Trichostatin A suppresses hearing loss by reducing oxidative stress and inflammation in an Alport syndrome model. by Yoon Seok Nam, Eun-Ji Gi, Yoo-Seung Ko, Sungsu Lee, Hyong-Ho Cho

“…HDAC inhibitors (HDACis) are chemical compounds that block the activity of histone deacetylase and are known to exert diverse biologic effects. We investigated the effect of Trichostatin A (TSA), an HDACi, to assess its potential to inhibit hearing deterioration in AS. …”
Get full text

Investigation of Cortical Signal Propagation and the Resulting Spatiotemporal Patterns in Memristor-Based Neuronal Network by Ke Ding, Zahra Rostami, Sajad Jafari, Boshra Hatef

“…In this study, it is shown that memristive neuronal network can represent plasticity phenomena observed in biological cortical synapses. A network of neuronal units as a two-dimensional excitable tissue is designed with 3-neuron Hopfield neuronal model for the local dynamics of each unit. …”
Get full text

Chrysosporium queenslandicum: a potent keratinophilic fungus for keratinous waste degradation by Tarun Kumar Kumawat, Anima Sharma, Seema Bhadauria

“…The aim of the present study is the degradation of keratinous wastes in an eco-friendly way by biological methods, which should further be helpful to reduce the wastes and recycled into valuable feed and fertilizers. …”
Get full text

Chemical and Pharmacological Evaluation of Hulls of Prunus dulcis Nuts by Muhammad Nasimullah Qureshi, Sodik Numonov, Haji Akber Aisa

“…Researchers have shown that the almond hulls, normally wasted after utilization of nuts, contain a number of biologically active compounds based on which the present study has been carried out. …”
Get full text

Manipulating Intracellular Oxidative Conditions to Enhance Porphyrin Production in <i>Escherichia coli</i> by Bahareh Arab, Murray Moo-Young, Yilan Liu, C. Perry Chou

“…Being essential intermediates for the biosynthesis of heme, chlorophyll, and several other biologically critical compounds, porphyrins have wide practical applications. …”
Get full text

Thermoregulatory integration in hand prostheses and humanoid robots through blood vessel simulation by Sang-Mi Jeong, Jonguk Yang, Youngsoo Kang, Hee Sung Seo, Keumyoung Seo, Taekyung Lim, Sanghyun Ju

“…This innovative technique facilitates further advancements, blurring the lines between artificial aids and natural biological systems.…”
Get full text

Herb-disease association prediction model based on network consistency projection by Lei Chen, Shiyi Zhang, Bo Zhou

“…Abstract A growing number of biological and clinical reports indicate the usefulness of herbs in the treatment of complex human diseases, giving an essential supplement for modern medicine. …”
Get full text

Transcriptome sequencing reveals regulatory genes associated with neurogenic hearing loss by Fengfeng Jia, Fang Wang, Song Li, Yunhua Cui, Yongmei Yu

“…Enrichment analysis revealed biological processes and pathways associated with hearing loss, highlighting the involvement of circadian rhythm disruption and other neuro-related disorders. …”
Get full text

Occupational risk factors for sleep quality among Serbian airline pilots by Marko Stojanović, Dejan Nesic, Miloš Maksimović, Zorica Terzić-Šupić, Jovana Todorović, Ivana Topalović, Željko Vlaisavljević, Jelena Ilić Živojinović

“…Demographic, occupational, lifestyle, biological and psychological variables were obtained through validated questionnaires. …”
Get full text

Novel inhibitors of the (VIBVN) NAT protein identified through pharmacophore modeling by Wei Wei, Xionghao Li, Ning Hou, Aowei Xie, Huicong Liang, Ting Gao, Xiaoli Jing, Liqin Li, Jiejie Hao, Ximing Xu

“…Our study revealed that AK-968-11563024 forms stable interactions with PHE124, HIS167, and TRP230, which may contribute to its biological activity. Our findings provide a valuable foundation for the future development of drugs targeted therapeutics against (VIBVN)NAT.…”
Get full text

Optimization of Distillation Conditions for Improved Recovery of Phthalides from Celery (Apium graveolens L.) Seeds by Adam Kokotkiewicz, Anna Badura, Żaneta Tabaczyńska, Andżelika Lorenc, Adam Buciński, Maria Luczkiewicz

“…The mentioned compounds exhibit a number of biological effects (including hypotensive, lipid-lowering, neuroprotective, and cytotoxic) and are also responsible for distinctive aroma of the plant. …”
Get full text

Symptom-based depression subtypes: brain dynamic specificity and its association with gene expression profiles by Qunjun Liang, Zhifeng Zhou, Shengli Chen, Shiwei Lin, Xiaoshan Lin, Ying Li, Yingli Zhang, Bo Peng, Gangqiang Hou, Yingwei Qiu

“…Finally, gene expression underlying the CCA model, along with its biological encoding process, performed using a postmortem gene expression atlas revealed distinct gene enrichments for different subtypes. …”
Get full text

Physically engineered extracellular vesicles targeted delivering miR-21-5p to promote renoprotection after renal ischemia-reperfusion injury by Di Wu, Wenjie Ma, Liucheng Wang, Chengcheng Long, Silin Chen, Jingyu Liu, Yiguan Qian, Jun Zhao, Changcheng Zhou, Ruipeng Jia

