Spatial scales matter in designing buffer zones for coastal protected areas along the East Asian-Australasian Flyway by Roger H. Lee, Ivan H.Y. Kwong, Tom C.H. Li, Paulina P.Y. Wong, Yik-Hei Sung, Yat-Tung Yu

“…However, limited monitoring and research efforts have been directed towards areas beyond protected sites, despite their interconnectedness. …”
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Donor age contributes more to the rheological properties of stored red blood cells than donor sex and biological age distribution by Olga Mykhailova, Mackenzie Brandon-Coatham, Sanaz Hemmatibardehshahi, Mahsa Yazdanbakhsh, Carly Olafson, Qi-Long Yi, Tamir Kanias, Jason P. Acker

“…Donor variation in the age distribution of RBC subpopulations and its downstream effect on deformability serves as further evidence that factors beyond storage could potentially affect RCC quality and transfusion outcomes.…”
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From canonical to unique: extension of a lipophilicity scale of amino acids to non-standard residues by Antonio Viayna, Paulina Matamoros, David Blázquez-Ruano, William J. Zamora

“…In addition, our predictions were able to correctly predict the experimental hydrophobicity change due to the number of acetylated lysines in peptide pairs determined by HPLC, suggesting that our scale can be employed for proteomics studies that include post-translational modifications beyond acetylation.…”
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Development and psychometric validation of the frontline health workers’ occupational risk and characteristics in emergencies index (FORCE-index) – The covid Hospital cohort study... by Synne Øien Stensland, Kristina Bondjers, John-Anker Zwart, Leiv Arne Rosseland, Dan Atar, Jan Olav Christensen, Dagfinn Matre, Kristin Alve Glad, Tore Wentzel-Larsen, Hilde Wøien, Grete Dyb

“…Objectives: A lack of tools for the systematic identification of frontline health workers' changing occupational risks, characteristics, and needs, poses a major barrier to supporting vital personnel to stay in practice through health emergencies and beyond. The current study reports on the development and psychometric evaluation of the Frontline health workers’ Occupational Risk and Characteristics in Emergencies index (FORCE-index). …”
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Enhancing immunotherapy efficacy with synergistic low-dose radiation in metastatic melanoma: current insights and prospects by Zahid Rafiq, Mingyo Kang, Hampartsoum B. Barsoumian, Gohar S. Manzar, Yun Hu, Carola Leuschner, Ailing Huang, Fatemeh Masrorpour, Weiqin Lu, Nahum Puebla-Osorio, James W. Welsh

“…The convergence of LDRT with other disciplines holds immense potential for developing novel radiotherapy-combined modalities, paving the way for more effective and personalized treatment strategies in melanoma and beyond. Moreover, the dose-related toxicities of immunotherapies may be reduced by synergistic amplification of antitumor efficacy with LDRT.…”
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Influence of Tithonia diversifolia and cattle manures on the growth and yield of sesame (Sesamum indicum L.) by Ehiokhilen Eifediyi, Henry Ahamefule, Felix Ogedegbe, Taiwo Agbede, Isiaka Kareem, Appiah Ajayi

“…The cost of inorganic fertilizer is going beyond the reach of the average sesame farmer; the need therefore arises to synthesize farming practices that incorporate the rich organic materials locally available as a substitute for inorganic fertilizer for sustainable food production.Methods A study was conducted at the Teaching and Research Farm, University of Ilorin, Nigeria during the 2018 and 2019 cropping seasons, to evaluate the performance of sesame using T. diversifolia and cattle manures.  …”
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The Overaction of the Inferior Oblique Muscle and Associated Vertical Strabismus: Prevalence, Etiology and Diagnosis by Masoud Khorrami-Nejad, Huda Karim, Wisam Hatem, Mustafa Abdullah, Ali Gheibi, Mohammad Ghasemi Boromand

“…The mechanism of action of the IO muscle is complex and varies with the globe's position during contraction. Beyond horizontal and vertical movements, the IO muscle also contributes to torsional eye movements, impacting the diagnosis and treatment of vertical strabismus and cyclotropia. …”
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A qualitative study exploring depressed participants’ experiences of receiving Augmented Depression Therapy (ADepT) by Rebecca Watson, Kim A Wright, Nigel Reed, Barney Dunn, Emily Widnall, Kalliopi Demetriou, Laura Warbrick, Katie Marchant, Nicole Geschwind, Isabella Magner-Parsons, Rachel Barter

