ALKBH5 alleviates lower extremity arteriosclerosis by regulating ITGB1 demethylation and influencing macrophage polarization by Zeyu Guan, Xiaogao Wang, Chao Xu, Ran Lu

“…Methods: The m6A methylation levels in peripheral blood mononuclear cells (PBMCs) of patients with lower extremity atherosclerosis was investigated using the Dot blot method. …”
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Plasma S100A8/A9 level predicts response to immune checkpoint inhibitors in patients with advanced non-small cell lung cancer by Tadahiro Kuribayashi, Rie Kinoshita, Kiichiro Ninomiya, Go Makimoto, Toshio Kubo, Kammei Rai, Eiki Ichihara, Katsuyuki Hotta, Masahiro Tabata, Yoshinobu Maeda, Katsuyuki Kiura, Shinichi Toyooka, Masakiyo Sakaguchi, Kadoaki Ohashi

“…Abstract Blood-based predictive markers for the efficacy of immune checkpoint inhibitors (ICIs) have not yet been established. …”
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Longitudinal Associations between Obesity, Inflammation, and the Incidence of Type 2 Diabetes Mellitus among US Black and White Adults in the CARDIA Study by Sharon H. Jackson, Anna Bellatorre, Timothy McNeel, Anna María Nápoles, Kelvin Choi

“…Diabetes status was determined in wave 8 based on self-report, blood glucose level, and anti-hyperglycemic medication use in conjunction with a homeostatic model assessment-based classification for distinguishing diabetes subtype. …”
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Effects of plant- and animal-based-protein meals for a day on serum nitric oxide and peroxynitrite levels in healthy young men by Tomoko Kaneko, Masaki Yoshioka, Futo Kawahara, Natsumi Nishitani, Shoya Mori, Jiyeon Park, Takashi Tarumi, Keisei Kosaki, Seiji Maeda

“…Plant-based-protein meals contained no animal protein. Blood samples were collected in the morning after overnight fasting before and after the test meals consumption. …”
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Nursing of a patient with essential hypertension and severe anxiety treated with Traditional Chinese Medicine meridian-collateral measuring system combined with auricular acupoint... by ZHAO Jiaying (赵佳莹), ZHANG Shuqi (张树琦), YU Juan (于娟), HAO Yangyang (郝杨杨), ZHANG Xueyuan (张学媛), GUO Yanbing (郭雁冰), SONG Xueping (宋雪苹)

“…By testing the twelve meridians of the patients through the Meridian-Collateral measuring instrument, the auricular acupoint pressing therapy by syndrome differentiation, in combination with daily life guidance, emotional care, psychological counseling and health education, were carried out to reduce blood pressure, relieve anxiety, and improve the quality of life of the patient. …”
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Pathogenic and periodontal bacteria may contribute to the fatal outcome of critically ill elderly COVID-19 patients by L. Johana Madroñero, Eliana P. Calvo, Carolina Coronel-Ruiz, Myriam L. Velandia-Romero, María Angélica Calderón-Peláez, Jhann A. Arturo, Adriana P. Franco-Rodríguez, Ricardo Gutiérrez-Pérez, Lady S. López, Félix G. Delgado, Sigrid J. Camacho-Ortega, Lilia J. Bernal-Cepeda, Sonia P. Bohórquez, Jaime E. Castellanos

“…Airway samples were collected and the 16 S rRNA variable regions V3-V4 were amplified and sequenced using the Illumina MiSeq platform. Elevated levels of blood urea nitrogen, creatinine and lactate dehydrogenase, and higher frequencies of cardiovascular disease, diabetes mellitus and renal disease were observed in patients with a fatal outcome. …”
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Efficacy of traditional Chinese medicine Cordyceps sinensis as an adjunctive treatment in patients with renal dysfunction: a systematic-review and meta-analysis by Fenfang Wu, Chunhua Xu, Xinlei Si, Fei He, Kang Xu, Yu Zhang, Shan Lin

