Beneficial and harmful effects of duloxetine versus placebo, ‘active placebo’ or no intervention for adults with major depressive disorder: a systematic review with meta-analysis a... by Christian Gluud, Marija Barbateskovic, Joanna Moncrieff, Faiza Siddiqui, Janus C Jakobsen, Mathias Maagaard, Sophie Juul, Johanne Juul Petersen, Caroline Barkholt Kamp, Mark Abie Horowitz, Kiran Kumar Katakam

“…We requested clinical study reports from 36 competent authorities.Eligibility criteria for selecting studies All randomised clinical trials comparing duloxetine versus placebo, ‘active placebo’ or no intervention, irrespective of publication type, publication status, publication year and language for treatment of major depressive disorder in adults.Data extraction and synthesis Five authors in pairs extracted data using a standardised data extraction sheet. …”
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The Impact of the COVID-19 Pandemic on Health and Health Care Experience in Those With Polycystic Ovary Syndrome by Sydora BC, Wilke MS, Ghosh M, Vine DF

“…The pandemic further highlighted that those with PCOS often experience a lack of accessibility to multidisciplinary health care and supports needed to manage their condition.Plain Language Summary: Polycystic ovary syndrome (PCOS) is a complex disorder affecting up to 18% of women and can impact overall health and quality of life across the lifespan. …”
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Incident Heart Failure in Atherosclerotic Renal Artery Stenosis: A Post Hoc Analysis of the CORAL Trial by Rajesh Gupta, Michelle M. Estrella, Rebecca Scherzer, Pamela S. Brewster, Lance D. Dworkin, Hanh T. Nguyen, Yanmei Xie, Joachim H. Ix, Michael G. Shlipak, Timothy P. Murphy, Donald E. Cutlip, Eldrin F. Lewis, Christopher J. Cooper

“…The presence of diabetes, PVD, and worse kidney health at baseline were associated with future HF events. Plain-Language Summary: Renal artery stenosis has been linked with heart failure. …”
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A Prospective, Crossover, Randomized, Double-Blind Clinical Study Comparing the Effectiveness and Ocular Comfort of 0.1% Hyaluronic Acid and 0.3% Hyaluronic Acid in Patients With D... by Kim SJ, Yoo WS, Kwon LH, Kim RB, Yoon HJ, Yoon KC

“…Using both 0.1% HA and 0.3% HA in a tailored treatment approach can improve patient comfort and treatment outcomes.Plain Language Summary: Dry eye disease (DED) is a common condition that causes discomfort and vision problems. …”
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Autoinducer-2 enhances the defense of Vibrio furnissii against oxidative stress and DNA damage by modulation of c-di-GMP signaling via a two-component system by Heng Zhang, Wenjin Zhao, Wenguang Yang, Huimin Zhang, Xinyu Qian, Kai Sun, Qiao Yang, Xihui Shen, Lei Zhang

“…ABSTRACT As a universal language across the bacterial kingdom, the quorum sensing signal autoinducer-2 (AI-2) can coordinate many bacterial group behaviors. …”
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Association of delayed asthma diagnosis with asthma exacerbations in children by Chung-Il Wi, MD, Euijung Ryu, PhD, Katherine S. King, MS, Jung Hyun Kwon, MD, PhD, Joshua T. Bublitz, BS, Miguel Park, MD, Sergio E. Chiarella, MD, Jason D. Greenwood, MD, MS, Thanai Pongdee, MD, Lynnea Myers, PhD, Björn Nordlund, PhD, Sunghwan Sohn, PhD, Elham Sagheb, MS, Bhavani Singh Agnikula Kshatriya, MS, Dave Watson, PhD, Hongfang Liu, PhD, Beverley J. Sheares, MD, MS, Carla M. Davis, MD, Wade Schulz, MD, PhD, Young J. Juhn, MD, MPH

“…We defined onset date as the date when subjects first met predetermined asthma criteria ascertained by an electronic health records–based natural language processing algorithm. Delay in diagnosis (DD) was defined as first diagnosis >30 days from onset date (vs timely diagnosis [TD] within 30 days). …”
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The Comparison of Cost-Effectiveness Between Magnetic Resonance Spectroscopy and Provocative Discography in the Identification of Chronic Low Back Pain Surgery Candidates by Wilson L, Beall DP, Eastlack RK, Berven S, Lotz JC

“…MRS provides significant cost savings and leads to better surgical outcomes, making it a preferred choice for insurers and health systems.Plain Language Summary: Chronic low back pain (cLBP) is experienced by 20% of the US population. …”
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Application of home-based exercise therapy in community-dwelling elderly patients with mild cognitive impairment and depression (以家庭为基础的运动疗法在社区老年轻度认知障碍伴抑郁患者中的应用研究)... by ZHU Haiying (诸海英), PEI Hua (裴华), YUAN Hongyan (袁红艳), ZHANG Lianhua (张莲花)

