Systemic Immune-Inflammation Index (SII) and Neutrophil-to-Lymphocyte Ratio (NLR): A Strong Predictor of Disease Severity in Large-Artery Atherosclerosis (LAA) Stroke Patients by Liu K, Yang L, Liu Y, Zhang Y, Zhu J, Zhang H, He Z

“…Keting Liu,1,2,* Li Yang,1,* Yang Liu,3 Yun Zhang,1 Juncheng Zhu,4 Haofeng Zhang,5 Zemin He6 1Department of Neurology, Chengdu Seventh People’s Hospital (Affiliated Cancer Hospital of Chengdu Medical College), Chengdu, Sichuan Province, 610213, People’s Republic of China; 2Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong Province, 510515, People’s Republic of China; 3Department of Clinical Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan Province, 610075, People’s Republic of China; 4Department of Radiology, Chengdu Seventh People’s Hospital (Affiliated Cancer Hospital of Chengdu Medical College), Chengdu, Sichuan Province, 610213, People’s Republic of China; 5Department of Information, Chengdu Seventh People’s Hospital (Affiliated Cancer Hospital of Chengdu Medical College), Chengdu, Sichuan Province, 610213, People’s Republic of China; 6Department of Thoracic Surgery, The First People’s Hospital of Shuangliu District (West China Airport Hospital of Sichuan University), Chendu, Sichuan Province, 610200, People’s Republic of China*These authors contributed equally to this workCorrespondence: Zemin He, Email 993092572@qq.comBackground: Systemic immune-inflammation index (SII) and neutrophil-to-lymphocyte ratio (NLR) are novel inflammatory markers based on neutrophil, platelet and lymphocyte counts. …”
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Effects of Metabolic Factors on Left Ventricular Diastolic Function in Patients with Obstructive Sleep Apnea by Zhou YF, Chen SH, Wang WD, Chen JL, Cai PY, Li MM, Lin YL, Li WQ, Huang DH, Li J, Li YT, Lin HL

“…Yi-Fan Zhou,1,* Shu-Han Chen,1,* Wan-Da Wang,1 Jia-Le Chen,1 Ping-Yu Cai,1 Mei-Mei Li,1 Yue-Ling Lin,1 Wan-Qi Li,1 De-Hong Huang,1 Jun Li,1 Yue-Ting Li,2 Hui-Li Lin1 1Department of Cardiology, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, Fujian Province, People’s Republic of China; 2Department of Nephrology, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, Fujian Province, People’s Republic of China*These authors contributed equally to this workCorrespondence: Hui-Li Lin, Department of Cardiology, The Second Affiliated Hospital of Fujian Medical University, No. 34 North Zhongshan Road, Quanzhou, Fujian Province, 362000, People’s Republic of China, Tel +86 18876598756, Email 1627974150@qq.com Yue-Ting Li, Department of Nephrology, The Second Affiliated Hospital of Fujian Medical University, No. 34 North Zhongshan Road, Quanzhou, Fujian Province, 362000, People’s Republic of China, Tel +86 15359593070, Email liyt163@126.comPurpose: The effect of metabolic factors on cardiovascular risk in obstructive sleep apnea (OSA) is unclear. …”
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The Association Between Mitral Regurgitation and Long-Term Outcomes in Acute Myocardial Infarction Undergoing Percutaneous Coronary Intervention: A Retrospective Large Sample Cohor... by Yan N, Wu P, Zhu B, Ma A, Wang X, Hai X, Ma X, Jiang H, Yang S

