Colorectal Serrated Neoplasia: An Institutional 12-Year Review Highlights the Impact of a Screening Programme by A. J. McCarthy, S. M. O’Reilly, J. Shanley, R. Geraghty, E. J. Ryan, G. Cullen, K. Sheahan

“…All available and suitable slides were reviewed by one pathologist, who was blinded to the original diagnosis and the site of the polyp. …”
Get full text

Comparative thoracic radiography in healthy and tuberculosis-positive sun bears (Helarctos malayanus) by Kirsty Officer, Kirsty Officer, Natalie Webster, Alana J. Rosenblatt, Phorn Sorphea, Kris Warren, Kris Warren, Bethany Jackson, Bethany Jackson

“…Findings of two veterinary radiologists, blinded to clinical information, revealed high agreement on broad categorization of radiographic studies as normal, abnormal, or needing correlation with further information. …”
Get full text

Stigmatization of people with mental illness – a matter of milieu-specific worldviews? Results from a population-based survey in Germany by Jenny Spahlholz, Eva Baumann, Sven Speerforck, Sven Speerforck, Christian Sander, Christian Sander, Matthias C. Angermeyer, Georg Schomerus, Georg Schomerus

“…In addition to making blind spots more visible (i.e., schizophrenia), milieu-specific knowledge could be useful in deciding which intervention components are most appropriate for which milieu groups and how to apply them successfully.…”
Get full text

Validating a digital depression prevention program for adolescents in Jordan: cultural adaptation and user testing in a randomized controlled trial by Latefa Ali Dardas, Obada Al-leimon, Tracy Gladstone, Abd Arrahman Dabbas, Insaf Alammouri, Benjamin Van Voorhees

“…It evaluated the feasibility, cultural acceptability, and effectiveness of the translated and culturally adapted DHI, named Al-Khaizuran, with comparisons to school-based group CBT.MethodsA two-arm, single-blind randomized controlled trial with a mixed-methods design was conducted among 109 Jordanian adolescents aged 15–17 years experiencing mild to moderate depression. …”
Get full text

Evaluating a targeted selective speech, language, and communication intervention at scale – Protocol for the Happy Talk cluster randomised controlled trial. [version 2; peer review... by Pauline Frizelle, Darren Dahly, Aoife O'Shea, Aileen Murphy, Cristina McKean

“…Training/coaching includes core interaction skills (modelling, expanding, balancing questions and comments), early literacy and phonological awareness. Blinded assessments pre- and immediately post-intervention and at 6 months follow up, will measure the primary outcomes of children’s receptive and expressive language and functional impact, and secondary outcomes of quality of life. …”
Get full text

Elastosonographic Evaluation of Endometrium in Postmenopausal Bleeding by İsmail Burak Gültekin, Orhan Altınboğa, Serap Gültekin, Elif Akkaş Yılmaz, Gökşen İnanç İmamoğlu, Afra Alkan, Tuncay Küçüközkan

“…B-mode scanning, Doppler and real-time tissue elastography (RTE) were performed by the same single operator, blinded to the study design. The ultrasonographic findings (strain ratio, endometrial thickness, uterine artery Doppler indices) were evaluated between groups. …”
Get full text

Biologics for eosinophilic oesophagitis: a systematic review and meta-analysis by Beibei Zeng, Doudou Jia, Shengen Li, Xuna Liu, Boxu Zhu, Yanqi Zhang, Yan Zhuang, Fei Dai

“…In this review, we conducted a meta-analysis of all RCTS of biologics in the treatment of EoE to evaluate their efficacy and safety and discussed their treatment of non-EoE EGIDs.Methods We searched the PubMed, EMBASE, Cochrane Library, and Web of Science databases. Double-blind randomized controlled trials comparing biologics with placebo in patients with EoE and non-EoE EGIDs were collected and further screened for inclusion and exclusion. …”
Get full text

The Use of Electronic Consent (eConsent) Within the Ketamine for Long-Lasting Pain Relief After Surgery (KALPAS) Multicenter Trial by Doan LV, Burr J, Perez R, Martinez H, Cuevas R, Watt K, Wang J

“…It has streamlined the process of consenting patients and has been shown to benefit the research study team and participants.eConsent in the Ketamine Analgesia for Long-Lasting Pain Relief After Surgery (Kalpas) Study: The KALPAS study is a multicenter, double-blind, randomized controlled study investigating the effectiveness of ketamine in reducing chronic post-mastectomy pain in women undergoing mastectomy for oncologic indication. …”
Get full text

