Downregulation of the immunoproteasome subunit PSMB8 attenuates sepsis-associated acute kidney injury through the NF-κB pathway by Min Li, Wenjia Tong, Chao Dai, Guoping Lu, Danqun Jin, Fang Deng

“…PSMB8 knockdown substantially protected against renal injury by reducing blood urea nitrogen and creatinine levels and ameliorating inflammation. …”
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Waist Circumference, Body Mass Index, and Other Measures of Adiposity in Predicting Cardiovascular Disease Risk Factors among Peruvian Adults by K. M. Knowles, L. L. Paiva, S. E. Sanchez, L. Revilla, T. Lopez, M. B. Yasuda, N. D. Yanez, B. Gelaye, M. A. Williams

“…Compared to individuals with low-BMI and low-WC, men and women with high-BMI and high- WC had higher odds of elevated fasting glucose, blood pressure, TG, and reduced HDL, while only men in this category had higher odds of elevated CRP. …”
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Risk factors and machine learning prediction models for intrahepatic cholestasis of pregnancy by Yingchun Ren, Xiaoying Shan, Gengchao Ding, Ling Ai, Weiying Zhu, Ying Ding, Fuzhou Yu, Yun Chen, Beijiao Wu

“…Through univariable and lasso regression analysis, total bile acid, gamma-glutamyl transferase, multiple pregnancy, lymphocyte percentage, hematocrit, neutrophil percentage, prothrombin time, Aspartate aminotransferase, red blood cell count, lymphocyte count and platelet count were identified as risk factors of ICP. …”
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Machine learning models reveal microbial signatures in healthy human tissues, challenging the sterility of human organs by Anargyros Skoulakis, Anargyros Skoulakis, Giorgos Skoufos, Giorgos Skoufos, Armen Ovsepian, Armen Ovsepian, Artemis G. Hatzigeorgiou, Artemis G. Hatzigeorgiou

“…To validate the findings, we analyzed 38 healthy living tissue samples (samples from healthy tissues obtained from living individuals, not deceased) from an independent study, as the GTEx samples were derived from post-mortem biopsies.ResultsTissue-specific microbial signatures were identified in 11 out of the 28 tissues while the signatures for 8 tissues (Muscle, Heart, Stomach, Colon tissue, Testis, Blood, Liver, and Bladder tissue) demonstrated resilience to in silico contamination. …”
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Serum N-Glycan Profiling Predicts Prognosis in Patients Undergoing Hemodialysis by Shingo Hatakeyama, Maho Amano, Yuki Tobisawa, Tohru Yoneyama, Megumi Tsushima, Kazuko Hirose, Takahiro Yoneyama, Yasuhiro Hashimoto, Takuya Koie, Hisao Saitoh, Kanemitsu Yamaya, Tomihisa Funyu, Shin-Ichiro Nishimura, Chikara Ohyama

“…To evaluate the independent predictors for prognosis, patients' background, blood biochemistry, and N-glycans intensity were analyzed using Cox regression multivariate analysis. …”
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Association between Helicobacter pylori Infection and Occurrence of Anemia among Pregnant Women Attending Antenatal Care in Kulito Health Center, Halaba Zone, South Ethiopia, 2018 by Bahredin Abdella, Mohammed Ibrahim, Iyasu Tadesse, Kalkidan Hassen, Mekonnin Tesfa

“…Anemia in pregnancy is defined as a hemoglobin (Hb) concentration of less than 11 grams (gm)/deciliter (dl) in venous blood. Globally, it affects 1.62 billion people. …”
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Estimation of Abbreviated Cyclosporine A Area under the Concentration-Time Curve in Allogenic Stem Cell Transplantation after Oral Administration by Hanene ELjebari, Nadia Ben Fradj, Issam Salouage, Emna Gaies, Sameh Trabelsi, Nadia Jebabli, Mohamed Lakhal, Tarek Ben Othman, Anis Kouz

“…CsA LSSs were developed and validated from 60 ASCT patients via multiple linear regressions. All whole-blood samples were analyzed by fluorescence polarization immunoassay (FPIA-Axym). …”
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Non-pharmacological interventions for primary hypertension: a systematic review and network meta-analysis protocol by Tao Xu, Fan-rong Liang, Qifu Li, Taipin Guo, Ziwen Chen, Yun-Jie Shu, Xueli Zhou

“…Introduction Primary hypertension (PH) affects over one billion individuals globally, yet less than 30% achieve controlled blood pressure (BP) with medication. Many patients require a combination of multiple medications to reach targets, but adverse effects and financial burdens undermine adherence. …”
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Effect of Multimodal App-Based Interventions on Glycemic Control in Patients With Type 2 Diabetes: Systematic Review and Meta-Analysis by Emma Bodner, Lena Roth, Kathleen Wiencke, Christian Bischoff, Peter EH Schwarz

“…The outcome of interest was a reduction in glycated hemoglobin (hemoglobin A1c [HbA1c]; long-term blood glucose measurements). MethodsA systematic literature search was conducted in the literature bases PubMed, LIVIVO, and Cochrane, based on the predefined PICO (Population; Intervention; Control; Outcome) scheme. …”
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The effects of low-carbohydrate diet on glucose and lipid metabolism in overweight or obese patients with T2DM: a meta-analysis of randomized controlled trials by Wende Tian, Shuyu Cao, Yongxin Guan, Zihao Zhang, Qiyu Liu, Jianqing Ju, Ruixi Xi, Ruina Bai

