Biologic Therapies for Chronic Obstructive Pulmonary Disease: A Systematic Review and Network Meta-Analysis of Randomized Controlled Trials by Tyler Pitre, Daniel Lupas, Jasmine Mah, Matthew Stanbrook, Alina Blazer, Dena Zeraatkar, Terence Ho

“…However, in the subgroup of patients with blood eosinophils ≥300/mcL, both tezepelumab (MD 0.15 [95% CI 0.05 to 0.26]) and dupilumab (MD 0.13 [95% CI 0.06 to 0.19]) probably improved FEV1 above the MCID.Conclusion Dupilumab is effective at improving patient-relevant outcomes in COPD with higher eosinophil levels. …”
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Immunoregulative coating for scarless healing in anterior cruciate ligament reconstruction by Shuang Wang, Chao Xu, Yuanman Yu, Jie Li, Tianwu Chen, Jing Wang, Changsheng Liu

“…This shift releases endogenous factors that enhance blood vessel formation and new bone growth, ultimately achieving high-quality graft-bone integration. …”
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Involvement of Different CD4+ T Cell Subsets Producing Granzyme B in the Immune Response to Leishmania major Antigens by Ikbel Naouar, Thouraya Boussoffara, Melika Ben Ahmed, Nabil Belhaj Hmida, Adel Gharbi, Sami Gritli, Afif Ben Salah, Hechmi Louzir

“…The nature of effector cells and the potential immunogenicity of Leishmania major excreted/secreted proteins (LmES) were evaluated using peripheral blood mononuclear cells (PBMCs) from healed zoonotic cutaneous leishmaniasis individuals (HZCL) and healthy controls (HC). …”
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20(S)-Ginsenoside Rg3 Protects Kidney from Diabetic Kidney Disease via Renal Inflammation Depression in Diabetic Rats by Tong Zhou, Lin Sun, Shuo Yang, You Lv, Yue Cao, Xiaokun Gang, Guixia Wang

“…Plus, the urine protein decreased in the rats with the 20(S)-Rg3 treatment. Fasting blood glucose, creatinine, total cholesterol, and triglyceride levels in the 20(S)-Rg3 treatment group were all lower than those in the diabetic group. …”
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Innate Immune Effectors Play Essential Roles in Acute Respiratory Infection Caused by Klebsiella pneumoniae by Dong Liu, Zhifu Chen, Yue Yuan, Haiming Jing, Jintao Zou, Xiaoli Zhang, Xi Zeng, Weijun Zhang, Quanming Zou, Jinyong Zhang

“…Besides, innate immune effector depleted mice showed higher bacterial burdens in lungs and blood, companied with more severe lung damage and increased levels of cytokine/chemokine expression. …”
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Long-Term Effects of Metformin and Lifestyle Modification on Nonalcoholic Fatty Liver Disease Obese Adolescents by Lian Tock, Ana R. Dâmaso, Aline de Piano, June Carnier, Priscila L. Sanches, Henrique Manoel Lederman, Regina M. Y. Ernandes, Marco Túlio de Mello, Sérgio Tufik

“…The visceral, subcutaneous fat and degree of steatosis were measured by ultrasonography. Fasting blood samples were collected to analyze glucose, insulin, insulin resistance, and aminotransferases. …”
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Application Progress of Transcranial Direct Current Stimulation in Rehabilitation of Chronic Low Back Pain by SHI Jian, WAN Ruihan, WANG Yafei, GONG Chen, WANG Yuling

“…In addition, the mechanism of the effect of tDCS on CLBP may be related to its regulatory effects on pain-related neural signaling pathways, regional cerebral blood flow, and synaptic plasticity. In the future, high-quality clinical studies with multi-center, large samples, long-term follow-up, and comparison of different stimulus parameters of tDCS should be further carried out to explore the therapeutic potential of tDCS to treat patients with CLBP from multiple dimensions and optimize the stimulation protocols of tDCS.…”
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Ultrasound-assisted enzyme extraction of Dendrobium Officinale polysaccharides: Extraction process, characterization, immunomodulatory effects by Hengpu Zhou, Yingjie Dong, Zhangyun Wu, Xi Peng, Meiqiu Yan, Suhong Chen, Guiyuan Lv

