Association between changes in genital immune markers and vaginal microbiome transitions in bacterial vaginosis by Philipp Foessleitner, Briah Cooley Demidkina, Wafae El-Arar, Miles Goldenberg, Meena Murthy, Agnes Bergerat, Ofri Bar, Douglas S. Kwon, Caroline M. Mitchell

“…Improvement correlated with decreased monocytes (p = 0.005), while worsening was linked to increased monocytes (p < 0.001) and dendritic cells (p = 0.02). B cells (p = 0.02) and IFN-γ-induced chemokines - IP-10 (p = 0.007), MIG (p = 0.049), and ITAC (p = 0.005) - were associated with improvement. …”
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Immune Cell Profiling Reveals a Common Pattern in Premetastatic Niche Formation Across Various Cancer Types by Shigeaki Sugiyama, Kanae Yumimoto, Keiichi I. Nakayama

“…Results We found a common pattern of changes in both lung and peripheral immune cell profiles across the three cancer types, including a decrease in the proportion of eosinophils in the early premetastatic phase, an increase in that of regulatory T cells in the late premetastatic phase, and an increase in that of polymorphonuclear myeloid‐derived suppressor cells and a decrease in that of B cells in the micrometastatic phase. Machine learning using immune cell profiles could predict the metastatic phase with approximately 75% accuracy. …”
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Flow Cytometric Analysis of T, B, and NK Cells Antigens in Patients with Mycosis Fungoides by Serkan Yazıcı, Emel Bülbül Başkan, Ferah Budak, Barbaros Oral, Şaduman Balaban Adim, Zübeyde Ceylan Kalin, Güven Özkaya, Kenan Aydoğan, Hayriye Saricaoğlu, Şükran Tunali

“…Fluorescent labeled monoclonal antibodies were used to detect cell surface antigens: T cells (CD3+, CD4+, CD8+, TCRαβ+, TCRγδ+, CD7+, CD4+CD7+, CD4+CD7−, and CD71+), B cells (HLA-DR+, CD19+, and HLA-DR+CD19+), NKT cells (CD3+CD16+CD56+), and NK cells (CD3−CD16+CD56+). …”
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Characterization of serum metabolome and respiratory microbiota in children with influenza A virus infection by Xinyi Shi, Shenghao Hua, Zeyuan Chen, Weiyi Cao, Mengqing Xiao, Wenlong Pei, Zhe Cao, Zhan Zhang, Haibing Yang, Haibing Yang, Xuejun Shao, Yu Xia, Yu Xia

“…Compared with control group, IAV infection decreased the contents of platelet, white blood cell, lymphocyte, eosinophil, basophil, CD3+ T cells, CD4+ T cells, CD8+ T cells, and B cells, while increasing the number of red blood cell. …”
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Detection of serum soluble markers of immune activation in rheumatoid arthritis by T. Kogure, T. Itoh, Y. Shimada, T. Shintani, H. Ochiai, K. Terasawa

“…These findings indicate that B cells might be generally activated in RA, whereas T-cell activation in variable in each patient with RA, suggesting that sCD23 is a more indicative marker for the immune status of RA patients than sCD8 from the clinical aspects.…”
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Downregulation of MerTK in circulating T cells of patients with non-proliferative diabetic retinopathy by Shimiao Bu, Shimiao Bu, Jiang-Yue Ling, Jiang-Yue Ling, Xiaojun Wu, Xiaojun Wu, Liting Zhang, Liting Zhang, Xiangyu Shi, Lang Huang, Zheng Zhao, Ying Yang, Zongqin Xiang, Yong U. Liu, Yong U. Liu, Yufeng Liu, Yuehong Zhang, Yuehong Zhang

“…Patients with DM demonstrated a significant deviation in the PBMCs composition, particularly in B cells, CD4+ T cells, and NK cells, when compared to HDs. …”
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M cells targeted H. pylori antigen SAM-FAdE displayed on bacterium-like particles induce protective immunity by Furui Zhang, Jiale Chen, Zhen Zhang, Jing Wu, Yuliang Qu, Linhan Ni, Guolin Zhang, Kunmei Liu, Le Guo

