Pooled screening for CAR function identifies novel IL-13Rα2-targeted CARs for treatment of glioblastoma by Douglas A Lauffenburger, Khloe S Gordon, Caleb R Perez, Andrea Garmilla, Maxine S Y Lam, Joey J Y Aw, Anisha Datta, Andrea Pavesi, Michael E Birnbaum

“…It also showed significantly improved persistence and comparable tumor control in a microphysiological human in vitro model and a xenograft model of human glioblastoma, but also demonstrated increased off-target recognition of IL-13Rα1.Conclusion Taken together, this work demonstrates the utility of extending CARPOOL to diseases beyond hematological malignancies and represents the largest exploration of signaling combinations in human primary cells to date.…”
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Counterfactual Based Approaches for Feature Attributions of Stress Factors Affecting Rice Yield by Nisha P. Shetty, Balachandra Muniyal, Ketavarapu Sriyans, Kunyalik Garg, Shiv Pratap, Aman Priyanshu, Dhruthi Kumar

“…The findings highlight the significance of counterfactual explanations in agricultural ML models, as they provide a robust understanding of causal relationships, going beyond correlation‐based attributions. The study provides understandable and practical insights, allowing for focused actions to enhance productivity and adaptability in agriculture. …”
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Challenges of healthcare financing in the world’s largest refugee camp: a mixed-method study among healthcare stakeholders for Rohingya refugees in Bangladesh by Isabel Smith, Imdadul Haque Talukdar, Sayeeda Tarannum, M A Rifat, Priyanka Boga, Jubayer Mumin, Pablo André Veronés, Ziba Mahdi, Syeda Saima Alam, Arif Faysal Khan

“…Financial documents (available online) and reports from respective coordinating agencies were also reviewed.Setting Online key informant interviews (KIIs) were conducted from Stockholm with participants residing in Bangladesh between June 2022 and September 2022.Participants Eight KIIs were conducted with professional health programme managers, executives and personnel involved in policy coordination and implementation in refugee camps in Cox’s Bazar district of Bangladesh.Results We identified four themes and three subthemes outlining key challenges in healthcare funding, including decreasing funds (supported by a quantitative assessment) due to macroglobal issues, conflicting short-term and long-term priorities between implementing partners, insufficient efficacy due to challenges with collaborative priority-setting and implementing common processes, and a lack of consensus regarding equity between host and refugee communities.Conclusions The study identified unique challenges beyond the commonly discussed health financing issues in a resource-deficient setting: stakeholders’ conflicting priorities regarding funding and undecided equity issues among the host and refugee communities are worth scholarly and policy focus. …”
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Nature-based solutions for climate change adaptation and resilience in urban informal settlements: Insights from kibera, kenya and Villa 20, Argentina by Caroline Kibii, Flávia Guerra, Philip Bonera Bananayo, Simone Sandholz

“…Looking into NbS dimensions beyond environmental benefits can be particularly helpful to identify barriers, enablers but also transformative potentials, thereby supporting sustainable livelihoods, capacitation and participation of dwellers.…”
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Stabilized β-Catenin Ameliorates ALPS-Like Symptoms of B6/lpr Mice by Xiaoxie Xu, Jun Huang, Mei Zhao, Huanpeng Chen, Jinhua Mo, Xiaoqing Zhou, Qiao Su, Bolan Yu, Zhaofeng Huang

“…Meanwhile, stabilized β-catenin obviously decreased the numbers of spleen TCRβ+CD4−CD8− T (DNT) cells, and the levels of some serum proinflammatory factors also were lowered in β-catTglpr/lpr mice. Beyond that, stabilized β-catenin slightly lowered the levels of the serum autoantibodies and the scores of kidney histopathology of β-catTglpr/lpr mice compared with lpr/lpr mice. …”
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Irritable Bowel Syndrome: Gut Microbiota Dysbiosis and Psychological Co-morbidities by Bijita Bhowmick, Sharmistha Banerjee, Sanchaita Gayen, Supriya Samanta, Nilotpal Banerjee

“…The broader consequences of IBS extend beyond individual health, leading to considerable impairment in daily functioning, reduced workplace efficiency and diminished Quality of Life (QoL). …”
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Additives in foods marketed to children in Uruguay, an emerging Latin American country by Florencia Alcaire, Ana Giménez, Gastón Ares

“…These findings underscore the need to expand the current scope of regulations on marketing targeted at children beyond nutrients to include additives potentially linked to adverse health effects, such as artificial colourings.…”
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MHD flow of Williamson nanofluid using effective similarity variable considering viscous dissipation and thermal radiation over a non-linear stretching surface via OHAM by Muhammad Awais Sherani, Muhammad Sohail, Ibrahim Mahariq, Syed Tehseen Abbas

“…This evaluation goes beyond the localized impacts usually taken into account in each linear and non-linear stretching scenario, and instead focuses on global impact of the not Newtonian Williamson fluid factor. …”
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A Review on Deep Learning for Quality of Life Assessment Through the Use of Wearable Data by Vasileios Skaramagkas, Ioannis Kyprakis, Georgia S. Karanasiou, Dimitris I. Fotiadis, Manolis Tsiknakis

“…Quality of Life (QoL) assessment has evolved over time, encompassing diverse aspects of human existence beyond just health. This paper presents a comprehensive review of the integration of Deep Learning (DL) techniques in QoL assessment, focusing on the analysis of wearable data. …”
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Indoleamine 2,3-Dioxygenase (IDO) Expression Is an Independent Prognostic Marker in Esophageal Adenocarcinoma by Heike Loeser, Max Kraemer, Florian Gebauer, Christiane Bruns, Wolfgang Schröder, Thomas Zander, Hakan Alakus, Arnulf Hoelscher, Reinhard Buettner, Philipp Lohneis, Alexander Quaas

