Pulmonary Talcosis in an Immunocompromised Patient by Thanh-Phuong Nguyen, Sowmya Nanjappa, Manjunath Muddaraju, John N. Greene

“…We report an 82-year-old man who is diagnosed with Philadelphia chromosome positive pre-B cell acute lymphoblastic leukemia (ALL) treated with palliative imatinib who presented with chronic hemoptysis and dyspnea shortly after his diagnosis. …”
Get full text

A Case of Bing–Neel Syndrome Successfully Treated with Ibrutinib by Daniel S. O’Neil, Mark A. Francescone, Karen Khan, Alobeid Bachir, Owen A. O’Connor, Ahmed Sawas

“…Flow cytology of his cerebral spinal fluid demonstrated a lambda light chain-restricted population of B-cells consistent with a CD5+ CD10+ B-cell lymphoma. …”
Get full text

Costimulatory Pathways: Physiology and Potential Therapeutic Manipulation in Systemic Lupus Erythematosus by Nien Yee Kow, Anselm Mak

“…While SLE has classically been advocated as a B-cell or T-cell disease, it is unlikely that a particular cell type is more pathologically predominant than the others. …”
Get full text

Plasmablastic Lymphoma: A Review of Current Knowledge and Future Directions by Ghaleb Elyamany, Eman Al Mussaed, Ali Matar Alzahrani

“…The introduction of genes encoding artificial receptors called chimeric antigen receptors (CARs) and CAR-modified T cells targeted to the B cell-specific CD19 antigen have demonstrated promising results in multiple early clinical trials. …”
Get full text

Navigating transfusion challenges: Bombay blood group in focus by Romesh Jain, Vilasini Patil, Pratul Sinha, Snehashish Mishra, Rut Naik

“…In reverse grouping, there was 4 + reaction with A cell, B cell, and O cell and negative reaction with autocontrol. …”
Get full text

Advancing Multiple Myeloma Immunotherapy: A Review of Chimeric Antigen Receptor T-Cell and Bispecific T-Cell Engagers Cell Therapies in Revolutionizing Treatment by Rahul Navab, Pragyat Futela, Verkha Kumari, Jayesh Valecha, Ramansh Bandhu Gupta, Rohit Jain

“…CAR T-cell therapy involves modifying patient T-cells to target specific antigens, primarily B Cell Maturation Antigen (BCMA). BiTEs, on the other hand, are non-IgG-like bispecific antibodies designed to engage both CD3 and tumor-associated antigens. …”
Get full text

Visfatin/Nampt: An Adipokine with Cardiovascular Impact by Tania Romacho, Carlos F. Sánchez-Ferrer, Concepción Peiró

“…This adipokine was identical to two previously described molecules, namely, pre-B cell colony-enhancing factor (PBEF) and the enzyme nicotinamide phosphoribosyltransferase (Nampt). …”
Get full text

Tolosa-Hunt Syndrome in Double-Hit Lymphoma by Prakash Peddi, Kevin M. Gallagher, Chandrikha Chandrasekharan, Qi Wang, Eduardo Gonzalez-Toledo, Binu S. Nair, Reinhold Munker, Glenn M. Mills, Nebu V. Koshy

“…Here we present a first case of double-hit B cell lymphoma (DHL) relapsing and masquerading as Tolosa-Hunt syndrome. …”
Get full text

PTLD Burkitt Lymphoma in a Patient with Remote Lymphomatoid Granulomatosis by A. Stravodimou, A. Cairoli, T. Rausch, R. Du Pasquier, P. Michel

“…The majority of PTLD is of B-cell origin, and 90% are associated with the Epstein-Barr virus (EBV). …”
Get full text

Development of a broad-spectrum epitope-based vaccine against Streptococcus pneumoniae. by Md Nahian, Muhammad Shahab, Md Rasel Khan, Shopnil Akash, Tanjina Akhtar Banu, Murshed Hasan Sarkar, Barna Goswami, Sanjana Fatema Chowdhury, Mohammad Ariful Islam, Ahmed Abu Rus'd, Shamima Begum, Ahashan Habib, Aftab Ali Shaikh, Jonas Ivan Nobre Oliveira, Shahina Akter

“…Two potential vaccine candidates, CbpA and PspA, were identified, and their B-cell, CTL, and HTL epitopes were predicted and connected with suitable linkers, adjivant and PADRE sequence. …”
Get full text

HHV-8-Associated Lymphoproliferative Disorders and Pathogenesis in an HIV-Positive Patient by Carlo Guerrero, Tania Jain, Katalin Kelemen

“…The World Health Organization has recently updated the classification of HHV-8-associated LPDs by introducing HHV-8-positive germinotropic LPD (GLPD) in addition to the previously recognized entities of HHV-8-positive diffuse large B-cell lymphoma, not otherwise specified (DLBCL, NOS), primary effusion lymphoma (PEL), and HHV-8-positive multicentric Castleman’s disease (MCD). …”
Get full text

