Case Report: Dangerous liaisons between splenectomy and eltrombopag-induced chronic thromboembolic pulmonary hypertension in patients with immune thrombocytopenia: report of two ca... by Roberto Castelli, Enrico Atzori, Alessandro Palmerio Delitala, Salvatore Antonio Masala, Valentina Micheluzzi, Enrico Ponti, Enrico Ponti, Giuseppe Sanna, Dante Castro, Antonio Gidaro, Mattia Donadoni, Roberto Manetti, Pierluigi Merella, Nicia Isabella Profili, Andrea Maria D'Armini, Gavino Casu, Gavino Casu

“…IntroductionPrimary immune thrombocytopenia is an autoimmune bleeding disorder characterized by variable immune-mediated platelet destruction. …”
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Free DNA in Cystic Fibrosis Airway Fluids Correlates with Airflow Obstruction by Veronica Marcos, Zhe Zhou-Suckow, Ali Önder Yildirim, Alexander Bohla, Andreas Hector, Ljubomir Vitkov, Wolf Dietrich Krautgartner, Walter Stoiber, Matthias Griese, Oliver Eickelberg, Marcus A. Mall, Dominik Hartl

“…On the other hand, excessive NET formation has been linked to the pathogenesis of autoinflammatory and autoimmune disease conditions. We quantified free DNA structures characteristic of NETs in airway fluids of CF patients and a mouse model with CF-like lung disease. …”
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Intraoperative vascular anastomosis occlusion due to cold agglutinin disease during brain surgery: a case report by Kazuma Kitamura, Mayumi Nakanishi, Naokazu Fukuoka, Kumiko Tanabe, Yoshinori Kamiya

“…Abstract Background Cold agglutinin disease (CAD) is an autoimmune hemolytic anemia that induces blood coagulation and hemolysis upon exposure to cold temperatures. …”
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Pemphigus Vulgaris Presented with Cheilitis by Zaheer Abbas, Zahra Safaie Naraghi, Elham Behrangi

“…Pemphigus vulgaris is an autoimmune blistering disease affecting the mucous membrane and skin. …”
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Acute Glomerulonephritis in a Child with Chlamydia pneumoniae Infection: A Case Report by Giovanna Vitaliti, Raffaele Falsaperla, Leandra Giunta, Giuseppina Spataro, Venerando Rapisarda, Mario Velardita, Giuseppe Nunnari, Piero Pavone

“…Infectious diseases seem to be an important and independent risk factor for renal failure, but the underlying mechanism of renal involvement during some kinds of infectious diseases is still unclear, even if the literature data report immunomediated and/or autoimmune mechanisms to explain the pathogenic relationship between the two diseases. …”
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Effect of Human Mesenchymal Stem Cells on Xenogeneic T and B Cells Isolated from Lupus-Prone MRL.Faslpr Mice by Hong Kyung Lee, Eun Young Kim, Hyung Sook Kim, Eun Jae Park, Hye Jin Lee, Tae Yong Lee, Kyung Suk Kim, Sang-Cheol Bae, Jin Tae Hong, Youngsoo Kim, Sang-Bae Han

“…Systemic lupus erythematosus (SLE) is an autoimmune disease, which is characterized by hyperactivation of T and B cells. …”
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Exploring the interactions of rapamycin with target receptors in A549 cancer cells: insights from molecular docking analysis by Sanjeev K. Ganesh, C. Subathra Devi

“…This could also facilitate in understanding the possible action mechanisms of rapamycin in other diseases such as neurovegetative diseases, autoimmune diseases, etc.…”
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Advances and challenges in platelet counting: evolving from traditional microscopy to modern flow cytometry by Chen Yong, Hu Yonggang, Hu Hai

“…Platelet counting is a fundamental clinical test for diagnosing haemorrhagic diseases, coagulation abnormalities, and certain autoimmune disorders, and it also serves as a critical basis for decisions regarding platelet transfusion. …”
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Analysis of the Expression and Function of Immunoglobulin-Like Transcript 4 (ILT4, LILRB2) in Dendritic Cells from Patients with Systemic Lupus Erythematosus by Paola del Carmen Guerra-de Blas, Yael Sebastián Villaseñor-Talavera, Daniela de Jesús Cruz-González, Lourdes Baranda, Lesly Doníz-Padilla, Carlos Abud-Mendoza, Roberto González-Amaro, Adriana Elizabeth Monsiváis-Urenda

“…ILT4 was shown not to have a crucial role in regulating the maturation and function of DC from healthy controls but is partially involved in the maturation process and immunogenic capability of DC from SLE patients, suggesting that other inhibitory receptors, involved in the regulation of DC tolerogenic function, may be impaired in this autoimmune disease.…”
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Successful Modified Therapy in a Patient with Probable Infection-Associated Hemophagocytic Lymphohistiocytosis by Carl L. Kay, Matthew J. Rendo, Paul Gonzales, Sead G. Beganovic, Magdalena Czader

