Sex-specific differences in the efficacy of renal denervation in patients with resistant hypertension depending on visceral obesity and kidney function by Irina Zyubanova, Nadezhda Ryumshina, Victor Mordovin, Musheg Manukyan, Valeriya Lichikaki, Ekaterina Solonskaya, Anna Gusakova, Tatjana Suslova, Stanislav Pekarskiy, Simzhit Khunkhinova, Anastasia Popova, Veronika Rudenko, Alla Falkovskaya

“…ObjectiveTo investigate the sex differences in the efficacy of renal denervation (RDN) in patients with resistant hypertension (RHT) concerning the size of abdominal fat depots, changes in biomarkers of sympathetic activity, and renal function.Materials and methods24 men (56.5 ± 7.8 years) and 33 women (59.5 ± 8.4 years) with RHT were enrolled in the study and underwent RDN. 24-h ambulatory blood pressure (BP) [systolic/diastolic (SBP/DBP)], serum creatinine (with eGFR calculation), serum adipocytokines (leptin, adiponectin, resistin), serum metanephrines and normetanephrines were measured baseline and 12 months after RDN. …”
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β-Hydroxybutyrate-induced mitochondrial DNA (mtDNA) release mediated innate inflammatory response in bovine mammary epithelial cells by inhibiting autophagy by Yihui Huo, Taiyu Shen, Tianyin Feng, Moli Li, Wanli Zhao, Juan J. Loor, Ben Aernouts, Androniki Psifidi, Chuang Xu

“…Mitochondrial dysfunction and chronic inflammation in mammary tissue are linked to elevated blood ketone levels, particularly β-hydroxybutyrate (BHB). …”
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Growth and survival of giant gourami juvenile immersed in different doses of recombinant growth hormone by , Alimuddin, Sumie Etoh, Handika Gilang Pramana Putra, Odang Carman

“…Fish were reared for five weeks in glass aquaria at a stocking density of 7 fish/L, and fed with Artemia nauplii and blood worm twice a day ad libitum. The results showed that the average body weight of 30 mg/L r-OgGH treated fish (0.34 g) was 75% higher (p<0.05) than those of 10 mg/L (0.24 g) and control (0.19 g). …”
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Liver GlucokinaseA456V Induces Potent Hypoglycemia without Dyslipidemia through a Paradoxical Induction of the Catalytic Subunit of Glucose-6-Phosphatase by Anna Vidal-Alabró, Alícia G. Gómez-Valadés, Andrés Méndez-Lucas, Jordi Llorens, Ramon Bartrons, Jordi Bermúdez, Jose C. Perales

“…GKA456V overexpression markedly reduced blood glucose in the absence of dyslipidemia, in contrast to wild-type GK-overexpressing mice. …”
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Serum Apelin Levels and Correlation with illness Severity in Nonobese Patients with Bronchial Asthma by Rohan Pattanaik, Pratima Kumari Sahu, Monalisa Mohapatro, Jeetendra Kumar Patra, Nirjharini Dhal

“…Apelin is demonstrated in mature adipocytes and is highly expressed in pulmonary tissue, including bronchial and alveolar epithelial cells and small pulmonary blood vessels. Aim: The aim of this study was to evaluate the level of serum apelin in adult nonobese patients diagnosed with bronchial asthma cases and compare with healthy volunteers. …”
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Evaluation and Comparison of Iodine-Based and Biosynthesized Gold Nanoparticles as X-Ray Contrast Agent and Their Effects on Renal Functions in Male Wistar Rats by Paul Ayanlola, Gbadebo Isola, Waidi Saka, Margaret Akinloye, Abraham Aremu, Mustapha Lawal

“…The rats, excluding group A, were radiographed, and samples of blood and kidney tissue were collected on days 1 and 30 for the assessment of renal functions.Results: The rats injected with the AuNPs showed radiographic contrast with anatomical features better than those without CA and those injected with the ICA. …”
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Obesity-induced mesenteric PVAT remodelling is sexually dimorphic, but not driven by ovarian hormones by Lisa Ivatt, Mhairi Paul, Allende Miguelez-Crespo, Patrick W. F. Hadoke, Matthew A. Bailey, Ruth A. Morgan, Mark Nixon

“…Perivascular adipose tissue (PVAT), a metabolically active tissue surrounding blood vessels, plays a key role in regulating vascular tone. …”
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Skin and Soft Tissue Infections in Patients with Solid Tumours by Diamantis P. Kofteridis, Antonios Valachis, Eirini Koutsounaki, Sofia Maraki, Eleni Mavrogeni, Foteini N. Economidou, Dimitra Dimopoulou, Kostas Kalbakis, Vassilis Georgoulias, George Samonis

“…Severe sepsis on admission (𝑃=0.002) and prior blood transfusion (𝑃=0.043) were independent predictors of treatment failure. …”
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Body Mass Index at Pediatric Leukemia Diagnosis and the Risks of Relapse and Mortality: Findings from a Single Institution and Meta-analysis by Ashleigh M. Saenz, Stacie Stapleton, Raquel G. Hernandez, Greg A. Hale, Neil A. Goldenberg, Skai Schwartz, Ernest K. Amankwah

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Clinical Predictors of Aspirin Resistance in Patients with Type 2 Diabetes: A Systematic Review and Meta-Analysis by Fan Zhang, Hongyan Zheng

