4-Aminoquinoline as a privileged scaffold for the design of leishmanicidal agents: structure–property relationships and key biological targets by Angel H. Romero, Francisco Delgado

“…At the moment, there are neither approved vaccines nor effective drugs for the treatment of human leishmaniasis for any of its three typical clinical manifestations, and, importantly, the drugs of clinical use have several side effects, require complex administration regimens, present high cost, and are ineffective in many populations due to pathogen resistance. Moreover, beyond the pharmacological exigencies, there are other challenges concerning its parasitic nature, such as its great genetic plasticity and adaptability, enabling it to activate a battery of genes to develop resistance quickly. …”
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ECONOMIC SANCTIONS AS A CONCEPT OF POWER POLITICS by I. N. Timofeev

“…Recognition of sanctions’ legitimacy would mean the recognition of the right to interfere into sovereign affairs of the target-states beyond the UN Charter. The article provides a reflection of this debate, stressing on different interpretations of the concept of sanctions.The article makes a distinction between the concept of sanctions and the concept of trade wars. …”
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Staff development for generative artificial intelligence and collaborative learning using Iterationism as a theoretical framework by Nicholas Bowskill, David Hall, Melody Harrogate, Ebere Eziefuna, Ben Marler

“…This reflects a process-oriented view of learning with these technologies. Beyond developing theory for generative AI and learning, we make four contributions to the literature on third spaces. …”
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Navigating the current landscape of ocean observations: an overview from platform infrastructures to networks related to ocean time series by Anabel von Jackowski

“…Ocean observations harbor an extraordinary benefit for a large diversity of end-users far beyond the scientific community, and there is a need to engage the next generation of ocean leaders as we transition to live and manage this blue planet sustainably.…”
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Geographical Diversity in the Age Specific Anti Müllerian Hormone Levels in Infertile Women: A Hospital Based Cohort Study by Mir Jaffar, Syed Nawaz Ahmad, Monica, Mohammed Ashraf, Sabiha Anjum Shaik, Muhammed Asif

“…Results: AMH levels remarkably decreased with increasing age in the North Indian population, but in the South Indian population, they did not decline beyond 1.5 ng/mL. Further, in the North Indian population, AMH levels were significantly higher in the age group of 22–30 years (4.4 ng/mL) than in the South Indian population (2.04 ng/mL). …”
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Impact of the COVID-19 pandemic on suicide: evidence from South Korea by Dongyoung Kim, Pyoungsik Kim

“…Abstract Objectives The COVID-19 pandemic led to public health crises beyond the direct casualties from the virus itself. …”
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Learning Slope and Position Effects in Rey Auditory Verbal Learning Test: Diagnostic Value in Schizophrenia by M. Alfimova, V.V. Plakunova, V.E. Golimbet

“…Logistic regression differentiating patients and controls demonstrated that only the recency measure explained more variance above and beyond the total recall (p<0.001). In the schizophrenia group, a correlation analysis conditioned on total recall revealed an association between the recency and the RAVLT retroactive interference indicator (ρ=0.13; p=0.001), but not with symptoms, processing speed, or executive functions. …”
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Path Planning Optimization of Smart Vehicle With Fast Converging Distance-Dependent PSO Algorithm by Muhammad Haris, Haewoon Nam

“…In DSI-PSO, each particle computes a distance metric and leverages a sigmoid function to adaptively update its inertia weight. Beyond improving convergence speed, this approach also addresses path-planning challenges in autonomous vehicles. …”
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Why EU revenue matters: A case for an EU digital levy by Katerina Pantazatou

“…In this Article, I argue that beyond tax design considerations and potential constitutional impediments, the EU revenue side should be emphasised in the discussion. …”
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Target Threat Assessment in Air Combat Based on Improved Glowworm Swarm Optimization and ELM Neural Network by Yuan Cao, Ying-Xin Kou, An Xu, Zhi-Fei Xi

“…Aiming at the problem that traditional beyond-visual-range air combat threat assessment algorithms are susceptible to complex factors, there are correlations between assessment indicators, and accurate and objective assessment results cannot be obtained. …”
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Complexity in Individual Trajectories toward Online Extremism by Z. Cao, M. Zheng, Y. Vorobyeva, C. Song, N. F. Johnson

