Development of Prone Position Ventilation Device and Study on the Application Effect of Combined Life Support Technology in Critically Ill Patients by Yufeng Li, Qiaoqiao Hu, Wenjie Wang, Changhong Du, Siwen Fan, Linlin Xu, Songmei Li, Bei Chen

“…In patients receiving combined life support, the intervention group demonstrated improved catheter blood drainage and extended CRRT filter longevity. …”
Get full text

Therapy of genomic unstable solid tumours (WHO grade 3/4）in clinical stage III/IV using individualised neoantigen tumour peptides-INP trial (individualised neoantigen tumour peptid... by Ling Wang, Xia Chen, Juan Zhao, Jiaxi Tang, Wanyan Tang, Bin Liao, Weiqi Nian

“…Through the whole exome and transcriptome sequencing analysis of the fresh blood and tumour tissues of the enrolled patients, the 20 25-33aa antigen peptides with the highest mutation scores of the patients will be screened out, and the corresponding new antigen peptides will be synthesised and prepared. …”
Get full text

Artificial intelligence assisted risk prediction in organ transplantation: a UK Live-Donor Kidney Transplant Outcome Prediction tool by Hatem Ali, Arun Shroff, Tibor Fülöp, Miklos Z. Molnar, Adnan Sharif, Bernard Burke, Sunil Shroff, David Briggs, Nithya Krishnan

Get full text

The Role of Pyroptosis‐Related Gene Signature and Immune Infiltration in Juvenile Dermatomyositis by Qiao W, Zhu C, Huang D, Liu Y, Wang Z, Zhu T, Song Q, Yang X, Wang Y, Wang Y

“…Weizhou Qiao,1,* Cuiping Zhu,2,* Dan Huang,1 Yue Liu,1 Zengkai Wang,1 Tianjie Zhu,1 Qingyu Song,1 Xu Yang,1 Yueying Wang,1 Yushuang Wang1 1Department of Clinical Laboratory, Central Hospital of Dalian University of Technology, Dalian, 116033, People’s Republic of China; 2Blood Purification Center, Central Hospital of Dalian University of Technology, Dalian, 116033, People’s Republic of China*These authors contributed equally to this workCorrespondence: Weizhou Qiao, Department of Clinical Laboratory, Central Hospital of Dalian University of Technology, No. 826, Southwest Road, Shahekou District, Dalian, Liaoning, 116033, People’s Republic of China, Email qiaoweizhou2024@163.comObjective: Juvenile dermatomyositis (JDM) is a complex autoimmune disease, and its pathogenesis remains poorly understood. …”
Get full text

Exploring manual therapy in the management of irritable bowel syndrome in adults: A scoping review by Natalia Płóciennik-Korycka, Sara Maria Pani, Bogumiła Bruc, Paolo Contu, Magdalena Wrzesińska

“…Study quality was assessed using The National Heart, Lung and Blood Institute (NHLBI) Study Quality Assessment Tools. …”
Get full text

Symptom-related experience and sexual health of female patients with pulmonary arterial hypertension: protocol for a systematic review and qualitative meta-synthesis by Ye He, Zhu Yang, Lixiao Yang, Fangfang Ma

“…Introduction Pulmonary arterial hypertension (PAH) is a complex condition affecting quality of life, characterised by high blood pressure in the pulmonary arteries leading to heart strain. …”
Get full text

Secondary prevention of preeclampsia by Muhammad Ilham Aldika Akbar, Muhammad Ilham Aldika Akbar, Roudhona Rosaudyn, Khanisyah Erza Gumilar, Khanisyah Erza Gumilar, Renuka Shanmugalingam, Gustaaf Dekker, Gustaaf Dekker

“…Nitric oxide (NO) donors and L-arginine have been shown to effectively reduce vascular resistance and improving blood flow to placenta, potentially reducing PE risk. …”
Get full text

The Associations of Platelet Activation and Coagulation Parameters with Obstructive Sleep Apnoea: A Large-Scale Observational Study by Jundong Yang, Wenjun Xue, Zhicheng Wei, Caiqiong Hou, Huaming Zhu, Huajun Xu, Xiaolin Wu, Yunhai Feng, Xinyi Li

“…Obstructive sleep apnoea (OSA) is associated with an increased risk of cardiovascular disease, with alterations in coagulability suspected as the mediating factor. This study explored blood coagulability and breathing-related parameters during sleep in patients with OSA. …”
Get full text

Driving-Related Neuropsychological Performance in Stable COPD Patients by Foteini Karakontaki, Sofia-Antiopi Gennimata, Anastasios F. Palamidas, Theocharis Anagnostakos, Epaminondas N. Kosmas, Anastasios Stalikas, Charalambos Papageorgiou, Nikolaos G. Koulouris

“…Pulmonary function tests, arterial blood gases, and dyspnea severity were also recorded. …”
Get full text

Prophylactic ECMO Support during Elective Coronary Percutaneous Interventions in High-Risk Patients: A Single-Center Experience by Claudiu Ungureanu, Marc Blaimont, Hugues Trine, Pierre Henin, Romain Courcelle, Yves Laurent, Patrick Van Ruyssevelt, Caroline Lepièce, Vincent Huberlant

“…Regarding the complication rate, 2 patients suffered from limb ischemia and were treated by an antegrade perfusion, 1 patient had a femoral perforation that needed surgical repair, 6 patients had a hematoma, 5 patients had a significant drop in hemoglobin of more than 2 g/dl and received blood transfusions, 2 patients were treated for septicemia, and 2 patients needed hemodialysis. …”
Get full text