“…Results After 6 months of intervention, the score ofGDS in the intervention group was lower than that in the control group, with a significant difference (P＜0. 01); The total score of MoCA and subscale scores of Visuospatial/Executive, Attention, Language, Abstraction, Delayed recall and Orientation in the intervention group were higher than those in the control group (P＜0. 01); The score of BI in the intervention group was higher than that in the control group, with a significant difference (P＜0. 01). …”
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Effectiveness of acupuncture on glycolipid metabolism in patients with coronary heart disease: A systematic review and meta-analysis by Yuxin Sun, Yu Liu, Jian Xiong, Xiao Li, Ying Wei, Qianhua Zheng, Xiang Li, Wenchuan Qi, Fanrong Liang

“…Methods: From the time of library construction to August 18, 2023, Searches were conducted in eight databases, with no language restriction. Only RCTs that included acupuncture as a sole or secondary effect on glucose-lipid metabolism in coronary heart disease were included.Our primary outcome indicators were Low-density lipoprotein cholesterol(LDL-C), Hemoglobin A1c(HbA1c). …”
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Utilisation of ChatGPT and other Artificial Intelligence tools among medical faculty in Uganda: a cross-sectional study [version 2; peer review: 1 approved, 2 approved with reserva... by Job Kuteesa, Faith Oguttu, Ian Guyton Munabi, Aloysius Gonzaga Mubuuke, Sarah Kiguli, Ritah Nantale, David Mukunya, Elizabeth Ajalo, Frank Kayemba, Jonathan Babuya, Kennedy Pangholi, Amelia Margaret Namiiro, Suzan Langoya Akuu, Steven Ekak, Ronald Tweheyo, Kirsten Nantongo, Brenda Nakitto, Milton W. Musaba, Joseph Luwaga Mpagi

“…Background ChatGPT is a large language model that uses deep learning techniques to generate human-like texts. …”
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Sex and APOE genotype modulate neuropsychological profile and depression in temporal lobe epilepsy by Francesco Bruno, Francesco Bruno, Patrizia Spadafora, Ida Veltri, Mario L. Cuconati, Francesca Condino, Annamaria Cerantonio, Selene De Benedittis, Beatrice M. Greco, Beatrice M. Greco, Gemma Di Palma, Olivier Gallo, Luigi Citrigno, Antonio Qualtieri, Maurizio Cundari, Maurizio Cundari, Maurizio Cundari, Francesca Cavalcanti

“…However, the combined effects of APOE genotype and sex on cognitive performance and depression in temporal lobe epilepsy have not been previously investigated.ObjectiveThis study aims to (i) identify impaired cognitive performance and clinically relevant depression; (ii) explore the interaction between sex and APOE ε4 genotype on cognitive performance and depression in individuals with temporal lobe epilepsy.MethodsWe used a comprehensive battery of neuropsychological tests to assess domains such as learning and memory, attention, executive functions, language, and visuo-spatial constructional skills and the Hamilton Depression Rating Scale. …”
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Epilepsy care pathway: The Finnish model by Reetta Kälviäinen, Zakarya Hadj‐Allal, Jarkko Kirjavainen, Reina Roivainen, Tarja Linnankivi, Jukka Peltola, Kai Eriksson, Salla Lamusuo, Tuire Lähdesmäki, Johanna Annunen, Päivi Vieira, Virpi Tarkiainen, Leena Jutila, Anni Saarela, Leena Kämppi, Liisa Metsähonkala, Eija Gaily, Niina Lähde, Jaana Antinmaa, Sini Erme, Anna‐Leena Pirttisalo, Jari Virolainen, Milla Ylijoki, Laura Kela, Jonna Komulainen‐Ebrahim, Paula Sorjonen, Finnish Severe Epilepsy Coordination Group

“…This pathway can serve to model how integrated healthcare systems can effectively manage complex conditions. Plain Language Summary We describe the Finnish national epilepsy care pathway, which includes multiple levels of care, from initial diagnosis to long‐term care for all types of epilepsy, with a specific focus on rare and complex cases integrated with the European Reference Network (ERN) for Rare and Complex Epilepsies EpiCARE. …”
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Prospective Single-Arm Study of Remifentanil-Propofol Anesthesia with Manual Right Hypochondrial Compression for Painless Gastroscopy in Obese Patients by Wang M, Tang J, Pan Z, Jiang H, Hu D, Zhu B, Liang Z, Zhao X, Li Y

“…The finding might provide some new schedules for anesthetic management in the absence of advanced airway support instruments.Clinical Trial Registration: ChiCTR2300077889.Plain Language Summary: With the advancement of comfortable-oriented medication, gastroscopy is mostly performed under sedation and anesthesia. …”
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Women's experiences and acceptability of self-administered, home delivered, intravaginal 5-Fluorouracil cream for cervical precancer treatment in Kenya by Konyin Adewumi, Aparna Ghosh Kachoria, Everlyn Adoyo, Mercy Rop, Mercy Rop, Antony Owaya, Jennifer H. Tang, Jennifer H. Tang, Lisa Rahangdale, Lisa Rahangdale, Lisa Rahangdale, Chemtai Mungo, Chemtai Mungo, Chemtai Mungo