“…In addition, BLPs-SAM-FAdE can effectively target M ​​cell models and M cells of mouse Peyer’s patches (PPs) through oral immunization, promote the transport of particulate vaccines to dendritic cells (BMDCs) and stimulate their maturation, significantly increased proportion of plasma cells and germinal centers B cells. This indicates that the vaccination can induce notable antigen-specific mucosal immune responses (production of sIgA), CD4+ T cell responses (Th1/Th2/Th17) and humoral immune responses (production of serum IgG). …”
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Prognostic Significance and Therapeutic Potential of SERPINE1 in Head and Neck Squamous Cell Carcinoma by Changyu Zhu, Heshu Liu, Zhixin Li, Yijun Shi, Jingyang Zhao, Yuping Bai, Qian Chen, Wei Li

“…The infiltration levels of eight cell types, such as eosinophils, Tgd, and macrophages, showed a positive correlation with SERPINE1 expression, whereas infiltration levels of four cell types, including cytotoxic cells, B cells, and pDCs, displayed a negative correlation. …”
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Cigarette and e-cigarette reversely regulated autophagy via distinct level of ROS in vitro by Yao Wang, Jialing Zhong, Zuyi Jin, An Luo, Zehong Wu, Xingtao Jiang, Jianwen Chen, Peiqing Liu, Min Li

“…Furthermore, noteworthy differences in cellular mechanisms were observed between CSC and EAC-Cola in BEAS-2B cells, particularly in terms of ROS level and autophagy regulation. …”
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Conjugated Linoleic Acid Treatment Attenuates Cancerous features in Hepatocellular Carcinoma Cells by Zohre Miri-Lavasani, Shukoofeh Torabi, Roya Solhi, Bahareh Shokouhian, Parvaneh Afsharian, Zahra Heydari, Abbas Piryaei, Zahra Farzaneh, Nikoo Hossein-khannazer, Hamidreza Aboulkheyr Es, Ensieh Zahmatkesh, Andreas Nussler, Moustapha Hassan, Mustapha Najimi, Massoud Vosough

“…Materials and Method. Sk-Hep-1 and Hep-3B cells were treated with different doses of CLA or BIM5078 [1-(2′-chloro-5′-nitrobenzenesulfonyl)−2-methylbenzimidazole], an HNF4α antagonist. …”
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Prospective and Longitudinal Analysis of Lymphocyte Subpopulations in SARS-CoV-2 Positive and Negative Pneumonia: Potential Role of Decreased Naïve CD8⁺ in COVID-19 Pati... by Makhabbat Bekbossynova, Lyudmila Akhmaltdinova, Kuanysh Dossybayeva, Ainur Tauekelova, Zauresh Smagulova, Tatyana Tsechoeva, Gulsimzhan Turebayeva, Aliya Sailybayeva, Zhanar Kalila, Takhmina Mirashirova, Timur Muratov, Dimitri Poddighe

“…In the acute phase, the general lymphocyte immunophenotyping profile was comparable for most parameters between these groups, except for B cells. When B and T cells were analyzed according to the expression of memory markers, a significant decrease in naïve CD8⁺ T cells was observed in the SARS-CoV-2-positive pneumonia group during the acute phase. …”
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Epstein-Barr Virus- (EBV-) Immortalized Lymphoblastoid Cell Lines (LCLs) Express High Level of CD23 but Low CD27 to Support Their Growth by Hooi-Yeen Yap, Thin-Sam Siow, Sook-Khuan Chow, Sin-Yeang Teow

“…Increase expression of CD23 may play a role in EBV immortalization of B-cells and the growth and maintenance of the EBV-transformed LCLs while CD27 expression might have inhibitory effects on LCL proliferation. …”
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Single cell and spatial analysis of immune-hot and immune-cold tumours identifies fibroblast subtypes associated with distinct immunological niches and positive immunotherapy respo... by Benjamin H. Jenkins, Ian Tracy, Maria Fernanda S. D. Rodrigues, Melanie J. L. Smith, Begoña R. Martinez, Mark Edmond, Sangeetha Mahadevan, Anjali Rao, Hailing Zong, Kai Liu, Abhishek Aggarwal, Li Li, Lauri Diehl, Emma V. King, Jamie G. Bates, Christopher J. Hanley, Gareth J. Thomas

