A Novel Role for Brain Natriuretic Peptide: Inhibition of IL-1β Secretion via Downregulation of NF-kB/Erk 1/2 and NALP3/ASC/Caspase-1 Activation in Human THP-1 Monocyte by Letizia Mezzasoma, Cinzia Antognelli, Vincenzo Nicola Talesa

“…Dysregulation of both IL-1β and its related pathways is involved in inflammatory/autoimmune disorders and in a wide range of other diseases. …”
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Clinical Characterization of Patients with Chronic Spontaneous Urticaria according to Anti-TPO IgE Levels by Jorge Sánchez, Andres Sánchez, Ricardo Cardona

“…Chronic spontaneous urticaria (CSU) is a heterogeneous disease with some frequent comorbidities like autoimmune diseases, drug reactions, and inducible urticaria. …”
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Navigating large-volume subcutaneous injections of biopharmaceuticals: a systematic review of clinical pipelines and approved products by Philip Green, Andreas Schneider, Jakob Lange

“…These LVSCs are designed to target cancer and a range of non-cancer chronic disease states, including autoimmune, neurological, and cardiovascular diseases. …”
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Osteoprotegerin as an Emerging Biomarker of Carotid Artery Stenosis? A Scoping Review with Meta-Analysis by Jerzy Chudek, Marta Pośpiech, Anna Chudek, Michał Holecki, Monika Puzianowska-Kuźnicka

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Neuropsychiatric Involvement in Juvenile-Onset Systemic Lupus Erythematosus by Mohammad-Amin Khajezadeh, Gholamreza Zamani, Bobak Moazzami, Zahra Nagahi, Mahdie Mousavi-Torshizi, Vahid Ziaee

“…Systemic lupus erythematosus (SLE) is a complex autoimmune disorder characterized by multisystem involvement, including the nervous system. …”
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IMMUNE THROMBOTIC THROMBOCYTOPENIC PURPURA: PATHOPHYSIOLOGY, DIAGNOSIS AND OPEN ISSUES. by Silvia Maria Trisolini, Alessandro Laganà, Saveria Capria

“…Until now, the criteria for response to treatment mainly took into account the normalization of platelet count and discontinuation of PEX, now with the use of caplacizumab, leading to rapid normalization of platelet count, it has been necessary to redefine the response criteria, taking into account also the underlying autoimmune disease. Monitoring of ADAMTS13 activity is important to identify cases with low value of activity (<10IU/L), requiring the optimization of immunosuppressive therapy with addition of rituximab. …”
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Glucose-6-phosphate dehydrogenase deficiency with coinherited Gaucher disease: A rare association by Nupur Parakh, Kusha Sharma, Sunita Sharma, Priti Chatterjee, Varinder Singh

“…Few cases of GD with autoimmune hemolytic anemia have been reported. However, literature on GD with concomitant nonimmune hemolytic anemia is scarce. …”
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Clinical characteristics of anti-myelin oligodendrocyte glycoprotein antibody among aquaporin-4 negative neuromyelitis optica spectrum disorders in Egyptian patients by Sara I. Taha, Salwa I. Bakr, Nermeen T. Fouad, Dina Zamzam, Yasmine A. Mohamed

“…The presence of anti-MOG antibodies was not significantly associated with age (p = 0.696), gender (p = 0.232), type of relapse (p = 0.488), number of attacks (p = 0.968), family history of consanguinity (p = 0.211), family history of autoimmune disease (p = 0.608), nor with smoking (p = 0.608). …”
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Neuromyelitis optica spectrum disorder: epidemiology, pathogenesis, diagnosis, treatment, and prognosis by J. Čemerkaitė, I. Kaukėnaitė, R. Liutkevičienė

“…Factors leading to a worse prognosis include the severity of the first attack, higher number of relapses in the first two years, older age at the disease onset, and association with other autoimmune disorders. The overall 10-year mortality after diagnosis is 20-25%. …”
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The Economic and Humanistic Burden of Pediatric-Onset Multiple Sclerosis by Nupur Greene, Lita Araujo, Cynthia Campos, Hannah Dalglish, Sarah Gibbs, Irina Yermilov

“…**Background:** Multiple sclerosis (MS) is a chronic inflammatory autoimmune disease of the central nervous system. Pediatric-onset MS (POMS), defined as onset of MS before 18 years of age, is estimated to account for 2% to 5% of the MS population worldwide. …”
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The lymphocyte levels of Hashimoto thyroiditis patients were significantly lower than that of healthy population by Hui Xue, Ruyi Xu

“…Background and purposeHashimoto thyroiditis (HT) is an autoimmune disease without infectivity. We compared the differences of blood lymphocytes levels between HT patients and healthy people.Patients and methodsThis study included a total of 84 HT patients whose thyroid function was normal and 60 HT patients with abnormal thyroid function. …”
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Targeting Ferroptosis Attenuates Inflammation, Fibrosis, and Mast Cell Activation in Chronic Prostatitis by Dongxu Lin, Mengyang Zhang, Changcheng Luo, Pengyu Wei, Kai Cui, Zhong Chen

“…Methods. The experimental autoimmune prostatitis (EAP) was established through intradermal immunization of prostate extract. …”
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Nanoparticles containing intracellular proteins modulate neutrophil functional and phenotypic heterogeneity by Leonore Raudszus, Farbod Bahreini, Susanne Allan, Kai-Uwe Kalies, Charles C. Caldwell, Kathrin Kalies

