Human versus Analogue Insulin for Youth with Type 1 Diabetes in Low-Resource Settings (HumAn-1): protocol for a randomised controlled trial by Éimhín Ansbro, Jing Luo, Chung-Chou H Chang, Kaushik Ramaiya, Bruce L Rollman, Sylvia Kehlenbrink, Sae-Rom Chae, Abigail Foulds, Claire Josey, Christina Lalama, Margaret L Prust, Bedowra Zabeen, Graham Ogle

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Botulinum toxin type A for the treatment of patients with post-stroke spasticity in Thailand: cost-utility and budget impact analysis by Phorntida Hadnorntun, Pattara Leelahavarong, Tanawan Kongmalai, Varalak Srinonprasert, Juthamas Prawjaeng, Phakamas Tanvijit, Chuenchom Chueluecha, Nawarat Jintakul, Tipyarat Saringcarinkul, Witsanu Kumthornthip

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Effectiveness of multicomponent interventions in primary healthcare settings to promote continuous smoking cessation in adults: a systematic review by Carlos Martín Cantera, Elisa Puigdomènech, Jose Luis Ballvé, Olga Lucía Arias, Lourdes Clemente, Ramon Casas, Lydia Roig, Santiago Pérez-Tortosa, Laura Díaz-Gete, Sílvia Granollers

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Clinical and cost-effectiveness of Knee Arthroplasty versus Joint Distraction for Osteoarthritis (KARDS): protocol for a multicentre, phase III, randomised control trial by Deborah D Stocken, Dennis G McGonagle, David Murray, Catherine Reynolds, Catherine Fernandez, David R Ellard, Andrew Metcalfe, Hemant Sharma, Paul Harwood, Hamish Simpson, Hemant Pandit, Susanne Arnold, Cerys Joyce Tassinari, Ruchi Higham, Isabelle Louise Smith, Ruben Mujica-Mota, Thomas William Hamilton, Julie Croft

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Factors affecting the implementation of guideline-based prophylactic antiemetic therapy for chemotherapy-induced nausea and vomiting in Japan: a protocol for a hospital-based quali... by Yosuke Uchitomi, Junko Saito, Maiko Fujimori, Taichi Shimazu, Ayako Okuyama, Sadamoto Zenda, Ayumu Matsuoka, Akiko Yaguchi-Saito, Yuki Kaji, Miyuki Odawara, Aki Otsuki

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Duration of External Neck Stabilisation (DENS) following odontoid fracture in older or frail adults: protocol for a randomised controlled trial of collar versus no collar by John Norrie, Julie Woodfield, David J Lowe, Paul M Brennan, Catriona Keerie, Julia Lawton, Matthew J Reed, Andrew Stoddart, Julia Boyd, Helen Eborall, Gina Cranswick, James Tomlinson, Polly L Black, Sadaquate Khan, Patrick Statham, Ellie Edlmann, Phillip Correia Copley, Angela Niven, Susan Deborah Shenkin

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Protocol of an open-label safety and feasibility pilot study of ketamine-assisted psychotherapy for methamphetamine use disorder (the KAPPA trial) by Jonathan Brett, Celia Morgan, Nadine Ezard, Brendan Clifford, Krista J Siefried, Robert May, Liam Acheson, Kathryn Fletcher, Harriet MacDonald, Gillinder Bedi, Alexandre Guerin, Elizabeth Knock, Michael Millard, Jess Doumany

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Development of a core outcome set and core measurement set for kangaroo mother care: a study protocol by Yuan Li, Xia Li, Qiong Chen, Ying Xin Li, Han Mei Peng, Xue Mei Guo, Xiao Wen Li, Yan Ling Hu, Xing Li Wan

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Telehealth and patient satisfaction: a systematic review and narrative analysis by Clemens Scott Kruse, Nicole Krowski, Blanca Rodriguez, Lan Tran, Jackeline Vela, Matthew Brooks

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Intermittent pneumatic compression for venous thromboembolism prevention: a systematic review on factors affecting adherence by Richard Greenall, Rachel E Davis

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Ethnic differences between South Asians and white Caucasians in cardiovascular disease-related mortality in developed countries: a systematic literature review protocol by Olalekan Abdulrahman Uthman, Mubarak Patel, Salim Abatcha

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Systematic comparison of Mendelian randomisation studies and randomised controlled trials using electronic databases by Jie Zheng, George Davey Smith, Tom R Gaunt, Maria K Sobczyk