“…FRC-like were enriched in immune-hot HPV+ve tumours, associated with CD4 + T-cells and B-cells in tertiary lymphoid structures and regulated through non-canonical NF-κB signalling via lymphotoxin. …”
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Moringa oleifera Lam. leaf extract mitigates carbon tetrachloride-mediated hepatic inflammation and apoptosis via targeting oxidative stress and toll-like receptor 4/nuclear factor... by Samah M. Fathy, Mohammed S.M. Mohammed

“…The suppressing effect of MOLE on the boosted inflammatory pathway triggered by CCl4 was detected by measuring the protein levels of nuclear factor kappa-light-chain-enhancer of activated B-cells (NF-κB-p65), toll-like receptor 4 (TLR4), tumor necrosis factor-α (TNF-α), interleukin (IL)-6, IL-1β, and IL-8 as well as the relative expressions of nuclear factor kappa B (NF-κB), TNF-α, IL-1β, and TLR4 genes. …”
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The oncogenic roles of GPR176 in ovarian cancer: a molecular target for aggressiveness and gene therapy by Ning Yang, Wen-jing Yun, Zheng-guo Cui, Hua-chuan Zheng

“…Additionally, the effects of GPR176 on ovarian cancer cell phenotypes were investigated.Results GPR176 expression positively correlated with elder age, clinicopathological staging, tumour residual status, and unfavourable survival of ovarian cancer, but negatively with purity loss, infiltration of B cells, and CD8+ T cells. Gene Set Enrichment Analysis showed that differential expression of GPR176 was involved in focal adhesion, ECM-receptor interaction, cell adhesion molecules and so on. …”
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Causal relationship between immune cells and risk of heart failure: evidence from a Mendelian randomization study by Wenjing Cao, Zefu Yang, Liumei Mo, Zhenhao Liu, Jiawei Wang, Zhenhong Zhang, Kui Wang, Wei Pan

“…These immunophenotypes, 8 of which were in B cells, 5 in cDC, 2 in T cell maturation stage, 2 in monocytes, 3 in myeloid cells, 7 in TBNK and 13 in Treg. …”
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Characteristics of lower respiratory microbiota in children’s refractory Mycoplasma pneumoniae pneumonia pre- and post-COVID-19 era by Zhimin Xi, Jinglong Chen, Libo Wang, Aizhen Lu

“…The abundance of Mycoplasmoides pneumoniae positively correlated with the levels of D-dimer and LDH, negatively correlated with the counts of CD3+ T cells, CD8+ T cells, CD19+ B cells and CD16+CD56+ NK cells.DiscussionOur study showed that high abundance of MP was correlated with the severity of RMPP and decrease of immune cells. …”
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Identification of an Immune Gene-Based Cisplatin Response Model and CD27 as a Therapeutic Target against Cisplatin Resistance for Ovarian Cancer by Ying Guo, Na Yang, Gang Li, Xiurong Yin, Lixia Dong

“…Treg scores were significantly decreased in cisplatin-resistant than cisplatin-sensitive OV specimens, with the opposite results for naïve B cells and activated dendritic cells. Fourteen prognostic DEGs were identified and used to develop a cisplatin-response model. …”
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Breg Cells in Celiac Disease Isolated or Associated to Hashimoto’s Thyroiditis by Maria Giulia Santaguida, Ilenia Gatto, Giorgio Mangino, Camilla Virili, Ilaria Stramazzo, Poupak Fallahi, Alessandro Antonelli, Patrizia Gargiulo, Giovanna Romeo, Marco Centanni

“…Hashimoto’s thyroiditis (HT) may occur associated with celiac disease (CD). Regulatory B cells (Breg) subsets have been shown to play a significant role in autoimmune processes. …”
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A randomized, double‐blind, placebo‐controlled, multiple dose, parallel study to investigate the effects of a cathepsin S inhibitor in celiac disease by Darren Bentley, Marie Mannino, Marianne Manchester, Priscila Camillo Teixeira, Bernhard Reis, Malcolm Boyce, Sandra Nagel

“…Participants in the RO5459072 arm also showed decreased intestinal permeability, and a decrease in the number of circulating B cells, CD4+ and CD8+ T cells compared to baseline. …”
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