Partitioning the phenotypic and genetic variances of reaction norms by de Villemereuil, Pierre, Chevin, Luis-Miguel

“…We then further partition the genetic variance of the trait (additive or not) into an environment-blind component and a component arising from genetic variance in plasticity. …”
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Global hotspots and trends of nutritional supplements for sick populations from 2000 to 2024 by Chaofan Shi, Haitao Liu, Haitao Liu, Haitao Liu, Te Fu, Yuanquan Li, Haichang Zhao, Feiyue Liu

“…Research focuses on dietary supplementation, oxidative stress, in vitro injections, development, antioxidant activity, double-blind trials, lipid supplements, functional foods, the health of diseased populations, and the risks of NS.ConclusionDifferent supplements each possess unique benefits and should be chosen according to the type of disease to ensure they contain the corresponding nutrients. …”
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The Effects of Neuroinflammation Induced by Typhoid Vaccine on Resting and Task‐Based Electroencephalography by Julia R Plank, Joseph CC Chen, Frederick Sundram, Nicholas Hoeh, Suresh Muthukumaraswamy, Joanne C Lin

“…Methods In this randomized, crossover design, placebo‐controlled, double‐blind study, typhoid vaccine was administered to 20 healthy volunteers to induce a low level of neuroinflammation. …”
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Adipose-Derived Stromal Cells for Treatment of Patients with Chronic Ischemic Heart Disease (MyStromalCell Trial): A Randomized Placebo-Controlled Study by Abbas Ali Qayyum, Anders Bruun Mathiasen, Naja Dam Mygind, Jørgen Tobias Kühl, Erik Jørgensen, Steffen Helqvist, Jens Jørgen Elberg, Klaus Fuglsang Kofoed, Niels Groove Vejlstrup, Anne Fischer-Nielsen, Mandana Haack-Sørensen, Annette Ekblond, Jens Kastrup

“…MyStromalCell trial is a randomized double-blind placebo-controlled study including sixty patients with CCS/NYHA class II-III, left ventricular ejection fraction > 40%, and at least one significant coronary artery stenosis. …”
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L-Dopa Pharmacokinetic Profile with Effervescent Melevodopa/Carbidopa versus Standard-Release Levodopa/Carbidopa Tablets in Parkinson’s Disease: A Randomised Study by Fabrizio Stocchi, Laura Vacca, Paola Grassini, Stephen Pawsey, Holly Whale, Stefano Marconi, Margherita Torti

“…This was a single-centre, randomized, double-blind, double-dummy, two-period crossover study. …”
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Visual Imagery in Modern Mind-Body Practices: Biophotonic Information Transfer through Water-Mediated Neural Resonance by Valeriy Babelyuk, Igor Popovych, Olga Smoleńska, Anna Michalska, Radosław Muszkieta, Magdalena Hagner-Derengowska, Yuriy Dobrovolsky, Galyna Dubkova, Tetyana Korolyshyn, Walery Zukow

“…Recipients consuming treated water demonstrate neurophysiological changes, even under double-blind conditions. Conclusions. The reviewed research suggests a potentially viable mechanism for information transfer from practitioner to water through biophotonic emissions, with subsequent biological effects on recipients. …”
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Surgical planning of small intestine neuroendocrine tumors: the concept of mesenteric tumor deposits by Romain L’Huillier, Gilles Poncet, Arnaud Pasquer, Thomas Walter, Catherine Lombard-Bohas, Valérie Hervieu, Bénédicte Cayot, Pierre-Jean Valette, Helen Cheung, Laurent Milot

“…Preoperative CTs were reviewed, blinded from surgical and pathological data, by two radiologists. …”
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Efficacy and safety of Xiongzhitongluo granules in the treatment of acute ischemic stroke: study protocol for a randomized controlled trial by Yunmeng Chen, Jingjing Wei, Xiao Liang, Yue Liu, Lina Miao, Di Zhao, Yunfan Zhang, Hongxi Liu, Yunling Zhang

