Organ-based characterization of B cells in patients with systemic lupus erythematosus by Yunan Wang, Rui Zhao, Qian Liang, Shiwen Ni, Mei Yang, Liwei Qiu, Juan Ji, Zhifeng Gu, Chen Dong

“…Systemic lupus erythematosus (SLE) is a chronic, inflammatory, and progressive autoimmune disease. The unclear pathogenesis, high heterogeneity, and prolonged course of the disease present significant challenges for effective clinical management of lupus patients. …”
Get full text

Clinical Recommendations of the Russian Scientific Liver Society and Russian Gastroenterological Association on Diagnosis and Treatment of Liver Fibrosis, Cirrhosis and Their Compl... by V. T. Ivashkin, M. V. Maevskaya, M. S. Zharkova, S. B. Zhigalova, E. A. Kitsenko, G. V. Manukyan, A. S. Trukhmanov, I. V. Maev, I. N. Tikhonov, T. A. Deeva

“…Liver fibrosis develops with connective tissue accumulation in liver in the outcome of various chronic diseases, including alcohol misuse, viral hepatitises, autoimmune and more rare hereditary liver diseases. …”
Get full text

Oxidative stress: an overview of past research and future insights by Aaser M. Abdelazim, Mosleh M. Abomughaid

“…The obtained findings suggest that many diseases are linked to OS, including diabetes mellitusinflammation, cancers, autoimmune disorders and neurodegenerative diseases. …”
Get full text

False Positive B-Cells Crossmatch after Prior Rituximab Exposure of the Kidney Donor by Judith Desoutter, Marie-Joëlle Apithy, Ségolène Bartczak, Nicolas Guillaume

“…An unexpected positive crossmatch may be obtained in recipients with an autoimmune disease or preexisting antibodies not detected by single-antigen bead array due to complement interference or who have been previously treated by desensitization protocols such as rituximab, antithymocyte globulin, or intravenous immunoglobulins. …”
Get full text

C4d Deposition in Fetal Vessels of the Placenta in Neonatal Lupus Syndrome by Yuichiro Sato, Tomoko Yamaguchi, Jyunsuke Muraoka, Hajime Taniguchi, Atsushi Kisanuki, Kazunari Maekawa, Atushi Yamashita, Murasaki Aman, Yuki Kodama, Hiroshi Sameshima, Yujiro Asada

“…Neonatal lupus syndrome (NLS) is a rare, passively acquired autoimmune syndrome caused by maternal autoantibodies. …”
Get full text

Pulmonary Alveolar Proteinosis in Setting of Inhaled Toxin Exposure and Chronic Substance Abuse by Meirui Li, Salem Alowami, Miranda Schell, Clive Davis, Asghar Naqvi

“…PAP is categorized into three types: hereditary, autoimmune, and secondary. We report a case of secondary PAP in a 47-year-old man, whose risk factors include occupational exposure to inhaled toxins, especially aluminum dust, the use of anabolic steroids, and alcohol abuse, which in mice leads to alveolar macrophage dysfunction through a zinc-dependent mechanism that inhibits granulocyte macrophage-colony stimulating factor (GM-CSF) receptor signalling. …”
Get full text

Design and synthesis of amino-substituted N-arylpiperidinyl-based inhibitors of the (immuno)proteasome by Gobec Martina, Obreza Aleš, Jukič Marko, Baumgartner Ana, Mihelčič Nja, Potočnik Špela, Virant Julija, Mlinarič Irena, Stanislav Raščan, Sosič Gobec Izidor

“…The constitutive proteasome and the immunoproteasome represent validated targets for pharmacological intervention in the context of various diseases, such as cancer, inflammation, and autoimmune diseases. The development of novel chemical scaffolds of non-peptidic nature, capable of inhibiting different catalytically active subunits of both isoforms, is a viable approach against these diseases. …”
Get full text

Mesenchymal Stem Cell Conditioned Media Ameliorate Psoriasis Vulgaris: A Case Study by Rajasekar Seetharaman, Anjum Mahmood, Prashant Kshatriya, Divyang Patel, Anand Srivastava

“…Psoriasis, an autoimmune disease, affects a vast number of peoples around the world. …”
Get full text

Complement Diagnostics: Concepts, Indications, and Practical Guidelines by Bo Nilsson, Kristina Nilsson Ekdahl

“…Aberrations in the complement system have been shown to be direct or indirect pathophysiological mechanisms in a number of diseases and pathological conditions such as autoimmune disease, infections, cancer, allogeneic and xenogeneic transplantation, and inflammation. …”
Get full text

