MicroRNAs as Haematopoiesis Regulators by Ram Babu Undi, Ravinder Kandi, Ravi Kumar Gutti

“…Aberrant expression of miRNAs was observed in hematological malignancies including chronic myelogenous leukemia, chronic lymphocytic leukemia, multiple myelomas, and B cell lymphomas. In this review we have focused on discussing the role of miRNA in haematopoiesis.…”
Get full text

Primary Hepatic Lymphoma: A Challenging Diagnosis by D. Myoteri, D. Dellaportas, E. Arkoumani, A. Marinis, A. Zizi-Sermpetzoglou

“…After CT-guided biopsy, primary diffuse large B-cells non-Hodgkin lymphoma was revealed. Appropriate chemotherapy improved patient’s condition markedly. …”
Get full text

The Role of Protein Modifications of T-Bet in Cytokine Production and Differentiation of T Helper Cells by Sera Oh, Eun Sook Hwang

“…Numerous studies have demonstrated that T-bet plays multiple roles in many subtypes of immune cells, including B cell, dendritic cells, natural killer (NK) cells, NK T cells, and innate lymphoid cells. …”
Get full text

Systemic lupus erythematosus in a patient with 22q11.2 deletion syndrome: A case report and review of the literature by Chen Sun, Pingyang Han, Juzhen Yan

“…Thymic dysplasia, T-cell lymphopenia, and B-cell abnormalities collectively contribute to the immunodeficiency and autoimmune manifestations observed in individuals with 22q11.2DS. …”
Get full text

A Novel del(20q) in Aggressive Nodal Marginal Zone Lymphoma by Jason B. Kern, Deiter J. Duff, Jamie L. Odem, Magda Esebua, Lisa R. Smith, Donald Doll, Michael Wang

“…This was an unexpected finding, as del(20q) is associated with myelodysplastic syndromes and myeloproliferative neoplasms and rarely seen in diffuse large B-cell lymphoma, follicular lymphoma, and T-cell lymphoma, but has not previously been described in MZL. …”
Get full text

Oral plasmablastic lymphoma: at the origin of the discovery of an HIV infection by Rahman Nurhayu Ab, Hussain Faezatul Arbaeyah, Eng Kam Chuan

“…Introduction: Plasmablastic lymphoma is a rare and aggressive malignancy derived from a B cell lineage. It has a predilection for extranodal sites, particularly arises de novo in the oral cavity. …”
Get full text

Breast lymphomas: Clinical and pathological insights from a tertiary cancer care center in India by Neha Singh, Sadaf Hayat, Sujeet Kumar, Zachariah Chowdhury, Ipsita Dhal, Shashikant CU Patne, Kavya Kadali, Bal Krishna Mishra, Akhil Kapoor, Anuj Gupta, Anil Singh, Bipinesh Sansar

“…It was seen predominantly in females (82%) and the age range was 31 to 73 years. Diffuse large B cell lymphoma (DLBCL) was the predominant morphology (73%), along with single rare cases of ALK-negative anaplastic large cell lymphoma, Burkitt lymphoma, and small lymphocytic lymphoma. …”
Get full text

Autoimmune Gastrointestinal Paralysis: Failure of Conventional Treatment without Immunomodulation by Craig Weinkauf, Sean McPhillips, Robert Krouse, Ira Levine

“…Patients with neuroendocrine-derived tumors can develop B-cell reactivity towards the tumor with cross-reactivity for neurons located in the submucosal and myenteric ganglia of the ENS. …”
Get full text

Bio-mimetic strategies to re-activate apoptotic cell death for cancer treatments by Andrea Venerando, Denise Lovison, Rossella De Marco

“…The internal (or mitochondrial) and external (or death receptor) pathways are responsible for driving a series of molecular events that lead to apoptosis by releasing pro-apoptotic proteins, such as B-cell lymphoma-2 (BCL-2) homology 3 (BH3)-only proteins and second mitochondria-derived activator of caspases/diablo inhibitor of apoptosis protein-binding mitochondrial protein (SMAC/DIABLO), that in turn activate the caspase family of proteases. …”
Get full text

Characteristics of Suppressor Macrophages Induced by Mycobacterial and Protozoal Infections in relation to Alternatively Activated M2 Macrophages by Haruaki Tomioka, Yutaka Tatano, Win Win Maw, Chiaki Sano, Yuichi Kanehiro, Toshiaki Shimizu

“…During the course of Mycobacterium tuberculosis (MTB) and Mycobacterium avium-intracellulare complex (MAC) infections, the generation of macrophages which possess strong suppressor activity against host T- and B-cell functions is frequently encountered. This paper describes the immunological properties of M1- and M2-type macrophages generated in tumor-bearing animals and those generated in hosts with certain microbial infections. …”
Get full text

Tirosin Kinase Inhibitors in Chronic Graft versus Host Disease: From Bench to Bedside by Jacopo Olivieri, Sabrina Coluzzi, Imma Attolico, Attilio Olivieri

