Systemic Lupus Erythematosus Presenting as Anorexia Nervosa in a Middle‐Aged Woman: A Rare Case Report and Literature Review by Maen Nizam Baroudi, Anwar I. Joudeh, Mohammed Kays Alattiya, Abdo Qaid Ahmed Lutf, Hassan Abuzaid, Salah Mahdi

“…ABSTRACT Background Systemic lupus erythematosus (SLE) is a complex autoimmune disease with multisystemic involvement and unclear etiology. …”
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Methods of massive parallel reporter assays for investigation of enhancers by S. E. Romanov, D. A. Kalashnikova, P. P. Laktionov

“…Alterations of gene regulatory elements may cause various pathologies, including cancer, congenital disorders and autoimmune diseases. The development of high-throughput genomic assays has made it possible to significantly accelerate the accumulation of information about the characteristic epigenetic properties of regulatory elements. …”
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Long-term antibody responses to COVAXIN and COVISHIELD vaccines in rheumatoid arthritis patients and healthy control population – A cross-sectional study by Vijaya Prasanna Parimi, Anand Pyati, Madhavi Eerike

“…Background: Rheumatoid arthritis (RA) is a chronic autoimmune disease that causes inflammation and damage in the joints. …”
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Endocervical miRNA-142 expression in patients with pelvic inflammatory disease positive for Chlamydia trachomatis by Aliaa Zara Allah Hussein Al-Tememy, Maysaa S. Alshukri, Asmaa Kadhim Gatea

“…Changes in miRNA expression have been identified in many diseases, such as cardiac and autoimmune disorders, schizophrenia, and cancer. In this cross-sectional pilot investigation, samples were taken from control women who were not infected and from symptomatic women who were infected with C. trachomatis. …”
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Outcomes of Adult Liver Retransplantation: A Canadian National Database Analysis by Peter D. Yoon, Madhukar S. Patel, Carla F. Murillo Perez, Tommy Ivanics, Marco P.A.W. Claasen, Hala Muaddi, David Wallace, Bettina Hansen, Gonzalo Sapisochin

“…Results. 377 (6.5%) patients underwent liver retransplantation. Autoimmune liver disease and hepatitis C virus (HCV) were the most common underlying diagnoses. …”
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Mycophenolate mofetil: an update on its mechanism of action and effect on lymphoid tissue by Anna Krawczyk, Bernard Kravčenia, Tomasz Maślanka

“…IntroductionMycophenolate mofetil (MMF) is an immunosuppressive drug administered in the management of both autoimmune diseases and organ transplantation. The main aims of the study were: (a) to obtain information regarding the safety of using MMF in respect of its effect on normal T and B cells in lymphoid tissues; (b) to investigate whether the generation of inducible Foxp3-expressing regulatory T cells (Treg) might constitute additional mechanisms underlying the immunosuppressive properties of MMF.MethodsThe effect of MMF (in vivo studies) and its active metabolite, mycophenolic acid, (in vitro studies) on murine CD4+ and CD8+ T cells as well as B cells was determined, regarding: (a) absolute count, proliferation and apoptosis of these cells (in vitro studies); (b) absolute count of these cells in the head and neck lymph nodes, mesenteric lymph nodes and the spleen (in vivo studies).ResultsThe study found that the treatment of mice with MMF induced depletion of CD4+ and CD8+ T cells and B cells in lymph nodes and the spleen, and the magnitude of these effects should be considered as clinically relevant. …”
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Epidemiological, clinical and imaging profile of Multiple Sclerosis by Làzaro Aurelio Vàzquez Gòmez, Carlos Hidalgo Mesa, Benita Mabel Beltrán González, Yunier Broche Pérez, Ana María Mederos Herrera

“…<p><strong>Background:</strong> multiple sclerosis is a neurological, autoimmune, degenerative, chronic and progressive demyelinating disease associated with different genetic and environmental factors.…”
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DIABETES MELLITUS IN PATIENTS WITH LIVER CIRRHOSIS: NEW TREATMENT OPTIONS by L. Yu. Morgunov

“…There are common mechanisms that provoke metabolic and autoimmune disorders in the development of chronic hepatitis and cirrhosis, leading to steatosis, insulin resistance, impaired glucose tolerance and the development of diabetes mellitus. …”
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Case report: Rituximab combined with plasma exchange treatment for systemic lupus erythematosus complicated with thrombotic microangiopathy and non-cirrhotic portal hypertension by Jinmei Huang, Wei Fan, Xuyan Chen, Shufan Wu, Zhigao Dong, Yi Zhang, Yiwan Lin, Pingping Xiao

“…The patient was negative for hepatitis virus, autoimmune liver disease antibodies, ceruloplasmin, and tumor markers. …”
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Possible Implication of Local Immune Response in Darier's Disease: An Immunohistochemical Characterization of Lesional Inflammatory Infiltrate by Clelia Miracco, Francesco Pietronudo, Vasileios Mourmouras, Michele Pellegrino, Monica Onorati, Maria Grazia Mastrogiulio, Luca Cantarini, Pietro Luzi

