diabetic nephropathy in mice by Guangshan Zhao, Jianyuan Teng, Ruixia Dong, Qiuyan Ban, Lian Yang, Kang Du, Yifei Wang, Hanlin Pu, Chung S. Yang, Zhe Ren

“…Results showed that LYT infusions (1/100 and 1/50, m/V) as drinking fluid for 4 weeks reduced diabetic polydipsia and polyuria, enhanced glucose tolerance and insulin sensitivity, and lowered fasting blood glucose level. The underlying mechanisms involve downregulation of gluconeogenesis (lower protein levels of TXNIP and FBP and enzyme activity of FBP), upregulation of lipid catabolism (higher protein levels of CPT-1α and PPARα), downregulation of lipogenesis (lower protein level of SREBP-1), and modification of the structure and abundance of gut microbiota to modulate metabolic homeostasis. …”
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The value of inflammation-related indicators in chemotherapy efficacy and disease-free survival of triple-negative breast cancer by Jie Zhu, Jiale Cheng, Yuyuan Ma, Ying Wang, Zhonghua Zou, Wenjie Wang, Haihua Shi, You Meng

“…Platelet-to-lymphocyte ratio (PLR) and immune inflammatory index (SII) were obtained from blood routine. Levels of Ki-67 expression were detected by immunohistochemistry (IHC). …”
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Optimizing Flammulina velutipes residue use: impact on health metrics and performance in three-yellow chickens by Yuanxiao Li, Yuanxiao Li, Dan Liu, Wang Li, Wang Li, Longmei Zhao, Pinghua Cao, Yanbo Ma, Yanbo Ma, Ke Ding, Cai Zhang, Cai Zhang, Ning Liu

“…The experiment lasted for 48 days. Blood samples were collected from the jugular vein on days 28 and 48 to determine serum biochemical indices. …”
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WT1 Peptide Cancer Vaccine for Patients with Hematopoietic Malignancies and Solid Cancers by Yoshihiro Oka, Akihiro Tsuboi, Olga A. Elisseeva, Hiroko Nakajima, Fumihiro Fujiki, Manabu Kawakami, Toshiaki Shirakata, Sumiyuki Nishida, Naoki Hosen, Yusuke Oji, Ichiro Kawase, Haruo Sugiyama

“…CD8+ WT1-specific CTLs were also detected in peripheral blood or tumor-draining lymph nodes of cancer patients. …”
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Increased NTPDase Activity in Lymphocytes during Experimental Sepsis by Claudia de Mello Bertoncheli, Carine Eloise Prestes Zimmermann, Jeandre Augusto dos Santos Jaques, Cláudio Alberto Martins Leal, Jader Betsch Ruchel, Bruna Cipolatto Rocha, Kelly de Vargas Pinheiro, Viviane do Carmo Gonçalves Souza, Daniel Roulim Stainki, Sônia Cristina Almeida Luz, Maria Rosa Chitolina Schetinger, Daniela Bitencourt Rosa Leal

“…After 12 hours of surgery, lymphocytes were isolated from blood and NTPDase activity was determined. It was also performed the histology of kidney, liver, and lung. …”
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Identification and Characterization of Genes Associated with Intestinal Ischemia-Reperfusion Injury and Oxidative Stress: A Bioinformatics and Experimental Approach Integrating Hig... by Xie Y, Yang M, Huang J, Jiang Z

“…Yongguo Xie,1,&ast; Mingpu Yang,2,&ast; Juanjuan Huang,3 Zongbin Jiang4 1Department of Anesthesiology, The Second Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, 530007, People’s Republic of China; 2General Surgery, The Second Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, 530007, People’s Republic of China; 3Department of Microbiology, School of Basic Medical Sciences, Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, 530021, People’s Republic of China; 4Department of Pain Medicine, The Second Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, 530007, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Juanjuan Huang, Department of Microbiology, School of Basic Medical Sciences, Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, 530021, People’s Republic of China, Email hjjcbw@163.com Zongbin Jiang, Department of Pain Medicine, The Second Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, 530007, People’s Republic of China, Email jiangzongbin@sr.gxmu.edu.cnPurpose: Intestinal ischemia-reperfusion injury (IIRI) occurs as a result of temporary blood flow interruption, leading to tissue damage upon reperfusion. …”
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Single-cell transcriptome atlas of peripheral immune features to Omicron breakthrough infection under booster vaccination strategies by Yuwei Zhang, Shanshan Han, Qingshuai Sun, Tao Liu, Zixuan Wen, Mingxiao Yao, Shu Zhang, Qing Duan, Xiaomei Zhang, Bo Pang, Zengqiang Kou, Xiaolin Jiang, Xiaolin Jiang, Xiaolin Jiang

“…IntroductionThe high percentage of Omicron breakthrough infection in vaccinees is an emerging problem, of which we have a limited understanding of the phenomenon.MethodsWe performed single-cell transcriptome coupled with T-cell/B-cell receptor (TCR/BCR) sequencing in 15 peripheral blood mononuclear cell (PBMC) samples from Omicron infection and naïve with booster vaccination.ResultsWe found that after breakthrough infection, multiple cell clusters showed activation of the type I IFN pathway and widespread expression of Interferon-stimulated genes (ISGs); T and B lymphocytes exhibited antiviral and proinflammatory-related differentiation features with pseudo-time trajectories; and large TCR clonal expansions were concentrated in effector CD8 T cells, and clonal expansions of BCRs showed a preference for IGHV3. …”
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Clinical comparison and genetic analysis in pheochromocytoma with primary aldosteronism by Xurong Mai, Mitsuhiro Kometani, Toshiaki Kato, Ko Aiga, Shigehiro Karashima, Daisuke Aono, Seigo Konishi, Koshiro Nishimoto, Kazuyoshi Hosomichi, Atsushi Watanabe, Yuko Noda, Yoshiyu Takeda, Takashi Yoneda

“…No significant differences were found in blood pressure, serum potassium levels, or plasma aldosterone concentrations between the two groups. …”
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Sexual Dimorphism for the Association between Vitamin D and Insulin Resistance in Chinese People by Bing Han, Qin Li, Ningjian Wang, Yi Chen, Chunfang Zhu, Yingchao Chen, Fangzhen Xia, Zhen Cang, Meng Lu, Ying Meng, Chi Chen, Yingli Lu

“…The serum levels of 25(OH)D, fasting blood glucose (FBG), fasting insulin, HbA1c, and other metabolic parameters were tested. …”
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Possible linking and treatment between Parkinson’s disease and inflammatory bowel disease: a study of Mendelian randomization based on gut–brain axis by Beiming Wang, Xiaoyin Bai, Yingmai Yang, Hong Yang

“…Then, pleiotropic analysis under the composite null hypothesis (PLACO) with functional mapping combined with annotation of genetic associations (FUMA) analysis were conducted to identify pleiotropic genes. Next, blood, brain and intestine expression quantitative trait locus (eQTL) were taken to perform drug-target MR finding common causal genes in two diseases. …”
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