“…Ning Yan,1,* Peng Wu,1,2,* Baozhen Zhu,2,3 Ali Ma,2 Xin Wang,2 Xinrui Hai,2 Xueping Ma,1 Hao Jiang,4 Shaobin Yang1 1Heart Centre & Department of Cardiovascular Diseases, General Hospital of Ningxia Medical University, Yinchuan, People’s Republic of China; 2The First Clinical College of Ningxia Medical University, Yinchuan, People’s Republic of China; 3Department of Intervention, Tong Xin City People’s Hospital, Yinchuan, People’s Republic of China; 4Department of Cardiology, Yinchuan Hospital of Traditional Chinese Medicine, Yinchuan, People’s Republic of China*These authors contributed equally to this workCorrespondence: Hao Jiang, Department of Cardiology, Yinchuan Hospital of Traditional Chinese Medicine, Yinchuan, 750004, People’s Republic of China, Tel +18295496850, Email 18295496850@163.com Shaobin Yang, Heart Centre & Department of Cardiovascular Diseases, General Hospital of Ningxia Medical University, Yinchuan, Ningxia, 750004, People’s Republic of China, Tel +8613895625229, Email youngshb@126.comBackground: The relationship between mitral regurgitation (MR) and long-term outcomes in Chinese patients with acute myocardial infarction (AMI) undergoing percutaneous coronary intervention (PCI) remains scarce. …”
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Serum Lactate Dehydrogenase Is a Novel Predictor for the Severity in the Patients With MAFLD: A Cross-Sectional Study in Hefei, China by Yu L, Bao S, Zhu F, Xu Y, Zu F, Liu Y, Jiang R, Chen S, Chen W

“…Liang Yu,1,* Shiming Bao,2,* Feng Zhu,3,* Yanyan Xu,1 Fuqiang Zu,1 Yanwei Liu,1 Runbeng Jiang,1 Wei Chen,4 Song Chen5 1Department of General Surgery, The Second Affiliated Hospital of Anhui Medical University, Hefei, People’s Republic of China; 2Department of Emergency Surgery, Tongling People’s Hospital, Tongling, People’s Republic of China; 3Department of General Surgery, Tongling People’s Hospital, Tongling, People’s Republic of China; 4Department of General Surgery, the First Affiliated Hospital of Anhui Medical University, Hefei, People’s Republic of China; 5Department of General Surgery, the Affiliated Chuzhou Hospital of Anhui Medical University (The First People’s Hospital of Chuzhou), Chuzhou, People’s Republic of China*These authors contributed equally to this workCorrespondence: Song Chen, Department of General Surgery, the Affiliated Chuzhou Hospital of Anhui Medical University (The First People’s Hospital of Chuzhou), Chuzhou, People’s Republic of China, Email chensong101425@163.com Wei Chen, Department of General Surgery, the First Affiliated Hospital of Anhui Medical University, Hefei, People’s Republic of China, Email 13665560109@163.comBackground & Aims: The aim of this study was to assess the association between the level of lactate dehydrogenase (LDH) and the severity of metabolic syndrome (MetS) and Metabolic Associated Fatty Liver Disease (MAFLD) and the potential diagnostic value of LDH for identifying at-risk metabolic associated steatohepatitis (MASH).Methods: This cross-sectional, real-world retrospective study enrolled a total of 1118 obese patients in the department of bariatric surgery at the Second Affiliated Hospital of Anhui Medical University from January 1, 2018, to December 31, 2021. …”
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The Suppression of Signal Transducer and Activator of Transcription-3 in A549 human Lung Carcinoma Cells Induced by Marine Sponge Callyspongia aerizusa by Hadisaputri YE, Nurhaniefah AA, Mutakin M, Hendriani R, Rezano A, Sopyan I, Yusnaini Y, Asikin Y, Abdulah R

“…Yuni Elsa Hadisaputri,1,* Annida Adha Nurhaniefah,1,* Mutakin Mutakin,2 Rini Hendriani,3 Andri Rezano,4 Iyan Sopyan,5 Yusnaini Yusnaini,6 Yonathan Asikin,7 Rizky Abdulah3 1Department of Pharmaceutical Biology, Faculty of Pharmacy, Universitas Padjadjaran, Jatinangor, Indonesia; 2Department of Pharmaceutical Analysis and Medicinal Chemistry, Faculty of Pharmacy, Universitas Padjadjaran, Jatinangor, Indonesia; 3Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran, Jatinangor, Indonesia; 4Department of Biomedical Sciences, Cell Biology Division, Faculty of Medicine, Universitas Padjadjaran, Jatinangor, Indonesia; 5Department of Pharmaceutical and Pharmacy Technology, Faculty of Pharmacy, Universitas Padjadjaran, Jatinangor, Indonesia; 6Faculty of Fisheries and Marine Sciences, Universitas Halu Oleo, Kendari, Indonesia; 7Department of Bioscience and Biotechnology, Faculty of Agriculture, University of the Ryukyus, Okinawa, Japan*These authors contributed equally to this workCorrespondence: Yuni Elsa Hadisaputri, Department of Pharmaceutical Biology, Faculty of Pharmacy, Universitas Padjadjaran, Jl. …”
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Mitral Valve Repair by Irbaz Hameed, MD, Adham Ahmed, BS, Christina Waldron, BS, Percy T. Algarate, MD, Michal Kawczynski, MD, Maurish Fatima, MBBS, BS, Amnah Alhazmi, MBBS, Samantha Colon, BS, Alexandria Brackett, MA, MLIS, Samuel Heuts, MD, PhD, Peyman Sardari Nia, MD, PhD, Mario Gaudino, MD, PhD, Vinay Badhwar, MD, Arnar Geirsson, MD

