The Construction of Heterothallic Strains of <i>Komagataella kurtzmanii</i> Using the I-SceI Meganuclease by Daria D. Sokolova, Philipp I. Akentyev, Kristina O. Petrova, Lyudmila V. Lyutova, Aleksei A. Korzhenkov, Irek I. Gubaidullin, Stepan V. Toshchakov, Dmitry G. Kozlov

“…As a result, heterothallic strains designated ‘Y-727-2(alpha)’ and ‘Y-727-9(a)’, which correspond to the α and <b>a</b> mating type, respectively, were obtained. …”
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Impact of commercial gut health interventions on caecal metagenome and broiler performance by Gladys Maria Pangga, Banaz Star-Shirko, Androniki Psifidi, Dong Xia, Nicolae Corcionivoschi, Carmel Kelly, Callie Hughes, Ursula Lavery, Anne Richmond, Umer Zeeshan Ijaz, Ozan Gundogdu

“…The use of probiotics B, a commercial Bacillus strain-based formulation, was determined to contribute to the superior performance of birds. …”
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Multiple Sessions of Antimicrobial Photodynamic Therapy Improve Periodontal Outcomes in Patients with Down Syndrome: A 12-Month Randomized Clinical Trial by Rafael Ferreira, Sebastião Luiz Aguiar Greghi, Adriana Campos Passanezi Sant’Ana, Mariana Schutzer Ragghianti Zangrando, Carla Andreotti Damante

“…C = 4.84 mm; <i>p</i> < 0.05). <b>Conclusions:</b> aPDT improved periodontal health in the long term through a stable gain in attachment.…”
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Pour une théorie de la réception du discours grammatical by Jean-Rémi Lapaire

“…This article presents the results of a 2014-15 study involving a group of 33 students, enrolled in the first year of the English B.A. course at Université Bordeaux Montaigne, France. …”
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An Injectable Oil-Based Depot Formulation of <i>N</i>-Acyloxymethyl Prodrug of Ropivacaine for Long-Acting Local Analgesia: Formulation Development and In Vitro/In Vivo Evaluation by Xiaowei Liu, Ruihan Zhao, Peijie Xu, Jianqiang Qian, Peiyan Zhang, Xudong Xie, Yong Ling, Qimin Ge, Yong Chen

“…The aim of this study was to prepare an injectable oil-based formulation of ropivacaine (ROP) prodrug (ropivacaine stearoxil, ROP-ST) and to investigate the pharmacokinetics and pharmacodynamics after injectable administration. <b>Methods:</b> A novel <i>N</i>-acyloxymethyl prodrug of ROP, i.e., ROP-ST, was synthesized and its physicochemical properties such as log P, solubility and stability characterized. …”
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Current Updates on Molecular Diagnostic Assays Used for Detection of <i>Candida auris</i>: A Systematic Review by River Chun-Wai Wong, Alfred Lok-Hang Lee, Ingrid Yu-Ying Cheung, Viola Chi-Ying Chow, Margaret Ip, Christopher Koon-Chi Lai

“…This review aims to summarize a comprehensive update in the past 5 years. <b>Methods</b>: A systematic review was conducted to search for articles published in the period between 1 January 2020 and 20 November 2024 from various databases, including PubMed, Google Scholar, and Web of Science. …”
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Phytochemical Analysis and Anti-Inflammatory Activity of the Extracts of the African Medicinal Plant Ximenia caffra by Jing Zhen, Yue Guo, Tom Villani, Steve Carr, Thomas Brendler, Davis R. Mumbengegwi, Ah-Ng Tony Kong, James E. Simon, Qingli Wu

“…It was further demonstrated that the underlying therapeutic mechanism involves the suppression of NF-κB, a shared pathway between cell death and inflammation.…”
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Post-Marketing Pharmacovigilance of Canakinumab from the FDA Adverse Event Reporting System (FAERS) by Weidong Zhang, Yunzhou Chen, Zeyu Yao, Mengling Ouyang, Minghui Sun, Shupeng Zou

“…Additionally, a stratification analysis of serious infections was conducted at the system organ class (SOC) level. <b>Results:</b> A total of 28,496 canakinumab-related AEs were collected, and 71 suspicious signals detected. …”
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Comparison of some morphological characteristics of native turkish dog breeds by Metin Erdoğan, Cafer Tepeli, Ceyhan Özbeyaz, Mine D. Akbulut, Cevdet Uğuz

“…<p> <b>Materials and Methods:</b> A total of 130 dogs, comprised of 30 Kangal Shepherd Dogs, 33 Akbaş Shepherd Dogs, 14 white Kars Shepherd Dogs, 23 black Kars Shepherd Dogs, and 30 Turkish Tazı, were used in the study. …”
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Breeding value of prolific maize varieties with nicking of parental lines by E. B. Khatefov, R. A. Kudaev, R. S. Kushkhova

“…Statistical data processing was performed according to B. A. Dospekhov's technique, while biometric measurements and their description were provided according to the COMECON Unified Classifier. …”
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Lipidomic and Instrumental Evaluation of a Melatonin-Based In & Out Strategy Versus Topical Treatment in Skin Aging: A Randomized Prospective Trial by Francesca Colombo, Stefano Alfano, Massimo Milani