“…Perceived mechanisms of change were reorienting to the positive, engaging with valued goals, taking a proactive life stance, gaining confidence and motivation for change, breaking down tasks into small steps, cultivating self-care and self-compassion, enhancing help seeking and interpersonal effectiveness, changing the relationship to depression, and rediscovering the self beyond depression.Conclusions Findings suggest that the wellbeing focus of ADepT is acceptable and leads to positive impacts, supports the logic model underpinning the intervention, and warrants continuation to a definitive trial.Trial registration number ISRCTN85278228.…”
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Macrophage Activities in Myocardial Infarction and Heart Failure by Sophia Esi Duncan, Shan Gao, Michael Sarhene, Joel Wake Coffie, Deng Linhua, Xingru Bao, Zhang Jing, Sheng Li, Rui Guo, Jing Su, Guanwei Fan

“…Currently, it has been discovered that the study of macrophages goes far beyond its phagocytotic roles. If researchers in future confirm that macrophages play a vital role in the heart, they can be therapeutically targeted for cardiac healing.…”
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Identification of HPV16 E1 and E2-specific T cells in the oropharyngeal cancer tumor microenvironment by Christine McInnis, Lakshmi Srinivasan, Anthony J Coyle, Shilpa Bhatia, Glenn J Hanna, Ann Marie Egloff, Brinda Vijaykumar, Qiaomu Tian, Yanbo Sun, Del Leistritz-Edwards, Charles T Quinn, Ravi Uppaluri, Daniel C Pregibon

“…Conversely, cellular responses to E6 and E7 were limited in quantity and cytotoxic capacity, and tumor E6 and E7 expression persisted.Conclusions These data highlight antigenicity beyond HPV16 E6 and E7 and nominate candidates for antigen-directed therapies.…”
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Incidence and Predictors of Advanced Liver Fibrosis by a Validated Serum Biomarker in Liver Transplant Recipients by Mamatha Bhat, Kathleen C. Rollet-Kurhajec, Aparna Bhat, Amanda Farag, Marc Deschenes, Philip Wong, Peter Ghali, Giada Sebastiani

“…Advanced liver fibrosis was defined as FIB-4 > 3.25 beyond 12 months after LT. Results. Over 2030.5 person-years (PY) of follow-up, 189 (43%) developed FIB-4 > 3.25, accounting for an incidence of 9.3/100 PY (95% confidence interval [CI], 8.1–10.7). …”
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Perspectives of push-pull-mooring effects on a desire for switching to alternative crops among tobacco farmers in Thailand: A qualitative study by Chakkraphan Phetphum, Artittaya Wangwonsin, Atchara Prajongjeep, Saksin Simsin

“…Offering financial assistance and enhancing the production and marketing capabilities of alternative crops are essential steps toward facilitating a successful switch for farmers and ensuring a secure livelihood beyond tobacco farming.…”
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VSIG4+ tumor-associated macrophages mediate neutrophil infiltration and impair antigen-specific immunity in aggressive cancers through epigenetic regulation of SPP1 by Zongfu Pan, Jinming Chen, Tong Xu, Anqi Cai, Bing Han, Ying Li, Ziwen Fang, Dingyi Yu, Shanshan Wang, Junyu Zhou, Yingying Gong, Yulu Che, Xiaozhou Zou, Lei Cheng, Zhuo Tan, Minghua Ge, Ping Huang

“…Overall, our studies demonstrate the epigenetic regulation function of VSIG4 confers on TAMs an alternative pattern, beyond the checkpoint role of VSIG4, to shape the immunosuppressive tumor microenvironment and impair antigen-specific immunity against aggressive cancers. …”
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An innovative approach to prioritizing soil conservation areas under diverse scenarios by leveraging the complementary roles of soil retention services and soil erosion indicators by Eshetu Shifaw, Jinming Sha, Xiaomei Li, Peng Zhao, Jianwan Ji, Hao Zhang, Ashenafi Yimam Kassaye, Shuhui Lai, Zhonglin Ji, Yusheng Yang

