Is Myasthenia Gravis a Real Complication of the COVID-19 Vaccine? A Case Report-Based Systematic Review by Omid Mirmosayyeb, Elham Moases Ghaffary, Mahsa Mazdak, Zahra Bagheri, Sara Bagherieh, Vahid Shaygannejad

“…Myasthenia gravis (MG) is a neuromuscular, autoimmune disease that causes weakness by impairing neuromuscular transmission. …”
Get full text

Potential Application of Tregitopes as Immunomodulating Agents in Multiple Sclerosis by Wassim Elyaman, Samia J. Khoury, David W. Scott, Anne S. De Groot

“…The induction of immunologic tolerance is an important clinical goal in autoimmunity. CD4+ regulatory T (Treg) cells, defined by the expression of the transcription factor forkhead box P3 (FoxP3), play a central role in the control of autoimmune responses. …”
Get full text

Role of Interleukin- (IL-) 17 in the Pathogenesis and Targeted Therapies in Spondyloarthropathies by I-Tsu Chyuan, Ji-Yih Chen

“…Further evidence from human and animal studies have defined that IL-17 and IL-17-producing cells contribute to tissue inflammation, autoimmunity, and host defense, leading to the following pathologic events associated with SpA. …”
Get full text

The clinicoserological spectrum of inflammatory myopathy in the context of systemic sclerosis and systemic lupus erythematosus by John D Pauling, Sarah Skeoch, Julie J Paik

“…Autoimmune rheumatic diseases (ARDs) are characterized by a pathological triad composed of autoimmunity/inflammation, microangiopathy, and aberrant tissue remodeling. …”
Get full text

Antitumor Responses of Invariant Natural Killer T Cells by Jennie B. Altman, Adriana D. Benavides, Rupali Das, Hamid Bassiri

“…This body of literature suggests that NKT cells play diverse nonredundant roles in a number of disease processes, including the initiation and propagation of airway hyperreactivity, protection against a variety of pathogens, development of autoimmunity, and mediation of allograft responses. In this review, however, we focus on the role of a specific lineage of NKT cells in antitumor immunity. …”
Get full text

Immune Thrombocytopenia and JAK2V617F Positive Essential Thrombocythemia: Literature Review and Case Report by M. A. Sobas, T. Wróbel, K. Zduniak, M. Podolak-Dawidziak, J. Rybka, M. Biedroń, M. Sawicki, J. Dybko, K. Kuliczkowski

“…On the basis of this case history a possible role of autoimmunity as a predisposing factor to myeloproliferation has been discussed.…”
Get full text

The Danger Model Approach to the Pathogenesis of the Rheumatic Diseases by César Pacheco-Tena, Susana Aideé González-Chávez

“…We assume that tissular dysfunction is a prerequisite for chronic autoimmunity and propose two genetically conferred hypothetical roles for the tissular cells causing the disease: (A) the Impaired cell and (B) the paranoid cell. …”
Get full text

Progress in the Relationship between Vitamin D Deficiency and the Incidence of Type 1 Diabetes Mellitus in Children by Lian-Ping He, Yu-Xin Song, Ting Zhu, Wei Gu, Chang-Wei Liu

“…Type 1 diabetes mellitus (T1DM) is an autoimmune disease, due to a large number of islet β cells damaged, resulting in an absolute lack of insulin, ultimately relying on insulin therapy. …”
Get full text

The evolving spectrum of interstitial lung disease in myositis—Management pearls by Takahisa Gono

“…Idiopathic inflammatory myopathies (IIMs) are characterized by muscle inflammation caused by exacerbated autoimmunity reactions. Patients with IIMs also have extramuscular lesions, such as skin rash, arthritis, interstitial lung disease (ILD), and cardiomyopathy. …”
Get full text

Rodent Models for Investigating the Dysregulation of Immune Responses in Type 1 Diabetes by Feng-Cheng Chou, Heng-Yi Chen, Shyi-Jou Chen, Mei-Cho Fang, Huey-Kang Sytwu

“…Type 1 diabetes (T1D) is an autoimmune disease mediated by T cells that selectively destroy the insulin-producing β cells. …”
Get full text

