Spontaneous Pneumomediastinum due to Anti-Melanoma Differentiation-Associated Protein 5 Requiring a Bilateral Lung Transplant by Amrit Singh Jhajj, James Hok Shun Yeung, Fergus To

“…Therefore, the patient was begun on immunosuppressive therapy as the leading diagnosis included autoimmune myositis, possibly antisynthetase syndrome with interstitial lung disease (ILD). …”
Get full text

CLINICAL AND EPIDEMIOLOGIC CONSIDERATIONS ON THE INTERACTION BETWEEN TEMPOROMANDIBULAR DISORDERS AND JUVENILE IDIOPATHIC ARTHRITIS by Cristina Brăileanu, Cristian Guțu, Monica Mihaela Scutariu, Iulia Olaru, Mădălina Duceac (Covrig), Georgeta Zegan

“…Juvenile idiopathic arthritis (JIA) is the most common inflammatory autoimmune disorder with joint involvement in childhood and is implicated in the genesis of temporomandibular dysfunction. …”
Get full text

Posterior reversible encephalopathy syndrome: a case report and review of the literature by G. V. Urbonaitė, E. Audronytė, J. Valaikienė

“…PRES should be suspected when acute neurological symptoms develop in patients with renal insufficiency, arterial hypertension or fluctuations in blood pressure, eclampsia, sepsis, and autoimmune diseases who are taking immunosupressive or citotoxic medications. …”
Get full text

Polydeoxyribonucleotide Dermal Infiltration in Male Genital Lichen Sclerosus: Adjuvant Effects during Topical Therapy by Luigi Laino, Silvia Suetti, Isabella Sperduti

“…Lichen sclerosus (LS) is an autoimmune inflammatory skin disease that leads to tissue sclerosis. …”
Get full text

Mathematical insights on psoriasis regulation: Role of Th1 and Th2 cells by Amit Kumar Roy, Priti Kumar Roy, Ellina Grigorieva

“…Psoriasis is an autoimmune disorder, characterized by hyper-proli-feration of Keratinocytes for the abnormal activation of T Cells, Dendritic Cells (DCs) and cytokine signaling. …”
Get full text

Methadone-Induced Delayed Posthypoxic Encephalopathy: Clinical, Radiological, and Pathological Findings by Manoj Mittal, Yunxia Wang, Alan Reeves, Kathy Newell

“…Extensive work up was negative for any metabolic, infectious or autoimmune disorder. Brain biopsy showed significant axonal injury in the white matter. …”
Get full text

Bioinformatic analysis of ferroptosis related biomarkers and potential therapeutic targets in vitiligo by Linli Liu, Lingli Deng, Li Guan, Yuan Hu, Qianying Li, Chunshui Yu

“…Abstract Vitiligo is a complex autoimmune skin disorder characterized by depigmentation and immune dysregulation. …”
Get full text

Acute stimulation of PBMCs drives switch from dopamine-induced anti- to proinflammatory phenotype of monocytes only in women by Leonie Fleige, Silvia Capellino

“…Another contributing factor appears to be sex, as sex-specific differences in the dopaminergic pathway are described in the neurological context as well as in autoimmune diseases. However, a deeper understanding of these differences in peripheral immune cells remains limited. …”
Get full text

Chylous Ascites and Pleural Transudate: Rare Presentations in Systemic Lupus Erythematosus in Old Age by Guan-Liang Chen, Deng-Ho Yang, Wen-Hsiu Hsu

“…Systemic lupus erythematosus (SLE) is a systemic autoimmune disorder with involvement of multiple organs. …”
Get full text

PBC: Animal Models of Cholangiopathies and Possible Endogenous Viral Infections by Masashi Ninomiya, Yoshiyuki Ueno, Tooru Shimosegawa

“…Primary Biliary Cirrhosis (PBC) is considered an autoimmune disease characterized by immune-mediated destruction of the intrahepatic bile ducts and its characteristic serologic marker, the anti-mitochondrial antibody (AMA). …”
Get full text

The Relevance and Potential Role of Orbital Fat in Inflammatory Orbital Diseases: Implications for Diagnosis and Treatment by Prince Dadson, Peter Ngum, Luis Eduardo Juarez-Orozco, Michael Ntodie, Piotr Loba

“…Inflammatory orbital disease can affect any or all components of the orbit, often arising from various underlying pathologic conditions, including autoimmune, infectious, and vascular diseases. Typical signs and symptoms of orbital inflammation include swelling, redness, pain, discomfort, and potential loss of function. …”
Get full text

