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An anoikis-related signature predicts prognosis and immunotherapy response in gastrointestinal cancers
Published 2025-02-01“…S100A11 and TLR3, representative candidate genes, exhibited different expression patterns and biological functions.ConclusionThis study highlighted the significant potential of the Anoscore in predicting prognosis and guiding the selection of personalized therapeutic regimens for patients with GI cancers.…”
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17962
Proteomic Identification and Functional Analysis of Babesia microti Reveals Heparin-Binding Proteins
Published 2025-01-01“…Bioinformatics was utilized to analyze the subcellular localization and biological functions of these proteins. Candidate genes encoding proteins with strong heparin affinity will be expressed in a prokaryotic system to produce recombinant proteins. …”
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17963
The Life Mission Theory III. Theory of Talent
Published 2003-01-01“…We manifest our talents in a giving movement from the bottom of our soul trough our biological nature onto the subject and object of the outer world. …”
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17964
Potential and actual evapotranspiration and Landsat derived indices
Published 2024-07-01“…BACKGROUND AND OBJECTIVES: Evapotranspiration is an important component of water balance associated with the hydrological cycle and biological processes. Accurately estimating the rate of evapotranspiration is crucial for understanding fluctuations in water availability and effectively managing water resources in a sustainable manner. …”
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17965
Orientin Reduces the Effects of Repeated Procedural Neonatal Pain in Adulthood: Network Pharmacology Analysis, Molecular Docking Analysis, and Experimental Validation
Published 2023-01-01“…GO analysis indicated that the primary biological process (BP), molecular function (MF), and cellular component (CC) were protein phosphorylation, protein kinase activity, and vesicle lumen, respectively. …”
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Early selective attention to the articulating mouth as a potential female-specific marker of better language development in autism: a review
Published 2025-02-01“…Here we gather evidence from neurotypical infants and those with elevated likelihood of autism to uncover why biological sex, the development of selective attention to the mouth, and language acquisition could be intimately related in both populations. …”
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17967
Comprehensive computational analysis of differentially expressed miRNAs and their influence on transcriptomic signatures in prostate cancer
Published 2025-01-01“…This analysis uncovered their substantial impact on critical biological processes and molecular functions, such as cyclin-dependent protein kinase activity, mitotic DNA damage checkpoint signalling, stress-activated MAPK cascade, regulation of extrinsic apoptotic signalling pathway, and positive regulation of cell adhesion. …”
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17968
RETRACTED ARTICLE: Construction and validation of a machine learning-based immune-related prognostic model for glioma
Published 2024-10-01“…The model genes were further studied using GSCA, TISCH2, and HPA databases to understand their role in glioma pathology at the genomic, molecular, and single-cell levels, and validate the biological function of IKBKE in vitro experiments. Results In this study, a total of 199 genes associated with prognosis were identified using univariate Cox analysis. …”
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Single-cell RNA sequencing reveals the dysfunctional characteristics of PBMCs in patients with type 2 diabetes mellitus
Published 2025-01-01“…The differentially expressed genes, biological functions, cell cycle dynamics, and correlations between blood glucose indicators and genes in different cell types were analysed.ResultsThere were differences between the healthy and T2DM groups in terms of FBG and HbA1c (p<0.05 or p<0.01). …”
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Redox-Modulating Capacity and Effect of Ethyl Acetate Roots and Aerial Parts Extracts from <i>Geum urbanum</i> L. on the Phenotype Inhibition of the <i>Pseudomonas aeruginosa</i> L...
Published 2025-01-01“…(<i>Rosacea</i>) is a perennial herb known for many biological properties. This study aimed to investigate the redox-modulating capacity and effect of ethyl acetate (EtOAc) extracts from roots (EtOAcR) and aerial parts (EtOAcAP) of the Bulgarian plant on the phenotype inhibition of the <i>P. aeruginosa</i> Las/RhI quorum sensing (QS) system, which primarily determines drug resistance in pathogenic bacteria, including biofilm formation, motility, and pigment production. …”
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Identifying a Serum Exosomal-Associated lncRNA/circRNA-miRNA-mRNA Network in Coronary Heart Disease
Published 2021-01-01“…MicroRNAs (miRNAs) targeting DEMs were predicted using the Targetscan and miRanda databases, and miRNAs targeted by DELs and DECs were predicted using the miRcode and starBase databases, respectively. The biological functions and related signaling pathways of DEMs were analyzed using the David and KOBAS databases. …”
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17972
ADAM-10 Regulates MMP-12 during Lipopolysaccharide-Induced Inflammatory Response in Macrophages
Published 2022-01-01“…A disintegrin and metalloprotease 10 (ADAM-10), a member of the ADAM protease family, has biological activities related to TNF-α activation, cell adhesion, and migration, among other functions. …”
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17973
ZnO Nanoparticle-Assisted Synthesis of Thiazolo[3,2-α]Pyrimidine Analogs: Antibacterial and Antioxidant Activity, In Silico Molecular Docking, and ADMET Prediction Study
Published 2022-01-01“…Thus, according to our findings, both the biological activities and in silico computational results revealed that compounds 14, 16, and 18 are good antibacterial agents against P. aeruginosa and E. coli, whereas compound 19 was found to be a promising antibacterial agent against S. aureus and an antioxidant agent. …”
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