Risperidone versus placebo for aggression following traumatic brain injury: a feasibility randomised controlled trial by Paul Bassett, Tim Weaver, Shoumitro Deb, Mike Crawford, David Sharp, Lina Aimola, Verity Leeson, Mayur Bodani, Lucia Li

“…Objectives To conduct a feasibility randomised controlled trial of risperidone for the treatment of aggression in adults with traumatic brain injury (TBI).Design Multicentre, parallel design, placebo controlled (1:1 ratio) double-blind feasibility trial with an embedded process evaluation. …”
Get full text

Treatment outcomes of two surgical techniques in secondary reconstruction of unilateral cleft lip and ala nasi utilizing anthropometry assessment: a randomized controlled trial by Ebrahim Humadi, Mawia Karkoutly, Zafin Kara Beit

“…Methods It was a double-blinded, randomized, parallel-group, active-controlled trial with two arms. …”
Get full text

HEalth-Related Quality of Life-Intervention in Survivors of Breast and Other Cancers Experiencing Cancer-Related Fatigue and Associated Cognitive Symptoms Using TraditionAL Chinese... by Alexandre Chan PharmD, Daniella Chan BS, Ding Quan Ng BSPharm, Huang Fang Zheng MD, Quan Ming Tan MCM, Chia Jie Tan PhD, Jolene Hui Min Toh BS, Ning Yi Yap PhD, Yi Long Toh PhD, Yu Ke PhD, Edmund Chun Ann Wang BS, Queenie Pei Ni Lim BSocSc, Han Kiat Ho PhD, Lita Chew MMS, Tira J. Tan MBBS

“…Methods: In a single-centered, randomized, double-blinded, placebo-controlled pilot trial conducted from 2019 to 2022, fatigued cancer survivors ≥21 years old were recruited to receive the XBYRT intervention or placebo (5% diluted) once daily for the duration of 8 weeks. …”
Get full text

Does an increase in physiological indexes predict better cognitive performance: the PhyCog randomised cross-over protocol in type 2 diabetes by Frederic Dutheil, Guillaume T Vallet, Igor Tauveron, Julien S Baker, Valentin Magnon, Jordan Mille, Valentin Brusseau, Laetitia Silvert, Marie Izaute

“…Assessors will all be blinded to outcomes. To test the primary hypothesis, the relationship between improvement in physiological variables and improvement in cognitive variables (executive, memory and attention) will be collected.Ethics and dissemination This protocol was approved by the Est III French Ethics Committee (2020-A03228-31). …”
Get full text

Evaluation of waning of IgG antibody responses after rVSVΔG-ZEBOV-GP and Ad26.ZEBOV, MVA-BN-Filo Ebola virus disease vaccines: a modelling study from the PREVAC randomized trial by Simon Valayer, Marie Alexandre, Mélanie Prague, Abdoul Habib Beavogui, Seydou Doumbia, Mark Kieh, Brian Greenwood, Bailah Leigh, Marie Poupelin, Christine Schwimmer, Samba O. Sow, Irina Maljkovic Berry, Jens H. Kuhn, Daniela Fusco, Natasha Dubois Cauwelaert, Deborah Watson-Jones, Rodolphe Thiébaut, Yves Lévy, Yazdan Yazdanpanah, Laura Richert, Edouard Lhomme

“…Data from a large phase 2 randomized double-blind clinical trial (PREVAC) were used to evaluate waning of anti-Ebola virus (EBOV) glycoprotein (GP1,2) antibody concentrations after rVSVΔG-ZEBOV-GP or Ad26.ZEBOV, MVA-BN-Filo vaccination with linear mixed-effect regression models. …”
Get full text

Effect of intermittent theta burst stimulation combined with acoustic startle priming motor training on upper limb motor function and neural plasticity in stroke individuals: study... by Jing Zhang, Yu Chen, Mingzhu Wang, Nan Xia, Jinghong Li, Weiqiang Liang, Yangyang Yin, Linhan Zhai, Qiuxia Wang

“…This study aims to investigate the feasibility of segmentally modulating the cortico-reticular and reticulospinal tracts through ASP and iTBS while evaluating the resulting therapeutic effects.Methods and analysis This is a randomised, blinded interventional trial with three parallel groups. …”
Get full text

Heart–brain microvascular MRI study: protocol for a multicentre, observational, cohort study in the UK assessing associations between small vessel disease of the heart and brain by Colin Berry, Alex McConnachie, Peter Kellman, Terry Quinn, Paul Donnelly, Vanessa Orchard, Robert A Sykes, Gemma McKinley, Conor Patrick Bradley, Jodi Watt, Natasha Fullerton

