MicroRNAs as Immunotherapy Targets for Treating Gastroenterological Cancers by Yixin Yang, Christopher Alderman, Ayoub Sehlaoui, Yuan Xiao, Wei Wang

Get full text

Monascus red pigment influence on hydroxyapatite nanoparticles-mediated renal toxicity in rats by Nasser N. Alqurashy, Mokhtar I. Yousef, Ahmed A. Hussein, Maher A. Kamel, Abeer El Wakil

“…However, its interaction with biological systems is less exploited. This study aimed to characterize HANPs, examine their influence on kidneys, and explore the potential protective effects of naturally extracted red pigment (RP) from Monascus purpureus against HANPs-induced renal toxicity. …”
Get full text

Curcumin: Synthesis optimization and in silico interaction with cyclin dependent kinase by Ahmed Mahmood, Abdul Qadir Muhammad, Imtiaz Shafiq Muhammad, Muddassar Muhammad, Hameed Abdul, Nadeem Arshad Muhammad, Asiri Abdullah M.

“…Curcumin is a natural product with enormous biological potential. In this study, curcumin synthesis was revisited using different reaction solvents, a catalyst (n-butylamine) and a water scavenger [(n-BuO)3B], to develop the optimal procedure for its rapid acquisition. …”
Get full text

Chromosome-level genome assembly of Fistularia commersonii (Syngnathiformes, Fistulariidae) by Zufa Ding, Cheng Wang, Yuting Qian, Wenjun Chen, Dan Yu, Yang Liu, Liandong Yang, Ying Wang

Get full text

Layer-by-Layer CdS-Modified TiO2 Film Electrodes for Enhancing the Absorption and Energy Conversion Efficiency of Solar Cells by Ming Li, Yong Liu, Hai Wang, Wenxia Zhao, Hong Huang, Chaolun Liang, Youjun Deng, Hui Shen

Get full text

The Impact of a Music- and Movement-Based Intervention on Motor Competence, Social Engagement, and Behavior in Children with Autism Spectrum Disorder by Chayma Kanzari, Aymen Hawani, Karim Ben Ayed, Maher Mrayeh, Santo Marsigliante, Antonella Muscella

Get full text

Effect of Ionic Liquids on the Physical Properties of the Newly Synthesized Conducting Polymer by Dong Uk Lee, Jin Yeong Jeong, Ji Woong Han, Gi-Chung Kwon, Pankaj Attri, In Tae Kim

Get full text

RIOK1/2 Negatively Regulates the Antiviral Response by Targeting TBK1 in Yellow Catfish (<i>Pelteobagrus fulvidraco</i>) by Kejun Liu, Jiayang Huang, Yuting Gui, Qian Li, Lei Zhang, Shuting Xiong

Get full text

Changes in Vertical Stratification of Neotropical Nymphalid Butterflies at Forest Edges Are Not Directly Caused by Light and Temperature Conditions by Brian K. Oye, Ryan I. Hill

Get full text

Suaveolic Acid: A Potent Phytotoxic Substance of Hyptis suaveolens by A. K. M. Mominul Islam, Osamu Ohno, Kiyotake Suenaga, Hisashi Kato-Noguchi

Get full text

Comprehensive Screening and Identification of Phillyrin Metabolites in Rats Based on UHPLC-Q-Exactive Mass Spectrometry Combined with Multi-Channel Data Mining by Beibei Ma, Jiameng Li, Tianyu Lou, Yaoyue Liang, Chenxiao Wang, Ruiji Li, Tingting Wang, Jinhui Liu, Yudong Guo, Zhibin Wang, Jing Wang

“…The results showed that a series of biological reactions of phillyrin in vivo mainly included methylation, hydroxylation, hydrogenation, sulfonation, glucuronidation, demethylation, and dehydrogenation and their composite reactions. …”
Get full text

