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61
miRNAs Participate in MS Pathological Processes and Its Therapeutic Response
Published 2016-01-01“…It is believed that the increased migration of autoreactive lymphocytes across the blood-brain barrier (BBB) may be responsible for axonal demyelination of neurons. …”
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62
Efficacy of human umbilical cord mesenchymal stem cell in the treatment of neuromyelitis optica spectrum disorders: an animal study
Published 2025-02-01“…Conclusion Our results revealed that hUC-MSCs displayed therapeutic efficacy in NMOSD and showed potential in attenuating blood–brain barrier disruption, as well as AQP4 IgG and complement-induced astrocyte apoptosis.…”
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63
Parkinson’s disease and exosomes: from pathogenesis to diagnosis and treatment
Published 2021-06-01“…There is growing evidence of the importance of exosomes for cell-to-cell communication, mediating the exchange of biological information and substances, and the ability to cross the blood-brain barrier. Due to their ability to cross the blood-brain barrier, exosomes may be promising for drug or molecular transportation and help in the development of more effective treatments for PD and other diseases of the nervous system. …”
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64
Matrix Metalloproteinases in patients with Multiple Sclerosis.
Published 2007-05-01“…<strong>Fundament:</strong> The proteolitic rupture of the extracellular matrix due to metalloproteinase 2 and 9 is one of the aspects that can influence in the alteration of the permeability of the blood-brain barrier (BBB) in multiple sclerosis. <strong>Objective:</strong> To determine metalloproteinase activity with gelatinous activity in patients suffering from multiple sclerosis. …”
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65
Posterior Reversible Encephalopathy Syndrome as Presenting Form of Very Early Systemic Sclerosis
Published 2015-01-01“…Its mechanism depends on failure of the blood-brain barrier due to high systemic blood pressure (BP) and loss of integrity of vascular endothelium related with different triggers. …”
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66
Esophageal Gastrointestinal Stromal Tumor with Rare Intracranial Metastasis
Published 2020-01-01“…New tyrosine kinase inhibitors that may cross the blood-brain barrier could be the answer to these cases.…”
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67
A Diet Enriched in Docosahexanoic Acid Exacerbates Brain Parenchymal Extravasation of Apo B Lipoproteins Induced by Chronic Ingestion of Saturated Fats
Published 2012-01-01“…Chronic ingestion of saturated fatty acids (SFAs) was previously shown to compromise blood-brain barrier integrity, leading to brain parenchymal extravasation of apolipoprotein B (apo B) lipoproteins enriched in amyloid beta. …”
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68
Application of the Box–Behnken Design in the Development of Amorphous PVP K30–Phosphatidylcholine Dispersions for the Co-Delivery of Curcumin and Hesperetin Prepared by Hot-Melt Ex...
Published 2024-12-01“…In vitro permeability across the gastrointestinal tract and blood–brain barrier was evaluated using the parallel artificial membrane permeability assay. …”
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69
Systematic Study of Steroid Drugs’ Ability to Cross Biomembranes—The Possible Environmental Impact and Health Risks Associated with Exposure During Pregnancy
Published 2024-12-01“…Thirty-seven steroid drugs of different types were investigated in silico for their environmental and pharmacokinetic properties (partition between soil and water, bioaccumulation in aquatic organisms, ability to be absorbed from the gastrointestinal tract and to cross biological barriers—skin, blood–brain barrier and placenta) using on-line tools and novel QSAR models. …”
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70
Disseminated Histoplasmosis with Miliary Histoplasmosis, Neurohistoplasmosis, and Histoplasma capsulatum Bacteremia in Probable Neurosarcoidosis
Published 2018-01-01“…Patients with neurosarcoidosis are suspected to have blood-brain barrier dysfunction. Lumbar puncture should be considered as part of initial investigative studies for infection. …”
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71
Chemokines and Chemokine Receptors in Multiple Sclerosis
Published 2014-01-01“…The migration of autoimmune T cells and macrophages from blood to central nervous system as well as the destruction of blood brain barrier are thought to be the major processes in the development of this disease. …”
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72
The Role of C1-Esterase Inhibitors in the Management of Vasogenic Edema in Glioblastoma
Published 2020-01-01“…As the tumor grows and disrupts the blood-brain barrier (BBB), vasogenic edema can result. The edema has the potential to significantly contribute to a patient’s morbidity and mortality. …”
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73
Isolated Central Nervous System Involvement after Brentuximab Vedotin Treatment for HIV-Positive ALK-Negative Anaplastic Large Cell Lymphoma
Published 2024-01-01“…Herein, we present a case of HIV-associated ALCL with isolated CNS involvement that occurred following the discontinuation of ART that was administered after treatment with brentuximab vedotin (BV)—which does not cross the blood-brain barrier. At the time of CNS recurrence, the patient’s CD4 count was 9 cells/mm3. …”
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74
Receptor-Mediated Endocytosis and Brain Delivery of Therapeutic Biologics
Published 2013-01-01“…Transport of macromolecules across the blood-brain-barrier (BBB) requires both specific and nonspecific interactions between macromolecules and proteins/receptors expressed on the luminal and/or the abluminal surfaces of the brain capillary endothelial cells. …”
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75
Postmortem Cerebrospinal Fluid Pleocytosis: A Marker of Inflammation or Postmortem Artifact?
Published 2012-01-01“…There is theoretical and experimental evidence that the blood brain barrier to the movement of protein and cells is preserved in the first few hours after death. …”
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76
Immune Privilege as an Intrinsic CNS Property: Astrocytes Protect the CNS against T-Cell-Mediated Neuroinflammation
Published 2013-01-01“…They are responsible for formation of the blood-brain barrier (BBB) and make up the glia limitans. …”
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77
Lessons from a Mouse Model Characterizing Features of Vascular Cognitive Impairment with White Matter Changes
Published 2011-01-01“…The purpose of this paper is to provide a comprehensive summary of the achievements made with the model that shows good reproducibility of the white matter changes characterized by blood-brain barrier disruption, glial activation, oxidative stress, and oligodendrocyte loss following chronic cerebral hypoperfusion. …”
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78
Melatonin in Hypoxic-Ischemic Brain Injury in Term and Preterm Babies
Published 2019-01-01“…Melatonin efficacy, low toxicity, and ability to readily cross through the blood-brain barrier make it a promising molecule. A very interesting thing is the difference between the half-life of melatonin in preterm neonates (15 hours) and adults (45-60 minutes). …”
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79
Transport of Alzheimer's associated amyloid-β catalyzed by P-glycoprotein.
Published 2021-01-01“…P-glycoprotein (P-gp) is a critical membrane transporter in the blood brain barrier (BBB) and is implicated in Alzheimer's disease (AD). …”
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80
Gene Therapy for Glioblastoma Multiforme
Published 2025-01-01“…Significant limitations to effective GBM treatment include poor drug delivery across the blood–brain barrier, drug resistance, and complex genetic tumor alterations. …”
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