Acute Warfarin Toxicity as Initial Manifestation of Metastatic Liver Disease by Varalaxmi Bhavani Nannaka, Nihar Jani, Masooma Niazi, Dmitry Lvovsky

“…She rapidly deteriorated with acute respiratory failure requiring mechanical ventilation, profound shock requiring high dose vasopressor infusion, severe coagulopathy, worsening liver enzymes with worsening of lactic acidosis and severe metabolic abnormalities, and refractory to aggressive supportive care and died in less than 48 hours. Autopsy revealed that >90% of the liver was replaced by tumor masses.…”
Get full text

Distinctive Acellular Lipid Emboli in Hemoglobin SC Disease following Bone Marrow Infarction with Parvovirus Infection by Danielle M. Graff, Erin Owen, Robert Bendon, Salvatore Bertolone, Ashok Raj

“…An adolescent with mild hemoglobin SC disease presented with pelvic pain with subsequent respiratory and neurologic deterioration, which led to ultimately death. The autopsy demonstrated acellular fat emboli particularly in the lung and brain. …”
Get full text

A case of gangrenous cystitis with bilateral hydronephrosis 10 years after radiotherapy by Mariko Oniwa, Yuki Kataoka, Midori Yamada, Takuya Miyagawa, Takuro Sunada, Hideyuki Konishi, Gen Suzuki, Yoko Fujita

“…Imaging studies revealed bladder wall thickening, bilateral hydroureter formation, and hydronephrosis. Autopsy findings led to a diagnosis of gangrenous cystitis (GC). …”
Get full text

Diagnosing Sporadic Creutzfeldt-Jakob Disease in a Patient with a Suspected Status Epilepticus in the Intensive Care Unit by Harm J. van der Horn, Peter H. Egbers, Michaël A. Kuiper, Wouter J. Schuiling

“…All treatments were terminated, and autopsy confirmed sCJD. Conclusions. Clinical signs combined with MRI, EEG, and 14-3-3 and/or tau protein determination might be sufficient to diagnose or exclude sCJD and may therefore prevent the application of unnecessary diagnostic tests.…”
Get full text

Imaging Characteristics of Frozen Corpses: An Analysis Based on Postmortem Computed Tomography by Sunao Li, Wenju Jin, Jiahui He, Jun He, Mingjie Qiu, Wenjing Gao, Long Fu, Haibin Shen, Zhiyuan Xia, Xilian Ding

“…Background: As traditional autopsy rates decline, the importance of forensic imaging, particularly postmortem computed tomography (PMCT), grows for non-invasive cause of death determination and evidence collection in legal investigations, with unique considerations required for frozen corpses due to the lack of systematic imaging characteristic studies. …”
Get full text

Lung Metastases to the Heart with Atypical Clinical Manifestations of Cardiac Failure by Natalia HYRIAVENKO, Vladyslav SIKORA, Wireko Andrew AWUAH, Toufik ABDUL-RAHMAN, Mykola LYNDIN, Anatolii ROMANIUK

“…Posthumously, the anamnesis, autopsy results, and morphological examination were evaluated. …”
Get full text

Variations of Gastrocolic Trunk of Henle and Its Significance in Gastrocolic Surgery by Yuan Gao, Yun Lu

“…We characterized various variants and tributaries of Henle’s trunk using autopsy, vascular casting, 3D CT reconstruction, intraoperative anatomy, and Hisense CAS system and summarized and analyzed the tributaries of Henle’s trunk, to determine its influence on GI surgeries.…”
Get full text

Fatal Septic Shock in a Patient with Hemophagocytic Lymphohistiocytosis Associated with an Infectious Mononucleosis by Giorgio Berlot, Ariella Tomasini, Lorenzo Zandonà, Eugenio Leonardo, Rossana Bussani, Nadia Zarrillo

“…Despite the aggressive treatment, which included antibiotics, vasopressors, IV immunoglobulins, and the use of an extracorporeal device aimed to remove mediators released both during sepsis and the cytokine storm determined by the hemophagocytic lymphohistiocytosis, the patient died. At the autopsy, an extremely uncommon aggressive lymphoma of Epstein-Barr virus-positive T-lymphocytes with systemic involvement was discovered.…”
Get full text

Active Surveillance for Localized Prostate Cancer – Current Practices and Recommendations by Jennifer N. Wu, Marc A. Dall'Era

“…Prostate cancer is now the most commonly diagnosed solid tumor in American men, due in part to widespread screening and aggressive diagnostic practices. Prostate cancer autopsy studies show the uniquely high prevalence rates of small, indolent tumors in men dying of other causes. …”
Get full text

Proliferation Index and Karyometric Features of Pancreatic Intraductal Proliferative Lesions by Romana Tomaszewska, Krzysztof Okoń, Krystyna Nowak, Jerzy Stachura

“…The increasing frequency and poor prognosis in pancreatic cancer prompt us to search for morphological lesions being a substrate for its development. Studies of autopsy and surgically resected material as well as recent molecular studies have proved that one of the possible pathways of pancreatic neoplasia is the intraepithelial proliferation – dysplasia – cancer sequence. …”
Get full text