“…The CorCMR (coronary microvascular angina cardiovascular magnetic resonance imaging) brain imaging study will provide novel insights into the associations between small vessel disease of the heart and brain and related clinical significance.Methods and analysis The CorCMR brain imaging study is a prospective, observational, multicentre cohort study including a blinded, central analysis and independent clinical trials unit; a prespecified study nested within the CorCMR trial. …”
Get full text

Caloric labels do not influence taste pleasantness and neural responses to erythritol and sucrose by Aleksandra Budzinska, Laura Byl, Fabienne Teysseire, Emilie Flad, Patrick Dupont, Bettina Wölnerhanssen, Anne Christin Meyer-Gerspach, Lukas Van Oudenhove, Nathalie Weltens

“…Methods: We performed a within-subject, single-blind, counterbalanced fMRI study in 30 healthy males (mean ± SD: age 23 ± 0.6 years, BMI 22.5 ± 0.3 kg/m²). …”
Get full text

Effectiveness and safety profile of mesenchymal stem cell secretome as a treatment for severe cases of COVID-19: a randomized controlled trial [version 2; peer review: 1 approved,... by Hary Sakti Muliawan, Erlina Burhan, Mia Elhidsi, Heri Wibowo, Triya Damayanti, Jeanne Adiwinata Pawitan, Isabella Kurnia Liem, Ismail Hadisoebroto Dilogo, Mira Yulianti, Adityo Susilo, Irandi Putra Pratomo, Raden Rara Diah Handayani, Rahyussalim -, Murdani Abdullah, Cosphiadi Irawan, Robert Sinto, Dita Aditianingsih

“…We conducted a study to investigate secretomes’ effectiveness and safety profile as a treatment for severe COVID-19.  Methods: A double-blind, multicenter, randomized, placebo-controlled trial was conducted between February 2021 and July 2021 in three top COVID-19 referral hospitals in the Greater Jakarta area, Indonesia. …”
Get full text

DAILY – A personalized circadian Zeitgeber therapy as an adjunctive treatment for alcohol use disorder patients: results of a pilot trial by Naomi Springer, Naomi Springer, Lisa Echtler, Lisa Echtler, Paul Volkmann, Anisja Hühne-Landgraf, Anisja Hühne-Landgraf, Jasmin Hochenbleicher, Eva Hoch, Eva Hoch, Gabi Koller, Dominic Landgraf

“…The DAILY pilot study is a six-week monocentric trial with a controlled, randomized, single-blinded, parallel-group design. 41 AUD patients participated in the pilot study and were randomly assigned to an intervention group (IG) or a control group (CG).ResultsThe variability of daily activities was significantly lower in the IG group than in the CG group. …”
Get full text

Protocol for Home-Based Solution for Remote Atrial Fibrillation Screening to Prevent Recurrence Stroke (HUA-TUO AF Trial): a randomised controlled trial by Jing Tan, Yan Liang, Yong Liu, Wei Jiang, Duo Huang, Ning Tan, Chung-Wah Siu, Jo Jo Hai, Xiaoyu Huang, Jianfeng Ye, Ji-yan Chen, Chun Ka Wong, Mi Zhou, Li-Xue Yin, Ming-Liang Zuo, Kui Kai Lau, Zhen Lei, Yingqing Feng, Bryan P Yan, Wen-Sheng Yue, Wen-Jun Zhang, Yuk-Ming Lau, Hin-Wai LUI, Koon-Ho Chan, Toi Meng Mok, Weng-Chio Tam, Kun-Chong Tam, Xiuhua Feng, Xiaofei Jiang, Guanming Tan, Mario Alberto Evora

“…The objective of the study was to explore the use of long-term home-based ECG monitoring for AF detection and stroke prevention in patients with a history of stroke.Methods and analysis This prospective, randomised, open-label trial with blinded endpoint adjudication aimed to evaluate the efficacy of long-term home-based ECG monitoring for AF detection and stroke prevention in a 24-month period. …”
Get full text

Establishment of <i>Echinococcus granulosus EgM123</i> Recombinant Gene Rabies Virus SRV₉ and Identification of Its Biological Characteristics by Yueqi Yang, Mengdan Hou, Guicheng Su, Xiaoyan Ma, Xiaohui Su, Kunlei Li, Songhan Liu, Luheng Xiao, Jingjing Yao, Jiahao Zhai, Xiaoying Wei, Yang Zhou, Qianqian Lai, Yuwei Dong, Jieyu Liu, Shaohua Zhai

“…The recombinant virus was exposed to the sixth-generation blind passage, with the <i>N</i>, <i>P</i>, <i>G</i>, and <i>EgM123</i> genes amplified via RT-PCR, yielding targeted strips. …”
Get full text