“…This study aimed to evaluate the anti-aging effects of an “In & Out” regimen consisting of a Mel-based cream and dietary supplement in comparison with topical treatment alone, focusing on clinical and lipidomic changes involved in skin homeostasis. <b>Results:</b> A statistically significant variation was observed in both groups compared to baseline (T0) in terms of moisturization (+23.6% in Group A, +18.3% in Group B) and wrinkle depth (−18.5% in Group A, −9.4% in Group B, <i>p</i> < 0.05). …”
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Effect of Buffer Charge Redistribution on RF Losses and Harmonic Distortion in GaN-on-Si Substrates by Pieter Cardinael, Sachin Yadav, Bertrand Parvais, Jean-Pierre Raskin

“…Additionally, Coplanar Wave Guide (CPW) large-signal measurements under the same experimental conditions show a variation of <inline-formula> <tex-math notation="LaTeX">$2^{\mathrm{ nd}}$ </tex-math></inline-formula> harmonic power of up to 5dB. A thermally activated stress and relaxation behavior shows the signature of traps which are present in the C-doped layers. …”
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Prescription of Strong Opioids in Chronic Non-Cancer Pain in the Province of Valladolid (Spain) by Rodrigo Enríquez de Salamanca Gambara, Ana María Sierra Santos, Ana María Ruiz San Pedro, Federico Montero Cuadrado, Irene Muñoz León, Miguel Ángel Castro Villamor, Alicia Córdoba Romero, Ana María Del Olmo Tornero, Lucía Pérez Pérez, León Morales-Quezada

“…The number of defined daily doses (nº DDDs) and costs from 2020 to 2023 were analyzed. <b>Results:</b> A total of 3642 patients were included (0.7% of the population of Valladolid), 71.8% of whom were women. …”
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Comprehensive Evaluation of Inflammatory Biomarkers in Cervical Cancer Treated with Chemoradiotherapy by Timur Koca, Nurcihan Gocen Vardar, Rahmi Atıl Aksoy, Aylin Fidan Korcum

“…This study aims to comprehensively evaluate the predictive value of inflammatory biomarkers on survival outcomes in cervical cancer patients undergoing chemoradiotherapy. <b>Methods</b>: A total of 90 patients who had undergone chemoradiotherapy for cervical cancer were included. …”
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Blepharoplasty: historical aspects, terminology, and modern ideas by A.D. Kazantsev, E.P. Kazantseva, I.B. Alekseev

“…<p> <b>A.D. Kazantsev, E.P. Kazantseva, I.B. Alekseev</b> </p> <p> <b>Russian Medical Academy of Continuous Professional Education, Moscow, Russian Federation</b> </p> <p> <i>Visual contact is one of the important aspects of non-verbal communication. …”
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A Study of Synergy of Combination of Eosin B with Chloroquine, Artemisinin, and Sulphadoxine-Pyrimethamine on Plasmodium falciparum In Vitro and Plasmodium berghei In Vivo by Sedigheh Sadeghi, Zarrintaj Valadkhani, Alireza Sadeghi Tafreshi, Mohammad Arjmand, Hossein Nahravanian, Farideh Vahabi, Neda Soori, Maryam Mohammadi, Masoomeh Meigooni, Zahra Zamani

“…The effectiveness of eosin B, a laboratory stain, as a competent antimalarial agent was identified earlier. …”
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Therapeutic Drug Monitoring of Vancomycin in Hemodialysis Patients in a Hospital in North-East Romania by Aurelia Crețu, Luanda Irina Mititiuc, Iulia-Daniela Lungu, Mihaela Mihaila, Irina Dima, Adrian Covic, Cristina Mihaela Ghiciuc

“…We observed that a supratherapeutic AUC occurred when the loading dose was 1500 mg or 2000 mg, and in one case at 1000 mg with a low BMI. <b>Conclusions</b>: a therapeutic level of vancomycin can often be difficult to achieve because of different reasons, mainly in hemodialysis patients.…”
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Diagnostic Challenges in Uncommon Firearm Injury Cases: A Multidisciplinary Approach by Andrea Vittorio Maria Failla, Gabriele Licciardello, Giuseppe Cocimano, Lucio Di Mauro, Mario Chisari, Francesco Sessa, Monica Salerno, Massimiliano Esposito

“…Despite this, real-world case presentations can present uncertain elements, sometimes deviating from what is considered standard, and present uncommon features that are difficult for forensic pathologists and ballistic experts to explain. <b>Methods</b>: A retrospective analysis of autopsy reports from the Institute of Legal Medicine, University of Catania, covering 2019–2023, included 348 judicial inspections and 378 autopsies performed as part of the institute’s overall activities. …”
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Inhibition of Endothelial Cell Tube Formation by Anti-Vascular Endothelial Growth Factor/Anti-Angiopoietin-2 RNA Nanoparticles by Cheng Zhong, Zhanquan Shi, Chia-Yang Liu, Daniel W. Binzel, Kai Jin, Xin Li, Peixuan Guo, S. Kevin Li

“…<b>Background/Objectives</b>: A previous study showed that RNA nanoparticles with antiangiogenic aptamers (anti-vascular endothelial growth factor (VEGF) and anti-angiopoietin-2 (Ang2) aptamers) inhibited cell proliferation via WST-1 assay. …”
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Electrocardiographic Frontal QRS-T Angle Is Independently Associated with the Presence of Celiac Disease and Disease Duration by Betül Ayça Yamak, İbrahim Ethem Güven, Mustafa Candemir

“…This study aimed to evaluate myocardial repolarization properties in CD patients by assessing the frontal QRS-T Angle (fQRS-T) on electrocardiography (ECG). <b>Methods:</b> A total of 302 patients, including 150 CD patients and 152 control group patients, were included in the study. …”
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