Risk prediction model for poor prognosis after intravenous thrombolysis among ischemic stroke patients aged ≥ 80 years and analysis of follow-up by Ying Wang, Dongwei Liu, Mokhtar Aldhabi, Zuolei Chen, Le Feng, Huanmin Gao, Lin Yin

“…R software was utilized to develop a clinical prediction model and perform internal validation. 2: Ninety days, 180 days, and one year were designated as follow-up time points for all patients. 1.Patients aged ≥ 80 years had higher 90-day poor outcome and mortality (P < 0.001).However, there was no significant difference in symptomatic intracranial hemorrhage between the two groups (P > 0.05).Baseline NIHSS score (OR, 1.15; 95% CI,1.07–1.23; P < 0.001) and admission blood glucose (OR, 1.36; 95% CI,1.11–1.74; P = 0.007) were identified as independent predictors of poor prognosis at 90 days.The area of the prediction model under the receiver operator characteristic curve was 0.77. …”
Get full text

Effects of Adipose-tissue Derived Mesenchymal Stem Cells on PBMCs in Co-culture with HeLa Cell Line by Maryam Dorfaki, mahdi ghatrehsamani, fahimeh Lavi Arab, Mona Roozbehani, Majid Khoshmirsafa, Reza Falak, Fatemeh Keshavarz, Fatemeh Faraji

“…In this study we study investigated the effect of adipose tissue-derived MSCs on the apoptosis and proliferation of peripheral blood mononuclear cells (PBMCs) in co-culture with the HeLa cell line. …”
Get full text

« Mon seul Shakespeare » by Jacques Nichet

“…Bloody substitutes replace real blood! To the man who orders Claudio’s head to be brought to him, the Duke offers the severed pate of some « cadaver ex machina », namely that of the pirate Ragozine who has been good enough to die at the right moment! …”
Get full text

Exploring associations of financial well-being with health behaviours and physical and mental health: a cross-sectional study among US adults by Kai McKeever Bullard, Carla Mercado, Michele L F Bolduc, Desmond Banks, Courtni Andrews, Zoe R F Freggens, Rashid Njai

“…With increasing time since the last health service visit or screening, FWB was increasingly lower compared with adults with visits or screenings &lt;1 year (≥10 years or ‘never’, FWB ranged from −1 (blood sugar check) to −6.5 (dental examination/cleaning) points). …”
Get full text

MT-100, a human Tie2-agonistic antibody, improves penile neurovasculature in diabetic mice via the novel target Srpx2 by Fang-Yuan Liu, Young-Lai Cho, Fitri Rahma Fridayana, Lashkari Niloofar, Minh Nhat Vo, Yan Huang, Anita Limanjaya, Mi-Hye Kwon, Jiyeon Ock, Seon-Jin Lee, Guo Nan Yin, Nam-Kyung Lee, Ji-Kan Ryu

“…The angiopoietin-Tie2 signaling pathway plays a critical role in blood vessel development, formation, remodeling, and peripheral nerve regeneration. …”
Get full text

Dynamic Monitoring of sTREM-1 and Other Biomarkers in Acute Cholangitis by Jiahui Jiang, Xiaolei Wang, Tongtong Cheng, Mingyue Han, Xinxin Wu, Haitong Wan, DaojunYu

“…Our study is aimed at exploring the significance of white blood cell (WBC), C-reactive protein (CRP), procalcitonin (PCT), soluble triggering receptor expressed on myeloid cells 1 (sTREM-1), and temperature (T) alone or combined together in early identification and curative effect monitoring of AC with or without sepsis. …”
Get full text

Optimization of Protein Hydrolysate from Earthworms (<i>Perionyx excavatus</i>) of Angiotensin-I-Converting Enzyme Inhibitory Activity by One Variable at a Time by Phong Thanh Bui, Truc Anh Hoang, My Thi Thuy Pham, Linh Le Phuong Tran, Oanh Kim Nguyen

“…Hypertension, characterized by elevated blood pressure, is commonly treated with angiotensin-I-converting enzyme (ACE) inhibitors. …”
Get full text

Evaluation of the therapeutic efficacy of high-intensity focused ultrasound ablation combined with different drugs in the treatment of adenomyosis by Yu Dai, Ling Liu, Guiyuan Yu, Yan Peng, Na Chen, Jiahong Gao, Qiuling Shi, Ping Jin

“…Visual Analog Scale (VAS) and Pictorial Blood Loss Assessment Chart (PBAC) scores were used for evaluating symptom improvement.Results After propensity score matching (1:2), 38 patients were included in Group A and 76 in Group B. …”
Get full text

Comparative effective dose of ciprofol and propofol in suppressing cardiovascular responses to tracheal intubation by Min Liao, Xiao-Ru Wu, Jia-Ning Hu, Xing-Zhou Lin, Tang‑yuan‑meng Zhao, Hu Sun

“…Systolic and diastolic blood pressures (SBP and DBP) decreased significantly before and after intubation compared to baseline values in both groups (p< 0.05). …”
Get full text

Newcastle disease virus genotype VII.1.1 identified from backyard chickens with low antibody titer: Jimma Zone, Southwest Ethiopia. by Bezina Arega Emeru, Haregawi Tesfaye Desta, Yosef Deneke

“…Methods A total of 90 swab and blood samples were purposively collected from symptomatic backyard chicken in the period between February and April 2022. …”
Get full text