“…On the other hand, C. sinensis significantly reduced patients’ blood creatinine levels, shortened the oliguria period, and increased urine osmolality, indicating it can improve the function of glomeruli and renal tubules.ConclusionOur results indicate that C. sinensis can be considered a dependable clinical treatment for individuals with RD. …”
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The influencing factors of the erythropoietin resistance index and its association with all-cause mortality in maintenance hemodialysis patients by Xinju Zhao, Liangying Gan, Fan Fan Hou, Xinling Liang, Xiaonong Chen, Yuqing Chen, Zhaohui Ni, Li Zuo

“…Multivariate logistic regression showed that dialysis vintage (OR 0.957, 95% CI: 0.929–0.986), white blood cells (OR 0.900, 95% CI: 0.844–0.960), high flux dialyzer use (OR 0.866, 95% CI: 0.755–0.993), body mass index (OR 0.860, 95% CI: 0.828–0.892), males (OR 0.708, 95% CI: 0.625–0.801), and albumin (OR 0.512, 95% CI: 0.389–0.673) had a negative association with high ERI baseline (all p < 0.05). …”
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Circulating Tumor DNA Detection for Recurrence Monitoring of Stage I Non‐Small Cell Lung Cancer Treated With Microwave Ablation by Lin Cheng, Sheng Xu, Yu‐feng Wang, Sheng‐wei Li, Bin Li, Xiao‐Guang Li

“…Methods We recruited 43 patients with inoperative stage I NSCLC, all of whom underwent biopsy‐synchronous microwave ablation (MWA). Peripheral blood samples were collected at baseline (n = 43), within 1 h post‐MWA (n = 28), and at the landmark time point (n = 26) for MRD detection. …”
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Investigation of a Novel Noninvasive Risk Analytics Algorithm With Laboratory Central Venous Oxygen Saturation Measurements in Critically Ill Pediatric Patients by Sarah A. Teele, MD, MSHPEd, Avihu Z. Gazit, MD, Craig Futterman, MD, William G. La Cava, PhD, David S. Cooper, MD, MPH, MBA, Steven M. Schwartz, MD, MS, Joshua W. Salvin, MD, MPH

“…The central venous oxygen saturation (Svo2) enables an estimate of cardiac output yet obtaining these clinical data requires invasive procedures and repeated blood sampling. Interpretation remains subjective and vulnerable to error. …”
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T-cell immune status in patients with acute exacerbation of chronic obstructive pulmonary disease: a case-control study by Xiao-feng Xiong, Xiao-feng Xiong, Min Zhu, Min Zhu, Hong-xia Wu, Zuo-hong Wu, Li-li Fan, De-yun Cheng

“…The distribution of T cell subsets in peripheral blood of AECOPD, SCOPD, and healthy controls (HCs) was measured using multi-color flow cytometry, and the functional status was analyzed by additional staining of activation markers.ResultsA total of 43 HCs, 43 SCOPD patients, and 64 AECOPD patients were evaluated. …”
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The systemic oxidative stress index predicts clinical outcomes of esophageal squamous cell carcinoma receiving neoadjuvant immunochemotherapy by Jifeng Feng, Jifeng Feng, Liang Wang, Xun Yang, Qixun Chen, Qixun Chen

“…For prognostic prediction, a risk categorization method based on recursive partitioning analysis (RPA) was also created.ResultsFour SOS-related indicators, including albumin, creatinine, blood urea nitrogen, and direct bilirubin, were used to establish the SOSI. …”
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Molecular Detection of Anaplasma spp. and Ehrlichia spp. in Ruminants from Twelve Provinces of China by Haixiang Qiu, Patrick John Kelly, Jilei Zhang, Qinghua Luo, Yi Yang, Yongjiang Mao, Zhangping Yang, Jing Li, Hongzhuan Wu, Chengming Wang