Recurrent Thrombotic Vasculopathy in a Former Cocaine User by Preeti Jadhav, Hassan Tariq, Masooma Niazi, Giovanni Franchin

“…Further workup did not reveal any other, autoimmune or infectious, etiology of this clinical presentation. …”
Get full text

Profound Autonomic Instability Complicated by Multiple Episodes of Cardiac Asystole and Refractory Bradycardia in a Patient with Anti-NMDA Encephalitis by Stephanie R. Mehr, Roy C. Neeley, Melissa Wiley, Avinash B. Kumar

“…Anti-N-methyl-D-aspartate receptor encephalitis (anti-NMDARE) is autoimmune encephalitis primarily affecting young adults and children. …”
Get full text

Antineutrophil Cytoplasmic Antibody Induction due to Infection: A Patient with Infective Endocarditis and Chronic Hepatitis C by Fareed B. Kamar, T. Lee-Ann Hawkins

“…In the case of infective endocarditis, patients may present with multisystem disturbances resembling an autoimmune process, cases that may be rendered even trickier to diagnose in the face of a positive ANCA. …”
Get full text

Protection of Fecal Microbiota Transplantation in a Mouse Model of Multiple Sclerosis by Kanglan Li, Shouchao Wei, Li Hu, Xiaojian Yin, Yingren Mai, Chunmei Jiang, Xiaoping Peng, Xingxing Cao, Zhongkai Huang, Haihong Zhou, Guoda Ma, Zhou Liu, Huiliang Li, Bin Zhao

“…To evaluate the viability of FMT for MS treatment and its impact on MS pathology, we tested FMT in mice with experimental autoimmune encephalomyelitis (EAE), a mouse model of MS. …”
Get full text

Immunoregulation of NKT Cells in Systemic Lupus Erythematosus by Junwei Chen, Meng Wu, Jing Wang, Xiaofeng Li

“…Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease with different variety of clinical manifestations. …”
Get full text

T Lymphocyte Autoreactivity in Inflammatory Mechanisms Regulating Atherosclerosis by Elisabetta Profumo, Brigitta Buttari, Luciano Saso, Raffaele Capoano, Bruno Salvati, Rachele Riganò

“…These self-molecules activate autoimmune reactions mainly characterized by the production of Th1 cytokines, thus sustaining the inflammatory mechanisms involved in endothelial dysfunction and plaque development. …”
Get full text

A Case of Relapsing Polychondritis Initiating with Unexplained Fever by Kosuke Hirayama, Nozomi Iwanaga, Yasumori Izumi, Satoshi Yoshimura, Kazuhiro Kurohama, Mai Yamashita, Taichi Takahata, Ryuta Oku, Masahiro Ito, Atsushi Kawakami, Kiyoshi Migita

“…Relapsing polychondritis (RP) is a rare autoimmune disease affecting the multiple organ system. …”
Get full text

Pulmonary Alveolar Microlithiasis and Rheumatoid Arthritis: A Case Report and Review of the Literature by Waleed Hafiz, Ahmedhusam Alahmed, Mohammed Alahmadi, Rakan Alotaibi, Abdullah Alsharif, Safwan Alim, Mohammed Mokhtar, Kholoud Al-Maabdi, Omaima Badr

“…Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease characterized by chronic seropositive symmetrical inflammatory polyarthritis with numerous extra-articular manifestations. …”
Get full text

Salivary Cytokines as Potential Diagnostic Biomarkers for Systemic Lupus Erythematosus Disease by Zeineb Zian, Assia Bouhoudan, Nadira Mourabit, Gholamreza Azizi, Mohcine Bennani Mechita

“…Systemic lupus erythematosus (SLE) is a complex autoimmune inflammatory disease characterized by an unknown etiology and a highly variable clinical presentation. …”
Get full text

Single-Cell Transcriptome Analysis Profile of Meniscal Tissue Macrophages in Human Osteoarthritis by Jingbin Zhou, Zhihong Zhao, Chen He, Feng Gao, Yu Guo, Feng Qu, Yujie Liu

“…Unlike rheumatoid arthritis and other autoimmune diseases, inflammation in OA is chronic and, in relatively low grade, mainly mediated by the innate immune system, especially macrophages. …”
Get full text

Biological Properties and the Role of IL-25 in Disease Pathogenesis by Yuwan Liu, Zewei Shao, Guoqiang Shangguan, Qingli Bie, Bin Zhang

“…IL-17A, a prototype member of this family, is involved in the pathogenesis of allergies, autoimmune diseases, allograft transplantations, and malignancies. …”
Get full text