Physicochemical properties and drug likeness of hydroxycinnamic acids and their molecular docking with caffeine and amoxicillin: Potential anticancer drugs by Umer Sherefedin, Abebe Belay, Kusse Gudishe, Alemu Kebede, Alemayehu Getahun Kumela, Tesfaye Feyisa, Jebel Haji Mahamud, Shallo Fekadu

“…FA and p-CA also showed favorable pharmacokinetic properties, including high gastrointestinal absorption, low drug–drug interaction risks, and a predicted ability to permeate the blood–brain barrier. These findings support the therapeutic potential of HCAs, particularly p-CA, as promising anticancer agents, warranting further experimental and clinical investigations to optimize their efficacy and safety.…”
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Sulforaphane Wrapped in Self-Assembled Nanomicelle Enhances the Effect of Sonodynamic Therapy on Glioma by Yihong Li, Xuejie Yang, Zhen Wei, Heng Niu, Liyang Wu, Caijing Chen, Huina Liu, Ting Cai, Huadong Fan

“…<b>Background/Objectives:</b> The two obstacles for treating glioma are the skull and the blood brain–barrier (BBB), the first of which forms a physical shield that increases the difficulties of traditional surgery or radiotherapy, while the latter prevents antitumor drugs reaching tumor sites. …”
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Scalable Manufacturing Method for Model Protein-Loaded PLGA Nanoparticles: Biocompatibility, Trafficking and Release Properties by Selin Akpinar Adscheid, Marta Rojas-Rodríguez, Salma M. Abdel-Hafez, Francesco S. Pavone, Marc Schneider, Akif E. Türeli, Martino Calamai, Nazende Günday-Türeli

“…<b>Background and Objectives</b>: Drug delivery systems (DDSs) offer efficient treatment solutions to challenging diseases such as central nervous system (CNS) diseases by bypassing biological barriers such as the blood–brain barrier (BBB). Among DDSs, polymeric nanoparticles (NPs), particularly poly(lactic-co-glycolic acid) (PLGA) NPs, hold an outstanding position due to their biocompatible and biodegradable qualities. …”
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Mitochondrial-targeted therapies in traumatic brain injury: From bench to bedside by Sidra Tabassum, Silin Wu, Chang-Hun Lee, Bosco Seong Kyu Yang, Aaron M. Gusdon, Huimahn A. Choi, Xuefang S. Ren

“…Furthermore, we highlight the complex interplay between mitochondrial dysfunction, inflammation, and blood-brain barrier (BBB) integrity, elucidating how these interactions exacerbate injury and impede recovery. …”
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Chitinase-3-like-1: a multifaceted player in neuroinflammation and degenerative pathologies with therapeutic implications by Pharaoh Fellow Mwale, Cheng-Ta Hsieh, Ting-Lin Yen, Jing-Shiun Jan, Rajeev Taliyan, Chih-Hao Yang, Wen-Bin Yang

“…Despite its therapeutic potential, challenges remain in developing selective and safe CHI3L1-targeted therapies, particularly in ensuring effective delivery across the blood–brain barrier and mitigating off-target effects. This review addresses the complexities of targeting CHI3L1, highlights its potential in precision medicine, and outlines future research directions aimed at unlocking its full therapeutic potential in treating neurodegenerative diseases and brain pathologies.…”
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Targeting Cytokine-Mediated Inflammation in Brain Disorders: Developing New Treatment Strategies by Rahul Mallick, Sanjay Basak, Premanjali Chowdhury, Prasenjit Bhowmik, Ranjit K. Das, Antara Banerjee, Sujay Paul, Surajit Pathak, Asim K. Duttaroy

“…Still, they face substantial hurdles when applied to the central nervous system (CNS), such as the blood–brain barrier (BBB) and unwanted systemic effects. …”
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Improving natural red pigment production by Streptomyces phaeolivaceus strain GH27 for functionalization of textiles with in silico ADME prediction by Gehad H. El Sayed, Mohamed Fadel, Rasha Fouad, Hend M. Ahmed, Ahmed A. Hamed

