A Review of Clinical Applications and Side Effects of Methotrexate in Ophthalmology by Ge Wang, Xiaoyan Peng

“…Methotrexate (MTX) is a folate analog widely used against a range of diseases including malignancies and autoimmune disorders. Its high effectiveness-price ratio also won extensive application in ophthalmology. …”
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A case report of severe nasal ischemia from cold agglutinin disease and a novel treatment protocol including HBOT by Scott Kohlert, Laurie McLean, Dimitrios Scarvelis, Calvin Thompson

“…Abstract Cold agglutinin disease (CAD) is a rare condition leading to blood agglutination and autoimmune hemolytic anemia. Cutaneous ischemia resulting from CAD in the head and neck is uncommon. …”
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Multicentric Castleman’s Disease, Associated with Idiopathic Thrombocytopenic Purpura by Ruchi Sood, Harris C. Taylor, Hamed Daw

“…We present the third known association between MCD and previous immune thrombocytopenia in the absence of HIV and HHV-8 infection and review its association with other autoimmune disorders and attendant implications for pathogenesis. …”
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Bipolar Disorder as Comorbidity with Sjögren’s Syndrome: What Can We Do? by Selima Chebli, Yosra Zgueb, Uta Ouali, Sana Taleb, Fethi Nacef

“…This case report presents a patient with bipolar disorder as comorbidity with Sjögren’s syndrome, suggesting that bipolar disorder could be associated with this autoimmune disease, which could lead to delaying diagnosis and treatment. …”
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A Man with Rapidly Progressive Limb Gangrene by Ada Wing Tung Leung, Virginia Weng Nga Lao

“…Antiphospholipid syndrome (APS) and polyarteritis nodosa (PAN) are two distinct, but potentially overlapping, autoimmune disorders that are characterized by vascular morbidities. …”
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Adiponectin in Cardiovascular Inflammation and Obesity by Tamar R. Aprahamian, Flora Sam

“…This review explores the recently described role of adiponectin as an immunomodulatory factor and how it intersects with the inflammation associated with both cardiovascular and autoimmune pathologies.…”
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Review of Current First-Line Pharmacotherapy Strategies for Thyroid Eye Disease by Julia Ryniecka, Maciej Wojszczyk, Damian Zys, Piotr Pasek, Julia Kulbacka, Michalina Wójcikiewicz, Marta Chuncia-Ileczko, Julia Kacperczyk, Filip Arczewski, Karol Dziedzic

“… Thyroid eye disease (TED) is a challenging autoimmune disorder that often requires therapeutic intervention. …”
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The Role of Prolactin as a Disease Activity Indicator in Some Rheumatic Diseases by Mohamed Ismail Abdelkarem, HM Fayed, Wael Abd El-Mohsen Abady, Eman Abulhagag Mohammed Mahmoud

“…Background: Autoimmune rheumatic diseases, including rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), and scleroderma, predominantly affect women and are characterized by systemic inflammation, leading to organ failure. …”
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Abrupt onset or exacerbation of anorexia nervosa following recent infections: a mini-review and a case report with an atypical manifestation of PANS by Lavalle Raffaele, Tournour Cristina, Rubano Serena, Delsedime Nadia, Panero Matteo, Abbate-Daga Giovanni

“…Infections may trigger AN through autoimmune mechanisms or by initiating weight loss, particularly in younger patients. …”
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The association between dietary sodium density and Hashimoto’s thyroiditis in US adults by Peilin An, Silin Wang, Lingyun Liu, Xuelin Li, Xin Lv, Xin Lv

“…BackgroundHashimoto’s thyroiditis (HT) is an autoimmune thyroid disease characterized by the presence of antibodies against thyroid-specific antigens. …”
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What are the lived healthcare experiences of patients with primary sclerosing cholangitis? A community-based qualitative interview study by Sheila Greenfield, Gideon Hirschfield, Jayne Parry, Katherine Arndtz, Madeline Cameron

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Single Nucleotide Polymorphisms in PPARD Associated with Systemic Lupus Erythematosus in Chinese Populations by Yuan-yuan Qi, Ya-ling Zhai, Xin-ran Liu, Xiao-xue Zhang, Ya-fei Zhao, Xiang-hui Ning, Zhan-Zheng Zhao

