Drug-induced Leukocytoclastic Vasculitis Secondary to Trimethoprim/Sulfamethoxazole: A Case Report by Ambika Shivarajpur, Simon Londono, Justin Shaw, Christopher Boccio, Leonid Melnitsky, Jheanelle McKay, Brian Kohen, Eric Boccio

“…The condition is often idiopathic but can be associated with infections, neoplasms, autoimmune disorders, and certain drugs. Case Report: A 91-year-old female with past medical history of Alzheimer dementia and hypertension, being treated for lower extremity cellulitis, presented to the emergency department for an allergic reaction. …”
Get full text

Case Study: Chronic Recurrent Multifocal Osteomyelitis in the Femoral Diaphysis of a Young Female by Jeffrey S. Quon, Anne K. Dzus, David A. Leswick

“…Instead it is more likely the result of genetic, autoimmune, or autoinflammatory causes. Although CRMO has a benign course and responds well to anti-inflammatory medications, it can have a very aggressive clinical and imaging presentation overlapping with infectious osteomyelitis and malignancy. …”
Get full text

Neuropsychiatric Disorder Associated with Group G Streptococcus Infection by Rie Okumura, Sawako Yamazaki, Tsukasa Ohashi, Shinichi Magara, Jun Tohyama, Hiroshi Sakuma, Masaharu Hayashi, Akihiko Saitoh

“…Immune-mediated central nervous system manifestations of group A β-hemolytic Streptococcus (GABHS) infection include Sydenham’s chorea, pediatric autoimmune neuropsychiatric disorders associated with streptococcal infection (PANDAS)—which includes tic and obsessive compulsive disorders—and a variety of neurobehavioral disorders. …”
Get full text

Updates in Refractory Status Epilepticus by Rohit Marawar, Maysaa Basha, Advait Mahulikar, Aaron Desai, Kushak Suchdev, Aashit Shah

“…A large proportion of NORSE cases are eventually found to have an autoimmune etiology needing immunomodulatory treatment. …”
Get full text

Role of RING-Type E3 Ubiquitin Ligases in Inflammatory Signalling and Inflammatory Bowel Disease by Liguo Zhu, Ying Li, Longyuan Zhou, Guang Yang, Ying Wang, Jing Han, Li Li, Shenghong Zhang

“…These processes also occur in autoimmune diseases, especially inflammatory bowel disease (IBD). …”
Get full text

Vascular Endothelial Cell Function in Catastrophic Antiphospholipid Syndrome: A Case Report and Review of the Literature by B. Routy, T. Huynh, R. Fraser, C. Séguin

“…Catastrophic antiphospholipid syndrome (CAPS) is a rare autoimmune condition, which has been associated with a high mortality rate. …”
Get full text

Mesenchymal Stem Cells as Immunomodulators in a Vascularized Composite Allotransplantation by Yur-Ren Kuo, Chien-Chang Chen, Shigeru Goto, Pao-Yuan Lin, Fu-Chan Wei, Chao-Long Chen

“…Mesenchymal stem cells (MSCs) show promise as an immunomodulatory therapeutic agent and are currently being tested in preclinical and clinical settings as therapies for autoimmune disorders or transplant rejection. The mechanisms by which MSCs modulate the immune response are still under thorough investigation, but these most likely involve expression of local factors influencing T-cell regulation, modulation of cytokine expression (e.g., IL-10, TGF-β, TNF-, INF-γ, etc.), and interactions with dendritic or antigen presenting cells. …”
Get full text

Current Strategies to Generate Human Mesenchymal Stem Cells In Vitro by Jennifer Steens, Diana Klein

“…The use of these different MSCs for cell-based therapies has been extensively studied over the past years, which highlights the use of MSCs as a promising option for the treatment of various diseases including autoimmune and cardiovascular disorders. However, the proportion of MSCs contained in primary isolates of adult tissue biopsies is rather low and, thus, vigorous ex vivo expansion is needed especially for therapies that may require extensive and repetitive cell substitution. …”
Get full text

A Paraneoplastic Syndrome Characterized by Extremity Swelling with Associated Inflammatory Infiltrate Heralds Aggressive Transformation of Myelodysplastic Syndromes/Myeloproliferat... by James K. Mangan, Selina M. Luger

“…There has been a long history of reports describing a variety of paraneoplastic phenomena associated with myelodysplastic syndromes, particularly those with autoimmune manifestations. We report here a series of patients with an antecedent myelodysplastic syndrome (MDS) or myeloproliferative neoplasm (MPN) that underwent aggressive transformation to acute myeloid leukemia (AML). …”
Get full text

ALK-Negative Anaplastic Large Cell Lymphoma Presenting as Disseminated Intravascular Coagulation and Hemophagocytic Lymphohistiocytosis: A Potentially Fatal Presentation by Uroosa Ibrahim, Amina Saqib, Maryam Rehan, Jean Paul Atallah