Inflammation and Immune Response in COPD: Where Do We Stand? by Nikoletta Rovina, Antonia Koutsoukou, Nikolaos G. Koulouris

“…Furthermore, viral and bacterial infections interfere with the chronic inflammation seen in stable COPD and exacerbations via pathogen-associated molecular patterns (PAMPs). Finally, autoimmunity is another novel aspect that may play a critical role in the pathogenesis of COPD. …”
Get full text

An In Vitro Model of Gastric Inflammation and Treatment with Cobalamin by T. R. Elliott, A. L. Guildford

“…Pernicious anaemia (PA) is an autoimmune condition where antibodies target intrinsic factor and parietal cells, reducing the patient’s ability to absorb cobalamin promoting atrophic gastritis. …”
Get full text

Iodine Supplementation: Usage “with a Grain of Salt” by Alessandro Prete, Rosa Maria Paragliola, Salvatore Maria Corsello

“…Iodine-induced thyroid disorders include thyroid autoimmunity, thyrotoxicosis, iodine-induced goiter, and hypothyroidism. …”
Get full text

The Prevalence of Autoantibodies in Complex Regional Pain Syndrome Type I by Maaike Dirckx, Marco W. J. Schreurs, Marissa de Mos, Dirk L. Stronks, Frank J. P. M. Huygen

“…Autoimmunity has been suggested as one of the pathophysiologic mechanisms that may underlie complex regional pain syndrome (CRPS). …”
Get full text

Lower Frequency of CD62Lhigh and Higher Frequency of TNFR2+ Tregs Are Associated with Inflammatory Conditions in Type 1 Diabetic Patients by Monika Ryba, Karolina Rybarczyk-Kapturska, Katarzyna Zorena, Małgorzata Myśliwiec, Jolanta Myśliwska

“…Diabetes type 1 is a chronic autoimmune disease in which insulin-producing cells are gradually destroyed by autoreactive T cells. …”
Get full text

The Lipid Parameters and Lipoprotein(a) Excess in Hashimoto Thyroiditis by D. O. Yetkin, B. Dogantekin

“…The risk of atherosclerotic heart disease is increased in autoimmune thyroiditis, although the reason is not clear. …”
Get full text

Anti-Thyroid Peroxidase Antibodies and Male Gender Are Associated with Diabetes Occurrence in Patients with Beta-Thalassemia Major by Giovanni M. Pes, Francesco Tolu, Maria P. Dore

“…Age, gender, duration of chelation therapy, body mass index, and markers of pancreatic and extrapancreatic autoimmunity were analyzed. Results. Multiple logistic regression analysis showed that anti-thyroid peroxidase (TPO) antibodies (Ab) (OR = 3.36; p=0.008) and male gender (OR = 1.98; p=0.025) were significantly associated with glucose impairment, while the other variables were not. …”
Get full text

Balancing Inflammation: The Link between Th17 and Regulatory T Cells by Maggie L. Diller, Ragini R. Kudchadkar, Keith A. Delman, David H. Lawson, Mandy L. Ford

“…The balance between these two cell populations is essential for immune homeostasis and dysregulation of this balance has been implicated in a variety of inflammatory conditions including autoimmunity, allograft rejection, and tumorigenesis. …”
Get full text

CUZD1 and Anti-CUZD1 Antibodies as Markers of Cancer and Inflammatory Bowel Diseases by Christos Liaskos, Eirini I. Rigopoulou, Timoklia Orfanidou, Dimitrios P. Bogdanos, Christos N. Papandreou

“…CUZD1 appears to be one of the relatively few biomarkers that serve as both cancer biomarker and autoantigen of autoantibodies in an autoimmune disease unrelated to cancerous organs. This review discusses the role of CUZD1 in cancer and autoimmunity. …”
Get full text

An HLA-Transgenic Mouse Model of Type 1 Diabetes That Incorporates the Reduced but Not Abolished Thymic Insulin Expression Seen in Patients by Jeffrey Babad, Riyasat Ali, Jennifer Schloss, Teresa P. DiLorenzo

“…Type 1 diabetes (T1D) is an autoimmune disease characterized by T cell-mediated destruction of the pancreatic islet beta cells. …”
Get full text