“…By quantifying the trajectories that individuals follow on their journey toward expressing high levels of pro-ISIS support—irrespective of whether they then carry out a real-world attack or not—our findings can help move safety debates beyond reliance on static watch-list identifiers such as ethnic background or immigration status and/or postfact interviews with already convicted individuals. …”
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Chronic Non-communicable Diseases in Health Care Workers: a Multidisciplinary Approach by Teresa Rodríguez Rodríguez, Darianna María Muñiz Cabeza

“…<strong><br />Results:</strong> women (61 %) and subjects who completed studies beyond 12th grade (48.6 %) were more commonly affected by non-communicable diseases, as well as nurses (31 %) and physicians (27.8 %) in terms of occupation. …”
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Comparing the Efficacy of Probiotic Nutraceuticals and Probiotic Food (Curd) in Combination with Antidepressants for Depression by T. D. Sanmith, Jitendra Chourasiya, Nishant Patel

“…Conclusion: The study demonstrates the potential for slightly better outcomes with probiotic interventions alongside the antidepressant escitalopram over 4 weeks. Beyond symptom relief, this approach may offer lower side effects, potentially enhancing patient adherence. …”
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Analysis of Aeromagnetic Data for Enhancing Geologic Features Using Filtering Techniques Over the Congo Craton–Pan-African Belt Contact, Centre-East Cameroon by Jean Aimé Mono, Apollinaire Bouba, Olivier Ulrich Igor Owono Amougou, Jean Daniel Ngoh, Françoise Martine Enyegue A. Nyam, Théophile Ndougsa Mbarga

“…According to the ED, the depths of these lineaments extend beyond 1250 m. A spectral analysis conducted on a profile intersecting some of the significant anomalies on the reduction to the equator (RTE) map indicates that the average depths of superficial and deep magnetic sources along this profile are approximately 0.5 and 6.5 km, respectively. …”
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Characteristics and Functional Properties of Bioactive Oleogels: A Current Review by Md. Jannatul Ferdaus, Niaz Mahmud, Sudipta Talukder, Roberta Claro da Silva

“…The multifunctionality of oleogels extends their applications beyond fat replacements, e.g., food preservation, nutraceutical delivery, and even novel innovations like 3D food printing. …”
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Limits of competence of a forensic commodity expert in determining the characteristics of goods in cases of customs rules violation by S. О. Diachuk

“…When conducting a forensic commodity expert examination, a commodity expert may not exceed his or her powers and go beyond his or her competence when answering questions about determining the characteristics of the object of research according to the code of the UCC FEA. …”
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Firefighting with Conductive Aerosol-Assisted Vortex Rings by John LaRocco, Qudsia Tahmina, Stanley Essel, John Simonis

“…The computer vision system could also be used to further detect and target active fires. Beyond firefighting, the device can be adapted to applications ranging from manufacturing to aerospace. …”
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Level-Up Learning with CIGLE Framework: Enhancing Learning Through Interactive, Game-Based Collaboration for Effective Problem Solving by Ismat Zahra, Mai Neo, Soon Hin Hew

“…Several institutions promote student collaboration, which are beyond transmission of academic knowledge to the cultivation of critical thinking and problem-solving skills. …”
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Twin Subgraphs and Core-Semiperiphery-Periphery Structures by Ricardo Riaza

“…A standard approach to reduce the complexity of very large networks is to group together sets of nodes into clusters according to some criterion which reflects certain structural properties of the network. Beyond the well-known modularity measures defining communities, there are criteria based on the existence of similar or identical connection patterns of a node or sets of nodes to the remainder of the network. …”
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Proteome-wide mendelian randomization identifies causal plasma proteins in interstitial lung disease by Kunrong Yu, Wanying Li, Wenjie Long, Yijia Li, Yanting Li, Huili Liao, Jianhong Liu

“…Abstract Interstitial lung disease (ILD) has shown limited treatment advancements, with minimal exploration of circulating protein biomarkers causally linked to ILD and its subtypes beyond idiopathic pulmonary fibrosis (IPF). In this study, we aimed to identify potential drug targets and circulating protein biomarkers for ILD and its subtypes. …”
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