The theses for PhD degree by article Editorial

“…Zhernakova – Clinical neuroimmunoendocrinology of peptic ulcer in elderly patients. K.T. Umbetova – Autoimmune signs in patients with viral hepatites.A.A. …”
Get full text

Inflammatory Chemokine Expression via Toll-Like Receptor 3 Signaling in Normal Human Mesangial Cells by Hiroshi Tanaka, Tadaatsu Imaizumi

“…The activation of TLRs and their downstream immune responses can be induced by both infectious pathogens and noninfectious stimuli such as endogenous ligands, and this mechanism may be involved in the pathogenesis of autoimmune renal diseases. However, there are few data on the interaction between TLR3, MDA5, and RIG-I in autoimmune glomerular diseases. …”
Get full text

A Curious Case of Hemolytic Anemia with Pseudoreticulopenia by Scott Mayer, Nikhilesh Srinivasan, Jenny Nguyen, Ryan Spilman, Dmitriy Scherbak

“…Herein, we present a unique case of a Coombs-negative, steroid-refractory autoimmune hemolytic anemia (AIHA) complicated by pseudoreticulopenia, describe its clinical presentation, histopathologic findings, and management, and review the salient literature. …”
Get full text

Effect of Humulus lupulus L. (Hop) on Postmenopausal Sexual Dysfunction: A Randomized Clinical Trial by Zahra Vahedpoorfard, Samira Ferdosi, Habibollah Rahimi, Hossein Motedayyen

Get full text

Fatal Hypogammaglobulinemia 3 Years after Rituximab in a Patient with Immune Thrombocytopenia: An Underlying Genetic Predisposition? by Jean-François Viallard, Marie Parrens, Frédéric Rieux-Laucat

“…The heterozygous mutation in the FASL gene, not present in the Genome Aggregation Database or ClinVar database, could suggest atypical Autoimmune LymphoProliferative Syndrome and its role in this patient’s immunodepression is discussed. …”
Get full text

Vitamin D and Selenium: Review of Clinical Trials of Synergistic Effects on Thyroid Antibody Levels and Disease Progression in Hashimoto’s Thyroiditis by Agnieszka Starzyk, Piotr Charzewski

“… Introduction: Hashimoto's Thyroiditis (HT) is a common autoimmune thyroid disorder caused by genetic predispositions and environmental factors, such as iodine imbalance, selenium deficiency, and stress. …”
Get full text

Adalimumab‐Induced Cutaneous Lupus Erythematosus: Cases Presenting With Malar Rash and Panniculitis by Parvin Mansouri, Farahnaz Bidari‐Zerehpoosh, Nikoo Mozafari

“…ABSTRACT Tumor necrosis factor‐alpha (TNF‐α) inhibitors are commonly used for management of various autoimmune disorders but can rarely cause isolated cutaneous lupus. …”
Get full text

Alveolar Hemorrhage, a Rare and Life-Threatening Complication of Catastrophic Antiphospholipid Syndrome by Grace Loza, Carlos Hallo, Byron Chiliquinga, Alejandro Hallo

“…This life-threatening complication results from autoimmune damage to the alveolar blood vessels. Given the limited literature addressing the association of these two pathologies, we report a series of three cases with this complication and then compare our findings with 6 cases reported in the literature.…”
Get full text

A Novel Insight into the Role of PLA2R and THSD7A in Membranous Nephropathy by Pingna Zhang, Weijun Huang, Qiyan Zheng, Jingyi Tang, Zhaocheng Dong, Yuhua Jiang, Yuning Liu, Weijing Liu

“…Membranous nephropathy (MN) is an organ-restricted autoimmune disease mainly caused by circulating autoantibodies against podocyte antigens, including the M-type phospholipase A2 receptor (PLA2R) and thrombospondin domain-containing 7A (THSD7A). …”
Get full text

Mesenchymal Stem Cells as New Therapeutic Agents for the Treatment of Primary Biliary Cholangitis by Aleksandar Arsenijevic, C. Randall Harrell, Crissy Fellabaum, Vladislav Volarevic

“…Primary biliary cholangitis (PBC) is a chronic autoimmune cholestatic liver disease characterized by the progressive destruction of small- and medium-sized intrahepatic bile ducts with resultant cholestasis and progressive fibrosis. …”
Get full text

Interstitial Nephritis in a Patient with Inflammatory Bowel Disease by Payaswini Vasanth, Michelle Parmley, Jose Torrealba, Tamim Hamdi