“…To understand women's experiences with self-administered 5FU, we evaluated the acceptability of this intervention among trial participants.MethodsAll 12 participants from the Phase I trial completed a structured questionnaire and in-depth semi-structured interviews in their preferred language, focusing on their experiences with 5FU self-administration, challenges faced, and overall acceptability of the intervention, including whether they would use it again or recommend it to someone who needed it. …”
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Arbovirus vectors of epidemiological concern in the Americas: A scoping review of entomological studies on Zika, dengue and chikungunya virus vectors. by Reilly Jones, Manisha A Kulkarni, Thomas M V Davidson, RADAM-LAC Research Team, Benoit Talbot

“…<h4>Results</h4>A total of 96 studies were included in the scoping review after initial screening and subsequent exclusion of out-of-scope studies, secondary data publications, and studies unavailable in English language.<h4>Key findings</h4>We observed a steady increase in number of publications, from 2013 to 2018, with half of all studies published from January 2017 to March 2018. …”
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Social vulnerability and genetic service utilization among unaffected BRIDGE trial patients with inherited cancer susceptibility by Jemar R. Bather, Melody S. Goodman, Adrian Harris, Guilherme Del Fiol, Rachel Hess, David W. Wetter, Daniel Chavez-Yenter, Lingzi Zhong, Lauren Kaiser-Jackson, Rachelle Chambers, Richard Bradshaw, Wendy Kohlmann, Sarah Colonna, Whitney Espinel, Rachel Monahan, Saundra S. Buys, Ophira Ginsburg, Kensaku Kawamoto, Kimberly A. Kaphingst, on behalf of the BRIDGE research team

“…Covariates included study arm, study site, age, sex, race/ethnicity, language preference, rural residence, having a recorded primary care provider, and number of algorithm criteria met. …”
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Thrombolytic therapy for patients with acute ischemic stroke: systematic review and network meta-analysis of randomized trials by Li-Chao-Yue Sun, Wen-Shu Li, Wei Chen, Zhao Ren, Chun-Xing Li, Ze Jiang, Le Wang, De-Li Wang, Qing Xie

“…The efficacy and safety of tenecteplase and reteplase, compared to alteplase, remain unclear, as does the optimal dosing for these treatments.MethodA systematic search was conducted in PubMed, Web of Science, SCOPUS, and the Cochrane Central Register of Controlled Trials (CENTRAL) for relevant English-language studies up to July 5, 2024. Randomized controlled trials (RCTs) comparing standard-dose alteplase with varying doses of tenecteplase or reteplase in AIS patients were included. …”
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Feasibility, Usability, and Pilot Efficacy Study of a Software-Enabled, Virtual Pulmonary Rehabilitation with Remote Therapeutic Monitoring by Flynn S, Mosher CL, Cornelison S, Rao E, Metzler KA, Pu W, Davies J, Paladenech C, Doyle D, MacIntyre N, Ohar J

“…It could offer an alternative model that increases PR uptake for those unable or unwilling to attend in-person, center-based PR.Plain Language Summary: Pulmonary rehabilitation (PR) is a treatment program that improves breathlessness and quality of life for adults with lung diseases such as chronic obstructive pulmonary disease (COPD). …”
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Clinical and molecular outcomes from the 5-Year natural history study of SSADH Deficiency, a model metabolic neurodevelopmental disorder by Itay Tokatly Latzer, Jean-Baptiste Roullet, Wardiya Afshar-Saber, Henry H. C. Lee, Mariarita Bertoldi, Gabrielle E. McGinty, Melissa L. DiBacco, Erland Arning, Melissa Tsuboyama, Alexander Rotenberg, Thomas Opladen, Kathrin Jeltsch, Àngels García-Cazorla, Natalia Juliá-Palacios, K. Michael Gibson, Mustafa Sahin, Phillip L. Pearl

“…Results The 62 SSADHD subjects [53% females, median (IQR) age of 9.6 (5.4–14.5) years] included in the study had a reported symptom onset at ∼ 6 months and were diagnosed at a median age of 4 years. Language developmental delays were more prominent than motor. …”
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Local application of sodium thiosulfate as an otoprotectant for cisplatin-exposed patients – A narrative literature review to explore the potential benefit for children with cancer... by Nienke Streefkerk, Amirhossein Masroor, James I. Geller, Martine van Grotel, Marc Ansari, Eric Bouffet, Archie Bleyer, Brice Fresnau, Michael Sullivan, Alwin D.R. Huitema, Alexander E. Hoetink, Per Kogner, Rudolf Maibach, Allison F. O’Neill, Vassilios Papadakis, Kaukab M. Rajput, Gareth J. Veal, Penelope R. Brock, Annelot J.M. Meijer, Marry M. van den Heuvel-Eibrink

“…Background: Ototoxicity is a highly prevalent, serious, and irreversible side effect in cisplatin-treated childhood cancer patients, which can significantly impact speech-language development, psychosocial development, and quality of life. …”
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