“…Systemic lupus erythematosus (SLE) is a multifactorial autoimmune disease characterized by apoptotic clearance deficiency provoking autoimmune responses and leading to multiple organ damage. …”
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Insight into Neutrophil Extracellular Traps through Systematic Evaluation of Citrullination and Peptidylarginine Deiminases by Caitlyn L. Holmes, Daeun Shim, John Kernien, Chad J. Johnson, Jeniel E. Nett, Miriam A. Shelef

“…In rheumatoid arthritis, an autoimmune inflammatory arthritis, citrullinated proteins are targeted by autoantibodies and thus thought to drive disease. …”
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NOD-like receptor family pyrin domain containing 3 (rs10754558) gene polymorphism in chronic spontaneous urticaria: A pilot case-control study by Aya El Gendy, Fawzia Hassan Abo Ali, Shereen A. Baioumy, Sara I. Taha, Mahy El -Bassiouny, Osama M. Abdel Latif

“…It may also be associated with ASST positivity which suggests a connection between the C-allele and the autoimmune notion of CSU.…”
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Association of vitamin D receptor gene polymorphisms with rheumatoid arthritis by Noelia Marquez Pete, Cristina Perez Ramirez, Maria del Mar Maldonado Montoro, Fernando Martinez Martinez, Fernando Fernández-Llimos, Antonio Sánchez Pozo, María del Carmen Ramirez Tortosa, Alberto Jiménez Morales

“…Introduction Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease of unknown etiology which causes progressive deterioration of the joints, leading to severe pain and functional disability. …”
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Single-cell analyses of intestinal epithelium reveal the dysregulation of gut immune microenvironment in systemic lupus erythematosus by Qiaolin Wang, Yutong Wu, Lianlian Ouyang, Xiaoli Min, Meiling Zheng, Lingyu Gao, Xiaoyun Chen, Zhi Hu, Shuang Yang, Wenjuan Jiang, Sujie Jia, Qianjin Lu, Ming Zhao

“…Dysregulation of gut immune homeostasis was implicated in the pathogenesis of multiple autoimmune diseases, however, whether this homeostasis is disrupted in a lupus autoimmune background remains unclear. …”
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Second Cancers in a Patient with Gastric MALT Lymphoma by Lucy Navsaria, Alfonso Badillo, Michael Wang

“…Mucosa-associated lymphoid tissue (MALT) lymphoma is an extranodal low-grade B-cell lymphoma, which is thought to arise from a background of chronic immune stimulation, bacterial, viral, or autoimmune stimuli. Treatment advances have increased the number of MALT lymphoma survivors, but there is still debate as to whether these patients are at a higher risk of developing second cancers. …”
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Acquired von Willebrand Syndrome in IgM Monoclonal Gammopathy as the Presentation of Lymphoplasmacytic Lymphoma by Zachary Wolfe, Bradley Lash

“…Most commonly implicated are lymphoproliferative, myeloproliferative, cardiovascular, and autoimmune disorders. Unlike inherited von Willebrand disease (vWD), AVWS tends to present at an older age and without a family history of vWD. …”
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Bullous pemphigoid as a diagnostic and therapeutic challenge with a wide spectrum of dermatological symptoms by Przemysław Borowy, Olga Wcisłek, Julia Płonczyńska, Mateusz Heba, Bogdan Batko

“…Bullous pemphigoid (BP) is a chronic autoimmune skin disease. It is characterized by the presence of well-tense blisters in the area of erythematous-oedematous eruptions, as well as in the unaffected skin that often develops lesions triggered by medications or focal points. …”
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Erythema Multiforme Attributable to Herpes Simplex Virus: Clinical Aspects and Treatment by Aya Mtiri, Ghada Bouslama, Nour-sayda Ben Messouad, Iyadh Abidi, Souha Ben Youssef, Badreddine Sriha

“…Erythema multiforme is an acute mucocutaneous hypersensitivity reaction with various etiological factors, including herpes simplex virus, medications, autoimmune diseases, and malignancies, but the most common cause is infection by herpes simplex virus. …”
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