Oligodendrocyte Injury in Multiple Sclerosis. by Mateo Përgjegji, Klei Bame, Ketrina Ceka, Jera Cenalia , Sibora Bërdica , Teona Bushati

“… Introduction: Multiple sclerosis (MS) is a chronic autoimmune disorder of the central nervous system (CNS), marked by inflammation, demyelination, and significant oligodendrocyte injury. …”
Get full text

IgG4-Related Sclerosing Disease Causing Spinal Cord Compression: The First Reported Case in Literature by Nooraldin Merza, Ahmed Taha, John Lung, Anthony W. Benderman, Stephen E. Wright

“…It is an extremely rare disease that most frequently affects the pancreas causing autoimmune pancreatitis. It can also affect the gallbladder, salivary glands, and lacrimal glands causing respective organ-specific complications. …”
Get full text

Improving Survival in Decompensated Cirrhosis by Amar Nath Mukerji, Vishal Patel, Ashokkumar Jain

“…Sparing and judicious use of steroids needs to be borne in mind in treatment of ARDS and acute hepatitis from alcohol or autoimmune process.…”
Get full text

Immunoglobulin Gamma-Like Therapeutic Bispecific Antibody Formats for Tumor Therapy by Shixue Chen, Lingling Li, Fan Zhang, Yu Wang, Yi Hu, Lei Zhao

“…Bispecific antibodies (BsAbs) are a sort of dual functional proteins with specific binding to two distinct targets, which have become a focus of interest in antibody engineering and drug development research and have a promising future for wide applications in cancer immunotherapy and autoimmune disease. The key of clinical application and commercial-scale manufacturing of BsAbs is the amenability to assembly and purification of desired heterodimers. …”
Get full text

Follicular Helper CD4+ T Cells in Human Neuroautoimmune Diseases and Their Animal Models by Xueli Fan, Chenhong Lin, Jinming Han, Xinmei Jiang, Jie Zhu, Tao Jin

“…A balance of TFH cell generation and function is critical for protective antibody response, whereas overactivation of TFH cells or overexpression of TFH-associated molecules may result in autoimmune diseases. Emerging data have shown that TFH cells and TFH-associated molecules may be involved in the pathogenesis of neuroautoimmune diseases including multiple sclerosis (MS), neuromyelitis optica (NMO)/neuromyelitis optica spectrum disorders (NMOSD), and myasthenia gravis (MG). …”
Get full text

Untargeted metabolomic and proteomic analysis implicates SIRT2 as a novel therapeutic target for diabetic nephropathy by Ruijing Zhang, Runze Chang, Heng Wang, Jinshan Chen, Chuanlong Lu, Keyi Fan, Yuhang Zhang, Lizheng Li, Sheng Yan, Honglin Dong

“…This study aimed to explore the internal relationship between metabolic processes and autoimmune responses in patients with DN via untargeted metabolomics and Olink proteomics. …”
Get full text

The importance of inflammatory biomarkers in detecting and managing latent tuberculosis infection by Harinisri Gunasekaran, Harinisri Gunasekaran, Uma Devi Ranganathan, Uma Devi Ranganathan, Uma Devi Ranganathan, Ramalingam Bethunaickan, Ramalingam Bethunaickan, Ramalingam Bethunaickan

“…Infection with Mycobacterium tuberculosis (Mtb) triggers an autoimmune-like response in the host leading to further complications. …”
Get full text

Parameters of Somatosensory Evoked Potentials in Patients with Primary Sjӧgren’s Syndrome: Preliminary Results by Edyta Dziadkowiak, Agata Sebastian, Małgorzata Wieczorek, Elżbieta Kusińska, Marta Waliszewska-Prosół, Piotr Wiland, Maria Ejma

“…Primary Sjogren’s syndrome (pSS) is a chronic autoimmune disease. The aim of the study was to establish whether in patients with pSS without central nervous system (CNS) involvement, the function of the central portion of the sensory pathway can be challenged. …”
Get full text

Exosomes of Antler Mesenchymal Stem Cells Improve Postoperative Cognitive Dysfunction in Cardiopulmonary Bypass Rats through Inhibiting the TLR2/TLR4 Signaling Pathway by Chun Yang, Shengnan Sun, Qi Zhang, Jia Guo, Tengfei Wu, Ying Liu, Min Yang, Yan Zhang, Yinghua Peng

“…Exosomes are one of the important paracrine factors and have been reported as potential cell-free therapy for the treatment of autoimmune and central nervous system disorders. In this study, we examined exosomes derived from antler MSCs (AMSCs) of POCD rats after CPB and evaluated their potential regulatory mechanisms. …”
Get full text