Novel quinolines carrying pyridine, thienopyridine, isoquinoline, thiazolidine, thiazole and thiophene moieties as potential anticancer agents by Ghorab Mostafa M., Alsaid Mansour S., Al-Dosari Mohammed S., Ragab Fatma A., Al-Mishari Abdullah A., Almoqbil Abdulaziz N.

“…As a part of ongoing studies in developing new anticancer agents, novel 1,2-dihydropyridine 4, thienopyridine 5, isoquinolines 6–20, acrylamide 21, thiazolidine 22, thiazoles 23–29 and thiophenes 33–35 bearing a biologically active quinoline nucleus were synthesized. …”
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Association of Autoantibodies against M2-Muscarinic Acetylcholine Receptor with Atrial Fibrosis in Atrial Fibrillation Patients by Guiling Ma, Xuejiao Wu, Lijun Zeng, Jiawei Jin, Xingpeng Liu, Jianjun Zhang, Lin Zhang

“…Left atrial appendages were subjected to histological and molecular biological assays. Patients in the AF group received follow-up for two years. …”
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Adeno-Associated virus 8 delivers an immunomodulatory peptide to mouse liver more efficiently than to rat liver. by Yuqing Wang, Ayrea Hurley, Marco De Giorgi, Mark R Tanner, Rong-Chi Hu, Michael W Pennington, William R Lagor, Christine Beeton

“…Several of its analogs are some of the most potent and selective blockers of this channel. However, like most biologics, ShK and its analogs require injections for their delivery, and repeated injections reduce patient compliance during the treatment of chronic diseases. …”
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A preliminary account of Culicoides (Diptera: Ceratopogonidae) from the Andaman and Nicobar Islands with 13 new records and updated species inventory from India by Koustav Mukherjee, Surajit Kar, Atanu Naskar, Chandrakasan Sivaperuman, Dhriti Banerjee

“…Abstract Background The detection of multiple bluetongue virus serotypes, increasing trend in livestock density, rich biological diversity with high endemism, and the status of the Andaman and Nicobar Islands as a popular tourist destination underscore the need for a faunistic survey of medically and veterinary significant vector species, specifically Culicoides, in this region. …”
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Genetic analysis of ocular tumour-associated genes using large genomic datasets: insights into selection constraints and variant representation in the population by Jose S Pulido, Mandeep S Sagoo, Omar A Mahroo, Alexander Tanner

“…UniProt was used for further gene characterisation, and gene ontology Protein Analysis THrough Evolutionary Relationships was explored for common biological pathways. In addition, we identified genes with under-representation/over-representation of missense/synonymous variants.Results Fifty-seven genes were identified in association with ocular and extraocular tumours.Regarding haploinsufficiency, 41% of genes met the criteria for negative selection, with 57% categorised as tumour-suppressing and 39% as oncogenic. …”
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Exploring the molecular basis of efficient feed utilization in low residual feed intake slow-growing ducks based on breast muscle transcriptome by Lei Wu, Zhong Zhuang, Wenqian Jia, Yongpeng Li, Yijia Lu, Minghong Xu, Hao Bai, Zhixiu Wang, Guobin Chang, Yong Jiang

“…Our findings indicate that reduced mitochondrial energy metabolism may contribute to the RFI of slow-growing ducks, with PRKAG3 playing a pivotal role in this biological process. These findings provide novel insights into the molecular changes underlying RFI variation in slow-growing ducks.…”
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Potential and mechanisms of indigenous Indonesian medicinal plants in treating sexual dysfunction: A systematic review and pharmacological network overview by Sukardiman, Roihatul Mutiah, Rosita Handayani

“…These target genes are connected to the biological mechanisms underlying steroid hormone biosynthesis, which is essential for the formation of testosterone. …”
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Phytochemical, Physiochemical, Macroscopic, and Microscopic Analysis of Rosa damascena Flower Petals and Buds by Zead Helmi Abudayeh, Uliana Karpiuk, Narjes Armoon, Qais Abualassal, Eyad Mallah, Loay Khaled Hassouneh, Yousef Aldalahmeh

“…We have confirmed that not only buds but also flower petals could be a source of biologically active substances (BASs) such as essential oils, polysaccharides, and phenolic compounds. …”
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Comprehensive Analysis of Differentially Expressed miRNAs and mRNAs Reveals That miR-181a-5p Plays a Key Role in Diabetic Dermal Fibroblasts by Peng Liu, Yi Zhu, Qin Li, Biao Cheng

“…The human dermal fibroblast (HDF), which is an important kind of effector cell in the wound healing process, represents different biological behaviors in the normal and diabetic skins. …”
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Sedimentary Facies of the Longmaxi Formation Shale Gas Reservoir in the Weiyuan Area Based on Elemental Characteristics by Yijia Wu, Hongming Tang, Ying Wang, Jing Li, Yanxiang Zeng, Songlian Jiang, Yongcheng Mu

“…In this study, the ratio of uranium to thorium (U/Th), the total organic carbon (TOC), and the biological silicon content (SiBio) were selected as the characteristic parameters to precisely analyze the sedimentary environment and its impact on reservoir quality. …”
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Hydrochemical characteristics, water quality and diatom assemblage in Dordi River, Nepal by Punam Phuyal, Shraddha Ranabhat, Sanjal Khatri, Nabin Lamichhane, Ramesh Raj Pant, Lal Bahadur Thapa, Ram Kailash Prasad Yadav