“…It exhibited intermediate synthetic accessibility, exceptional permeability and absorption, elevated gastrointestinal absorption, and blood–brain barrier penetration; nonetheless, it did not adhere to the medicinal chemistry rule of three. …”
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Case report: Bevacizumab-induced cerebrovascular events: a case series report and literature review by Ke Chen, Boyang Jiang, Boyang Jiang, Huiping Yan, Huiping Yan, Liu Yang, Liu Yang, Zheling Chen, Zheling Chen

“…Bevacizumab has its advantages in terms of crossing the blood-brain barrier, increasing radiosensitivity, and reducing radiation-induced brain edema. …”
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Amyloid-β and heart failure in Alzheimer’s disease: the new vistas by Hayder M. Al-Kuraishy, Ghassan M. Sulaiman, Hamdoon A. Mohammed, Sohaib G. Mohammed, Ali I. Al-Gareeb, Ali K. Albuhadily, Retaj A. Dawood, Amer Al Ali, Mohammed H. Abu-Alghayth

“…Of note, Aβ is not only originated from the brain but also produced peripherally and, via the blood–brain barrier (BBB), can accumulate in the brain and result in the development of AD. …”
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Elevated Cerebrospinal Fluid Neopterin Concentration Is Associated with Disease Severity in Acute Puumala Hantavirus Infection by Timo Hautala, Terhi Partanen, Tarja Sironen, Saara-Mari Rajaniemi, Nina Hautala, Olli Vainio, Olli Vapalahti, Heikki Kauma, Antti Vaheri

“…These results reinforce the view that PUUV-HFRS is a general infection that affects the central nervous system and the blood-brain barrier.…”
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Development and preclinical testing of a naloxone prodrug depot for extended protection against opioid overdose by Hala Aldawod, Arjun D. Patel, Rasha Emara, Dengpan Liang, Joshua S. Ho, Toufiq Ul Amin, Md Tariqul Haque Tuhin, Abdulmalek Balgoname, Avishan Kiani, Jumana M. Ajlouny, Melanie A. Felmlee, Miki S. Park, Bhaskara R. Jasti, William K. Chan, James A. Uchizono, Mamoun M. Alhamadsheh

“…In male rats and cynomolgus monkeys, a single subcutaneous dose provides steady naloxone release over several days, reducing blood-brain barrier diffusion, withdrawal symptoms, and CNS toxicity. …”
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Intravenous Administration of Bone Marrow-Derived Mesenchymal Stem Cells Induces a Switch from Classical to Atypical Symptoms in Experimental Autoimmune Encephalomyelitis by Mónica Kurte, Javiera Bravo-Alegría, Alexander Torres, Vania Carrasco, Cristina Ibáñez, Ana María Vega-Letter, Catalina Fernández-O’Ryan, Carlos E. Irarrázabal, Fernando E. Figueroa, Rodrigo A. Fuentealba, Claudia Riedel, Flavio Carrión

“…The downregulation of IL-6 could restore the well-functioning of the blood-brain barrier of EAE mice, correlated with a decreased number of brain infiltrating leukocytes. …”
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Impact of MMP2 rs243865 and MMP3 rs3025058 Polymorphisms on Clinical Findings in Alzheimer’s Disease Patients by Vladimira Durmanova, Juraj Javor, Zuzana Parnicka, Gabriel Minarik, Agata Ocenasova, Barbora Vaseckova, Veronika Reznakova, Maria Kralova, Tomas Hromadka, Ivana Shawkatova

“…In the brain, the pathological role of MMPs includes the disruption of the blood-brain barrier leading to the induction of neuroinflammation. …”
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Phytocompounds from Indonesia Medicinal Herbs as Potential Apelin Receptor Agonist for Heart Failure Therapy: An In-silico Approach by Muhamad Rizqy Fadhillah, Wawaimuli Arozal, Muhammad Habiburrahman, Somasundaram Arumugam, Heri Wibowo, Suci Widya Primadhani, Aryo Tedjo, Surya Dwira, Nurul Gusti Khatimah