“…There is little information on anaplasmosis and ehrlichiosis in ruminants in China. 16S rRNA FRET-qPCRs were used to screen convenience whole blood samples from 2,240 domestic ruminants in 12 provinces of China for Anaplasma spp. and Ehrlichia spp. …”
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A study of the clinico-demographical profile of different dengue serotypes circulating in a Southern district of West Bengal, India by Sayani Bose, Feradica D Laloo, Partha Pratim Maity, Anirban Bhaduri

“…Materials and Methods: This study was conducted at the Department of Microbiology at Tamralipto Government Medical College and Hospital, East Midnapore, West Bengal. Blood collected from patients suffering from fever <5 days was tested for Dengue NS1. …”
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Relationship of monocyte to high-density lipoprotein ratio (MHR) and other inflammatory biomarkers with sarcopenia: a population-based study by Zhiwei Xue, Jian Cao, Jianhui Mou, Rui Wang, Peng Liu

“…Abstract Objectives In previous studies, several inflammatory biomarkers derived from complete blood cell counts (CBC), such as systemic immune inflammation index (SII), neutrophil-to-lymphocyte ratio (NLR), and non‑high‑density lipoprotein cholesterol to high‑density lipoprotein cholesterol ratio (NHHR) have been identified as predictors of sarcopenia. …”
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De Novo Acute Myeloid Leukemia with Combined CBFB-MYH11 and BCR-ABL1 Gene Rearrangements: A Case Report and Review of Literature by Venkata Rakesh Sethapati, Ra’ed Jabr, Leyla Shune, Wissam El Atrouni, Patrick R. Gonzales, Wei Cui, Shivani Golem

“…We present a case of a 55-year-old male with elevated white blood cell count. Bone marrow evaluation and flow cytometry analysis were compatible with AML with monocytic features. …”
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Risk factors for renal insufficiency and survival implications after radical nephrectomy and thrombectomy in renal cell carcinoma with tumor thrombus: a systematic review by Zhigao Huang, Zhuo Liu, Lin Zhuo, Xin Ma, Zhenbin Jiang, Kewei Chen, Jiyuan Chen, Yuxuan Li, Guoliang Wang, Xiaojun Tian, Hongxian Zhang, Lei Liu, Lulin Ma, Kai Hong, Shudong Zhang

“…Necessary managements like supplying blood volume, diuretic therapy and renal replacement therapy should be applied. …”
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A multifunctional mesoporous silica drug delivery nanosystem that ameliorates tumor hypoxia and increases radiotherapy efficacy by Yanhong Chu, LiFeng Wang, Yaohua Ke, Xiaoyu Feng, Wenmei Rao, Wei Ren, Kai Xin, Yan Wang, Lixia Yu, Baorui Liu, Qin Liu

“…Tumor cells treated with RT combined with these nanoparticles displayed reduced oxidative stress, alleviated hypoxia, and normalized blood vessel formation. Notably, all mice in the RT + PD-1 + MSN@R837-Mn/ZnO2 group achieved complete tumor regression with extended survival. …”
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Cardiac Resynchronization Therapy Reduces Metaboreflex Contribution to the Ventilatory Response in Heart Failure Population by Jérémie Jaussaud, Laurie Aimable, Pierre Bordachar, Pierre Dos Santos, Laurent Barandon, Philippe Ritter, Raymond Roudaut, Hervé Douard

“…RCO was achieved by inflation of bilateral upper thigh tourniquets 30 mmHg above peak systolic blood pressure during 3 minutes after peak exercise. …”
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Trends and contributors of complete continuum of maternal healthcare service utilization in Ethiopia: a multivariate decomposition analyses by Ayal Debie, Molla M. Wassie, Claire T. Roberts, Murthy N. Mittinty, Annabelle Wilson, Jacqueline H. Stephens

“…As such, equalizing the number of women who attended school at secondary level or higher, had television, initiated antenatal care (ANC) visits in the first trimester, were aware of pregnancy-related complications, delivered by caesarean section for their most recent childbirth, were from poorer households, gave urine and blood samples during pregnancy in 2019–2011 levels, would reduce the differences between 2011 to 2019 in complete CMHS utilization. …”
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