Altered cortical activation patterns in post-stroke patients during walking with two-channel functional electrical stimulation: a functional near-infrared spectroscopy observationa... by Sheng Xu, Shizhe Zhu, Minyao Li, Tianjiao Zhang, Qinglei Wang, Youxin Sui, Ying Shen, Kan Chaojie, Ren Zhuang, Chuan Guo, Tong Wang, Lan Zhu, Lan Zhu

“…This observational study was conducted to discern distinct activation patterns in 19 stroke patients during sessions with and without FES, while using functional near-infrared spectroscopy (fNIRS) to monitor changes in blood oxygen levels. Our findings revealed only a significant reduction in ΔOxy-Hb in the contralesional pre-motor cortex (z = −2.803, p = 0.005) during the FES-on walking sessions compared to the FES-off sessions. …”
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Causal Association Between Obstructive Sleep Apnea and Migraine: A Bidirectional Mendelian Randomization Study by Wang YP, Wei HX, Hu YY, Zhang C, Niu YM

“…Yu-Pei Wang,1,* Hui-Xia Wei,2,* Yuan-Yuan Hu,3 Chao Zhang,4 Yu-Ming Niu3– 5 1Department of Stomatology, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei, 442000, People’s Republic of China; 2Department of Anesthesiology, Taihe Hospital, Hubei University of Medicine, Shiyan, 442000, People’s Republic of China; 3Department of Stomatology, Gongli Hospital of Shanghai Pudong New Area, Shanghai, People’s Republic of China; 4Center for Evidence-Based Medicine and Clinical Research, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei, 442000, People’s Republic of China; 5Hubei Key Laboratory of Embryonic Stem Cell Research, Hubei Provincial Clinical Research Center for Umbilical Cord Blood Hematopoietic Stem Cells, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei, 442000, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yu-Ming Niu, Department of Stomatology, Gongli Hospital of Shanghai Pudong New Area, Shanghai, People’s Republic of China, Tel +86 13581370999, Email niuyuming@yeah.net Chao Zhang, Center for Evidence-Based Medicine and Clinical Research, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei, 442000, People’s Republic of China, Email zhangchao0803@126.comObjective: Patients with obstructive sleep apnea (OSA) frequently suffer from migraine, however the causal relationship between OSA and migraine is unknown. …”
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Right Gastroepiploic Artery as an Alternative for Arterial Reconstruction in Living Donor Liver Transplantation by Klaus Steinbrück, Reinaldo Fernandes, Marcelo Enne, Rafael Vasconcelos, Giuliano Bento, Gustavo Stoduto, Thomas Auel, Lúcio Filgueiras Pacheco-Moreira

“…Background. An adequate blood flow is directly related to graft survival in living donor liver transplantation. …”
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Structured follow-up pathway to support people after transient ischaemic attack and minor stroke (SUPPORT TIA): protocol for a feasibility study and process evaluation by Grace M Turner, Melanie Calvert, Sue Jowett, Robbie Foy, Jonathan Mant, Sarah Tearne, Lou Atkins, Rachael Jones, Smitaa Patel, Phillip Collis

“…The clinic appointment will collect body mass index, blood pressure, cholesterol and medication. Assessment of feasibility and acceptability will include quantitative process variables (such as recruitment and questionnaire response rates), structured observations of study processes, and interviews with a subsample of participants and clinical staff.Ethics and dissemination Favourable ethical opinion was gained from the Wales Research Ethics Committee (REC) 1 (23 February 2021, REC reference: 21/WA/0036). …”
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Inflammatory Markers and Obstructive Sleep Apnea in Obese Children: The NANOS Study by Alex Gileles-Hillel, María Luz Alonso-Álvarez, Leila Kheirandish-Gozal, Eduard Peris, José Aurelio Cordero-Guevara, Joaquin Terán-Santos, Mónica Gonzalez Martinez, María José Jurado-Luque, Jaime Corral-Peñafiel, Joaquin Duran-Cantolla, David Gozal

“…In this cross-sectional, prospective multicenter study, healthy obese Spanish children (ages 4–15 years) were randomly selected and underwent nocturnal PSG followed by a morning fasting blood draw. Plasma samples were assayed for multiple inflammatory markers. …”
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Histology Assessment of Chitosan–Polyvinyl Alcohol Scaffolds Incorporated with CaO Nanoparticles by Carlos David Grande-Tovar, Jorge Ivan Castro Castro, Lemy Vanessa Barba-Rosado, Paula A. Zapata, Daniel Insuasty, Carlos-Humberto Valencia-Llano

“…During the degradation process, the material fragmented and was absorbed by inflammatory cells, which promoted the proliferation of collagen fibers and blood vessels. These findings highlight the potential of incorporating CaO NPs in soft tissue regeneration scaffolds.…”
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Identification of serum tRNA-derived small RNAs biosignature for diagnosis of tuberculosis by Zikun Huang, Qing Luo, Cuifen Xiong, Haiyan Zhu, Chao Yu, Jianqing Xu, Yiping Peng, Junming Li, Aiping Le