“…The water quality parameters of the river like temperature, pH, electric conductivity (EC), total dissolved solids (TDS), dissolved oxygen (DO), turbidity, and total alkalinity (TA) were measured in-situ, whereas concentrations of major ions (Ca2+, Mg2+, K+, Na+, NH4+, HCO3–, Cl–, SO42–, NO3–, and PO43–), biological oxygen demand (BOD) and chemical oxygen demand (COD) were analyzed in the laboratory by collecting water samples from different parts of the river. …”
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Impact of nutrient dynamics on chlorophyll-a concentrations in non-interconnected lakes: A study in the Vellore and Chennai region by Raghul Mageswaran, Porchelvan Ponnusamy

“…An integrated approach was employed, combining physio-chemical and biological analysis, Principal Component Analysis and GIS mapping. …”
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Multiomic quantification of the KRAS mutation dosage improves the preoperative prediction of survival and recurrence in patients with pancreatic ductal adenocarcinoma by Won-Gun Yun, Daeun Kim, Youngmin Han, Wooil Kwon, Seong-Geun Lee, Jin-Young Jang, Daechan Park

“…We aimed to evaluate the prognostic value of the dosage of the KRAS G12 mutation, a key pancreatic ductal adenocarcinoma (PDAC) variant and to investigate the biological mechanism of the prognosis associated with the dosage of the KRAS G12 mutation. …”
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A pan-cancer analysis of homeobox family: expression characteristics and latent significance in prognosis and immune microenvironment by Yuanhui Wang, Jie Gao, Ziyi Ren, Ziyi Shen, Wei Gu, Qinyi Miao, Xiaomeng Hu, Xiaomeng Hu, Yan Wu, Yan Wu, Wei Liu, Jia Jia, Jia Jia, Yi Cai, Chunpeng (Craig) Wan, Lei Sun, Tingdong Yan, Tingdong Yan

“…BackgroundThe Homeobox (HOX) gene family are conserved transcription factors that are essential for embryonic development, oncogenesis, and cancer suppression in biological beings. Abnormally expressed HOX genes in cancers are directly associated with prognosis.MethodsPublic databases such as TCGA and the R language were used to perform pan-cancer analyses of the HOX family in terms of expression, prognosis, and immune microenvironment. …”
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Ethnobiological survey on medicinal plants used by gaddi and gujjar tribes of riparian region of Beas River of Himachal Pradesh in North Western Himalayas, India by Neha Thakur, Nitesh Kumar, Sanjeev Kumar, Anju Sharma, Yogesh K. Ahlawat, Anurag Malik, Meraj Ahmed

“…Ethnobotanical research is essential for exploring these diverse biological resources for medicinal uses. This study aimed to record the traditional knowledge of the tribal communities in Himachal Pradesh concerning the use of medicinal plants for treating diseases in humans and livestock. …”
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Clinical features of cystic neutrophil granulomatous mastitis in 62 cases by Mengjie Wang, Dongxiao Zhang, Na Fu, Min Liu, Hongkai Zhang, Shuo Feng, Yifei Zeng, Wenjie Zhao, Jianchun Cui, Khattak Mazher Mansoor

“…Methods: In this meticulous investigation, we examined and analyzed the biological data, clinical features, ultrasound imaging, and histopathological morphological information of 62 patients diagnosed with CNGM through pathological examination. …”
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MEG3 Alleviated LPS-Induced Intestinal Injury in Sepsis by Modulating miR-129-5p and Surfactant Protein D by Xianjin Du, Dan Tian, Jie Wei, Chen Yan, Peng Hu, Xu Wu, Wenbin Yang

“…In our present study, we investigated the biological function of MEG3 in sepsis, especially during the intestinal injury. …”
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The identity of the offender as an element of forensic characteristics of premeditated murder of a hostage or a kidnapped person by V. V. Kikinchuk, T. V. Bilyk

“…Based on research using the method of generalization of practice and statistics, the following definition of the offender who committed the premeditated murder of a hostage or kidnapped person is proposed: the offender is a subject of crime, which in his or her inherent manner of behavior, formed under the influence of socio-political, moral and ethical, biological, economic, psychological and legal norms in combination with other circumstances, with direct intent, committed actions aimed at hostage-taking or kidnapping, which subsequently led to the death of the victims. …”
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Construction of a rodent neural network-skeletal muscle assembloid that simulate the postnatal development of spinal cord motor neuronal network by Haiyang Yu, Shangbin Yang, Yuanfeng Chen, Chuangran Wu, Jing Xu, Yue Yang, Rongjie Wu, Yinan Guo, Zhen Chen, Ying Ding, Xiang Zeng, Ge Li, Yuanhuan Ma, Qiujian Zheng, Yuanshan Zeng, Biqin Lai

“…Our study aimed to construct rodent bioengineered spinal cord neural network-skeletal muscle (NN-SkM) assembloids to elucidate the interactions between spinal cord neural stem cells (SC-NSCs) and SkM cells and their biological effects on the development and maturation of postnatal spinal cord motor neural circuits. …”
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Revealing novel protein interaction partners of glyphosate in Escherichia coli by Alix Sarah Aldehoff, Dominique Türkowsky, Patrick Lohmann, Masun Nabhan Homsi, Ulrike Rolle–Kampczyk, Elke Ueberham, Jörg Lehmann, Martin von Bergen, Nico Jehmlich, Sven–Bastiaan Haange

“…Non-target organisms are commonly exposed to glyphosate as a matter of its mode of application, with its broader environmental and biological impacts remaining under investigation. Glyphosate displays structural similarity to phosphoenolpyruvate (PEP), thereby competitively inhibiting the 5-enolpyruvylshikimate-3-phosphate synthase (EPSPS), crucial for the synthesis of aromatic amino acids in plants, fungi, bacteria, and archaea. …”
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