EXtending Omalizumab Treatment Intervals in patients with Chronic spontaneous urticaria (EXOTIC): protocol of a multicentre, randomised, open-label, non-inferiority trial by Alexander Egeberg, Ditte Georgina Zhang, Christian Vestergaard, Simon Francis Thomsen, Jennifer Astrup Sørensen, Misbah Noshela Ghazanfar, Zarqa Ali, Jacob Thyssen

“…The primary endpoint is the absolute difference in average UCT score between treatment arms at week 36. Blood samples, Weekly Urticaria Activity Score, Chronic Urticaria Quality of Life Questionnaire, Dermatology Life Quality Index and records of side effects and flares will be obtained throughout the study at weeks 0, 12, 24 and 36.Ethics and dissemination The study has been approved by the Scientific Ethical Committee of the Capital Region in Denmark, the local Data Protection Agency and the Danish Medicines Agency. …”
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Bicarbonates for the Prevention of Postoperative Renal Failure in Endovascular Aortic Aneurysm Repair: A Randomized Pilot Trial by Véronique Brulotte, François A. Leblond, Stéphane Elkouri, Éric Thérasse, Vincent Pichette, Pierre Beaulieu

“…Biomarkers of renal injury from urine (interleukin-18 (IL-18), neutrophil gelatinase-associated lipocalin (NGAL), N-acetyl-β-D-glucosaminidase (NAG), and kidney injury molecule 1 (KIM-1)) and blood (NGAL, cystatin C) were measured at baseline and 3, 24, and 48 h postoperatively. …”
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Medication following bariatric surgery for type 2 diabetes mellitus (BY-PLUS) study: rationale and design of a randomised controlled study by Alexander Dimitri Miras, Carel le Roux, Alexis Sudlow, Ricardo Vitor Cohen, Hassan Kahal, Dimitri J Pournaras, Jill Townley, Helen Heneghan

“…Patients will be randomised 1:1 to receive either bariatric surgery and standard medical care or bariatric surgery and intensive goal-directed medical therapy, titrated to specific targets for glycated haemoglobin (HbA1c), blood pressure (BP) and low-density lipoproteins (LDL) cholesterol. …”
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Liver Surgery for Hepatocellular Carcinoma: Laparoscopic versus Open Approach by C. G. Ker, J. S. Chen, K. K. Kuo, S. C. Chuang, S. J. Wang, W. C. Chang, K. T. Lee, H. Y. Chen, C. C. Juan

“…The operation time was 156.3 ± 308.2 and 190.9 ± 79.2 min for LR and OR groups, respectively. The necessity for blood transfusion was found in 8 patients (6.9%) and 106 patients (50.9%) for LR and OR groups. …”
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Total Intravenous Anaesthesia with High-Dose Remifentanil Does Not Aggravate Postoperative Nausea and Vomiting and Pain, Compared with Low-Dose Remifentanil: A Double-Blind and Ran... by Seong-Hyop Kim, Chung-Sik Oh, Tae-Gyoon Yoon, Min Jeng Cho, Jung-Hyun Yang, Hye Ran Yi

“…Mean systemic arterial blood pressure (MBP), heart rate, and BIS did not differ significantly before and after endotracheal intubation in the H group. …”
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Sulforaphane enhances Nrf2-mediated antioxidant responses of skeletal muscle induced by exhaustive exercise in HIIT mice by Yangwenjie Wang, Yang Xiang, Ruiqi Wang, Xiangning Li, Jianxiong Wang, Siwang Yu, Ying Zhang

“…Importantly, SFN treatment improved antioxidative capacity of skeletal muscle in response to the acute exhaustive exercise by increasing mRNA and nucleoprotein expression of Nrf2 and these genes involved in antioxidant generation and decreasing blood creatine kinase (CK) and 4-hydroxy-2-nonenal (4-HNE)-modified protein levels in the HIIT mice.…”
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Hematological Parameters and Hemozoin-Containing Leukocytes and Their Association with Disease Severity among Malaria Infected Children: A Cross-Sectional Study at Pawe General Hos... by Muluken Birhanu, Yaregal Asres, Wondimagegn Adissu, Tilahun Yemane, Endalew Zemene, Lealem Gedefaw

“…Demographic and clinical data were collected using structured questionnaire. Blood specimen was collected from each study participant for hematological investigations. …”
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Characterization of the Sodium Multi-Vitamin Transporter in the Mosquito <i>Anopheles stephensi</i> and Its Capacity to Mobilize Pantothenate and Biotin by Jun Isoe, Brendan F. Riske, Megan E. Dobson, Hannah L. Kaylor, Jessica C. Brady, Yared Debebe, Laura M. Saavedra, Shirley Luckhart, Michael A. Riehle

“…We also assessed the distribution of Pan in various adult tissues and examined the impact of provisioning Pan to the mosquito via a sugar or blood meal on mosquito survival and reproduction. …”
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Endocrine disruptor (17 β-estradiol) removal by poly pyrrole-based molecularly imprinted polymer: kinetic, isotherms and thermodynamic studies by Samaneh Mohebbi, Aram Dokht Khatibi, Davoud Balarak, Maryam Khashij, Edris Bazrafshan, Mohammad Mehralian

“…MIP was utilized to pre-concentrate and separate E2 in real samples (urine, blood, hospital wastewater, tap water). This method shows promise for efficient and selective removal of E2 from aqueous solutions.…”
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Awareness About Diabetes And Its Complications Among Patients With Diabetes Mellitus by Faiza Batool, Kausar Malik, Lubna Meraj, Shazia Siddiq, Abbas Majeed, Sadia Khan