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A Genome-Wide Analysis of Long Noncoding RNAs in Circulating Leukocytes and Their Differential Expression in Type 1 Diabetes Patients by Yihan Liu, Xiaoming Du, Jia Cui, Changlong Li, Meng Guo, Jianyi Lv, Xin Liu, Jingtao Dou, Xiaoyan Du, Hongjuan Fang, Zhenwen Chen

“…A total of 14,930 lncRNAs and 16,063 mRNAs were identified in the peripheral blood leukocyte of T1D patients. After optimization using an adjusted p value (threshold of <0.05), 393 circulating lncRNAs were identified, of which 69 were downregulated and 324 were upregulated in T1D patients. …”
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Successful Treatment of Myeloid Sarcoma in an Elderly Patient with Myelodysplastic Syndrome with Reduced-Dose Azacitidine by Kazuya Sato, Nodoka Tsukada, Junki Inamura, Shigetsuna Komatsu, Keisuke Sato, Masayo Yamamoto, Motohiro Shindo, Kentaro Moriichi, Yusuke Mizukami, Mikihiro Fujiya, Yoshihiro Torimoto, Toshikatsu Okumura

“…MDS-EB-2 quickly progressed to AML with the appearance of peripheral blood blasts and 25% bone marrow blasts. Monotherapy with reduced-dose AZA (37.5 mg/m2 for 7 days, every 4–6 weeks) was restarted, and the MS quickly disappeared. …”
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Exome sequencing in Nigerian children with early‐onset epilepsy syndromes by Ibitayo Abigail Ademuwagun, Yagoub Adam, Solomon Oladapo Rotimi, Steffen Syrbe, Maximilian Radtke, Julia Hentschel, Johannes R. Lemke, Ezekiel Adebiyi

“…Methods The study involved sampling of patients diagnosed with early‐onset epilepsy syndromes at the Lagos State University Teaching Hospital (LASUTH) Neurology clinic. Venous blood samples were collected, and genomic DNA was isolated and purified. …”
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Hantavirus and Leptospira are important causes of nonspecific acute febrile syndrome, Meta, Colombia by Liliana Sánchez-Lerma, Salim Mattar, Verónica Contreras, Jorge Miranda, Vaneza Tique, Virginia Rodríguez, Derly Rodriguez, Sonia Lopez, Andrés Rojas-Gulloso

“…All enrolled patients underwent routine hematology and blood biochemistry examinations. RT-qPCR was performed for Dengue and serology for laboratory diagnoses using ELISA and MAT for Hantavirus and Leptospirosis, respectively. …”
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Clinical case of a pelvic fracture with massive retroperitoneal hematoma by D.A. Krishtafor, A.A. Krishtafor, A.V. Tsarev, D.V. Balyk, A.Y. Halushchak, V.A. Pelekh

“…Despite immobilization of the fracture and massive transfusion, it was not possible to stabilize the patient's hemodynamics and improve the parameters of the patient's general blood analysis. Due to the clinic of active bleeding, the patient repeatedly underwent control ultrasound examinations of the abdominal cavity and pleural sinuses, but the presence of free fluid in the abdominal cavity could be confirmed only after 12 hours of treatment. …”
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Study of Radioclinical and Risk Factors of Cerebral Venous Thrombosis: A Retrospective Analysis of Patients Presenting to a Tertiary Hospital in Mogadishu, Somalia by Adam BA, Osman AA, Sheikh Hassan M, Sidow NO, Osman Hidig MF, Mohamed AA, Ibrahim AA, Mohamed SA, Mohamed YG, Ahmed SA, Jeele MOO, Hassan MO

“…Bakar Ali Adam,1,2 Ahmed Adam Osman,3 Mohamed Sheikh Hassan,1,2 Nor Osman Sidow,1 Mohamed Farah Osman Hidig,1 Abdulkadir Ahmed Mohamed,1 Abdiwahid Ahmed Ibrahim,1 Said Abdi Mohamed,1 Yahye Garad Mohamed,3 Said Abdirahman Ahmed,4 Mohamed Osman Omar Jeele,5 Mohamed Omar Hassan4 1Department of Neurology, Mogadishu Somali Turkish Training and Research Hospital, Mogadishu, Somalia; 2Faculty of Medicine and Surgery, Mogadishu University, Mogadishu, Somalia; 3Department of Radiology, Mogadishu Somali Turkish Training and Research Hospital, Mogadishu, Somalia; 4Department of Cardiology, Mogadishu Somali Turkish Training and Research Hospital, Mogadishu, Somalia; 5Department of Internal Medicine, Mogadishu Somali Turkish Training and Research Hospital, Mogadishu, SomaliaCorrespondence: Bakar Ali Adam, Email atiika2009@gmail.comBackground: Cerebral venous thrombosis (CVT) is a rare but potentially life-threatening condition characterized by the formation of a blood clot in the dural venous sinuses or cerebral veins. …”
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The valve-sparing aortic root replacement: Results of the David I technique by B. M. Todurov, I. O. Stetsyuk, O. V. Zelenchuk, I. Yu. Mokryk, L. R. Stetsiuk, V. B. Demyanchuk, N. V. Malova

