Comparative Assessment of 0.5% Levobupivacaine and 0.5% Ropivacaine for Anaesthetic Potency in Mandibular Third Molar Extractions: A Randomised Controlled Trial by Prachi Surolia, Rajanikanth Kambala, Nitin Bhola, Anchal Agarwal

“…Materials and Methods: A prospective, randomised, triple-blind trial was conducted in the Department of Oral and Maxiilofacial Surgery at Sharad Pawar Dental College and Hospital, Datta Meghe Institute of Higher Education and Research, Wardha, Maharashtra, India from November 2023 to May 2024 on 60 healthy patients, aged 18-40 years, who required extraction of an impacted mandibular third molar, were included in the study. …”
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Investigating the impact of couple counseling based on the CHARMS model on sexual quality of life and marital satisfaction of wives of men suffering from myocardial infarction: a r... by Delniya Ghafuri, Soheila Rabeipoor, Kamal Khademvatani, Samira Barjasteh, Atefeh Yas

“…The data analyst was blinded to the group allocation. Findings The average age of women in the intervention and control groups was 45.16 ± 5.90 and 44.75 ± 4.94 years, respectively, with most being housewives and having two children. …”
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Impact of the Mediterranean Diet on Patients With Psoriasis: Protocol for a Randomized Controlled Trial by Javier Perez-Bootello, Emilio Berna-Rico, Carlota Abbad-Jaime de Aragon, Ruth Cova-Martin, Leticia Goni, Asuncion Ballester-Martinez, Pedro Jaen-Olasolo, Nehal Mehta, Joel M Gelfand, Miguel Angel Martinez-Gonzalez, Alvaro Gonzalez-Cantero

“…MethodsAn open-label, single-blinded (evaluator) randomized controlled trial was designed to assess the impact of a high-intensity MedDiet intervention in patients with mild-to-moderate psoriasis. …”
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Evaluation of a Guided Chatbot Intervention for Young People in Jordan: Feasibility Randomized Controlled Trial by Anne Marijn de Graaff, Rand Habashneh, Sarah Fanatseh, Dharani Keyan, Aemal Akhtar, Adnan Abualhaija, Muhannad Faroun, Ibrahim Said Aqel, Latefa Dardas, Chiara Servili, Mark van Ommeren, Richard Bryant, Kenneth Carswell

“…MethodsA 2-arm, single-blind, feasibility randomized controlled trial was conducted among 60 young people aged 18 years to 21 years living in Jordan with self-reported elevated levels of psychological distress. …”
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Caffeinated chewing gum enhances maximal strength and muscular endurance during bench press and back squat exercises in resistance-trained men by Li Ding, Jue Liu, Yi Yao, Li Guo, Bin Chen, Yinhang Cao, Olivier Girard

“…The aim of this study was to determine the efficacy of caffeinated chewing gum on maximal strength and muscular endurance during bench press and back squat exercises.MethodsIn a randomized, double-blind design, 16 resistance-trained males (age: 21.6 ± 2.0 years, height: 176.8 ± 6.1 cm, mass: 79.6 ± 8.8 kg) chewed either caffeinated gum (3 mg/kg) or a placebo gum on two occasions, 1 week apart. …”
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Application of a methodological framework for the development and multicenter validation of reliable artificial intelligence in embryo evaluation by D. Gilboa, Akhil Garg, M. Shapiro, M. Meseguer, Y. Amar, N. Lustgarten, N. Desai, T. Shavit, V. Silva, A. Papatheodorou, A. Chatziparasidou, S. Angras, J. H. Lee, L. Thiel, C. L. Curchoe, Y. Tauber, D. S. Seidman

“…Three datasets were used: the training and validation dataset (n = 16,935 embryos), the blind test dataset (n = 1,708 embryos; 3 clinics), and the independent dataset (n = 7,445 embryos; 7 clinics) derived from previously unseen clinic cohorts. …”
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Comparison of analgesic efficacy of diclofenac suppository with intramuscular diclofenac sodium in post-operative pain relief after cesarean delivery in the first 24 hours by Sidra Khan, Noreen Majeed, Ruqya, Mehreen Mehdi, Faiza Safdar, Saana Bibj

