Topical chlorhexidine 0.2% versus topical natamycin 5% for fungal keratitis in Nepal: rationale and design of a randomised controlled non-inferiority trial by Victor Hu, David Macleod, Helen Anne Weiss, Matthew J Burton, Simon Arunga, Astrid Leck, Sanjay Kumar Singh, Jeremy John Hoffman, Reena Yadav, Sandip Das Sanyam, Pankaj Chaudhary, Abhishek Roshan, Einoti Matayan

“…Alternative antifungal medications are needed to treat this blinding disease.Chlorhexidine is an antiseptic agent with antibacterial and antifungal properties. …”
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Examining the effect of direct-from-blood bacterial testing on antibiotic administration and clinical outcomes: a protocol and statistical analysis plan for a pragmatic randomised... by Li Wang, Wesley H Self, Todd W Rice, Matthew W Semler, Karen F Miller, Cheryl L Gatto, Andrea Fletcher, Romney M Humphries, Joanna L Stollings, Adrienne Baughman, Jakea Johnson, Edward T Qian, Mary Lynn Dear, David C Gaston, Ariel A Lewis, George E Nelson, Benjamin J Ereshefsky, Matthew A Christensen, Ritu Banerjee, Dan Albert, Alison Benton, Laura Bobbitt, Carleigh Burns, Timothy Duff, David C. Gaston, MLS Sharon Glover, Allyson Hobbie, Austin Ing, Gabriel Kemp, Sheryl Mangrum, Geoff Mavrak, Kelly Moser, David Mulherin, Shannon Pugh, Matthew Rodgers, Chrissie Schaeffer, Adam Turner, Sabrina Shipman, Halden Z VanCleave, Hamilton Wen Li Wang, LaKeysha Wiggins

“…This manuscript describes the protocol and statistical analysis plan for a randomised trial designed to evaluate the effect of blood cultures plus direct-from-blood bacterial testing results compared with blood culture results alone on antibiotic administration and clinical outcomes.Methods and analysis We are conducting a prospective, single-centre, parallel-group, non-blinded, pragmatic, randomised trial. The trial will enrol 500 adult patients presenting to the emergency department at Vanderbilt University Medical Center with suspected bacterial infection who have been initiated on empiric intravenous vancomycin. …”
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Deficiency of ATF3 facilitates both angiotensin II‐induced and spontaneously formed aortic aneurysm and dissection development by activating cGAS–STING pathway by Yifan Du, Poyi Hu, Xiangchao Ding, Dashuai Wang, Jingjing Luo, Sheng Le, Lingyun Ren, Manhua Chen, Ping Ye, Jiahong Xia

“…We ensured the unbiased nature of our assessment by conducting morphological evaluations with two independent observers in a blinded manner. We identified elevated expression of ATF3 in both human sporadic AAD tissues and mouse AAD models. …”
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Validation of a data-driven motion-compensated PET brain image reconstruction algorithm in clinical patients using four radiotracers by Ole L. Munk, Anders B. Rodell, Patricia B. Danielsen, Josefine R. Madsen, Mie T. Sørensen, Niels Okkels, Jacob Horsager, Katrine B. Andersen, Per Borghammer, Joel Aanerud, Judson Jones, Inki Hong, Sven Zuehlsdorff

“…Methods We conducted technical validation experiments of the algorithm using Hoffman brain phantom scans during a series of controlled movements, followed by two blinded reader studies assessing image quality between standard images and MoCo images in 38 clinical patients receiving dementia scans with [18F]Fluorodeoxyglucose, [18F]N-(3-iodopro-2E-enyl)-2beta-carbomethoxy-3beta-(4’-methylphenyl)-nortropane, [18F]flutemetamol, and a research group comprising 25 elderly subjects scanned with [18F]fluoroethoxybenzovesamicol. …”
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The Role of Establishing a Multidisciplinary Team for Idiopathic Granulomatous Mastitis in Improving Patient Outcomes and Spreading Awareness about Recent Disease Trends by Rami J. Yaghan, Nehad M. Ayoub, Shadi Hamouri, Alia Al-Mohtaseb, Maha Gharaibeh, Lamees Yaghan, Mahmoud Al-Dari, Hiba Al-Kaff, Nabil A. Al-Zoubi