“…Our team developed Xiongzhitongluo granules specifically for AIS and is conducting a randomized controlled trial (RCT) to validate their effectiveness.Methods and analysisThis multi-center, randomized, double-blind, placebo-controlled clinical trial includes 120 participants randomly allocated to the intervention or placebo group. …”
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Cost-effectiveness of metacognitive therapy for cardiac rehabilitation participants with symptoms of anxiety and/or depression: analysis of a randomised controlled trial by David Reeves, Calvin Heal, Patrick Joseph Doherty, Gemma E Shields, Adrian Wells, Lora Capobianco, Anthony Heagerty, Deborah Buck, Linda M Davies, Elizabeth Camacho

“…The objective of this within-trial economic evaluation was to compare the cost-effectiveness of metacognitive therapy (MCT) plus usual care (UC) to UC, from a health and social care perspective in the UK.Methods A multicentre, single-blind, randomised controlled trial (ISRCTN74643496) was conducted in the UK involving 332 patients with CR with elevated symptoms of anxiety and/or depression and compared group-based MCT with UC. …”
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Evaluation of Comparative Efficacy of Ashwagandha (Withania somnifera) vs Brahmi (Bacopa monnieri Linn) on Stress Level and Quality of Sleep in the Subjects Experiencing Mental Str... by Mohnish Vijay Gokhale, Vaishali Kuchewar, Pankaj Yadav, Bhishmani Tarare

“…Materials and Methods: It is a double-blind standard control clinical trial and the study will be undertaken at Department of Kayachikitsa, Mahatma Gandhi Ayurved Hospital and Research Centre (MGACHRC) at Salod (H), Wardha, Maharashtra, India starting from January 2024 to June 2025. …”
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Effect of icatibant on sweating-induced dermal pain by Shunsuke Takahagi, Shunsuke Takahagi, Daiki Matsubara, Emi Murakami, Yumi Aoyama, Shinya Imamura, Atsushi Fukunaga, Atsushi Fukunaga, Yoshiko Oda, Hiroyuki Murota, Michihiro Hide, Michihiro Hide

“…This study aimed to evaluate the analgesic effect of icatibant, a bradykinin B2 receptor antagonist, for the dermal pain induced by sweating stimuli and explored the role of bradykinin in its pathomechanism.MethodsThis single-blind, randomized, crossover study enrolled adult patients who had experienced severe sweating-induced dermal pain. …”
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Effect of porcine collagen matrix versus rotated pedicle palatal connective tissue flap on the soft-tissue closure after the immediate posterior implantation: study protocol for a... by Wei Zhang, Si Chen, Chenyang Zhang, Shuobo Fang, Zhengjie Dong, Tong Chen, Wanqi Lv, Keyi Hao

“…This study aims to use 3D integration technology to evaluate the effect of porcine collagen matrix versus rotated pedicle palatal connective tissue flap (RPPCTF) on the soft-tissue closure after the immediate maxillary posterior implantation.Methods and analysis This is a single-centre, evaluator-blinded, randomised, two-arm parallel-group controlled trial. …”
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Statistical analysis plan for the LAST ACT clinical trial; a Leukotriene A4 hydrolase Stratified non-inferiority Trial of Adjunctive Corticosteroids for HIV-negative adults with Tu... by Joseph Donovan, Dong Huu Khanh Trinh, Ronald B. Geskus, Marcel Wolbers, Guy E. Thwaites, Nguyen Thuy Thuong Thuong, Le Thanh Hoang Nhat

“…The trial was an LTA4H genotype stratified, parallel group, randomised, double blind, placebo-controlled multi-centre Phase III trial of dexamethasone given for 6–8 weeks in addition to standard anti-tuberculosis drugs. …”
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Synovitis scoring in hand osteoarthritis with ultrasonography: the performance of the Global OMERACT/EULAR Ultrasound Synovitis Score (GLOESS) is comparable to synovial thickening... by Féline P B Kroon, Margreet Kloppenburg, Frits R Rosendaal, Marion C Kortekaas, Maria Antonietta D’Agostino, Coen van der Meulen

“…This study aimed to assess ultrasound scoring of synovitis and the additional value of the Global OMERACT/EULAR Ultrasound Synovitis Score (GLOESS) in hand osteoarthritis.Methods Data from the randomised, double-blinded Hand Osteoarthritis Prednisolone Efficacy (HOPE) trial were used. …”
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AxiWorm: a new tool using YOLOv5 to test antiparasitic drugs against Trichinella spiralis by Javier Sánchez-Montejo, Miguel Marín, María Alejandra Villamizar-Monsalve, María del Carmen Vieira, Belén Vicente, Rafael Peláez, Julio López-Abán, Antonio Muro