“…This advanced conservation prioritization framework can be replicated in regions beyond the UBNB.…”
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Relationship Between Frequency Domain Indicators of Heart Rate Variability and Both Age and Duration of Illness in Patients with Headache: A Cross-Sectional Study by Jong-Ho Kim, Jong-Hee Sohn, Sung-Mi Hwang, Jae-Jun Lee, Young-Suk Kwon

“…<b>Results</b>: In a smooth curve through the scatterplot using the locally estimated scatterplot smoothing line, low frequency/high frequency (LF/HF) declined beyond around 60 years of age, while the total power (TP) decreased until about 50 years of age, after which there was no discernible change. …”
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Variations in carbon stocks across traditional and improved agroforestry in reference to agroforestry and households’ characteristics in Southeastern Ethiopia by Boja Tilinti, Mesele Negash, Zebene Asfaw, Teshale Woldeamanuel

“…Thus, HGAF should be managed as a viable land use option to help mitigate climate change, while also offering food and income opportunities for smallholder farmers in the studied region and beyond.…”
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Altered Hemodynamics Associated with Pathogenesis of the Vertebral Artery Dissecting Aneurysms by Akira Kurata, Sachio Suzuki, Kazuhisa Iwamoto, Kuniaki Nakahara, Katsutoshi Abe, Madoka Inukai, June Niki, Makoto Sasaki, Kiyotaka Fujii, Shingo Konno, Shinichi Kan, Kazuaki Fukasaku

“…Division was into 3 types: Type I without any deviation, Type II with mild-to-moderate deviation but not over the midline; and Type III with marked deviation over to the contralateral side beyond the midline. Results. The most frequent type of VA running was Type III for the affected and Type I nonaffected side, with this being found in all 17 patients except one. …”
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Evidence of Divergent Amino Acid Usage in Comparative Analyses of R5- and X4-Associated HIV-1 Vpr Sequences by Gregory C. Antell, Will Dampier, Benjamas Aiamkitsumrit, Michael R. Nonnemacher, Vanessa Pirrone, Wen Zhong, Katherine Kercher, Shendra Passic, Jean Williams, Yucheng Liu, Tony James, Jeffrey M. Jacobson, Zsofia Szep, Brian Wigdahl, Fred C. Krebs

“…To test the hypothesis that HIV-1 tropism extends beyond the envelope into the vpr gene, studies were performed to identify the associations between coreceptor usage and Vpr variation in HIV-1-infected patients. …”
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Exploring how PRIME-Parkinson care is implemented and whether, how and why it produces change, for who and under what conditions: a protocol for an embedded process evaluation with... by Yoav Ben-Shlomo, Sabi Redwood, Judi Kidger, Emma Tenison, Heather Brant, Emily J Henderson, Fiona Lithander, Katherine Lloyd, Safi Smith

“…Given that this intervention is novel and complex, understanding whether and how the intervention will be acceptable, implementable, cost-effective and scalable across contexts are key questions beyond that of whether ‘it works’. We describe an embedded process evaluation to answer these questions, which aims to support interpretation of the trial results, refinement of the intervention and support future scaling of the PRIME-Parkinson model of care.Methods and analysis A mixed-methods approach will be used to collect data across four process evaluation domains: implementation, mechanism of change, acceptability and context. …”
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Spinal presentations in children with type 1 spinal muscular atrophy on nusinersen treatment across the SMA-REACH UK network: a retrospective national observational study by Francesco Muntoni, Giovanni Baranello, Pinki Munot, Mariacristina Scoto, Adnan Manzur, Marion Main, Evelin Milev, Lianne Abbott, Victoria Selby, Amy Wolfe, Annemarie Rohwer, Catherine Rye, Sarah Gregson, Grainne NicFhirleinn, Rosanna Raab, Heather McMurchie, Angela Topping, Faye Mason, Jennie Sheehan, Felicity Vann, Steph Wadsworth, José Longatto, Lindsey Pallant, Nick Emery, Jenny Moustoukas, Sarah D’Urso, Kay White, Efthymia Panagiotopoulou

“…Background Prior to the introduction of disease-modifying treatments (DMTs), children with type 1 spinal muscular atrophy (SMA) typically did not survive beyond the age of 2 years; management was mainly palliative. …”
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