A guide to selecting high-performing antibodies for Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform (PPP2R5D) for use in Western Blot, immunoprecipi... by Carl Laflamme, Kathleen Southern, Riham Ayoubi, Maryam Fotouhi, Charles Alende

“…Pathogenic mutations in the PPP2R5D gene are linked to clinical symptoms characterized by neurodevelopmental delay, intellectual disability, and autism spectrum disorders. The etiology of these genetic disorders remains unknown, which can partly be due to the lack of independently characterized antibodies. …”
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Unveiling the role of lncRNA ERDR1 in immune cell regulation by Aihua Shu, Xu Tian, Jie Yue, Yuxia Jiang, Yifei Liu

“…Furthermore, Erdr1 has been implicated in the mitigation of several diseases, including acne, wound healing, osteoarthritis, melanoma, gastric cancer, obesity, and autism. Given its complex biological functions and mechanisms, Erdr1 presents itself as a promising biomarker and a potential therapeutic target for a range of immune cell-related disorders.…”
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A Review of Human Studies Assessing the Efficacy of Cannabidiol for Anxiety Disorders by Kuba Borys Romańczuk, Katarzyna Kamińska-Omasta, Bartosz Omasta, Olga Krupa, Paulina Dorota Pietrukaniec, Zofia Martyna Wójcik, Kinga Furtak, Szymon Przemysław Stolarczyk, Magdalena Agata Czerska, Daria Rybak

“…This systematic review assesses the current evidence on the efficacy of CBD in treating anxiety and related disorders, including post-traumatic stress disorder (PTSD), social anxiety disorder (SAD), and autism spectrum disorder (ASD). Unlike open-label trials prone to placebo bias, this study reviews randomized, double-blind, placebo-controlled trials. …”
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Marigold: a machine learning-based web app for zebrafish pose tracking by Gregory Teicher, R. Madison Riffe, Wayne Barnaby, Gabrielle Martin, Benjamin E. Clayton, Josef G. Trapani, Gerald B. Downes

“…Abstract Background High-throughput behavioral analysis is important for drug discovery, toxicological studies, and the modeling of neurological disorders such as autism and epilepsy. Zebrafish embryos and larvae are ideal for such applications because they are spawned in large clutches, develop rapidly, feature a relatively simple nervous system, and have orthologs to many human disease genes. …”
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Molecular switch of the dendrite-to-spine transport of TDP-43/FMRP-bound neuronal mRNAs and its impairment in ASD by Pritha Majumder, Biswanath Chatterjee, Khadiza Akter, Asmar Ahsan, Su Jie Tan, Chi-Chen Huang, Jen-Fei Chu, Che-Kun James Shen

“…The misregulation of this switch could contribute to the pathogenesis of FMRP-related neurodisorders including the autism spectrum disorder (ASD). It also could indicate a molecular connection between ASD and neurodegenerative disease-related protein TDP-43 and opens up a new perspective of research to elucidate TDP-43 proteinopathy among patients with ASD.…”
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N100 Repetition Suppression Indexes Neuroplastic Defects in Clinical High Risk and Psychotic Youth by Joseph Gonzalez-Heydrich, Michelle Bosquet Enlow, Eugene D’Angelo, Larry J. Seidman, Sarah Gumlak, April Kim, Kristen A. Woodberry, Ashley Rober, Sahil Tembulkar, Kyle O’Donnell, Hesham M. Hamoda, Kara Kimball, Alexander Rotenberg, Lindsay M. Oberman, Alvaro Pascual-Leone, Matcheri S. Keshavan, Frank H. Duffy

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Design and psychometric testing of a moral intelligence instrument for pre-hospital emergency medical services personnel: a sequential-exploratory mixed-method study by Fateme Mohammadi, Rasoul Salimi, Salman Khazaei, Mostafa Bijani

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Self-beneficial transactional social dynamics for cooperation in Shwachman-Diamond syndrome: a mixed-subject analysis using computational pragmatics by Arthur Trognon, Arthur Trognon, Arthur Trognon, Natacha Stortini, Natacha Stortini, Coralie Duman, Coralie Duman, Nami Koïdé, Ewa Skupinska, Ewa Skupinska, Hamza Altakroury, Alizée Poli, Alizée Poli, Loann Mahdar-Recorbet, Loann Mahdar-Recorbet, Blandine Beaupain, Jean Donadieu, Michel Musiol, Michel Musiol, Michel Musiol

