Metabonomics Research Progress on Liver Diseases by Mengqian Yu, Ying Zhu, Qingwei Cong, Chunyan Wu

“…Many other liver diseases, such as drug-induced liver injury (DILI), alcoholic liver disease (ALD) and nonalcoholic fatty liver disease (NAFLD), and autoimmune liver diseases, still do not have definite diagnostic markers; the diagnosis consists of history, medical imaging, and the relevant score. …”
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Interleukin-17A Exacerbates Ferric Chloride-Induced Arterial Thrombosis in Rat Carotid Artery by Francesco Maione, Antonio Parisi, Elisabetta Caiazzo, Silvana Morello, Fulvio D'Acquisto, Nicola Mascolo, Carla Cicala

“…Interleukin-17A (IL-17A), the most widely studied member of the IL-17 cytokine family, is a cytokine which emerged to be critical for host defense as well as in the pathogenesis of autoimmune disorders. Moreover, IL-17A is involved in the pathogenesis of cardiovascular diseases, such as atherosclerosis and acute coronary syndrome and in the cardiovascular risk associated with systemic immunological disorders. …”
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Cellular rejuvenation protects neurons from inflammation-mediated cell death by Sienna S. Drake, Abdulshakour Mohammadnia, Aliyah Zaman, Christine Gianfelice, Kali Heale, Adam M.R. Groh, Elizabeth M.-L. Hua, Matthew A. Hintermayer, Yuancheng Ryan Lu, David Gosselin, Stephanie Zandee, Alexandre Prat, Jo Anne Stratton, David A. Sinclair, Alyson E. Fournier

“…Here, we profile the transcriptome of retinal ganglion cells (RGCs) in experimental autoimmune encephalomyelitis (EAE) mice. Pathway analysis identifies a transcriptional signature reminiscent of aged RGCs with some senescent features, with a comparable signature present in neurons from patients with MS. …”
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Cyclic Peptides as Protein Kinase Modulators and Their Involvement in the Treatment of Diverse Human Diseases by Lorena Martínez-Alcantar, Laura Hernández-Padilla, Alma Laura Díaz-Pérez, Lizbeth Guadalupe Villalón-Magallán, Mayra Xóchitl Durán-Maldonado, César Díaz-Pérez, Marlene E. Campos-Morales, Citlali Figueroa-Guzmán, Jesús Campos-García

“…Nevertheless, modifications in the expression due to mutations or their dysregulation can lead to diseases, including autoimmune disorders, cardiovascular problems, diabetes, neurological diseases, and cancers. …”
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Advance in identified targets of berberine by Penghai Sun, Ziyuan Wang, Yinchao Ma, Yuan Liu, Yintong Xue, Yan Li, Xiang Gao, Yuedan Wang, Ming Chu, Ming Chu, Ming Chu, Ming Chu

“…Berberine is an isoquinoline alkaloid, which has demonstrated significant therapeutic potential in the treatment of various diseases, including tumors, acute and chronic infections, autoimmune disorders, and diabetes. Studies have demonstrated that berberine exhibits polypharmacological effects, including antibacterial, anti-inflammatory, antioxidant, and hypoglycemic activities. …”
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Anesthetic Management of an Obstetric Patient with Behçet’s Disease Complicated by Transverse Myelitis by Sara Alwatban, Etedal AlAamri, Abdullah Alraffa, Mona Alkhawajah

“…Behçet disease is also a rare autoimmune disease. Transverse myelitis can be a manifestation of neuro-Behçet’s disease. …”
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Chemogenomics for steroid hormone receptors (NR3) by Espen Schallmayer, Laura Isigkeit, Lewis Elson, Susanne Müller, Stefan Knapp, Julian A. Marschner, Daniel Merk

“…Although several NR3 ligands such as glucocorticoids are invaluable drugs, this family is only partially explored, for example, in autoimmune diseases and neurodegeneration, but may hold therapeutic potential in new areas. …”
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Class IV Lupus Nephritis in the Setting of Serologically Quiescent Disease and Normal Urine Sediment in a Patient with Late-Onset Systemic Lupus Erythematosus by Benedicta Nnodum, Lauren Dudley

“…Systemic lupus erythematosus (SLE) is a chronic inflammatory autoimmune disease that may affect any organ of the body. …”
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Recognizing Presentations of Pemphigoid Gestationis: A Case Study by Sadie Henry

“…Pemphigoid gestationis (PG) is an autoimmune blistering disease that occurs in approximately 1 in 50,000 pregnancies. …”
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Protein Phosphatase 2A: Role in T Cells and Diseases by Suyasha Roy, Lalit Batra