“…It mitigates damage to the thymus and spleen tissues, increases white blood cell counts, regulates the ratio of T lymphocytes and the levels of related factors, enhances macrophage phagocytic function to improve nonspecific immune responses, and boosts the levels of immunoglobulins IgA and IgG to enhance specific immune function. …”
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A Randomized, Double-Blind, Placebo-Controlled Trial Protocol Using the Fuzhengxiaoliu Patch for the Management of Primary Liver Cancer Pain by Li S, Wang B, Deng J, Li H, Wu Y, Fang Y, Yan B, Chen Y

“…The trial will enrol 72 participants with primary liver cancer with cancer pain (damp-heat stagnation and toxin and blood stasis syndrome). The primary objective is to measure the reduction in pain using FZXLP in combination with tegafur, gimeracil and oteracil potassium capsule (S-1) compared to the placebo group with S-1. …”
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Association of frequent intradialytic hypotension with the clinical outcomes of patients on hemodialysis: a prospective cohort study by Yuanhao Wu, Jianda Lu, Tingting Wang, Xiaoye Zhu, Jun Xue, Li You

“…In 2015, Flythe proposed a definition of IDH (Definition 1 in this study): nadir systolic blood pressure (SBP) <90 mmHg during hemodialysis for patients with pre-dialysis SBP <159 mmHg, and nadir SBP <100 mmHg during hemodialysis for patients with pre-dialysis SBP ≥160 mmHg. …”
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Impact of Agroindustrial Waste Fermented with Bacteria and Yeasts and Their Effect on Productive, Hematological, and Microbiota Indicators in Guinea Pigs (<i>Cavia porcellus</i>) by José E. Miranda-Yuquilema, Juan Taboada-Pico, Daniel Luna-Velasco, Mercy Cuenca-Condoy, Wilfrido Briñez

“…Results: The parameters evaluated were toxicity, productive parameters, occurrence of diarrhea and mortality, and blood profile. The results showed a significant increase in the weight of the animals consuming probiotics, especially at higher doses. …”
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Prospective study of change in liver function and fat in patients with colorectal liver metastases undergoing preoperative chemotherapy: protocol for the CLiFF Study by Katharine Cresswell, Juan W Valle, Michael Braun, Kat L Parmar, Derek O'Reilly, Jo H Naish, Steve R Williams, William K Lloyd, Lee Malcomson, Colin Bamford, Andrew G Renehan

“…Secondary outcome measures include: routinely measured liver function blood tests, anthropometric measurements, postoperative histology and digital quantification of fat, postoperative complications and mortality and quality of life.Ethics and dissemination The study was approved by a National Health Service Research Ethics Committee and registered with the Health Research Authority. …”
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Diagnostic prediction model for screening of elevated low-density and non-high-density lipoproteins in young Thai adults between 20 and 40 years of age by Phichayut Phinyo, Wuttipat Kiratipaisarl, Vithawat Surawattanasakul, Wachiranun Sirikul

“…Three predictors—gender, diastolic blood pressure and metabolic age—were identified in the non-HDL-C model with AuROC 0.722 (95% CI 0.705 to 0.738), good calibration and utility in 9%–55% probability range.Discussion and conclusion Overall results demonstrated acceptable discrimination for non-HDL-C model but inadequate performance of LDL-C model for clinical practice. …”
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The Effects of Induction and Treatment of Intracranial Hypertension on Cerebral Autoregulation: An Experimental Study by Marcelo de Lima Oliveira, Angela Macedo Salinet, Ricardo de Carvalho Nogueira, Alessandro Rodrigo Belon, Wellingson Silva Paiva, Brasil Chian Ping Jeng, Manoel Jacobsen Teixeira, Edson Bor-Seng-Shu