“…Diagnosis by TCB has replaced blind surgical excision. More data regarding predictors of recurrence is accumulating.…”
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Is the topical application of sesame oil (Sesamum indicum L.) combined with standard care valuable and safe for managing infusion-related phlebitis: Evidence from a systematic revi... by Morteza Nasiri, Leila Amirmohseni, Mohammad Farzollah Abbasi, Fatemeh Yarahmadi, Sahar Zonoori, Mahya Torkaman, Elham Sadeghi Moghimi, Mehrnaz Ardaneh, Masoomeh Asadi

“…Thus, to build a valid conclusion about the efficacy and safety of SO in managing IRP, more high-quality RCTs must be conducted considering an active placebo control intervention along with a well-designed randomization and blinding approach, as well as a better description of safety parameters and the quality control information of the SO used. …”
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Pharmacological management of gambling disorder: A systematic review and network meta-analysis by Konstantinos Ioannidis, Cinzia Del Giovane, Charidimos Tzagarakis, Jeremy E. Solly, Samuel J. Westwood, Valeria Parlatini, Henrietta Bowden-Jones, Jon E. Grant, Samuele Cortese, Samuel R. Chamberlain

“…Methods: Based on our pre-registered protocol [CRD42022329520], a structured search was conducted across broad range of databases, for double-blind randomized controlled trials (RCTs) of medications for gambling disorder. …”
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Deflection of screen surface and spatial deformation law of screen apertures during 1 mm elastic screening by Haishen JIANG, Ran YANG, Runyu LIU, Shijie YU, Peng GUO, Miao PAN, Long HUANG, Chenlong DUAN

“…During the vibration process of the elastic screen surface, the deflection deformation characteristics of screen surface could effectively overcome the problem of screening blind zones in the edge area and ensure the effective opening area of screen surface. …”
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Investigation of the use of a sensor bracelet for the presymptomatic detection of changes in physiological parameters related to COVID-19: an interim analysis of a prospective coho... by Stefanie Aeschbacher, David Conen, Diederick E Grobbee, Raphael Twerenbold, Thomas Lung, Theo Rispens, Jakob Kjellberg, Lorenz Risch, Martin Risch, Marianna Mitratza, Harald Renz, Spiros Denaxas, Billy Franks, Diederick Grobbee, Martina Rothenbühler, Janneke Wijgert, Santiago Montes, Richard Dobson, Hans Reitsma, Christian Simon, Titia Leurink, Charisma Hehakaya, Patricia Bruijning, Kirsten Grossmann, Ornella C Weideli, Marc Kovac, Fiona Pereira, Nadia Wohlwend, Corina Risch, Dorothea Hillmann, Daniel Leibovitz, Vladimir Kovacevic, Andjela Markovic, Paul Klaver, Timo B Brakenhoff, George S Downward, Ariel Dowling, Maureen Cronin, Brianna M Goodale, Brianna Goodale, Ornella Weideli, Regien Stokman, Hans Van Dijk, Eric Houtman, Jon Bouwman, Kay Hage, Lotte Smets, Marcel van Willigen, Maui Chodura, Niki de Vink, Tessa Heikamp, Timo Brakenhoff, Wendy van Scherpenzeel, Wout Aarts, Alison Kuchta, Antonella Chiucchiuini, Steve Emby, Annemarijn Douwes, George Downward, Nathalie Vigot, Pieter Stolk, Duco Veen, Daniel Oberski, Amos Folarin, Pablo Fernandez Medina, Eskild Fredslund