“…The statistically significant impact of age on patients' knowledge regarding blood sugar levels (P=0.009) and foot care (P=0.013) Conclusion: There is a significant lack of awareness among individuals with diabetes, highlighting the urgent need for educational initiatives. …”
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Interleukin-29 Enhances Synovial Inflammation and Cartilage Degradation in Osteoarthritis by Lingxiao Xu, Qiuyue Peng, Wenhua Xuan, Xiaoke Feng, Xiangqing Kong, Miaojia Zhang, Wenfeng Tan, Meilang Xue, Fang Wang

“…The mRNA levels of IL-29 and its specific receptor IL-28Ra in peripheral blood mononuclear cells (PBMCs) were significantly increased in OA patients when compared to healthy controls (HC). …”
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Impact of Organ Donor Pretreatment With Anti-Thymocyte Globulin in a Murine Model of Allogenic Kidney Transplantation by An He, An He, Yiren Yang, Katja Kotsch, Arne Sattler

“…ATG pre-treatment of potential donors led to a broad depletion of T- and NK cells in peripheral blood, non-lymphoid (including kidney) and lymphoid organs within 48 h, whereas myeloid cells were spared. …”
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Common Risk Factors of Myocardial Infarction and Some Socio Demographic Characteristics in Sulaimani City by Bayan Omar Sharif, Samir Y. Lafi

“…Conclusions: In Sulaimani city of Iraq the strong predictors of heart attack were included:  sedentary lifestyle, high body mass index, positive family history, unhealthy diet, smoking cigarette, high blood pressure, dyslipidemia, and Diabetes Mellitus.     …”
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The Prediction Model of High-Frequency Ultrasound Combined with Artificial Intelligence-Assisted Scoring System Improved the Diagnosis of Sclerosing Adenosis and Early Breast Cance... by Ma B, Wu G, Zhu H, Liu Y, Hu W, Zhao J, Liu Y, Liu Q

“…In the training group, the AUC of the sonographer and AI in differential diagnosis was 0.67(95% CI, 0.62– 0.71) and 0.89(95% CI, 0.84– 0.93), respectively, and the sonographer’s assessment showed better sensitivity (1.00 VS 0.73), but AI showed a higher accuracy rate (0.66 VS 0.80).Conclusion: Age, lesion size, burr, blood flow, and AI risk score are independent predictors of sclerosing adenosis and early breast cancer. …”
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Surgical Outcomes and Associated Morbidity of Active and Expectant Management of Second-Trimester Placenta Accreta Spectrum (PAS) by Jessian L. Munoz, Rachel Counts, Amanda E. Lacue, Kayla E. Ireland, Patrick S. Ramsey, Kristyn Brandi

“…Intraoperatively, no differences were noted in operative time (191.5 vs. 203 min, <i>p</i> = 0.85), blood loss (2300 vs. 2600 cc, <i>p</i> = 0.85), or incidental cystotomy (1 vs. 7, <i>p</i> = 0.10). …”
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One year of treating patients with open fractures of the lower extremity in a new military trauma center in Korea: a case series by Ji Wool Ko, Giho Moon, Jin Geun Kwon, Kyoung Eun Kim, Hankaram Jeon, Kyungwon Lee

“…No cases with serious blood loss or coagulopathies were found, but most cases had a significant elevation of creatinine kinase. …”
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Factors associated with prolonged length of stay following cardiac surgery in a major referral hospital in Oman: a retrospective observational study by Paul Aylin, Ahmed Almashrafi, Hilal Alsabti, Mirdavron Mukaddirov, Baskaran Balan

“…Factors associated with prolonged overall postoperative LOS included the body mass index, the type of surgery, cardiopulmonary bypass machine use, packed red blood cells use, non-elective surgery and number of complications. …”
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Antiviral and anti-inflammatory activities of favipiravir and quinine sulfate against dengue virus serotype 1 in vitro by Regita Aulia Rosalina, Beti Ernawati Dewi, Fithriyah Fithriyah

“…The anti-inflammatory activities of FVP and QS were measured by the relative expression of TNF-α, IL-6, IL-10 cytokines, and the transcription factor NF-κB from DENV-1 infected peripheral blood mononuclear cells (PBMC) in vitro. The results showed that the IC50, CC50, and selectivity index (SI) for FVP were 2.72 μg/mL, 156.78 μg/mL, and 58, respectively. …”
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An optimized data analytics pipeline for improving healthcare diagnosis using ensemble learning by Lomat Haider Chowdhury, Shaira Tabassum, Swakkhar Shatabda, Ashir Ahmed

“…To reaffirm the rectification of our model, we experimented with it on another COVID-19 routine blood test dataset. In both cases, our proposed model acquired better results regarding different performance measures. …”
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Comparison of Insulin Lispro Protamine Suspension with NPH Insulin in Pregnant Women with Type 2 and Gestational Diabetes Mellitus: Maternal and Perinatal Outcomes by Antonietta Colatrella, Natalia Visalli, Santina Abbruzzese, Sergio Leotta, Marzia Bongiovanni, Angela Napoli

“…In this retrospective study, for maternal outcome we recorded time and mode of delivery, hypertension, glycaemic control (fasting blood glucose and HbA1c), hypoglycemias, weight increase, and insulin need. …”
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