“…Methodology This RCT was done in  the department of Obstetrics and Gynecology, --removed for blind review---from 1st March 2018 till 30th August 2018. …”
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Use of artificial intelligence for gestational age estimation: a systematic review and meta-analysis by Sabahat Naz, Sahir Noorani, Syed Ali Jaffar Zaidi, Abdu R. Rahman, Saima Sattar, Jai K. Das, Jai K. Das, Zahra Hoodbhoy

“…The pooled mean error in GA estimation based on 2D images (n = 6) and blind sweep videos (n = 4) was 4.32 days (95% CI: 2.82, 5.83; l2: 97.95%) and 2.55 days (95% CI: −0.13, 5.23; l2: 100%), respectively. …”
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Effect of Esketamine on Cognitive Recovery After Propofol Sedation for Outpatient Colonoscopy: A Randomized Clinical Trial by Liu D, Gao X, Zhuo Y, Cheng W, Yang Y, Wu X, Yang H, Yao Y

“…This study investigated the effects of esketamine on multiple dimensions of recovery, particularly cognition, in patients undergoing colonoscopy with propofol-based sedation.Patients and Methods: We conducted this randomized, double-blinded, placebo-controlled trial from January 6, 2023, to May 20, 2024, at two hospitals in China. …”
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Dynamics of epidemiological indicators of glaucoma in the Republic of Bashkortostan for the period of 2010–2016 by M.M. Bikbov, A.E. Babushkin, I.I. Khusnitdinov, L. Kh. Murova, E.N. Matyukhina

“…In the course of conducted analysis, there was a decrease in patients, who underwent surgical treatment (from 27.9% to 23.7%), blind in one and both eyes (from 17.3% to 12.6%). …”
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Chronic Rhinosinusitis with Nasal Polyps and Biologics: A Call for Better Data Standardisation and Presentation in Clinical Studies by Kariyawasam HH, Langan D, Rimmer J

“…Here we report the need for urgent improvement in double-blind randomised controlled trials of biologics in CRSwNP, having previously undertaken a systematic review and meta-analysis of such studies. …”
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Dexmedetomidine versus Dexamethasone as an Adjuvant to Ropivacaine in Transversus Abdominis Plane Block in Infraumbilical Surgeries for Postoperative Analgesia: A Randomised Clinic... by Anupama Kumari, Aarjvi Patel, Payal Berawala, Sara Mary Thomas

“…Materials and Methods: In this randomised double-blinded prospective clinical study, conducted in the Department of Anaesthesia, Shrimati Bhikhiben Kanjibhai Shah Medical Institute and Research Centre (SBKS MIRC), Piparia, Vadodara, Gujarat, India from March 2023 to September 2024. 80 patients of American Society of Anaesthesiologists (ASA) I and II, aged 18-60 years, undergoing elective infraumbilical surgeries (open abdominal hysterectomy and open bilateral inguinal hernia repair) under spinal anaesthesia were randomly allocated into two groups of 40 patients each. …”
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Artificial intelligence-assisted clinical decision support for childhood asthma management: A randomized clinical trial. by Hee Yun Seol, Pragya Shrestha, Joy Fladager Muth, Chung-Il Wi, Sunghwan Sohn, Euijung Ryu, Miguel Park, Kathy Ihrke, Sungrim Moon, Katherine King, Philip Wheeler, Bijan Borah, James Moriarty, Jordan Rosedahl, Hongfang Liu, Deborah B McWilliams, Young J Juhn

“…Study subjects were stratified into three strata (based on asthma severity, asthma care status, and asthma diagnosis) and were blinded to the assigned groups.<h4>Measurements</h4>Intervention was a quarterly A-GPS report to clinicians including relevant clinical information for asthma management from EHRs and machine learning-based prediction for risk of asthma exacerbation (AE). …”
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Effects of olive leaf extract on exercise performance and muscle mitochondrial response in young healthy adults by Clément Lanfranchi, Nadège Zanou, Jérôme Feige, Umberto DeMarchi, Aurélie Hermant, Ornella Cominetti, Eugenia Migliavacca, Alba Moreno-Asso, Astrid Hostrman, Sara Mistro, Nicolas Place

“…Methods In a crossover (OLE vs. placebo), double-blind study, eleven healthy males performed a single session of MICT (1h at 50% maximal aerobic power). …”
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The effect of nursing care provided to coronary intensive care patients according to their circadian rhythms on sleep quality, pain, anxiety, and delirium: a randomised controlled... by Meryem Pelin, Havva Sert