“…A correlation of 92% was found in a blinded comparison with bare-eye assessment by experienced technicians. …”
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Effectiveness of nurse-led volunteer support and technology-driven pain assessment in improving the outcomes of hospitalised older adults: protocol for a cluster randomised control... by Max K Bulsara, Christopher Etherton-Beer, Rosemary Saunders, Kate Crookes, Mustafa Atee, Caroline Bulsara, Beverley Ewens, Olivia Gallagher, Renee M Graham, Karen Gullick, Sue Haydon, Kim-Huong Nguyen, Bev O'Connell, Karla Seaman, Jeff Hughes, Seng Giap Marcus Ang, Debra Scaini

“…Two interventions that have the potential to prevent progression of frailty and improve patient outcomes in hospitalised older adults but have yet to be subject to clinical trials are nurse-led volunteer support and technology-driven assessment of pain.Methods and analysis This single-centre, prospective, non-blinded, cluster randomised controlled trial will compare the efficacy of nurse-led volunteer support, technology-driven pain assessment and the combination of the two interventions to usual care for hospitalised older adults. …”
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Supplemental oxygen strategies in infants with bronchopulmonary dysplasia after the neonatal intensive care unit period: study protocol for a randomised controlled trial (SOS BPD s... by Anton H van Kaam, Wes Onland, Irwin K M Reiss, Peter H Dijk, Arend F Bos, Eleni-Rosalina Andrinopoulou, E Villamor, LGM van Rooij, M de Jong, JS von Lindern, Lucas Goossens, Stephanie Balink, Elianne J L E Vrijlandt, Anthon R Hulsmann, Debbie H Nuytemans, Arwen J Sprij, André A Kroon, Marielle Pijnenburg, MGA Baartmans, GJ Blok, WP de Boode, HD Buiter, CE Counsilman, CA Dalen Meurs, ACM Dassel, AM de Grauw, MEN van den Heuvel, JLAM van Hillegersberg, JCR van Hoften, JHL van Hoorn, CH ten Hove, A Kamerbeek, AAMW van Kempen, LH van der Meer, RMJ Moonen, EEM Mulder, HJ Niemarkt, MAG van Scherpenzeel-de Vries, IAM Schiering, RNGB Tan

“…The aim of this study is to compare the use of a higher oxygen saturation limit (≥95%) to a lower oxygen saturation limit (≥90%) after 36 weeks PMA in infants diagnosed with moderate or severe BPD.Methods and analysis This non-blinded, multicentre, randomised controlled trial will recruit 198 preterm born infants with moderate or severe BPD between 36 and 38 weeks PMA. …”
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Effects of photobiomodulation therapy in patients with chronic non-specific low back pain: protocol for a randomised placebo-controlled trial by Lucíola da Cunha Menezes Costa, Shaiane Silva Tomazoni, Leonardo Oliveira Pena Costa, Layana de Souza Guimarães, Amanda Costa Araujo, Dafne Port Nascimento, Flávia Cordeiro de Medeiros, Marina Athayde Avanzi

“…Therefore, the objective of this clinical trial is to evaluate the effects of PBMT in patients with chronic non-specific LBP in the short, medium and long term.Methods and analyses This is a prospectively registered, two-arm randomised placebo-controlled trial with blinded patients, assessors and treatment providers. …”
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Prioritization of the effective factors in reducing energy consumption in a residential building using computer simulation by N. Amani, F. Tirgar Fakheri, K. Safarzadeh

“…Energy reduction of about 101.5 kWh was also obtained after external movable awning and internal blind. CONCLUSION: The most commonly used materials were analyzed by the Design Builder software. …”
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Vaginal hysterectomy versus vaginal assisted NOTES hysterectomy (VANH): a protocol for a randomised controlled trial by Merel Kimman, Ilse Bekkers, Lynn Hoen, Huib A A M van Vliet, Nicol A C Smeets, Anne Damoiseaux, Martine M L H Wassen

“…The aim of this study is to compare hysterectomy by VANH versus VH for same-day discharge (SDD), complications, surgical outcomes, postoperative recovery, quality of life, costs and cost-effectiveness.Methods and analysis The study is a single-blinded, multicentre, randomised controlled trial. …”
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