“…Gambogic acid demonstrated favorable pharmacokinetic properties: good bioavailability, minimal blood-brain barrier penetration, no cytochrome P450 (CYP) enzyme interactions, and low toxicity. …”
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A covalent peptide-based lysosome-targeting protein degradation platform for cancer immunotherapy by Youmei Xiao, Zhuoying He, Wanqiong Li, Danhong Chen, Xiaoshuang Niu, Xin Yang, Wenxuan Zeng, Mengfan Wang, Yuzhen Qian, Ye Su, Feiyu Luo, Guanyu Chen, Juan Liu, Xinghua Sui, Xiuman Zhou, Yanfeng Gao

“…The ability of antibody-based LYTACs to penetrate solid tumor is limited as well, especially to cross the blood-brain barrier (BBB). Here, we propose a covalent chimeric peptide-based targeted degradation platform (Pep-TACs) by introducing a long flexible aryl sulfonyl fluoride group, which allows proximity-enabled cross-linking upon binding with the protein of interest. …”
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iPSC-derived exosomes as amphotericin B carriers: a promising approach to combat cryptococcal meningitis by Jingyu Zhao, Jingyu Zhao, Wei Fang, Yangjie Gao, Jiquan Chen, Guizhen Wang, Julin Gu

“…Amphotericin B (AmB) serves as the cornerstone treatment for CM; however, its clinical application is restricted due to limited penetration of the blood–brain barrier and associated nephrotoxicity.ObjectiveThis study investigates the use of exosomes derived from induced pluripotent stem cells (iPSC-Exos) as carriers for AmB in treating CM, aiming to enhance therapeutic efficacy and safety and reduce AmB toxicity.MethodsExosomes were extracted from iPSC culture supernatants using ultrafiltration and ultracentrifugation. …”
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Utility of 5-ALA for resection of CNS tumours other than high-grade gliomas: a protocol for a systematic review by Michael D Jenkinson, Ashwin Venkatesh, Colin Watts, Michael T C Poon, Victoria Wykes, Stephen John Price, Puneet Plaha, Georgios Solomou, Melissa Gough, Conor S Gillespie, Aref-Ali Gharooni, Waqqas Patel

“…Introduction 5-aminolevulinic acid (5-ALA) is a proagent developed for fluorescent-guided surgery for high-grade glioma patients associated with a significant increase in resection conferring survival. 5-ALA was shown to penetrate the blood–brain barrier accumulating in malignant glioma cells with high selectivity, sensitivity and positive predictive value. …”
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Recent Advances in the Mechanisms of Postoperative Neurocognitive Dysfunction: A Narrative Review by Tingting Wang, Xin Huang, Shujun Sun, Yafeng Wang, Linlin Han, Tao Zhang, Tianhao Zhang, Xiangdong Chen

“…Among these, neuroinflammation, mediated by pathways such as the NLRP3 inflammasome and blood–brain barrier disruption, emerges as a pivotal driver, triggering cascades that exacerbate neuronal injury. …”
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Tissue Distribution of Total Flavonoids Extracts of Drynariae Rhizoma in Young and Old Rats by UPLC–MS/MS Determination by Yue Zhang, Xia Lei, Hongdan Xu, Guoliang Liu, Yeqiu Wang, Huifeng Sun, Fang Geng, Ning Zhang

“…Tissues distribution showed neoeriocitrin, luteolin-7-O-β-D-glucoside, astragalin, naringin, and naringenin could transfer across the blood-brain barrier, which may form the basis of TFDR entering the brain to play an anti-AD role. …”
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NeuTox 2.0: A hybrid deep learning architecture for screening potential neurotoxicity of chemicals based on multimodal feature fusion by Xudi Pang, Xuejun He, Ying Yang, Ling Wang, Yuzhen Sun, Huiming Cao, Yong Liang

“…Four datasets were used to profile neurotoxicity; these were related to blood–brain barrier permeability, neuronal cytotoxicity, microelectrode array–based neural activity, and mammalian neurotoxicity. …”
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