Woxuanzhongzhou formula improves DHEAS and high-fat diet-induced IR and anovulatory mice via AMPK/PGC1- α/Irisin pathway by Haijuan Liu, Guohua Wang, Conglu Sui, Yanan Guo, Xiangyu He

“…Following model induction, metformin and WXZZ were administered by gavage. Body weight, fasting blood glucose (FBG), fasting insulin (FINS) levels, the homeostatic model assessment of insulin resistance (HOMA-IR), and gonadal hormones were measured. …”
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The Role of Physical Activity in Reducing Endometriosis Pain by Emilia Bąk, Daria Michałka, Natalie Papachristoforou, Zuzanna Gałuszka, Monika Makar, Tomasz Bartuś, Żaneta Góra, Justyna Głowacka, Aleksandra Kocjan, Radosław Chmiel

“…Research findings indicate that regular physical exercise of varying intensity can provide benefits by reducing inflammation, improving pelvic blood flow, and reducing muscle tension. The impact of physical activity on the hormonal system, including the modulation of endorphin levels and the endocannabinoid system, may contribute to pain relief. …”
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Clinical characteristics and risk factors of Clostridioides difficile infection in children with diarrhoea by Ning Wang, Kun Jiang, Jinyue Huang, Mengzhu Hou, Lu Wang, Wei Wang, Yulian Fang

“…ObjectiveTo investigate the clinical characteristics and risk factors of Clostridioides difficile infection (CDI) in children with diarrhea, and to provide evidence for the clinical prevention and treatment of CDI.MethodsThe clinical data of 192 children with diarrhoea suspected of CDI admitted from August 2020 to March 2023 were retrospectively analysed and divided into two groups according to whether CDI occurred, and the clinical characteristics and risk factors of the two groups were analysed statistically.ResultsThere were 85 cases of CDI in children with diarrhoea, 60 males (70.6%) and 25 females (29.4%), with a male to female ratio of 2.4:1; clinical manifestations were mostly fever, diarrhoea, abdominal pain, vomiting and blood in stool, with no statistically significant differences compared to the non-infected group. …”
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Role of serum sodium on heart, anemia, and diabetes patients by Mahashweta Das, Sunit Kumar Medda, Shipra Banik, Rabindra Nath Das

“…It is derived herein that mean SNa is positively associated with the marginal effects of platelets count (PLC) (P = 0.0019), anemia status (ANS) (P = 0.1053) (partially), creatinine phosphokinase (CRP) (P = 0.0462), smoking habit (SMH) (P= 0.1017), SEX (P = 0.0029), and the joint interaction effects (JIEs) of ejection fraction (EJF) and the status of high blood pressure (HBP), i.e., EJF*HBP (P = 0.1398); ANS and death event (DEE), i.e., ANS*DEE (P = 0.0009); age and time to follow-up (TTF), i.e., AGE*TTF (P = 0.0700); age and serum creatinine (SEC), i.e., AGE*SEC (P = 0.0901); EJF and SEC, i.e., EJF*SEC (P = 0.0044); and CRP and TTF, i.e., CRP*TTF (P = 0.0021). …”
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Sociodemographic and lifestyle predictors of incident hospital admissions with multimorbidity in a general population, 1999–2019: the EPIC-Norfolk cohort by Kay-Tee Khaw, Robert Luben, Shabina Hayat, Nicholas Wareham, Paul P Pharoah

“…In the subset free of the most serious diseases at baseline, current smoking (OR 1.86, 95% CI 1.60 to 2.15), body mass index >30 kg/m² (OR 1.48, 95% CI 1.30 to 1.70) and physical inactivity (OR 1.16, 95% CI 1.04 to 1.29) were positively associated and plasma vitamin C (a biomarker of plant food intake) per SD increase (OR 0.86, 95% CI 0.81 to 0.91) inversely associated with incident 10-year multimorbidity after multivariable adjustment for age, sex, social class, education, alcohol consumption, systolic blood pressure and cholesterol. Results were similar when re-examined for a further time period in 2009–2019.Conclusion Age, male sex and potentially modifiable lifestyle behaviours including smoking, body mass index, physical inactivity and low fruit and vegetable intake were associated with increased risk of future incident hospital admissions with multimorbidity.…”
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Glycemic Management of Patients with Hospital Hyperglycemia: A Retrospective Cohort Study on Adults Admitted in the Non-ICU Wards by Zheng R, Zeng X, Shen R, Wang Y, Liu J, Zhang M