“…Various aspects of this theory have been challenged with a potential role for the underlying autoimmune disorder. Steroids are the mainstay of treatment and mycophenolate mofetil might be an effective alternative. …”
Get full text

Systemic lupus erythematosus in a patient with 22q11.2 deletion syndrome: A case report and review of the literature by Chen Sun, Pingyang Han, Juzhen Yan

“…There is a known association between 22q11.2 deletion syndrome (22q11.2DS), immunodeficiency and autoimmune diseases. However, the co-occurrence of 22q11.2DS and systemic lupus erythematosus (SLE) has been rarely reported. …”
Get full text

Role of Myokines in Myositis Pathogenesis and Their Potential to be New Therapeutic Targets in Idiopathic Inflammatory Myopathies by Vlad Mageriu, Emilia Manole, Alexandra E. Bastian, Florica Staniceanu

“…Idiopathic inflammatory myopathies (IIM) represent a heterogeneous group of autoimmune diseases whose treatment is often a challenge. …”
Get full text

An Obstetrics Index for the Assessment of Risk Levels of “High Risk Pregnancy” Groups by M. Sinan Beksaç, Emine Aydın, Mert Tuğral, Ergün Karaağaoğlu

“…RESULTS: The mean BOIp (±SD) values are 0,41±0,22; 0,29±0,21; and 0,40±0,23 for Control, MTHFR and Autoimmune groups respectively. We have demonstrated statistically significantly decreased BOIp level in MTHFR group compared to the other groups (p:0,002). …”
Get full text

Adipokines as Drug Targets in Diabetes and Underlying Disturbances by Vinícius Andrade-Oliveira, Niels O.S. Câmara, Pedro M. Moraes-Vieira

“…Several adipokines contribute to the self-styled “low-grade inflammatory state” of obese and insulin-resistant subjects, inducing the accumulation of metabolic anomalies within these individuals, including autoimmune and inflammatory diseases. Thus, adipokines are an interesting drug target to treat autoimmune diseases, obesity, insulin resistance, and adipose tissue inflammation. …”
Get full text

Anti-HMGCR Specificity of HALIP: A Confirmatory Study by Andrés Baucells, Maria Angeles Martínez, Marcelo Alvarado-Cardenas, Anaís Mariscal, Laura Martinez-Martinez, Cándido Juárez, Albert Selva-O’Callaghan

Get full text

Identifying effective immune biomarkers in alopecia areata diagnosis based on machine learning methods by Qingde Zhou, Lan Lan, Wei Wang, Xinchang Xu

“…Abstract Background Alopecia areata (AA) is a common non-scarring hair loss disorder associated with autoimmune conditions. However, the pathobiology of AA is not well understood, and there is no targeted therapy available for AA.  …”
Get full text

In silico data mining of large-scale databases for the virtual screening of human interleukin-2 inhibitors by Halim Sobia Ahsan, Zaheer-Ul-Haq, Khan Ajmal, Al-Rawahi Ahmed, Al-Harrasi Ahmed

“…Uncontrolled activated T cells play a key role in the pathophysiology by stimulating inflammation and autoimmune diseases like arthritis, psoriasis and Crohn’s disease. …”
Get full text

Variations in Rodent Models of Type 1 Diabetes: Islet Morphology by Lesya Novikova, Irina V. Smirnova, Sonia Rawal, Abby L. Dotson, Stephen H. Benedict, Lisa Stehno-Bittel

“…This study focused on 1 toxin-induced and 2 autoimmune rodent models of T1D: BioBreeding Diabetes Resistant rats, nonobese diabetic mice, and Dark Agouti rats treated with streptozotocin. …”
Get full text

pVAXhsp65 Vaccination Primes for High IL-10 Production and Decreases Experimental Encephalomyelitis Severity by Sofia Fernanda Gonçalves Zorzella-Pezavento, Fernanda Chiuso-Minicucci, Thais Graziela Donegá França, Larissa Lumi Watanabe Ishikawa, Larissa Camargo da Rosa, Priscila Maria Colavite, Bianca Balbino, Camila Marques, Maura Rosane Valerio Ikoma, Ana Paula Masson, Célio Lopes Silva, Alexandrina Sartori

“…Experimental autoimmune encephalomyelitis (EAE) is a demyelinating pathology of the central nervous system (CNS) used as a model to study multiple sclerosis immunopathology. …”
Get full text