“…The cerebral static autoregulation (sCA) index was evaluated using cerebral blood flow velocities (CBFV) obtained with Doppler ultrasound. …”
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Factors determining first influenza vaccination among individuals with type 2 diabetes in the CONSTANCES cohort by age group (younger than 65 years or 65 and older) by Sylvain Paquet, Virginie Ringa, Henri Panjo, Jeanne Sassenou, Marie Zins, Laurent Rigal

“…The factors related to the first influenza vaccination differed significantly between the persons with diabetes younger than 65 years and those aged at least 65 years: age (OR = 1.01/OR = 0.89—P-interaction<0.001), poor perceived health (OR = 1.24/OR = 0.79—P-interaction = 0.048), and indicators of diabetes treatment quality [at least 2 hbA1c assays/year (OR = 1.91/0 R = 0.90—P-interaction<0.001), and blood pressure < 140/90 (OR = 1.24/OR = 0.90—P-interaction = 0.059)]. …”
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Epigenetics and Inflammatory Markers: A Systematic Review of the Current Evidence by Valentina Gonzalez-Jaramillo, Eliana Portilla-Fernandez, Marija Glisic, Trudy Voortman, Mohsen Ghanbari, Wichor Bramer, Rajiv Chowdhury, Tamar Nijsten, Abbas Dehghan, Oscar H. Franco, Jana Nano

“…Therefore, we aimed to systematically review studies investigating the association between DNA methylation and histone modifications with circulatory inflammation markers in blood. Five bibliographic databases were screened until 21 November of 2017. …”
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Unhealthy Phenotype as Indicated by Salivary Biomarkers: Glucose, Insulin, VEGF-A, and IL-12p70 in Obese Kuwaiti Adolescents by Mor-Li Hartman, J. Max Goodson, Ping Shi, Jorel Vargas, Tina Yaskell, Danielle Stephens, Maryann Cugini, Hatice Hasturk, Roula Barake, Osama Alsmadi, Sabiha Al-Mutawa, Jitendra Ariga, Pramod Soparkar, Jawad Behbehani, Kazem Behbehani, Francine Welty

“…Previously, we have shown that certain salivary metabolic markers can act as surrogates for blood concentrations. Methods. Salivary samples of whole saliva were collected from 8,317 adolescents. …”
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Pioglitazone Attenuates Drug-Eluting Stent-Induced Proinflammatory State in Patients by Blocking Ubiquitination of PPAR by Zhongxia Wang, Tao Zhang, Lizhe Sun, Ruifeng Li, Yuanyuan Wei, Xiaojuan Fan, Zuyi Yuan, Junhui Liu, Tao Chen

“…Herein, we investigated the antiinflammatory effects of pioglitazone (PIO) on circulating peripheral blood mononuclear cells (MNCs) in patients after coronary DES implantation. …”
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Akkermansia muciniphila Enhances the Antitumor Effect of Cisplatin in Lewis Lung Cancer Mice by Zhuo Chen, Xiang Qian, Shasha Chen, Xiaoxuan Fu, Guanjun Ma, Aiqin Zhang

“…Compared with the CDDP group, CDDP combining with Akk slowed down the growth of tumor volume, downregulated the levels of ki-67, p53, and factor-associated suicide (Fas) ligand proteins and upregulated Fas proteins, increased the levels of interferon-γ, interleukin-6, and tumor necrosis factor-α, and suppressed the expression of CD4+CD25+Foxp3+ Treg in mouse peripheral blood and spleen. In addition, transcriptome analysis indicated that Akk combining with CDDP increased obviously the levels of IFI27l2 and IGFBP7 and was related to those pathways including the cytokine-cytokine receptor interaction, Th17 cell differentiation, FOXO, JAK-STAT, and PI3K-Akt signaling pathways. …”
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Assessment of factors implicated in bone fusion after percutaneous endoscopic lumbar intervertebral fusion by Zheng Huang, Xialin Li, Weihong Yi, Junfeng Gong, Yue Zhou, Yu Tang

“…Data on age, operative time, blood loss, drainage, hospital stay, surgical level, osteoporosis, endplateitis, body mass index, lumbar curvature, and bone morphogenetic protein (BMP) use were collected. …”
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