“…N-EVs inherited the characteristic membrane proteins of NEs along with the biological functions of EPCs-EVs. Results from in vitro and in vivo experiments demonstrated that N-EVs significantly enhanced the targeting efficiency of EVs towards IRI kidneys via P-selectin glycoprotein ligand-1 (PSGL-1). …”
Get full text

C5a-C5aR1 axis mediates lung inflammation and fibrosis induced by single-walled carbon nanotubes via promoting neutrophils recruitment by Jiaojiao Zhu, Xiang Zhang, Lanlan Li, Hongxu Yang, Hang Liu, Danyang Wu, Zikai Liu, Bin Liu, Tong Shen

“…In conclusion, our study provides novel insights into the underlying biological mechanism that C5a-C5aR1 axis regulates neutrophils recruitment-mediated lung injury induced by SWCNT, may help to develop therapeutic strategies for SWCNT-provoked lung injury.…”
Get full text

Treatment goals and preferences of pediatric psoriasis patients, young adults, and parents by Mirjam J. Schaap, Susanne C. E. Broekhuis, Saskia Spillekom-van Koulil, Hans M. M. Groenewoud, Elke M. G. J. de Jong, Marieke M. B. Seyger

“…Psychosocial goals were more important for women and patients on biologics.Conclusion Young psoriasis patients and parents mainly strive to clear lesions and itch with effective and safe treatment. …”
Get full text

Effects of palm bunch ash and mycorrhiza on cucumber (Cucumis sativum L) performance on coarse-textured soil of Calabar, Southern Nigeria by Okechukwu Umunnakwe, Joyce Akpan, Francis Nwagwu, Edet Imuk, Bini Ebri

“…Data were collected on crop growth and yield indices, soil properties (physical, chemical and biological) each year, then combined and analyzed. Duncan’s Multiple Range Test (DMRT) at 5% probability was used to compare the means.Results There was increase in soil pH, organic carbon, phosphorus, potassium, calcium and magnesium as a result of PBA and mycorrhiza applications. …”
Get full text

Biomedical application of gelatin-PVA-silk fibre composite reinforced with copper and manganese substituted hydroxyapatite by Sabareeswari Kalidas, Shanmugam Sumathi

“…The fabricated scaffold, owing to its high porosity, mechanical properties and significant biological compatibility holds promise for Bone tissue engineering applications.…”
Get full text

Synthesis and Microbiological Activity of Some Newly Synthesized Derivatives of 2-Oxo-2H-chromen-2-one by Majlinda Daci-Ajvazi, Sevdije Govori, Shuhreta Omeragiq

“…By the action of 2-amino-5-methylthio-1,3,4-thiadiazole, 3-amino-5-methylisoxazole, 2-amino-6-fluorobenzothiazole, 2-amino-5-chloropyridine, respectively, on 4-chloro-2-oxo-2H-chromene-3-sulfonyl chloride, the corresponding 9-methylthio-7,7-dioxo-7,7a-dihydro-5-oxo-7λ6,10-dithia-8,11-diaza-cyclopenta[b] phenantren-6-one, 9-methyl-7,7-dioxo-7H-5,8-dioxa-7λ6-thia-7a,11-diaza-cyclopenta[b] phenantren-6-one, 9-fluoro-7,7-dioxo-7H-5-oxa-7λ6,12-dithia-7a,13-diaza-indeno[1,2-b] phenantren-6-one and 9-Chloro-7,7-dioxo-7H-5-oxa-7λ6-thia-7a,12-diaza-benzo[α]anthracen -6-one were formed and they have been isolated in satisfying yields. Based on the biological activity of chromene-2-ones and heterocyclic compounds condensed in position 3 and 4, we also studied microbiological activity of these new compounds (5-8), against Staphylococcus aureus ATCC 25923, Streptococcus pneumoniae, Aeromonas Salmonicida, Bacillus spp and some of them exhibited significant activity.…”
Get full text

Comprehensive characterization of higher order structure changes in methionine oxidized monoclonal antibodies via NMR chemometric analysis and biophysical approaches by Mingyue Li, Victor A. Beaumont, Shahajahan Akbar, Hannah Duncan, Arch Creasy, Wenge Wang, Kelly Sackett, Lisa Marzilli, Jason C. Rouse, Hai-Young Kim

“…The higher order structure (HOS) of monoclonal antibodies (mAbs) is an important quality attribute with strong contribution to clinically relevant biological functions and drug safety. Due to the multi-faceted nature of HOS, the synergy of multiple complementary analytical approaches can substantially improve the understanding, accuracy, and resolution of HOS characterization. …”
Get full text

Brighter children? The association between seasonality of birth and child IQ in a population-based birth cohort by Vincent W V Jaddoe, Régine P M Steegers-Theunissen, Henning Tiemeier, Albert Hofman, Frank C Verhulst, Nina H Grootendorst-van Mil

“…In the current study, we explored the role of sociodemographic and biological factors in the association between season of birth and child IQ.Design In a prenatally recruited birth cohort (born in 2002–2006), we examined the association between season of birth and non-verbal IQ at age 6 years among 6034 children. …”
Get full text