“…While these processes ideally trigger healing and a return to balance, overshooting neutrophil function can lead to life-threatening infections such as sepsis or persistent inflammation observed in various autoimmune diseases. However, recent evidence highlights a phenotypic and functional heterogeneity of neutrophils that extends well beyond their traditional - potentially harmful- role as first responders. …”
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Mixed Pulmonary Infection, Asthma, and Nephrotic Syndrome in a Patient Diagnosed with Selective IgA Deficiency: A Case Report by Yan C, Qiu J, Pan X, Huang X, Pan L, Wang C, Mao M

“…Chenxi Yan, Junke Qiu, Xiaohong Pan, Xiaoqin Huang, Lei Pan, Caihong Wang, Minjie Mao Zhejiang Provincial Hospital of Integrated Traditional Chinese and Western Medicine, Zhejiang, 310003, People’s Republic of ChinaCorrespondence: Minjie Mao, Zhejiang Provincial Hospital of Integrated Traditional Chinese and Western Medicine, 208 huancheng East Road, Gongshu District, Hangzhou, 310003, People’s Republic of China, Tel +86 15825500408, Email maominjie0909@163.comAbstract: Patients with selective IgA deficiency could have various clinical presentations ranging from asymptomatic to severe respiratory or gastrointestinal tract infection, as well as autoimmune disease and allergic reactions. Selective IgA deficiency is relatively common in Caucasians, but it is rare in the Asian population, meaning it could be easily missed in the clinic. …”
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Prevalence and distribution of hypertension and related risk factors in Jilin Province, China 2015: a cross-sectional study by Bin Liu, Wei Sun, Junduo Wu, Tianyi Li, Xianjing Song, Yangyu Zhang, Yingyu Liu, Longbo Li, Yunpeng Yu, Yihang Liu, Chao Qi

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Diagnostics and Treatment of Esophageal Achalasia (Clinical Guidelines of the Russian Gastroenterological Association, Russian Scientific Medical Society of Internal Medicine, Russ... by V. T. Ivashkin, A. S. Trukhmanov, I. V. Maev, O. M. Drapkina, A. I. Martynov, O. A. Storonova, E. A. Godgello, M. P. Korolev, T. L. Lapina, P. V. Pavlov, A. V. Paraskevova, I. A. Tarasova, E. D. Fedorov, A. T. Tskhovrebov, M. P. Shapka, A. L. Shestakov, A. V. Yurasov

“…The following hypotheses have been proposed as the main mechanisms for the development of achalasia: genetic predisposition, exposure to viral infections, and idiopathic autoimmune triggers. Patients with suspected achalasia require a comprehensive instrumental examination, including esophagogastroduodenoscopy, timed barium esophagogram, and esophageal manometry. …”
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Rare and common single nucleotide variants in childhood-onset systemic lupus erythematosus by Elisabet Svenungsson, Iva Gunnarsson, Lars Rönnblom, Ingrid E Lundberg, Andreas Jönsen, Niklas Hagberg, Leonid Padyukov, Marie Wahren-Herlenius, Christopher Sjöwall, Solbritt Rantapää-Dahlqvist, Sule Yavuz, Øyvind Molberg, Dag Leonard, Andrei Alexsson, Maija-Leena Eloranta, Ann-Christine Syvänen, Johanna K Sandling, Gunnel Nordmark, Roland Jonsson, Roald Omdal, Christine Bengtsson, Anders A Bengtsson, Pascal Pucholt, Kerstin Lindblad-Toh, Sergey V Kozyrev, Peter Söderkvist, Johanna Dahlqvist, Jonas Carlsson Almlöf, Daniel Eriksson, Ahmed Sayadi, Åsa Karlsson, Gerli Rosengren Pielberg, Anna Lobell, Eva Murén, Kerstin M Ahlgren, Nils Landegren, Olle Kämpe, Fabiana HG Farias, Argyri Mathioudaki, Jennifer Meadows, Jessika Nordin

“…Background SLE is a systemic autoimmune disease with a large number of common risk gene variants, but several rare gene variants can cause monogenic SLE. …”
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Macrophage activation syndrome in a patient with systemic lupus erythematous triggered by tuberculous meningitis by Noura Alowais, Noura Zamani, Faisal Elbadawi, Hassan Ahmed, Pankhi Dutta, Aesha Sharif

“…Background: Hemophagocytic lymphohistiocytosis (HLH), is characterized by systemic uncontrolled inflammation resulting from immune dysregulation secondary to various triggers, including genetics, infections, autoimmune diseases, and malignancies. Macrophage activation syndrome (MAS) is an immune dysregulation phenomenon, in which an underlying rheumatological disease is present. …”
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Markers of Anemia in Children with Type 1 Diabetes by Ewa Rusak, Anna Rotarska-Mizera, Piotr Adamczyk, Bogdan Mazur, Joanna Polanska, Agata Chobot

“…Methods. 94 (59% ♀) T1D children without other autoimmune disorders, aged 12.5 ± 4.1 years, T1D duration: 4.2 ± 3.6 years, HbA1c 7.3 ± 1.5% (57 ± 12.6 mmol/mol). …”
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A Novel Liposome Formulation Carrying Both an Insulin Peptide and a Ligand for Invariant Natural Killer T Cells Induces Accumulation of Regulatory T Cells to Islets in Nonobese Dia... by Hidetoshi Akimoto, Emi Fukuda-Kawaguchi, Omar Duramad, Yasuyuki Ishii, Kazunari Tanabe

“…Type 1 diabetes (T1D) is an autoimmune disease caused by the destruction of pancreatic β cells by autoantigen-reactive diabetogenic cells. …”
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