“…Moreover accumulating in vitro data confirm that TKIs, interacting with the TCR and other signalling molecules, carry potent immunomodulatory effects, being involved in both T-cell and B-cell response. Translation to the clinical setting revealed that treatment with Imatinib can achieve encouraging responses in patients with autoimmune diseases and steroid-refractory cGVHD, showing a favourable toxicity profile. …”
Get full text

CEACAM5 exacerbates asthma by inducing ferroptosis and autophagy in airway epithelial cells through the JAK/STAT6-dependent pathway by Si Liu, Li Chen, Yunxiao Shang

“…CEACAM5 expression was elevated in asthmatic mouse lung tissues and IL-13-stimulated Beas-2B cells, primarily in bronchial epithelial cells. …”
Get full text

Acute Left Internal Carotid Artery and Right Popliteal Artery Occlusion Related to Cisplatin-Gemcitabine Based Chemotherapy by Saman Zafar, Rashmika Potdar, Andrew Tiu, Gabor Varadi, John Leighton

“…We report a case of a 64-year-old male with Diffuse Large B-Cell Non-Hodgkin’s Lymphoma who presented with left-sided headache and right calf pain two weeks after starting Rituximab/Gemcitabine/Cisplatin/Dexamethasone chemotherapy. …”
Get full text

Successful Treatment of Severe Type B Lactic Acidosis in a Patient with HIV/AIDS-Associated High-Grade NHL by Marco Mejia, Ariel Perez, Harold Watson, Daniel Sanchez, Jorge Parellada, Mario Madruga, S. J. Carlan

“…Biopsy of the abdominal mass demonstrated a high-grade diffuse large B-cell lymphoma. The patient’s lactic acidosis resolved after starting chemotherapy, and a complete response was evident on PET-CT after a third cycle of rituximab, etoposide, prednisone, vincristine, cyclophosphamide, and doxorubicin (EPOC-RR). …”
Get full text

Autoimmune Hepatitis: Progress from Global Immunosuppression to Personalised Regulatory T Cell Therapy by Nwe Ni Than, Hannah C. Jeffery, Ye H. Oo

“…Innate immune cells are crucial in the initial onset of disease and their response is followed by adaptive T (Th1, Th17, and cytotoxic T cells) and B cell responses evidenced by liver histology and peripheral blood serology. …”
Get full text

Survival Analysis by Penalized Regression and Matrix Factorization by Yeuntyng Lai, Morihiro Hayashida, Tatsuya Akutsu

“…We tried L1- (lasso), L2- (ridge), and L1-L2 combined (elastic net) penalized regression for diffuse large B-cell lymphoma (DLBCL) patients' microarray data and found that L1-L2 combined method predicts survival best with the smallest logrank P value. …”
Get full text

Large-scale manufacturing and characterization of CMV-CD19CAR T cells by Stephen J Forman, Xiuli Wang, Ryan Urak, Miriam Walter, Min Guan, Tianxu Han, Vibhuti Vyas, Sheng-Hsuan Chien, Brenna Gittins, Mary C Clark, Sally Mokhtari, Angelo Cardoso, Don J Diamond, John Zaia, Ryotaro Nakamura

“…Background Adoptive transfer of CD19-specific chimeric antigen receptor (CD19CAR) T cells can induce dramatic disease regression in patients with B cell malignancies. CD19CAR T cell therapy may be limited by insufficient engraftment and persistence, resulting in tumor relapse. …”
Get full text

SARS-CoV-2 infections in pediatric and young adult recipients of chimeric antigen receptor T-cell therapy: an international registry report by Hongyan Liu, Colleen Callahan, Shannon L Maude, Kevin Owen McNerney, Rebecca M Richards, Paibel Aguayo-Hiraldo, Friso G Calkoen, Julie-An Talano, Amy Moskop, Adriana Balduzzi, Jennifer Krajewski, Hema Dave, Anant Vatsayan, Yimei Li, Kara Lynn Davis

“…Patients undergoing chimeric antigen receptor (CAR) T-cell therapy for relapsed/refractory B-cell malignancies are uniquely immunosuppressed due to CAR T-mediated B-cell aplasia (BCA). …”
Get full text

Apelin Protects Primary Rat Retinal Pericytes from Chemical Hypoxia-Induced Apoptosis by Li Chen, Yong Tao, Jing Feng, Yan Rong Jiang

“…Furthermore, exogenous recombinant apelin effectively prevented hypoxia-induced apoptosis through downregulating active-caspase 3 expression and increasing the ratio of B cell lymphoma-2 (Bcl-2)/Bcl-2 associated X protein (Bax) in pericytes. …”
Get full text

Primary Hairy Cell Leukemia/Lymphoma of the Breast: A Case Report and Review of the Literature by Monika Pilichowska, Ahmad Shariftabrizi, Ian Mukand-Cerro, Kenneth Miller

“…Hairy cell leukemia/lymphoma (HCL) is a rare B-cell neoplasm primarily involving spleen, bone marrow, and blood. …”
Get full text