“…Our proposed RNN algorithm identified 68% of COVID-19 positive participants 2 days prior to SO and will be further trained and validated in a randomised, single-blinded, two-period, two-sequence crossover trial.Trial registration numberISRCTN51255782; Pre-results.…”
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Effects of traditional Chinese medicine massage therapy on pain, functional activity, muscle activation patterns and proprioception in knee osteoarthritis: a randomised controlled... by Xin Zhou, Cheng Tang, Bowen Zhu, Yangyang Fu, Min Fang, Sitong Fang, Qingguang Zhu, Yuen Yee Janice Hiew

“…Outcome assessors and data analysts will be blinded to the allocations, and the participants will not disclose their specific allocations. …”
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Sucrose-Sweetened Drinks Reduce the Physical Performance and Increase the Cardiovascular Risk in Physically Active Males by Raianne dos Santos Baleeiro, Aparecida Patricia Guimarães, Perciliany Martins de Souza, Rafael da Silva Andrade, Karina Barbosa de Queiroz, Daniel Barbosa Coelho, Emerson Cruz de Oliveira, Lenice Kappes Becker

“…Seventeen volunteers consumed a placebo drink (Pd; carbohydrate free) and an excessive SSB drink (eSSBd = Pd plus 300 g sucrose). In a blind randomized crossover study, the subjects were assigned to Pd or eSSBd groups for 15 days. …”
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Randomized Clinical Trial of Intraocular Pressure-Lowering Medications on Preventing Spikes in Intraocular Pressure Following Intravitreal Anti-Vascular Endothelial Growth Factor I... by Piriya Soomsawasdi, Kulawan Rojananuangnit, Eakkachai Arayangkoon, Ratchada Chantiwas, Sureeporn Pengrungreungwong, Nontakorn Preawsampran, Natnaree Tinpowong, Rujira Samakhararaksakul, Kanokwan Katkingkaew, Natthapuch Seekhum, Wanwisa Sathim

“…Methods This randomized double-blind clinical trial included one eye of each participant indicated for treatment with intravitreal injection of anti-VEGF agents (bevacizumab, aflibercept, and ranibizumab) and randomly allocated to one of the three prophylactic anti-glaucoma medications, with each drug further divided into one- and two-drop regimens before intravitreal injection. …”
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Robotic-assisted surgery and kinematic alignment in total knee arthroplasty (RASKAL study): a protocol of a national registry-nested, multicentre, 2×2 factorial randomised trial as... by Ian A Harris, Samuel J MacDessi, Aziz Bhimani, Darren B Chen, Ian Harris, Michelle Lorimer, David Parker, Tamara Hooper, Richard Boyle, Jonathan Mulford, Daniel Franks, Gregory C Wernecke, Durga Bastiras, Emma Heath, Anthony Leong, Brett Fristch, David Penn, George Kirsh, John Limbers, Julian Yu, Maurice Guzman, Peter McEwen

“…This study aims to assess the effectiveness of RAS, KA or both to improve clinical outcomes, functional measures, radiographic precision and prosthetic survivorship when compared with current gold standards of surgical care.Methods and analysis A national registry-nested, multicentre, double-blinded, 2×2 factorial, randomised trial will be undertaken with 300 patients undergoing primary unilateral TKA performed by 15 surgeons. …”
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Validation of insurance claims data on aetiology, surgical type and prosthesis for isolated valve surgery: a retrospective observational surgery by Shao-Wei Chen, Victor Chien-Chia Wu, Pao-Hsien Chu, An-Hsun Chou, Chun-Yu Chen, Feng-Cheng Chang, Yi‐Hsin Chan, Chia-Pin Lin, Yu-Ting Cheng, Bo-Cheng Hou, Jo-Ting Huang