“…During statistical analysis, the groups were coded as Group A and Group B, ensuring blinding for the statistician. Results The intervention group’s sleep quality increased compared to the control group (post-test SQ-CC total scores: intervention group 22.41 ± 6.67 vs. control group 50.45 ± 10.63, p < 0.001). …”
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Efficacy and Safety of Ultrasound-Guided Radiofrequency Treatment for Chronic Pain in Patients with Knee Osteoarthritis: A Systematic Review and Meta-Analysis by Yuzhao Huang, Qiufang Deng, Liuqing Yang, Jiahui Ma, Ziyang Wang, Dong Huang, Ling Luo, Haocheng Zhou

“…In addition, the outcomes were blindly assessed in the meta-analysis from all studies according to evaluation of bias, which could affect the reality of the data. …”
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Predictive value of ENLIGHT-DP in patients with metastatic lung adenocarcinoma treated with immune checkpoint inhibitors and platinum chemotherapy directly from histopathology slid... by Eli Pikarsky, Anna Elia, Gal Dinstag, Omer Tirosh, Tuvik Beker, Ranit Aharonov, Hovav Nechushtan, Leon Gugel, Yaron Kinar, Michael Tabi, Tzivia Gottlieb, Aron Popovtzer, Johnathan Arnon, Yakir Rottenberg, Philip Blumenfeld

“…We present an analysis of ENLIGHT-DP, a novel transcriptome-based biomarker directly from histopathology slides, in patients with lung adenocarcinoma (LUAD) treated with ICI and platinum-based chemotherapy.Methods We retrospectively scanned high-resolution H&amp;E slides from pretreatment tumor-tissue samples of 50 patients with metastatic LUAD treated with first-line ICI with (46) or without (4) platinum-based chemotherapy and applied our ENLIGHT-DP pipeline to generate, in a blinded manner, an individual prediction score. ENLIGHT-DP predicts response to ICI and targeted therapies given H&amp;E slide scans in two steps: (1) predict individual messenger RNA expression directly from high-resolution H&amp;E scanned slides using DeepPT, a digital-pathology-based algorithm. (2) Use these values as input to ENLIGHT, a transcriptome-based platform that predicts response to ICI and targeted therapies derived from drug-specific networks of gene expressions. …”
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Effect of peer support nursing on improvement of caregiver preparedness for care of low anal fistula in infants (同伴支持式护理提升婴儿低位肛瘘照顾者准备度的研究)... by GUO Yufan (郭雨凡), WANG Yanmei (王晏美), LI Jianan (李佳楠), LAI Lixia (来丽霞), WANG Yanzhi (王艳芝)

“…Methods A prospective, randomized, single-blind control study was conducted, and 60 cases of infants with anal fistula were included and randomly divided into two groups. …”
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Efficacy of an avocado-based Mediterranean diet on serum lipids for secondary prevention after ischemic stroke: a randomized phase 2 controlled pilot trial by Verónica V. Olavarría, Paola R. Campodónico, Valeska Vollrath, Paula von Geldern, Carolina Velásquez, Patricia Pavez, Barbara Valente, Pamela Donoso, Alexandra Ginesta, Gabriel Cavada, Enrico Mazzon, Víctor Navia, Matías Guzmán, Pablo Brinck, Andrés Gallardo, Pablo Gonzalez, Pablo M. Lavados

“…Methods The Avocado-Based Mediterranean Diet on Serum Lipids for Secondary Prevention after Ischemic Stroke (ADD-SPISE) was a prospective, randomized, open-label, blinded outcome assessment, phase 2, clinical trial. …”
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Prospective Analysis of Confocal Laser Endomicroscopy for Assessment of the Resection Bed for Bladder Tumor by Ben-Max de Ruiter, Jan E. Freund, C. Dilara Savci-Heijink, Jons W. van Hattum, Marinka J. Remmelink, Theo M. de Reijke, Joyce Baard, Guido M. Kamphuis, D. Martijn de Bruin, Jorg R. Oddens

“…Results at first cystoscopy 3 mo after TURBT are reported. A panel of two blinded observers evaluated the CLE images. The diagnostic accuracy of CLE for detection of detrusor muscle (DM) and residual tumor (rT) was calculated using 2 × 2 tables. …”
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