“…Weight loss, reduced BMI, lower diastolic blood pressure, and decreased waist circumference were additional benefits.ConclusionLow-carbohydrate diets may enhance glycemic control and lipid profiles in overweight or obese T2DM patients, warranting consideration in T2DM management. …”
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Psychological and autonomous nervous system features of functional gastric dyspepsia and irritable bowel syndrome, duloxetine treatment efficacy by A. P. Pogromov, G. M. Dyukova, M. L. Leonova

“…Bristol stool scale (Rome-III 2006), laboratory and instrumental methods: upper endoscopy, colonoscopy, morphological study, Helicobacter pylori breath test, routine blood biochemical tests were used. Analysis of the «associated» or extraintestinal symptoms was carried out by Screening for Somatoform Symptoms questionnaire – SOMS-2 (Rief, 1996). …”
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Crocin Monotherapy in Non-Central Diabetic Macular Edema by Mojtaba Mojtahedzadeh, Masoud Reza Manaviat, Seyed Reza Mirjalili, Adeleh Sahebnasagh, Mohammad Khan Ardani, Farahnaz Hoseinzadeh, Fatemeh Saghafi

“…Central subfield thickness (CST), visual acuity, fasting blood sugar (FBS), and HbA1c were assessed once before and once after the study (day 90). …”
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Combination of autoimmune hepatitis to non-alcoholic steatohepatitis (Clinical case) by A. A. Driga, M. V. Mayevskaya, V. T. Ivashkin

“…In physical status asthenia, body mass index of 49,8 kg/m2, subicteric sclerae drawn attention. Blood pressure was 130/90 mm Hg, patient had hepatomegaly (+5 cm). …”
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AMH Is a Good Predictor of Metabolic Risk in Women with PCOS: A Cross-Sectional Study by Miaoxian Ou, Pei Xu, Han Lin, Kaichi Ma, Mingxing Liu

“…There was no statistically significant relationship between blood pressure, serum glucose profile, or lipid levels and AMH. …”
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DOCK4 Is a Platinum-Chemosensitive and Prognostic-Related Biomarker in Ovarian Cancer by Qianqian Zhao, Jie Zhong, Ping Lu, Xiao Feng, Ying Han, Chenqi Ling, Wenke Guo, Weijin Zhou, Fudong Yu

“…Meanwhile, DOCK4 is detected in plasma and enriched in neutrophil and monocyte cells of the blood. We further found that there were significant correlations between DOCK4 expression and the levels of CD4+ T cell infiltration, dendritic cell infiltration, and neutrophil infiltration in OV. …”
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Endothelial tip-cell position, filopodia formation and biomechanics require BMPR2 expression and signaling by Christian Hiepen, Mounir Benamar, Jorge Barrasa-Fano, Mar Condor, Mustafa Ilhan, Juliane Münch, Nurcan Hastar, Yannic Kerkhoff, Gregory S. Harms, Thorsten Mielke, Benjamin Koenig, Stephan Block, Oliver Rocks, Salim Abdelilah-Seyfried, Hans Van Oosterwyck, Petra Knaus

“…Abstract Blood vessel formation relies on biochemical and mechanical signals, particularly during sprouting angiogenesis when endothelial tip cells (TCs) guide sprouting through filopodia formation. …”
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The prevalence of small airways disease and association with handgrip strength in young Hispanic farmworkers by Yutong Dong, Pam Cromer, Debbie Layman, Michelle Altvater, Yanbin Dong, Haidong Zhu

“…Smoking, body mass index, blood pressures, hemoglobin A1C and lipids were not predictors in either model. …”
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The Transcultural Diabetes Nutrition Algorithm: A Canadian Perspective by Réjeanne Gougeon, John L. Sievenpiper, David Jenkins, Jean-François Yale, Rhonda Bell, Jean-Pierre Després, Thomas P. P. Ransom, Kathryn Camelon, John Dupre, Cyril Kendall, Refaat A. Hegazi, Albert Marchetti, Osama Hamdy, Jeffrey I. Mechanick

“…Assessing glycaemic index (GI) (the ranking of foods by effects on postprandial blood glucose levels) and glycaemic load (GL) (the product of mean GI and the total carbohydrate content of a meal) will be a central part of the Canadian tDNA and complement nutrition therapy by facilitating glycaemic control using specific food selections. …”
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Associations of macrosomia with sociodemographic, anthropometric, lifestyle factors and perinatal outcomes in Southwest Nigeria by Ikeola A. Adeoye, Joshua I. Fakorede, Mobolaji M. Salawu, Kofoworola I. Adediran

“…Explanatory variables were sociodemographic, anthropometric, and maternal lifestyle factors. Maternal blood glucose and lipids were assessed between 24 and 28 weeks’ gestation. …”
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A clinical decision model for failed adrenal vein sampling in primary aldosteronism by Sophie N. M. ter Haar, Sofie J. van Goor, Eleonora P. M. Corssmit, Arian R. van Erkel, Bartholomeus E. P. B. Ballieux, Olaf M. Dekkers, Olaf M. Dekkers, Michiel F. Nijhoff

“…This study aimed to develop a clinical decision model using only measurements from the left adrenal vein (LAV) and peripheral blood (IVC) to differentiate between PA subtypes.MethodsThe retrospective cohort study included 54 PA patients who underwent bilaterally successful AVS. …”
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