“…The gold standard was defined as a blinded retrospective review of operation notes. Claims data, including ICD diagnostic codes, ICD procedural codes and NHI supply codes for surgical materials, were validated. …”
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Open-label dose-extending placebos for opioid use disorder: a protocol for a randomised controlled clinical trial with methadone treatment by Annabelle M Belcher, Thomas O Cole, Aaron D Greenblatt, Stephen W Hoag, David H Epstein, Michael Wagner, Amy S Billing, Ebonie Massey, Kristen R Hamilton, Zofia K Kozak, Christopher J Welsh, Eric Weintraub, Emerson M Wickwire, Eric D Wish, Ted J Kaptchuk, Luana Colloca

“…Throughout this study time period, methadone dosages will be adjusted by an addiction clinician blind to patient assignment, per standard clinical methods. …”
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Diagnósticos de enfermagem no setor de emergência: uma revisão integrativa by Daniel da Silva Rodrigues, Roberta Teixeira Prado, Maria Paula Taligliatti Luciano, Stephany Fabiane de Moura Costa, Isabella Lusvardi do Pinho Mellado, Rossana Gomes Machado Arruda, Suellen Cristina Dias Emidio

“…Methodology: Integrative review carried out in the PubMed, SciELO, Web of Science and Scopus databases, via Portal Capes with triple-blind selection, from October 2023 to January 2024. …”
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Diagnostic Accuracy of Detective Flow Imaging Endoscopic Ultrasonography for Evaluating Blood Flow Within Mural Nodules of Intraductal Papillary Mucinous Neoplasms by Kazuki Endo, Haruo Miwa, Kazuya Sugimori, Kozue Shibasaki, Shoichiro Yonei, Yugo Ishino, Shotaro Tsunoda, Hayato Yoshimura, Akihiro Funaoka, Hiromi Tsuchiya, Ritsuko Oishi, Yuichi Suzuki, Satoshi Komiyama, Takashi Kaneko, Manabu Morimoto, Kazushi Numata, Shin Maeda

“…Three expert endosonographers blinded to the patients’ clinical data assessed the MN images obtained with CE-EUS and DFI-EUS. …”
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L’échelon manquant ? Les archives municipales en Algérie : histoire de fonds et possibilités historiographiques by Thierry Guillopé

“…Their interest lies not least in helping to fill in some of the blind spots in historiography. They would enable us to undertake a history of urban property and neighbourhood social life, agricultural practices, justice, etc. …”
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The Physiological Impacts of the Low- and Moderate-Volume-HIIT with or without Nano-Curcumin Supplement in Women in Menopause with Obesity by Valiollah Dabidi Roshan, Sepideh Noorbakhsh, Seyedeh Fatemeh Ziatabar Ahmadi, Mehdi Nikseresht

“…Tabata exercise has been proposed as an extremely time-efficient high-intensity interval training (HIIT) method to achieve health benefits, but direct comparisons between the low-volume-HIIT (LV-HIIT), moderate-volume-HIIT (MV-HIIT) with and without nano-curcumin (NaC) supplement for 8-week on cardiovascular hemodynamic, respiratory function, muscular fitness, and physical performance in the obese menopause women are limited. In a double blind, randomized, placebo-controlled study, 53, moderately obese menopause women (average age 45–60 yrs, BMI > 30 kg/m2, WC for >85 cm, and body fat > 35%) were randomly assigned to undertake either LV-HIIT, MV-HIIT, or NaC supplement (daily 80 mg in two 40-mg capsules) for two sessions per week for 8 weeks. …”
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Conditional diffusion-generated super-resolution for myocardial perfusion MRI by Changyu Sun, Changyu Sun, Neha Goyal, Yu Wang, Darla L. Tharp, Senthil Kumar, Talissa A. Altes

“…PerfGen outperformed GAN-based approach in sharpness (4.36 ± 0.38 vs. 4.89 ± 0.22) and overall image quality (4.14 ± 0.28 vs. 4.89 ± 0.22), as assessed by two experts in a blinded evaluation (P < 0.05) in prospective study.DiscussionThis work demonstrates the capability of diffusion-based generative models in generating high-resolution myocardial perfusion MRI from conditional low-resolution images. …”
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