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Innovative models of healthcare delivery: an umbrella review of reviews by Frances Rapport, Jeffrey Braithwaite, Yvonne Zurynski, Peter D Hibbert, Kate Churruca, Louise A Ellis, Chiara Pomare, Robyn Clay-Williams, Stephanie Best, Janet C Long, Gaston Arnolda, Bróna Nic Giolla Easpaig, Zeyad Mahmoud, Mitchell N Sarkies, Hoa Mi Nguyen, Karen Hutchinson, Gilbert Thomas Knaggs, Katherine Maka, Elizabeth E Austin, Diana Fajardo Pulido, Sarah Hatem, Natalie Roberts, Emilie Francis Auton, Genevieve Dammery, Isabelle Meulenbroeks, Ann Carrigan, Mai-Tran Nguyen

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Beneficial and harmful effects of duloxetine versus placebo, ‘active placebo’ or no intervention for adults with major depressive disorder: a systematic review with meta-analysis a... by Christian Gluud, Marija Barbateskovic, Joanna Moncrieff, Faiza Siddiqui, Janus C Jakobsen, Mathias Maagaard, Sophie Juul, Johanne Juul Petersen, Caroline Barkholt Kamp, Mark Abie Horowitz, Kiran Kumar Katakam

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Information needs and mHealth applications for carers of people with dementia in managing behavioural and psychological symptoms of care recipients: an integrative review protocol by Samath Dharmaratne, Thilanka Jagoda, Sarath Rathnayake

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Antireflux mucosal valvuloplasty versus proton pump inhibitors for the treatment of patients with gastro-oesophageal reflux disease in a tertiary healthcare centre in China: study... by Xiaofen Lv, Yunqing Zeng, Wenlong Ma, Jiaoyang Lu

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Ethical challenges in palliative sedation of adults: protocol for a systematic review of current clinical practice guidelines by Cécile Jaques, Ralf J Jox, Martyna Tomczyk

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BIOSKIN: A Protocol for the Copenhagen Translational Skin Immunology Biobank and Research Programme by Lone Skov, Jeanne Duus Johansen, Marianne Bengtson Løvendorf

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Determinants of subjective well-being among migrant and local elderly in China: a cross-sectional study by Chonghua Wan, Rassamee Sangthong, Liu Yuxi, Thammasin Ingviya

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Mesothelioma and Radical Surgery 2 (MARS 2): protocol for a multicentre randomised trial comparing (extended) pleurectomy decortication versus no (extended) pleurectomy decorticati... by Liz Darlison, John Edwards, Apostolos Nakas, Nick A Maskell, Wendy Underwood, Chris Rogers, Matthew Callister, David Waller, Richard Milton, Victoria Ashford-Turner, Paul Taylor, Claire Matthews, Victoria Hughes, Kelvin Lau, Alan Kirk, Robert C Rintoul, Elizabeth A Stokes, Kate Ashton, Daisy Elliott, Rosie Harris, Marie Kirwan, Juliette Novasio, Sara Waplington, Eric Lim, Holly Mckeon, Charlotte Jacobs, Laura White, Mary O’Brien, Judith Moore, Louise Li, Nicola Mills, Sanjay Popat, Suzanne Miller, Nadia Yousaf, D A Fennell, Clinton Ali, Andrea Bille, Liz Fuller, Andreea Ionescu, Manjusha Keni, Pek Koh, Talal Mansy, Dakshinamoorthy Muthukumar, Tony Pope, Amy Roy, Riyaz Shah, Jonathan Shamash, Zacharias Tasigiannopoulos, Sarah Treece, Katherine Joyce, Barbara Warnes, Athanasia Gravani, Rachel Brophy, Nicola Farrar, Jane Elliott, Philip Noyes, Louise Nelson, Sara Tenconi, Laura Socci, Hilary Wood, Helena Hanratty, Helena Stanley, Robert Rintoul, Amy Gladwell, Jenny Castedo, Amanda Stone, Charlotte Ingle, Hayley Hewer, Eleanor Aynsley, Andrea Watson, Alison Hassall, Masuma Begum, Christopher Worth, Ellie Piggott, Elizabeth Nadin, Yvonne Summers, Raffaele Califano, Laura Cove-Smith, Matt Evison, Maria Blinston, Amal Ismail, Rachel Chant, Asmita Desai, Ian Morgan, Victoria Lake, Nichola Harris, Simon Hodge, Nadza Tokaca, Adam Januszewski, Avani Athauda, Anisha Ramessur, Emily Grist, Niamh Colman, Michael Flynn, Joan Joyce, Sarah Vaughan, Maria Piga, Derya Sahin, Agnieszka Yongue, Emma Turay, Jaishree Bhosle, Rajiv Kumar, Charlotte Milner-Watts, Jessica Brown, David Walder, Alexandros Georgiou, Xiaorong Wu, Naila Kaudeer, Kroopa Joshi, Michael Davidson, Shelize Khakoo, Bee Ayite, Kathryn Priest, James Dobbyn, Vasanthi Prathapan, Deborah McCrimmon, Natalie Ash, Alison Norton, Bianca Peet, Libby Hennessy, Rosemary Johnson

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