“…PP2A activation has shown to reduce neuroinflammation in a mouse model of experimental autoimmune encephalomyelitis (EAE) and is now used to treat multiple sclerosis (MS) clinically. …”
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Misleading Rare Case of Idiopathic Hypertrophic Pachymeningitis by Ahmad Rezaee Azandaryani, Amir Mohammad Salehi

“…MRI identified diffuse nodular dural thickening with internal septations and different internal hemorrhagic stages on the right side with no evidence of brain parenchymal involvement and according to the serology and autoimmune screening tests, and IHP was diagnosed for the patient. …”
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Imaging Assessment of Cardiovascular Disease in Systemic Lupus Erythematosus by Sara C. Croca, Anisur Rahman

“…Systemic lupus erythematosus is a multisystem, autoimmune disease known to be one of the strongest risk factors for atherosclerosis. …”
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Impact of anxiety and depression on disease activity and quality of life in patients with lupus nephritis by Ritambra Dadwal, Pragya Pathak, Arunkumar Subbiah, Ujjwal Dahiya

“…Background of the Study: Lupus is an autoimmune disease that affects multiple body systems and requires long-term treatment. …”
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Gut Microbiome: An Intersection between Human Genome, Diet, and Epigenetics by Abdullahi Y. Muhammad, Malik Amonov, Atif A. Baig, Farrukh J. Alvi

“…Specific genetic variants in genes that are responsible for maintaining the composition of the gut commensal, such as genes of the immune system, are described to result in gut dysbiosis that can lead to the development of several autoimmune diseases such as inflammatory bowel disease and type-1 diabetes. …”
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Graves’ Disease Presenting as a Unilateral Breast Mass by Neeka N. Akhavan, Edlira Maska

“…Graves’ disease is an autoimmune thyroid disorder that is the most common cause of hyperthyroidism. …”
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Transient Complete Recovery of Chronic Refractory Idiopathic Thrombocytopenic Purpura after Treatment with Monoclonal Antibody Targeting SARS-CoV-2 Spike Protein by Pooja Gogia, Yiqing Xu

“…Idiopathic thrombocytopenic purpura (ITP), also known as immune thrombocytopenic purpura, is an immune-mediated acquired disease characterized by transient or persistent decrease of the platelet count due to autoimmune-related destruction of platelets. Therapy for ITP relies on competing and inhibiting the autoantibody binding and destruction (intravenous immunoglobulin and anti-D immunoglobulin and spleen tyrosine kinase (Syk) inhibitor fostamatinib), augmenting platelet production (thrombopoietin receptor agonists), immunosuppression to reduce the autoantibody production, as well as splenectomy. …”
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Oral supplementation with propionate is reflected in the serum of healthy individuals by Maximilian Schröder, Arijan Pasic, Frank Hirche, Svitlana Rozanova, Melissa Sgodzai, Barbara Gisevius, Lea Horstkemper, Ralf Gold, Katrin Marcus, Kalliopi Pitarokoili, Jeremias Motte, Katalin Barkovits, Gabriele Stangl, Anna Lena Fisse

“…Supplementing PA has shown benefits for autoimmune diseases. A comprehensive understanding of the PA pharmacokinetics is essential for the optimal design and execution of studies utilizing orally administered PA. …”
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Roles of Lymphocyte Kv1.3-Channels in the Pathogenesis of Renal Diseases and Novel Therapeutic Implications of Targeting the Channels by Itsuro Kazama

“…Using selective channel inhibitors in experimental animal models, in vivo studies then revealed the clinically relevant relationship between the channel expression and the pathogenesis of autoimmune diseases. In renal diseases, in which “chronic inflammation” or “the overstimulation of cellular immunity” is responsible for the pathogenesis, the overexpression of Kv1.3-channels in lymphocytes promotes their cellular proliferation and thus contributes to the progression of tubulointerstitial fibrosis. …”
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Cross-Talk between Apolipoprotein E and Cytokines by Hongliang Zhang, Li-Min Wu, Jiang Wu

“…Despite its importance in lipid transport and atherosclerosis pathogenesis, apoE is associated with neurodegenerative disorders such as Alzheimer's disease (AD) and Parkinson disease, and autoimmune disorders such as multiple sclerosis and psoriasis. …”
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Glutamate Receptors in Neuroinflammatory Demyelinating Disease

“…The main features of MS can be reproduced in the inducible animal counterpart, experimental autoimmune encephalomyelitis (EAE). The search for new MS treatments invariably employs EAE to determine drug activity and provide a rationale for exploring clinical efficacy. …”
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