“…Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening disorder that can be familial in etiology or a result of infections, malignancy, and autoimmune or inflammatory disorders. Disseminated intravascular coagulation (DIC) is common in patients admitted to intensive care units and can confound and delay the diagnosis of HLH. …”
Get full text

A Rapid and Satisfactory Outcome with Combined Immunosuppressive Therapy in Acquired Haemophilia A with Underlying Tuberculosis by G. A. C. Gamakaranage, C. Kulathilake, P. G. N. Nadeeshani, K. H. B. P. Fernandopulle, C. S. Moonesinghe, D. Gunawardena, R. S. Gamage, N. Perera, J. Indrakumar

“…The common underlying diseases are autoimmune disorders, malignancies, infections, and drugs. …”
Get full text

A Case of Rituximab Use as an Induction and Maintenance of Remission in ANCA-Associated Vasculitis by Neveen Awad, Shahd Hafiz, Abdurahman Albeity, Hani Almoallim

“…Antineutrophil cytoplasmic antibody- (ANCA-) associated vasculitis (AAV) is a multisystem autoimmune disease affecting mainly microscopic blood vessels due to circulating autoantibodies against neutrophil cytoplasmic antigens. …”
Get full text

Celiac Disease and Dermatologic Manifestations: Many Skin Clue to Unfold Gluten-Sensitive Enteropathy by Marzia Caproni, Veronica Bonciolini, Antonietta D'Errico, Emiliano Antiga, Paolo Fabbri

“…Among these there are both autoimmune, allergic, and inflammatory diseases, but also a more heterogeneous group called miscellaneous. …”
Get full text

The Clinical Trials of Mesenchymal Stromal Cells Therapy by Mohammad Reza Kouchakian, Neda Baghban, Seyedeh Farzaneh Moniri, Mandana Baghban, Shabnam Bakhshalizadeh, Vahid Najafzadeh, Zahra Safaei, Safoura Izanlou, Arezoo Khoradmehr, Iraj Nabipour, Reza Shirazi, Amin Tamadon

“…Safety, accessibility, and isolation from patients without ethical concern make MSCs valuable sources for cell therapy approaches in autoimmune, inflammatory, and degenerative diseases. …”
Get full text

Evolution of 𝜷-Cell Replacement Therapy in Diabetes Mellitus: Islet Cell Transplantation by Cyrus Jahansouz, Cameron Jahansouz, Sean C. Kumer, Kenneth L. Brayman

“…Of these individuals, 5 to 10% have been diagnosed with Type 1 diabetes mellitus (T1DM), an autoimmune disease. Although it often appears in childhood, T1DM may manifest at any age, leading to significant morbidity and decreased quality of life. …”
Get full text

Unexplained Findings of Kayser-Fleischer-Like Rings in a Patient with Cryptogenic Cirrhosis by Mahreema Jawairia, Miral Subhani, Ghulam Siddiqui, Apsara Prasad, Ghulamullah Shahzad, Kaleem Rizvon, Paul Mustacchia

“…Cryptogenic cirrhosis (CC) is defined as cirrhosis occurring in an individual without an identifiable cause of liver disease, such as excessive alcohol consumption, viral hepatitis infection, hemochromatosis, autoimmune hepatitis, primary biliary cirrhosis, primary sclerosing cholangitis, chronic intake of medications that could induce cirrhosis, alpha-1-antitrypsin deficiency, Wilson’s disease, or any other rare cause of cirrhosis according to the clinical context. …”
Get full text

Genetic Associations in Acquired Immune-Mediated Bone Marrow Failure Syndromes: Insights in Aplastic Anemia and Chronic Idiopathic Neutropenia by Irene Mavroudi, Helen A. Papadaki

“…Increasing interest on the field of autoimmune diseases has unveiled a plethora of genetic factors that predispose to these diseases. …”
Get full text

RETROSPECTIVE AND COMPARATIVE STUDY OF 42 CASES OF ANEMIA IN DOGS by Daniela Mihaela Neagu, Vlad Luca, Răzvan Codea, Cristian Popovici, Alexandra Biriș

“…The results of the study revealed several causes of anemia, being classified as hemorrhages: by intoxication, trauma or postoperative hemorrhages; hemolysis: autoimmune, parasitic; and production deficits: mainly following chronic renal failure.…”
Get full text

Innovative Lipid Nanoparticles Co-Delivering Hydroxychloroquine and siRNA for Enhanced Rheumatoid Arthritis Therapy by Yanru Feng, Xintong Pan, Ziqian Li, Yue Li, Ya’nan Sun, Shaokun Yang, Chaoxing He, Yunjie Dang, Lu Huang, Bai Xiang

“…<b>Background:</b> Rheumatoid arthritis (RA) is a debilitating autoimmune disorder characterized by chronic inflammation and joint damage. …”
Get full text

Pseudoseptic Arthritis: A Case Series and Review of the Literature by Brian P. Oppermann, Jonida K. Cote, Stephanie J. Morris, Thomas Harrington

“…Majority of these patients had known autoimmune inflammatory arthritis or microcrystalline inflammatory arthritis. …”
Get full text