“…Our study emphasizes the importance of immunomodulation in EAC marking IDO as a potential biomarker. Beyond this, IDO might indicate a subgroup of EAC with an explicit survival benefit.…”
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Functional Involvement of Melatonin and Its Receptors in Reproductive Regulation of the Marine Teleost, Large Yellow Croaker (<i>Larimichthys crocea</i>) by Xudong Liang, Jixiu Wang, Baoyi Huang, Haojie Yuan, Yucheng Ren, Chenqian Wu, Tianming Wang, Jingwen Yang

“…Enzyme- linked immunosorbent assay (ELISA) results further demonstrated that in vitro melatonin incubation in the brain of <i>L. crocea</i> influenced gonadotropin-releasing hormone (GnRH) and testosterone secretion in a dose-dependent manner, suggesting actions beyond the classical hypothalamic–pituitary–gonadal (HPG) axis. …”
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The Analytical Approach to Evaluate the Load-Displacement Relationship of Rock Bolts by Jianhang Chen, Shengli Yang, Hongbao Zhao, Junwen Zhang, Fulian He, Shuaifeng Yin

“…However, once Young’s modulus of the confining medium was beyond a critical limit, it had marginal effect on the peak load of rock bolts. …”
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Bridging the Gap: Misaligned Perceptions of Urban Agriculture and Health Between Planning and Design Experts and Urban Farmers in Greater Lomé, Togo by Akuto Akpedze Konou, Kossiwa Zinsou-Klassou, Pablo Txomin Harpo De Roulet, Armel Firmin Kemajou Mbianda, Jérôme Chenal

“…In particular, the amount of land devoted to UA in these cities exceeds that used in Western countries, presenting challenges in areas such as land tenure. Beyond land tenure, UA also intersects with significant health concerns, as it contributes to food security, nutrition, and urban environmental health. …”
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Social Justice and Health Equity in the Teaching and Learning Environment: Perspectives of Academic Leaders in Health Profession Education Programmes by Benita Cohen, Debra Beach Ducharme, Moni Fricke, Alan Katz, Laura MacDonald, Donna Martin, Christen Rachul, Gayle Restall, Dana Turcotte

“… It is the responsibility of all health profession education programmes to prepare their graduates to champion social justice and health equity (SJ/HE) within and beyond the healthcare system. However, little is known about the perspectives of educational leaders within health professional programmes regarding the teaching and learning environment (TLE) with respect to SJ/HE. …”
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Enhancing the Strength and Durability Behaviour of Concrete Produced with Brown-Loamy Kaolin Clay Polymer by Patrick Zievie, Peter Paa-Kofi Yalley, Humphrey Danso, Kwaku Antwi

“…Again, there was a significant decrease in water absorption and sulphate attack up to the 15% replacement level. Beyond the 15% and up to the 20%, the decrease was minimal. …”
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Informed Design of a Gravity Science Experiment for the Future Geophysical Investigation of the Uranian Moons by Valerio Filice, Gael Cascioli, Sébastien Le Maistre, Rose-Marie Baland, Antony Trinh, Erwan Mazarico, Sander Goossens

“…The outer solar system beyond Saturn remains unexplored by dedicated orbital missions. …”
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Revisiting the Link Between HLA‐DRB1 Alleles and Autoantibodies in Rheumatoid Arthritis: Association of non‐Shared Epitope Alleles *09 and *15 With High Levels of Anti–Citrullinate... by Denis Lagutkin, Luis Panaifo, Ahmad‐Fauzi Nurul‐Aain, Lena Israelsson, Monika Hansson, Karin Lundberg, Lars Alfredsson, Johan Askling, RACI consortium, Lars Klareskog, Chun‐Lai Too, Leonid Padyukov

“…Conclusion These results indicate a new, previously overlooked, role for the HLA locus in the regulation of the levels of ACPA RA‐specific autoantibodies that goes beyond the shared epitope‐defined gene variants.…”
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COSMIC’s Large-scale Search for Technosignatures during the VLA Sky Survey: Survey Description and First Results by C. D. Tremblay, J. Sofair, L. Steffes, T. Myburgh, D. Czech, P. B. Demorest, R. A. Donnachie, A. W. Pollak, M. Ruzindana, Siemion A. P. V., S. S. Varghese, S. Z. Sheikh

“…Developing algorithms to search through data efficiently is a challenging part of searching for signs of technology beyond our solar system. We have built a digital signal processing system and computer cluster on the backend of the Karl G. …”
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Real-World Effectiveness of Portable Air Cleaners in Reducing Home Particulate Matter Concentrations by Frederic T. Lu, Robert J. Laumbach, Alicia Legard, Nirmala T. Myers, Kathleen G. Black, Pamela Ohman-Strickland, Shahnaz Alimokhtari, Adriana de Resende, Leonardo Calderón, Gediminas Mainelis, Howard M. Kipen

“…However, the performance of PACs in naturalistic settings and spaces beyond the room containing the PAC is not well characterized. …”
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Multiscale Granger dependencies in the precipitation network of the island of Sicily by Vera Pecorino, Alessandro Pluchino, Alessandro Pluchino, Andrea Rapisarda, Andrea Rapisarda, Andrea Rapisarda, Kateřina Hlaváčková-Schindler

“…Granger causality networks reveal scale-invariant dependencies, with stronger and sparser connections at timescales that extend beyond 6 h, with a notable westward flow of predictive information. …”
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