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Lack of Antilipoprotein Lipase Antibodies in Takayasu's Arteritis by Jozélio Freire de Carvalho, Rosa Maria Rodrigues Pereira, Vilma Santos Trindade Viana, Eloísa Bonfá, Yehuda Shoenfeld

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Haemophagocytic Lymphohistiocytosis with Leptospirosis: A Rare but Devastating Complication by B. M. Munasinghe, A. G. Arambepola, N. Pathirage, U. P. M. Fernando, N. Subramaniam, S. Nimalan, T. Gajanthan

“…Secondary haemophagocytic lymphohistiocytosis (sHLH), often associated with an array of infections, malignancies, and autoimmune diseases, is rarely seen with leptospirosis, which carries a relatively poor prognosis even with modern state-of-the-art medical care. …”
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Atypical Sjögrenʼs Syndrome Initially Presenting as Lymphocytic Interstitial Pneumonitis followed by Immune Thrombocytopenia by Maham Mehmood, Abhishrut Jog, Masooma Niazi, Arlene Tieng, Giovanni Franchin

“…Sjögrenʼs syndrome is an autoimmune disease characterized primarily by decreased exocrine gland function leading to eye and mouth dryness. …”
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Profiling Serum Cytokines and Anticytokine Antibodies in Psoriasis Patients by Dan Hong, Xiuting Liu, Xiaonan Qiu, Siyao Lu, Yanyun Jiang, Guozhen Tan, Zhenrui Shi, Liangchun Wang

“…Anticytokine autoantibodies (ACAAs) were detected in various autoimmune diseases but remained largely unknown in psoriasis. …”
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CLINICAL CHARACTERISTICS OF DEBUT AND RISK FACTORS OF PEDIATRIC MULTIPLE SCLEROSIS by Валерий Иванович Ларькин, Игорь Иванович Ларькин, Татьяна Аркадьевна Морозова, Степан Евгеньевич Аполлонов

“…Risk factors for MS: family history of MS and autoimmune diseases (AID) in 25 %, obesity in 25 %, concomitant AIDS in 10 %. …”
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Characterization of novel human endogenous retrovirus structures on chromosomes 6 and 7 by Nicholas Pasternack, Nicholas Pasternack, Ole Paulsen, Avindra Nath

“…We examined a cohort of 222 individuals for HML-2 proviruses 6q14.1 and 7p22.1a, two loci that are capable of producing full-length viral proteins and have been previously implicated in several cancers, autoimmune disorders and neurodegenerative diseases, using long-read DNA sequencing. …”
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Quality of Life in Patients with Melasma by Reza Almasi Ghale, Maryam Nasimi, Saeideh Alidoost, Marjan Talebi, Rouzbeh Almasi Ghale, Mehregan Rahmani, Farkhondeh Pouresmaeili

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Safety, Tolerability, and Pharmacokinetics of NIM‐1324 an Oral LANCL2 Agonist in a Randomized, Double‐Blind, Placebo‐Controlled Phase I Clinical Trial by Andrew Leber, Raquel Hontecillas, Nuria Tubau‐Juni, Josep Bassaganya‐Riera

“…ABSTRACT NIM‐1324 is an oral investigational new drug for autoimmune disease that targets the Lanthionine Synthetase C‐like 2 (LANCL2) pathway. …”
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Disputable issues of the surgical strabismus correction in patients with Graves’ ophthalmopathy by D.S. Atarshchikov, E.Yu. Korchemkina

“…Korchemkina² </p> <p> ¹Central Clinical Hospital and Polyclinic of the Department for Presidential Affairs, Moscow, Russian Federation </p> <p> ²Academy of Postgraduate Education of the Federal Scientific and Clinical Center of the Federal Medical Biological Agency of Russian Federation, Moscow, Russian Federation </p> <p> Graves’ ophthalmopathy (GO) is an autoimmune disease characterized by lymphocytic infiltration, fibroblast activation and the accumulation of collagen and glycosaminoglycans in the orbital tissues and extraocular muscles. …”
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RNAI-MEDIATED SILENCING OF MATRIX METALLOPROTEINASE 1 IN EPIDERMAL KERATINOCYTES INFLUENCES THE BIOLOGICAL EFFECTS OF INTERLEUKIN 17A by J. A. Mogulevtseva, A. V. Mezentsev, S. A. Bruskin

“…Matrix metalloproteinases (MMPs) are important for the pathogenesis of psoriasis and other autoimmune disorders. In the extracellular matrix, accumulation of proinflammatory cytokines, such as interleukin 17A (IL-17A), leads to induction of several MMPs, including MMP1. …”
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