“…Ruoxuan Zheng,1,2 Xiangman Zeng,1 Ruiting Shen,1 Yueqiu Wang,1 Jing Liu,1,3 Mingchen Zhang1 1Department of Endocrinology and Metabolism, Ningbo No.2 hospital, Ningbo, Zhejiang Province, People’s Republic of China; 2School of Medicine, Ningbo University, Ningbo, Zhejiang Province, People’s Republic of China; 3Cixi Biomedical Research Institute, Wenzhou Medical University, Ningbo, Zhejiang Province, People’s Republic of ChinaCorrespondence: Mingchen Zhang, Department of Endocrinology and Metabolism, Ningbo No.2 hospital, Ningbo, Zhejiang Province, People’s Republic of China, Email zhangmc1015@163.comPurpose: To identify the key populations for Hospital Hyperglycemia (HH) management and to assess recent trends in the management of HH.Patients and Methods: This retrospective study analyzed 1,136,092 point-of-care blood glucose (POC-BG) measurements from 40,758 patients with HH in non-intensive care unit (non-ICU) wards at Ningbo No.2 hospital from January 2020 to December 2022. …”
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The Treg/Th17 Imbalance in Patients with Obstructive Sleep Apnoea Syndrome by Jin Ye, Hui Liu, Gehua Zhang, Peng Li, Zhiyuan Wang, Shaotong Huang, Qintai Yang, Yuan Li

“…Our purpose is to assess the pattern of Th17 cells and CD4+CD25+Foxp3+ regulatory T (Treg) cells in peripheral blood of patients with OSAS. Fourty-four OSAS men and 20 healthy volunteers were enrolled. …”
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Effect of adipose tissue deposition on insulin resistance in middle‐aged and elderly women: Based on QCT and MRI mDIXON‐Quant by Ying Liu, Lei Gao, Mengfei Wu, Boyang Yang, Dongxue Ren, Zekun Zhang, Wei Zhang, Yan Wang

“…Methods All participants underwent quantitative computed tomography (QCT) and MRI mDIXON‐Quant examination and calculated the TyG index based on the fasting blood glucose and triacylglycerol. Bounded by the median TyG index, all participants were divided into low TyG group and high TyG group. …”
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Adipose tissue-derived microRNA-450a-5p induces type 2 diabetes mellitus by downregulating DUSP10 by Jiaojiao Zhu, Yanting Hou, Wei Yu, Jingzhou Wang, Xiaolong Chu, Xueting Zhang, Huai Pang, Dingling Ma, Yihan Tang, Menghuan Li, Chenggang Yuan, Jianxin Xie, Cuizhe Wang, Jun Zhang

“…Here, we confirmed that visceral adipose tissue and serum microRNA-450a-5p content increased under obesity and T2DM, and it was significantly positively associated with fasting blood glucose, triglycerides, cholesterol, low-density lipoproteins-cholesterol levels of the subjects. …”
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Exosomes derived from hUC-MSCs exhibit ameliorative efficacy upon previous cesarean scar defect via orchestrating β-TrCP/CHK1 axis by Xiaoling Zeng, Yuan Liao, Dan Huang, Jing Yang, Zhihua Dai, Zhengyong Chen, Xin Luo, Han Gong, Shengwen Huang, Leisheng Zhang

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Investigating male factors and their relationships with reproductive health outcomes: a case-control study protocol for Towards Optimal Fertility, Fathering, and Fatherhood studY (... by Fabian Yap, See Ling Loy, Yin Bun Cheung, Jerry Kok Yen Chan, Keith Godfrey, Chee Wai Ku, Jun Wei Pek, Melissa D/O Tharmalingam Durgahshree, Melinda Chan, Yie Hou Lee

“…Male and female participants will complete questionnaires on sociodemographics, general health and lifestyle factors, and their anthropometry and body fat composition will be measured. Blood and semen samples from the male participants will be collected for biochemical, molecular and semen analyses. …”
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Comparison of Ziziphus jujube Mill. Syrup versus polyethylene glycol in children with functional constipation: a randomized clinical trial by Fatemeh Keihanian, Shohreh Maleknejad, Amin Saeidinia, Soheil Soltanipour, Amir Pirooz

“…At the beginning and end of the study, liver and kidney function tests and blood sugar levels were checked. Data were analyzed using SPSS software version 19 at a significance level of 0.05. …”
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Developing a Transparent Anaemia Prediction Model Empowered With Explainable Artificial Intelligence by Muhammad Sajid Farooq, Muhammad Hassan Ghulam Muhammad, Oualid Ali, Zahid Zeeshan, Muhammad Saleem, Munir Ahmad, Sagheer Abbas, Muhammad Adnan Khan, Taher M. Ghazal

“…The worldwide health epidemic of anaemia which is a condition with low levels of red blood cells or haemoglobin requires accurate prediction models to act promptly and improve patient outcomes because it is widespread and has different causes. …”
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The relationship between gallstone disease and the genetic variants of the sterol transporter adenosine triphosphate–binding cassette G8 and G5 in Egyptians by Menna A. Hassan, Salwa M. Abo El-Khair, Noha M. Mesbah, Dina M. Abo-Elmatty, Asmaa R. Abdel-Hamed

