Advanced delivery systems for gene editing: A comprehensive review from the GenE-HumDi COST Action Working Group by Alessia Cavazza, Francisco J. Molina-Estévez, Álvaro Plaza Reyes, Victor Ronco, Asma Naseem, Špela Malenšek, Peter Pečan, Annalisa Santini, Paula Heredia, Araceli Aguilar-González, Houria Boulaiz, Qianqian Ni, Marina Cortijo-Gutierrez, Kristina Pavlovic, Inmaculada Herrera, Berta de la Cerda, Emilio M. Garcia-Tenorio, Eva Richard, Sergio Granados-Principal, Arístides López-Márquez, Mariana Köber, Marijana Stojanovic, Melita Vidaković, Irene Santos-Garcia, Lorea Blázquez, Emily Haughton, Dongnan Yan, Rosario María Sánchez-Martín, Loubna Mazini, Gloria Gonzalez Aseguinolaza, Annarita Miccio, Paula Rio, Lourdes R. Desviat, Manuel A.F.V. Gonçalves, Ling Peng, Cecilia Jiménez-Mallebrera, Francisco Martin Molina, Dhanu Gupta, Duško Lainšček, Yonglun Luo, Karim Benabdellah

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Foreword by E Murer, P Niederer, B Radanov, A Rumo-Jungo, M Sturzenegger, F Walz

“…In recent years, whiplash has become a nightmare for doctors, lawyers, rehabilitation specialists, bioengineers and insurers, not only in Switzerland, but across the whole of western Europe, North America and Australia.…”
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Salivary gland stem/progenitor cells: advancing from basic science to clinical applications by Jimpi Langthasa, Li Guan, Shyam Lal Jinagal, Quynh-Thu Le

“…Additionally, we highlight recent advances in cell- and tissue-based therapies, such as SSPC transplantation and bioengineered organ replacements. The challenges in translating SSPC research into effective clinical therapies are also discussed, alongside proposed solutions and future research directions.…”
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Substrate-dependent lipid and β-carotene production in engineered Yarrowia lipolytica: a comparative study by Raúl Robles-Iglesias, Jean-Marc Nicaud, María C. Veiga, Christian Kennes

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Recipe for Success: Suggestions and Recommendations for the Isolation and Characterisation of Bacteriocins by Ellen Twomey, Colin Hill, Des Field, Máire Begley

“…We have also identified bioengineered derivatives of the prototype lantibiotic nisin which possess more desirable properties than the wild-type, such as enhanced antimicrobial activity. …”
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The Prospects for the Therapeutic Implications of Genetically Engineered Probiotics by Sayyeda Farwa Mazhar, Muhammad Afzal, Ahmad Almatroudi, Samman Munir, Usman Ali Ashfaq, Maria Rasool, Hammad Raza, Hafiz Muhammad Waqas Munir, Muhammad Shahid Riaz Rajoka, Mohsin Khurshid

“…This article focuses on the approaches of bioengineered probiotics and discusses the potential prospects for their therapeutic applications including immunomodulation, cognitive health, and anticancer therapeutics.…”
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IL-10 Induction from Implants Delivering Pancreatic Islets and Hyaluronan by Paul L. Bollyky, Robert B. Vernon, Ben A. Falk, Anton Preisinger, Michel D. Gooden, Gerald T. Nepom, John A. Gebe

“…The second device is a bioengineered implant consisting of a polyvinyl alcohol sponge scaffold, supportive collagen hydrogel, and alginate spheres mediating sustained release of HA in fluid form. …”
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Engineered a dual-targeting biomimetic nanomedicine for pancreatic cancer chemoimmunotherapy by Meng Wang, Qida Hu, Junmin Huang, Xinyu Zhao, Shiyi Shao, Fu Zhang, Zhuo Yao, Yuan Ping, Tingbo Liang

“…To this end, we developed a biomimetic dual-targeting nanomedicine (PG@KMCM) where gemcitabine-loaded poly (lactic-co-glycolic acid) (PLGA) nanoparticles are coated with a layer of bioengineered cancer cell membrane that stably expresses peptides targeting M2-like macrophages (M2pep) while reserving tumor-associated antigens (TAAs). …”
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Targeting the B-Cell Pathway in Lupus Nephritis: Current Evidence and Future Perspectives by Panagiotis Pateinakis, Athina Pyrpasopoulou

“…B-cells have, in the last decade, emerged as a promising new therapeutic target, as biological treatments successfully attempting B-cell depletion, inhibition of B-cell proliferation and differentiation, or modulation of B-cell function have become bioengineered. Clinical trials have so far proved controversial regarding the efficacy of these new agents. …”
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Construction of a rodent neural network-skeletal muscle assembloid that simulate the postnatal development of spinal cord motor neuronal network by Haiyang Yu, Shangbin Yang, Yuanfeng Chen, Chuangran Wu, Jing Xu, Yue Yang, Rongjie Wu, Yinan Guo, Zhen Chen, Ying Ding, Xiang Zeng, Ge Li, Yuanhuan Ma, Qiujian Zheng, Yuanshan Zeng, Biqin Lai

“…Our study aimed to construct rodent bioengineered spinal cord neural network-skeletal muscle (NN-SkM) assembloids to elucidate the interactions between spinal cord neural stem cells (SC-NSCs) and SkM cells and their biological effects on the development and maturation of postnatal spinal cord motor neural circuits. …”
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Molecular Characterization and Antibacterial Potential of Endophytic Fungal Isolates from Selected Mangroves along the Coastline of Kenya by Teresia Nyambura Wacira, Huxley Mae Makonde, Carren Moraa Bosire, Cromwell Mwiti Kibiti

“…In addition, the genes responsible for the enhanced bioactivity in these isolates can be characterized and bioengineered for pharmaceutical application.…”
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Injected Human Muscle Precursor Cells Overexpressing PGC-1α Enhance Functional Muscle Regeneration after Trauma by Deana Haralampieva, Souzan Salemi, Thomas Betzel, Ivana Dinulovic, Stefanie D. Krämer, Roger Schibli, Tullio Sulser, Christoph Handschin, Simon M. Ametamey, Daniel Eberli

“…Moreover, we aimed at establishing a feasible methodology for noninvasive PET visualization of implanted cells and their microenvironment in muscle crush injury model. PGC-1α-bioengineered muscles showed enhanced marker expression for myogenesis (α-actinin, MyHC, and Desmin), vascularization (VEGF), neuronal (ACHE), and mitochondrial (COXIV) activity. …”
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Identification of robust and abundant reference transcripts for EV mRNA cargo normalization by Antje M. Zickler, Radosław Grochowski, André Görgens, Erik Bäcklin, Maximilian Kordes, J.-Matthias Löhr, Joel Z. Nordin, Samir EL Andaloussi, Daniel W. Hagey

“…Extracellular vesicles (EVs) have been investigated intensively because of their potential as biomarkers of disease and their versatility as bioengineered therapeutic nanoparticles. EVs carry diverse biomolecular cargo, but absolute quantification has been challenging due to a lack of established molecular standards. …”
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Emerging Strategies in Cartilage Repair and Joint Preservation by Mircea Adrian Focsa, Sorin Florescu, Armand Gogulescu

“…In response, regenerative medicine has developed advanced therapeutic strategies, including cell-based therapies, gene editing, and bioengineered scaffolds, to promote cartilage regeneration and restore joint function. …”
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