“…In adults, HLH is typically a complication of infections, autoimmune diseases, and malignancies. While the disease is often fatal, classic management of HLH revolves around early diagnosis and initiation of protocolized therapy. …”
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A Comprehensive Dataset on Microbiome Dynamics in Rheumatoid Arthritis from a Large-Scale Cohort Study by Jing Li, Jun Xu, Jiayang Jin, Congmin Xu, Yuzhou Gan, Yifan Wang, Ruiling Feng, Wenqiang Fan, Yingni Li, Xiaozhen Zhao, Yucui Li, Shushi Gong, Linchong Su, Yueming Cai, Lianjie Shi, Xiaolin Sun, Yang Xiang, Qingwen Wang, Ru Li, Jinxia Zhao, Yulan Liu, Junjie Qin, Zhanguo Li, Jing He

“…This large-scale dataset is expected to be a foundation for collaborative research, advancing our understanding of the microbiome’s systemic effects in RA and other autoimmune diseases and potentially guiding new therapeutic approaches.…”
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Elevated Troponin Serum Levels in Adult Onset Still’s Disease by Carlo Umberto Manzini, Lucio Brugioni, Michele Colaci, Maurizio Tognetti, Amelia Spinella, Marco Sebastiani, Dilia Giuggioli, Clodoveo Ferri

“…Diagnosis is based on typical AOSD symptoms after the exclusion of well-known infectious, neoplastic, or autoimmune/autoinflammatory disorders. In the case of abrupt, recent onset AOSD, it could be particularly difficult to make the differential diagnosis and in particular to early detect the possible heart involvement. …”
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Lupus Enteritis as an Initial Presentation of Systemic Lupus Erythematosus by Sisira Sran, Manpreet Sran, Narmisha Patel, Prachi Anand

“…Systemic lupus erythematosus (SLE) is an autoimmune disorder which can affect multiple organs and clinical presentation is often a myriad of symptoms; therefore, the index of suspicion should rise when evaluating patients with multiorgan symptomatology. …”
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Mast Cell-Mediated Inhibition of Abdominal Neutrophil Inflammation by a PEGylated TLR7 Ligand by Tomoko Hayashi, Shiyin Yao, Brian Crain, Michael Chan, Howard B. Cottam, Fitzgerald Lao, Dennis A. Carson, Maripat Corr

“…To abate the deleterious recruitment of neutrophils in sterile inflammation, we repeatedly administered a TLR7 ligand that hyposensitized to TLR7 and receptors that converged on the MyD88-signaling intermediary and reduced cellular infiltration in murine autoimmune models of multiple sclerosis and arthritis. …”
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Embolic Stroke as the Initial Manifestation of Systemic Lupus Erythematosus by Reshma M. Khan, Rajaie Namas, Sachin Parikh, Bernard Rubin

“…She underwent transesophageal echocardiogram (TEE), which showed severe mitral regurgitation and thickening of mitral valve leaflets consistent with Libman-Sacks endocarditis. Autoimmune workup was positive for IF-ANA, anti-RNP, and anti-Smith antibody. …”
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Hemophagocytic Lymphohistiocytosis Associated with Respiratory Syncytial Virus Infection in an Immunocompetent Elderly Patient by Ralph Kamel, Rubal Sharma, Divya Asti, Arshpal Gill, Yevgeniy Skaradinskiy

“…The secondary form presents later in life and is associated with several conditions mainly malignancy, autoimmune diseases, viral or bacterial infections, and hematological diseases. …”
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Regenerative Therapy of Type 1 Diabetes Mellitus: From Pancreatic Islet Transplantation to Mesenchymal Stem Cells by Nadine E. Rekittke, Meidjie Ang, Divya Rawat, Rahul Khatri, Thomas Linn

“…Type 1 diabetes is an autoimmune disease resulting in the permanent destruction of pancreatic islets. …”
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Probiotics, Prebiotics, and Synbiotics: Gut and Beyond by Usha Vyas, Natarajan Ranganathan

“…Perturbation of the intestinal microbiota may lead to chronic diseases such as autoimmune diseases, colon cancers, gastric ulcers, cardiovascular disease, functional bowel diseases, and obesity. …”
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Muscle-Specific Tyrosine Kinase-Associated Myasthenia Gravis: A Neuromuscular Surprise by Hassam Ali, Rahul Pamarthy, Nayab Ahsan, null WashmaAwan, Shiza Sarfraz

“…Myasthenia gravis is a neuromuscular autoimmune disease that results in skeletal muscle weakness that worsens after periods of activity and improves after rest. …”
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Neglected-Noncompliant Type 1 Diabetes Mellitus with Complications by Afdal ., Eka Agustia Rini

“…This situation is caused by the autoimmune processes that destroy pancreatic β cells<br />resulting in the production of insulin is reduced even halted, the sufferer will require exogenous insulin intake. …”
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