“…Various laboratory investigations were measured using enzymatic colorimetric methods, and hematology analyzer was used for the whole blood count test. Results Between patients with gallstone disease and healthy controls, there were statistically significant differences in the distribution of these genes polymorphisms. …”
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Phenotypic Characterization and Antibiotic Resistance Patterns of Extended-Spectrum β-Lactamase- and AmpC β-Lactamase-Producing Gram-Negative Bacteria in a Referral Hospital, Saudi... by Mutasim E. Ibrahim, Mohammed Abbas, Abdullah M. Al-Shahrai, Bahaeldin K. Elamin

“…GNB (n = 311) were recovered from patients’ clinical specimens including sputum, urine, wound pus, blood, tracheal aspirates and high vaginal swabs, umbilical discharge, eye discharge, and cerebrospinal fluids. …”
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Prevalence and risk factors associated with prehypertension in Shunde District, southern China by Yuli Huang, Yunzhao Hu, Xiaoyan Cai, Wenke Qiu, Changhua Liu, Dingji Zhu, Jinghai Hua, Yanxian Wu, Dingli Xu

“…Objective To explore the prevalence and combined cardiovascular risk factors of prehypertension in southern China.Design A retrospective study; the logistic regression model was used to find the risk factors of prehypertension.Setting The study was conducted in Shunde District, southern China, using the community-based health check-up information.Participants Participants aged ≥35 years with complete health check-up information data between January 2011 and December 2013 were enrolled and divided into hypertension, prehypertension and optimal blood pressure (BP) groups. Prehypertension was further divided into low-range (BP 120–129/80–84 mm Hg) and high-range (BP 130–139/85–89 mm Hg) subgroups.Outcome measures The prevalence of prehypertension and the combined cardiovascular risk factors within the prehypertensive subgroups.Results Of the 5362 initially reviewed cases (aged ≥35 years), 651 were excluded because of missing data. …”
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The role of endothelial cell-related gene COL1A1 in prostate cancer diagnosis and immunotherapy: insights from machine learning and single-cell analysis by Gujun Cong, Jingjing Shao, Feng Xiao, Haixia Zhu, Peipei Kang

“…Targeting endothelial cells and related signaling pathways can improve the effectiveness of immunotherapy by normalizing tumor blood vessels and promoting immune cell infiltration. …”
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Factors associated with risk analysis for asymptomatic left ventricular diastolic dysfunction in nondialysis patients with chronic kidney disease by Yajuan Gao, Shengnan Chen, Jiani Fu, Cui Wang, Yali Tang, Yongbai Luo, Xiaozhen Zhuo, Xueying Chen, Yan Shen

“…The multivariate logistic regression analysis revealed that increased age (OR 1.237; 95% confidence interval (CI) 1.108–1.381, per year), diabetic nephropathy (DN) and hypertensive nephropathy (HTN) (OR 25.000; 95% CI 1.355–48.645, DN and HTN vs chronic interstitial nephritis), progression of CKD stage (OR 2.785; 95% CI 1.228–6.315, per stage), increased mean arterial pressure (OR 1.154; 95% CI 1.051–1.268, per mmHg), increased urinary protein (OR 2.825; 95% CI 1.484–5.405, per g/24 h), and low blood calcium (OR 0.072; 95% CI 0.006–0.859, per mmol/L) were factors associated with risk for ALVDD in nondialysis CKD patients after adjusting for other confounding factors. …”
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Studying sex differences in responses to fibroblast growth factor 21 administration in obese mice consuming a sweet-fat diet by N. М. Bazhan, T. V. Jakovleva, A. Yu. Kazantseva, N. E. Kostina, P. E. Orlov, N. Yu. Balybina, K. О. Baranov, E. N. Makarova

“…Body weight, weights of different types of food, blood parameters, glucose tolerance, gene and protein expression in the liver, gene expression in the white, brown adipose tissues, and the hypothalamus were assessed. …”
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Tissue Distribution of Total Flavonoids Extracts of Drynariae Rhizoma in Young and Old Rats by UPLC–MS/MS Determination by Yue Zhang, Xia Lei, Hongdan Xu, Guoliang Liu, Yeqiu Wang, Huifeng Sun, Fang Geng, Ning Zhang

“…Tissues distribution showed neoeriocitrin, luteolin-7-O-β-D-glucoside, astragalin, naringin, and naringenin could transfer across the blood-brain barrier, which may form the basis of TFDR entering the brain to play an anti-AD role. …”
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