“…Unlike behaviors classically observed in other pathologies such as autism spectrum disorders, where responses are influenced by the directness of communication, SDS behaviors were driven by personal gain, regardless of the indirectness of requests. …”
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A bioinformatic search for correspondence between differentially expressed genes of domestic versus wild animals and orthologous human genes altering reproductive potential by M. P. Ponomarenko, I. V. Chadaeva, P. M. Ponomarenko, A. G. Bogomolov, D. Yu. Oshchepkov, E. B. Sharypova, V. V. Suslov, A. V. Osadchuk, L. V. Osadchuk, Yu. G. Matushkin

“…A genome-wide comparison among humans, several domestic animals, and some of their wild congeners has given rise to the concept of self-domestication syndrome, which includes autism spectrum disorders. In our previous study, we created a bioinformatic model of human self-domestication syndrome using differentially expressed genes (DEGs; of domestic animals versus their wild congeners) orthologous to the human genes (mainly, nervous-system genes) whose changes in expression affect reproductive potential, i.e., growth of the number of humans in the absence of restrictions caused by limiting factors. …”
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Comparative effectiveness of physical activity interventions on cognitive functions in children and adolescents with Neurodevelopmental Disorders: a systematic review and network m... by Ruiyuan Tao, Yijian Yang, Mark Wilson, Jeremy R. Chang, Chang Liu, Cindy H. P. Sit

“…This study aimed to compare the effectiveness of different types of PA interventions on cognitive functions in children and adolescents with NDDs, with additional analyses examining intervention effects across specific NDD types including attention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD). Methods In this systematic review and network meta-analysis, seven databases (Web of Science, PubMed, Medline, APA PsycINFO, Embase, CINAHL, and SPORTDiscus) for randomized controlled trials from database inception to September 2023 were searched. …”
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Understanding social behaviours across neurodiverse young people: roles of social cognition and self-regulation by Iciar Iturmendi-Sabater, Evdokia Anagnostou, Marc A. Fournier, Jennifer Crosbie, Russell Schachar, Robert Nicolson, Stelios Georgiadis, Elizabeth Kelley, Jessica Jones, Jessica Brian, Hsiang-Yuan Lin, Meng-Chuan Lai

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Neurotrophin-3 as a mediator in the link between PM2.5 exposure and psychiatric disorders: A Mendelian randomization study by Yuan Zhang, Wei Wang, Xuening Zhang, Ran Jing, Xin Wen, Peng Xiao, Xinjie Liu, Zengle Zhao, Tongmin Chang, Yufei Li, Wen Liu, Chenxi Sun, Xiaorong Yang, Lejin Yang, Ming Lu

“…Additionally, PM2.5 was not significantly associated with autism spectrum disorders (OR: 1.24, 95 % CI: 0.83–1.65), post-traumatic stress disorder (OR: 1.51, 95 % CI: 1.11–1.91), obsessive-compulsive disorder (OR: 0.81, 95 % CI: −0.07–1.69), or anorexia nervosa (OR: 1.42, 95 % CI: 0.86–1.98). …”
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Clinical and molecular outcomes from the 5-Year natural history study of SSADH Deficiency, a model metabolic neurodevelopmental disorder by Itay Tokatly Latzer, Jean-Baptiste Roullet, Wardiya Afshar-Saber, Henry H. C. Lee, Mariarita Bertoldi, Gabrielle E. McGinty, Melissa L. DiBacco, Erland Arning, Melissa Tsuboyama, Alexander Rotenberg, Thomas Opladen, Kathrin Jeltsch, Àngels García-Cazorla, Natalia Juliá-Palacios, K. Michael Gibson, Mustafa Sahin, Phillip L. Pearl

“…Language developmental delays were more prominent than motor. Autism, epilepsy, movement disorders, sleep disturbances, and various psychiatric behaviors constituted the core of the disorder’s clinical phenotype. …”
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