Consensus guidelines for the management of treatment-naïve chronic lymphocytic leukaemia in Singapore (2024) by Yeow Tee Goh, Yvonne Loh, Esther Chan, Yuh Shan Lee, Venkata Sreekanth Sampath, Daryl Tan, Shin Yeu Ong, Chandramouli Nagarajan

“…Due to the superior efficacy of targeted agents (Bruton's tyrosine kinase inhibitors [BTKis] and B-cell lymphoma 2 inhibitors [BCL2is]), sthese are favoured over standard chemotherapy or chemotherapy-immunotherapy, especially for patients with del(17p) or TP53 mutation, and less fit patients. …”
Get full text

A Rare Case of Immunotactoid Glomerulopathy Associated with Hodgkin Lymphoma by Keiki Nagaharu, Yuka Sugimoto, Keiki Kawakami

“…In hematologic malignancies, multiple myeloma and other mature B-cell malignancies are the most common hematologic malignancies, and Hodgkin lymphoma (HL) is extremely rare. …”
Get full text

A Rare Case of Primary Bilateral Adrenal Lymphoma by Veeraraghavan Meyyur Aravamudan, Phang Kee Fong, Yang Shiyao Sam, Pavel Singh, Siok-Bian Ng, Gollamudi Satya Pavan Kumar

“…Histology of adrenal gland biopsy showed features consistent with diffuse large B-cell lymphoma. She was started on R-CHOP chemotherapy and had a good clinical response and remained in complete remission for five months after chemotherapy.…”
Get full text

Acute Lymphoblastic Leukemia following Lenalidomide Maintenance for Multiple Myeloma: Two Cases with Unexpected Presentation and Good Prognostic Features by Abdullah M. Khan, Jameel Muzaffar, Hermant Murthy, John R. Wingard, Jan S. Moreb

“…One patient was diagnosed on routine biopsy performed as part of requirements of the clinical trial. Both patients had B-cell ALL, without known poor risk cytogenetics, and were managed with standard induction therapies resulting in complete remission. …”
Get full text

MicroRNA-155: Regulation of Immune Cells in Sepsis by Ming Chen, Fuquan Wang, Haifa Xia, Shanglong Yao

“…MicroRNAs are small noncoding RNAs which regulate gene expression at the posttranscriptional level. miR-155 is encoded by the miR-155 host gene (miR155HG), also known as the noncoding B cell integration cluster (BIC). MicroRNAs are widely expressed in various hematopoietic cells and are involved in regulating the immune system. …”
Get full text

Aerobic Exercise Regulates Apoptosis through the PI3K/Akt/GSK-3β Signaling Pathway to Improve Cognitive Impairment in Alzheimer’s Disease Mice by Yan Peng, Rui Chi, Gang Liu, Weijie Tian, Jun Zhang, Rihui Zhang

“…After the exercise intervention, we evaluated the learning memory ability (positioning, navigation, and spatial search) of mice using a Morris water labyrinth, Nissl staining, immunohistochemistry, and protein application to detect hippocampal PI3K/Akt/GSK-3β signaling pathway protein and hippocampal neuronal cell apoptosis protein B cell lymphoma 2 (Bcl-2) and apoptosis-promoting protein bcl-2-related X (Bax) protein expression. …”
Get full text

Design of Epitope-Based Peptide Vaccine against Pseudomonas aeruginosa Fructose Bisphosphate Aldolase Protein Using Immunoinformatics by Mustafa Elhag, Ruaa Mohamed Alaagib, Nagla Mohamed Ahmed, Mustafa Abubaker, Esraa Musa Haroun, Sahar Obi Abd Albagi, Mohammed A. Hassan

“…The protein sequences were obtained from NCBI, and prediction tests were undertaken to analyze possible epitopes for B and T cells. Three B cell epitopes passed the antigenicity, accessibility, and hydrophilicity tests. …”
Get full text

The Dual Role of HLA-G in Cancer by Nathalie Rouas-Freiss, Philippe Moreau, Joel LeMaoult, Edgardo D. Carosella

“…Aside from these numerous studies on solid tumors, recent data showed that HLA-G inhibits the proliferation of malignant B cells due to the interaction between HLA-G and its receptor ILT2, which mediates negative signaling on B cell proliferation. …”
Get full text

Respiratory Syncytial Virus Infections in Infants Affected by Primary Immunodeficiency by Marcello Lanari, Silvia Vandini, Maria Grazia Capretti, Tiziana Lazzarotto, Giacomo Faldella

“…Respiratory syncytial virus (RSV) is one of the most frequent pathogens during early infancy and the infection is more severe in immunocompromised infants than in healthy infants, as a result of impaired T- and B-cell immune response unable to efficaciously neutralize viral replication, with subsequent increased viral shedding and potentially lethal lower respiratory tract infection. …”
Get full text