“…Conclusions: Markers associated with dyslipidemia and blood glucose levels are robust indicators of AR in individuals with T2DM. …”
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Sex differences of molecular mechanisms of insulin sensitivity in young and adult C57BL/6J mice by T. V. Yakovleva, A. Yu. Kazantseva, E. N.  Makarova, N. M. Bazhan

“…It was shown that insulin sensitivity in females was higher than in males regardless of age because the level of glucose in blood plasma of females does not differ from that in males, whereas female insulin levels were lower than male insulin levels. …”
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Utility of Integrated Analysis of Pharmacogenomics and Pharmacometabolomics in Early Phase Clinical Trial: A Case Study of a New Molecular Entity by Jaeseong Oh, Sojeong Yi, Namyi Gu, Dongseong Shin, Kyung-Sang Yu, Seo Hyun Yoon, Joo-Youn Cho, In-Jin Jang

“…The pharmacogenomics screening was performed from whole blood samples using the Affymetrix DMET (Drug-Metabolizing Enzymes and Transporters) Plus microarray, and confirmation of genetic variants was performed using real-time polymerase chain reaction. …”
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Polytrauma in Older Adults Leads to Significantly Increased TIMP-1 Levels in the Early Posttraumatic Period by Mareen Braunstein, Thomas Kusmenkov, Wolf Mutschler, Christian Kammerlander, Wolfgang Böcker, Viktoria Bogner-Flatz

“…The aim of this study was to evaluate the differences in serum protein dynamics in older and younger polytraumatized adults. Methods. Blood samples were drawn immediately within 90 minutes after trauma and subsequently after 6, 12, 24, 48, and 72 h. …”
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Streptococcus suis-associated neonatal meningitis and sepsis: characterization, antimicrobial resistance, and public health implications by Giovanna Fusco, Rubina Paradiso, Lorena Cardillo, Maria Antonia Salvia, Saveria Dodaro, Veronica Del Monaco, Gianfranco Scarpelli, Francesca Greco, Antonio Rinaldi, Lorella Barca, Stefania Ambrogio, Antonio Limone, Esterina De Carlo, Giorgia Borriello

“…Streptococcus (S.) suis was isolated from cerebrospinal fluid and blood. Next-generation sequencing revealed that the strain was serotype 2 sequence type 1, and contained the ermB and tet(W) genes, which are responsible for resistance to macrolides and tetracycline, along with several pilus-associated genes and 20 virulence factors. …”
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Neonatal outcomes in offspring of mothers with pregestational diabetes: a hospital-based multicentre prospective cohort study protocol by Manu Raj, Vishnu Renjith, Renjitha Bhaskaran, Anju Philip Thurkkada, Radhamany Kunjukutty, Sobha S Nair, Annie Soman, Sethulakshmi Ramachandran

“…PGDM will be diagnosed by the following criteria—FBS ≥126 mg% OR HbA1c ≥6.5 mg% OR Random blood glucose ≥200 mg% on the initial visit or documented prior to the index pregnancy. …”
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Protein quality of four indigenous edible insect species in Nigeria by Florence Inje Oibiokpa, Helmina Olufunmilayo Akanya, Ali Audu Jigam, Abubakar Ndaman Abubakar, Evans Chidi Egwim

“…After the feeding trial periods, the rats were sacrificed, blood samples collected and organs excised for various analyses. …”
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Luteolin Regulates the Differentiation of Regulatory T Cells and Activates IL-10-Dependent Macrophage Polarization against Acute Lung Injury by Ke Xie, Yu-sen Chai, Shi-hui Lin, Fang Xu, Chuan-jiang Wang

“…The proportion of Tregs in splenic mononuclear cells and peripheral blood mononuclear cells (PBMCs) was quantified. Furthermore, in vitro, we evaluated the effects of luteolin on Treg differentiation, and the effects of IL-10 immune regulation on macrophage polarization were examined. …”
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PI3Kδ inhibitor linperlisib combined with gemcitabine and oxaliplatin for relapsed or refractory diffuse large B-cell lymphoma: a multicenter, single-arm phase Ib/II trial by Peng Sun, Hong Cen, Haiyan Yang, Rui Huang, Zhen Cai, Xuekui Gu, Hanying Bao, Zusheng Xu, Zuhong Xu, Zhi-Ming Li

“…Frequently observed adverse events included decreases in neutrophil counts (74.4%), white blood cell counts (64.1%) and platelet counts (64.1%). …”
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Clinical efficacy and learning curve of percutaneous endoscopic cervical discectomy for symptomatic cervical spondylotic radiculopathy by Xiao Sun, Lijuan Zhan, Zhongxin Tang, Mingkui Shen, Haijun Ma, Jun Tan

“…Patient demographics, operation time, estimated intraoperative blood loss, complications, postoperative hospital stay, total hospitalization cost, neck dysfunction index (NDI), arm and neck visual analog scale (VAS) scores were compared and analyzed. …”
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Plasma proteome fingerprint in kidney diseases by Kirill S. Nikolsky, Arthur T. Kopylov, Valeriya I. Nakhod, Natalia V. Potoldykova, Dmitry V. Enikeev, Tatiana V. Butkova, Liudmila I. Kulikova, Kristina A. Malsagova, Vladimir R. Rudnev, Denis V. Petrovskiy, Alexander A. Izotov, Anna L. Kaysheva

“…This study aimed to analyze the features of the protein composition of blood plasma in patients with the most common kidney pathologies: kidney calculus, kidney cyst, and kidney cancer.MethodsThe study involved 75 subjects. …”
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