“…This is partly due to limited surgeon and center experience and lack of centralization of care for this technically challenging operation. Objectives: The authors evaluate the association between annual case volume and contemporary long-term outcomes of patients undergoing isolated MVr. …”
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Effects of Dexmedetomidine as an Adjuvant in Preoperative Ultrasound-Guided Internal Branch of Superior Laryngeal Nerve Block on Postoperative Sore Throat and Hemodynamics in Patie... by Chen Z, Zhang L, Lu G, Zhang Y, Zhao D, Zhao S, Zhang H, Jin Y, Zhao X, Jin Y

“…Zheping Chen,1– 3,* Le Zhang,2,3,* Guodong Lu,2,3 Yizheng Zhang,2,3 Dexu Zhao,2,3 Shanshan Zhao,2,3 He Zhang,2,3 Yuelong Jin,4 Xin Zhao,2,3 Yanwu Jin2,3 1Shanghai Key Laboratory of Anesthesiology and Brain Functional Modulation, Translational Research Institute of Brain and Brain-Like Intelligence, Clinical Research Center for Anesthesiology and Perioperative Medicine, Department of Anesthesiology and Perioperative Medicine, Shanghai Fourth People’s Hospital, School of Medicine, Tongji University, Shanghai, 200434, People’s Republic of China; 2Department of Anesthesiology, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, 250033, People’s Republic of China; 3The second Clinical College of Shandong University, Jinan, 250033, People’s Republic of China; 4Department of Epidemiology and Health Statistics, School of Public Health, Wannan Medical College, Wuhu, 241001, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xin Zhao; Yanwu Jin, Department of Anesthesiology, The Second Hospital, Cheeloo College of Medicine, Shandong University, 247 Bei Yuan Street, Jinan, 250033, People’s Republic of China, Email lujnzx@sohu.com; jinyanwu_aa@163.comBackground: Postoperative sore throat (POST) is a significant adverse effect after endotracheal intubation, especially with double-lumen endotracheal tubes (DLTs). …”
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Effect of Physical Activity on Physical and Mental Health in Young Cancer Patients and Survivors: A Systematic Review of RCTs and CCTs by Ann Christin Schneider, Sofia Anzeneder, Lars Rehbein, Eva Katharina Brack, Mirko Schmidt, Valentin Benzing

“…We examined RCTs and CCTs investigating PA interventions in children and adolescents with cancer, during or after treatment, that reported outcomes related to physical or mental health and/or quality of life. Two authors independently screened studies for inclusion, extracted data, and assessed the risk of bias. …”
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FERN: is it possible to conduct a randomised controlled trial of intervention or expectant management for early-onset selective fetal growth restriction in monochorionic twin pregn... by Kerry Woolfall, Jamie J Kirkham, Jane Sandall, Mariana Popa, Enrico Lopriore, Mark Turner, Shakila Thangaratinam, Aris T Papageorghiou, Andrew Sharp, Lawrence Impey, Andy Healey, Jessica Mendoza, Asma Khalil, Dharmintra Pasupathy, Brigitte Vollmer, Zarko Alfirevic, Rajeswari Parasuraman, Jan Deprest, Richard Edmund Ashcroft, Kurt Hecher, Smriti Prasad, Baskaran Thilaganathan, Richard J Jackson, Tracy Karen Mitchell, Natasha Fenwick, Monique C Haak, Liesbeth Lewi, Shauna Leven, Fabricio Da Silva Costa, Odai Yaghi, Tracey Ricketts, George Attilakos, Carolyn Bailie, Christine Cornforth, Mark Denbow, Louise Hardman, Jane Harrold, Joel Marsden, Tommy Mousa, Surabhi Nanda, Michelle Watson, Karen Wilding, Dilly Anumba, Edward D Johnstone, Yoav Yinon, Ahmet Baschat