Exploiting Microwave Imaging Methods for Real-Time Monitoring of Thermal Ablation by Rosa Scapaticci, Gennaro G. Bellizzi, Marta Cavagnaro, Vanni Lopresto, Lorenzo Crocco

“…In this respect, microwave imaging can be a potential candidate to monitor the overall treatment evolution in a noninvasive way, as it takes direct advantage from the dependence of the electromagnetic properties of biological tissues from temperature. This paper explores such a possibility by presenting a proof of concept validation based on accurate simulated imaging experiments, run with respect to a scenario that mimics an ex vivo experimental setup. …”
Get full text

Insights into the lemon (Citrus limon) epiphytic microbiome: impact of the biocontrol yeast Clavispora lusitaniae 146 by Maria Cecilia Rasuk, José Matías Irazoqui, María Florencia Perez, Martina María Pereyra, Pedro Eugenio Sineli, Anja Poehlein, Rolf Daniel, Julian Rafael Dib

“…Although strain 146 has proven to be an effective agent, the influence of a microbial biological control agent on the postharvest lemon microbiome has not been studied until now. …”
Get full text

De novo design of protein minibinder agonists of TLR3 by Chloe S. Adams, Hyojin Kim, Abigail E. Burtner, Dong Sun Lee, Craig Dobbins, Cameron Criswell, Brian Coventry, Adri Tran-Pearson, Ho Min Kim, Neil P. King

“…Multivalent forms of both minibinders induce NF-κB signaling in TLR3-expressing cell lines, demonstrating that they may have therapeutically relevant biological activity. Our work provides a foundation for the development of specific, stable, and easy-to-formulate protein-based agonists of TLRs and other pattern recognition receptors.…”
Get full text

Morphometrics and evolution: the challenge of crossing rugged phenotypic landscapes with straight paths by P. D. Polly

“…Ancestral reconstruction of horn morphology based on two mammalian ungulates illustrates how biologically improbable results can arise from the mathematical properties of geometric morphometric morphospaces. …”
Get full text

Plucked Human Hair Shafts and Biomolecular Medical Research by Kevin Schembri, Christian Scerri, Duncan Ayers

“…The hair follicle is a skin integument at the boundary between an organism and its immediate environment. The biological role of the human hair follicle has lost some of its ancestral importance. …”
Get full text

MetaQ: fast, scalable and accurate metacell inference via single-cell quantization by Yunfan Li, Hancong Li, Yijie Lin, Dan Zhang, Dezhong Peng, Xiting Liu, Jie Xie, Peng Hu, Lu Chen, Han Luo, Xi Peng

“…Inspired by cellular development, MetaQ conceptualizes each metacell as a collective ancestor of biologically similar cells. By quantizing cells into a discrete codebook, where each entry represents a metacell capable of reconstructing the original cells it quantizes, MetaQ identifies homogeneous cell subsets for efficient and accurate metacell inference. …”
Get full text

Improving diversification by a hybrid bat-Nelder-Mead algorithm and DDE for rapid convergence to solve global optimization by Enas Suhail, Mahmoud El-Alem, Omar Bazighifan, Ahmed Zekri

“…Delay differential equations and algorithms hold a crucial position in the exploration of some biological systems and several models in real-world applications. …”
Get full text

Zinc Transporters, Mechanisms of Action and Therapeutic Utility: Implications for Type 2 Diabetes Mellitus by Stephen A. Myers, Alex Nield, Mark Myers

“…Zinc is an essential trace element that plays a vital role in maintaining many biological processes and cellular homeostasis. Dysfunctional zinc signaling is associated with a number of chronic disease states including cancer, cardiovascular disease, Alzheimer’s disease, and diabetes. …”
Get full text

HisCoM-GGI: Software for Hierarchical Structural Component Analysis of Gene-Gene Interactions by Sungkyoung Choi, Sungyoung Lee, Taesung Park

“…We expect that HisCoM-GGI software will provide advanced accessibility to researchers in genetic interaction studies and a more effective way to understand biological mechanisms of complex diseases.…”
Get full text