PULMONARY EMBOLISM IN THE PRACTICE OF AN OBSTETRICIAN-GYNECOLOGIST (CLINICAL CASE) by Елена Владимировна Рудаева, Юлия Валерьевна Васютинская, Любовь Борисовна Николаева, Светлана Ивановна Елгина, Кира Борисовна Мозес

“…Diagnosis of PE is very difficult and is not diagnosed at all in 50-80% of cases. At autopsy, it is important not only to diagnose PE but also to establish its source. …”
Get full text

Fatal Haemorrhagic Stroke Due to Concomitant Abuse of Sildenafil and Alcohol: A Case Report by Jithin Laxminarayana V, Azmath Tabassum, Kapil D, Nagamohan Rao B V, Kattamreddy Ananth Rupesh

“…We present the case of a 39-year-old male with no significant medical history who suffered a fatal stroke after consuming high doses of sildenafil while intoxicated with alcohol. Notable findings at autopsy include left ventricular hypertrophy, left capsuloganglioninc bleed and atherosclerotic changes in the coronary arteries. …”
Get full text

Lymphomatoid granulomatosis. Case Presentation by Marisela García de la Torre, Yanelka Bouza Jiménez, Stephany Milagros Acosta País, Maribel Misa Menéndez

“…On January 15, the clinical condition of the patient worsened with high fever, disorientation, marked excitement, awareness and respiratory insufficiency, and he died on the 16th. Autopsy revealed lymphomatoid granulomatosis as the main cause of death.…”
Get full text

Animal Models of Diabetic Retinopathy: Summary and Comparison by Angela Ka Wai Lai, Amy C. Y. Lo

“…Although clinical assessment and retinal autopsy of diabetic patients provide information on the features and progression of DR, its underlying pathophysiological mechanism cannot be deduced. …”
Get full text

Extensive Bone Marrow Necrosis: Initial Presentation in Sickle Cell Anemia—A Case Report and Review of the Literature by Sameera A. Alsafwani, Abdulwahed Al-Saeed, Rehab Bukhamsin

“…Bone marrow necrosis (BMN) is a rare clinical entity that was first described in an autopsy of a sickle cell disease (SCD) patient and is defined as ill-defined necrotic cells in an amorphous eosinophilic background with preservation of cortical bone. …”
Get full text

Adipocyte heterogeneity and tumor infiltration of adipose tissue in patients with metastatic breast cancer by Hava Izci, Gitte Zels, Anirudh Pabba, Marion Maetens, François Richard, Maxim De Schepper, Josephine Van Cauwenberge, Ha-Linh Nguyen, Kristien Borremans, Sophia Leduc, Karen Van Baelen, Sigrid Hatse, Tatjana Geukens, Amena Mahdami, Hans Wildiers, Patrick Neven, Wouter Van Den Bogaert, Giuseppe Floris, Christine Desmedt

“…A trend towards smaller adipocytes in mammary fat at autopsy versus diagnosis was observed, suggesting potential age and/or treatment effects. …”
Get full text

JC Virus PCR Detection Is Not Infallible: A Fulminant Case of Progressive Multifocal Leukoencephalopathy with False-Negative Cerebrospinal Fluid Studies despite Progressive Clinica... by Mohamed-Ali Babi, William Pendlebury, Steven Braff, Waqar Waheed

“…The patient passed away 3 months from the onset of her neurological symptoms. Autopsy confirmed the diagnosis of PML with presence of JC-polyoma virus by immunohistochemical staining. …”
Get full text

Suicide in New Zealand by Said Shahtahmasebi

“…A straightforward contextual analysis of this information suggests that (i) only five cases had contact with mental health services, in two of the cases this was due to a previous suicide attempt and in the other three it was due to drug and alcohol dependency; (ii) mental illness as the cause of suicide is fixed in the public mindset, (iii) this in turn makes psychological autopsy type studies that seek information from families and friends questionable; (iv) proportionally more females attempt, but more men tend to complete suicide; and (v) not only is the mental health-suicide relationship tenuous, but suicide also appears to be a process outcome. …”
Get full text

Fetal sirenomelia type VI. A case report by Lilian Rachel Vila Ferrán, María Antonia Ocaña Gil

“…Gustavo Aldereguía Lima General University Hospital in Cienfuegos, where a clinical autopsy was performed on the product of conception, diagnosing type VI sirenomelia with a single femur and tibia, absence of feet, agenesis of internal and external genitalia, bladder, ureters, urethra and anus and fusion of the sacrum to the iliac bones, a single umbilical artery and rectal atresia. …”
Get full text

Gas-Forming Pyogenic Liver Abscess with Septic Shock by Muhammad S. Khan, Muhammad K. Ishaq, Kellie R. Jones

“…The very rapid clinical course makes it difficult to diagnose on time, and most cases are diagnosed at autopsy. Therefore it is important to consider C. perfringens infection in any severely ill patient with fever and evidence of hemolysis. …”
Get full text