“…The average duration of the operations was 291.23 ± 12.67 minutes, the total duration of artificial blood circulation was 170.28 ± 8.77 minutes, aorta clamping time – 122.02 ± 5.92 minutes. …”
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Association between Circulating B-Type Natriuretic Peptide and Diabetic Peripheral Neuropathy: A Cross-Sectional Study of a Chinese Type 2 Diabetic Population by Pijun Yan, Qin Wan, Zhihong Zhang, Yong Xu, Ying Miao, Pan Chen, Chenlin Gao

“…Circulating levels of BNP were significantly and positively associated with systolic blood pressure (P=0.035), neutrophil-to-lymphocyte ratio (P=0.007), creatinine (P=0.030), vibration perception threshold values (P=0.021), and the prevalence of diabetic foot ulceration (P=0.039), peripheral arterial disease (P=0.013), DPN (P=0.032), and diabetic nephropathy (P=0.020) and negatively with lymphocyte count (P=0.003) and ankle-brachial index (P=0.038), irrespective of age, sex, and body mass index. …”
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Development and internal validation of the Edmonton Obesity Staging System-2 Risk screening Tool (EOSS-2 Risk Tool) for weight-related health complications: a case-control study in... by Evan Atlantis, P Fahey, Kathryn Williams, Paul Dugdale, James Rufus John, SL Hocking, Kath Peters

“…Of 14 candidate risk factors, 6 (family history of diabetes, hypertension, high sugar in blood/urine, high cholesterol and self-reported bodily pain and disability) were automatically included based on definitional or obvious correlational criteria. …”
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A New Antibody–Cytokine Construct Targeting Natural Killer Cells: An Immunotherapeutic Approach to Chronic Lymphocytic Leukemia by Michela Flego, Mauro Andreotti, Francesca Romana Mauro, Maria Beatrice Arasi, Silvia Zamboni, Zuleika Michelini, Sara Pepe, Clementina Maria Galluzzo, Roberta Amici, Diego Moricoli, Chiara Mazzei, Alessandro Ascione, Alessandra Mallano

“…We designed and developed a cis-acting immunocytokine composed of an anti-CD56 single-chain Fragment variable (scFv) and IL15, labeled scFvB1IL15. scFvB1IL15 was tested in vitro on peripheral blood mononuclear cells (PBMCs) obtained from both different healthy donors (HDs) and CLL patients in order to evaluate its ability to target NK cells and enhance their activation and NK-mediated directed cytotoxicity. scFvB1IL15 specifically induced strong degranulation and cytokine and chemokine production in NK cells in both HD- and CLL patient-derived PBMC samples. …”
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Potential effects of induced focal ischemia in the motor cortex of rats undergoing experimental periodontitis by Victória dos Santos Chemelo, Marco Aurelio M. Freire, Leonardo Oliveira Bittencourt, Deborah Ribeiro Frazão, Deiweson Souza-Monteiro, Sabrina C. Cartagenes, Walace Gomes-Leal, Cristiane do Socorro Ferraz Maia, Gabriel S. Rocha, Daniel Falcao, Rafael Rodrigues Lima

“…Stroke is a severe medical condition resulting from an interruption in the blood supply to the brain, ultimately compromising tissue homeostasis. …”
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Comparison of the Effects of Mesenchymal Stem Cells with Their Extracellular Vesicles on the Treatment of Kidney Damage Induced by Chronic Renal Artery Stenosis by Crysthiane Saveriano Rubiao Andre Ishiy, Milene Subtil Ormanji, Edgar Maquigussa, Rosemara Silva Ribeiro, Antonio da Silva Novaes, Mirian Aparecida Boim

“…Stenotic animals showed a progressive increase in systolic blood pressure (SBP), while animals treated with ASCs, MVs, and EXs showed a stabilization of SBP, and this stabilization was similar among the different treatments. …”
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Age influences the circulating immune profile in pediatric sepsis by Grace Fisler, Grace Fisler, Grace Fisler, Mariana R. Brewer, Mariana R. Brewer, Mariana R. Brewer, Omar Yaipen, Clifford S. Deutschman, Clifford S. Deutschman, Clifford S. Deutschman, Matthew D. Taylor, Matthew D. Taylor, Matthew D. Taylor

“…Patients were included if they were &lt; 21 years, admitted to the PICU, and received fluid resuscitation and antibiotics. Peripheral blood mononuclear cells were isolated from samples collected on PICU day 1.ResultsEighty patients were enrolled. …”
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