“…Engagement of at least 50 UK clinicians is planned for WP3.Ethics and dissemination This study has received ethical approval from the Health Research Authority (HRA) South West—Cornwall and Plymouth Ethics Committee (REC reference 20/SW/0156, IRAS ID 286337). …”
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Compassionate Use of Omadacycline in a Down Syndrome Pre-Schooler With Critically Ill Atypical Pneumonia Caused by Macrolide-Resistant Mycoplasma Pneumoniae by Wu D, Xie FJ, Wang YJ, Jiang XH, Zhang GL, Zhang H, Zhu YC, Zhang Y, Tang YJ, Lin YL, Xu JX, Zhang JN, Liu BW, Kang K, Gao Y

“…Di Wu,1,* Feng-Jie Xie,2,* Ya-Jun Wang,3,* Xiao-Hui Jiang,1,* Guo-Li Zhang,3,* Hong Zhang,2 Yu-Cheng Zhu,4 Yan Zhang,4 Yu-Jia Tang,1 Yi-Lu Lin,1 Jia-Xi Xu,5 Jia-Ning Zhang,5 Bo-Wen Liu,5 Kai Kang,5 Yang Gao1 1Department of Critical Care Medicine, The Sixth Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province, People’s Republic of China; 2Department of Critical Care Medicine, The Hongqi Hospital Affiliated to Mudanjiang Medical University, Mudanjiang, Heilongjiang Province, People’s Republic of China; 3Department of Pediatrics, The Sixth Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province, People’s Republic of China; 4Department of Critical Care Medicine, The Hongxinglong Hospital of Beidahuang Group, Shuangyashan, Heilongjiang Province, People’s Republic of China; 5Department of Critical Care Medicine, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province, People’s Republic of China*These authors contributed equally to this workCorrespondence: Kai Kang, Department of Critical Care Medicine, The First Affiliated Hospital of Harbin Medical University, 23 Youzheng Street, Nangang District, Harbin, Heilongjiang Province, 150001, People’s Republic of China, Tel +86-13904618016, Email janekk79@126.com Yang Gao, Department of Critical Care Medicine, The Sixth Affiliated Hospital of Harbin Medical University, 998 Aiying Road, Songbei District, Harbin, Heilongjiang Province, 150027, People’s Republic of China, Tel +86-13045160709, Email gaoyang0312@126.comBackground: Rapid and accurate identification of causative organisms and prompt initiation of pathogen-targeted antibiotics are crucial for managing atypical pneumonia. …”
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Gender Analysis, Milk Value Chain, Kabale Uganda. Kabale: Kabale University. by Tugume, Samuel

“…While comparing the challenges faced by the male and female genders, men have better access to education and training than women(4.2 vs. 2.2) women perform a larger share of unpaid or underpaid labour(4.6 vs. 1.7), women face greater challenges in accessing markets and value-addition opportunities. (4.6 vs. 2.1); women likely have less time to dedicate solely to farm activities (4.2 vs. 2.3); men hold more decision-making authority (3.9 vs. 2.7) while both genders might face challenges in accessing these services, but women are still disadvantaged (4.7 vs. 4.5). …”
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Exploring Mortality and Prognostic Factors of Heart Failure with In-Hospital and Emergency Patients by Electronic Medical Records: A Machine Learning Approach by Yu CS, Wu JL, Shih CM, Chiu KL, Chen YD, Chang TH

“…., Taipei, 11049, Taiwan; 5Graduate Institute of Biomedical Informatics, College of Medical Science and Technology, Taipei Medical University, New Taipei City, 235603, Taiwan; 6Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, 11031, Taiwan; 7Cardiovascular Research Center, Taipei Medical University Hospital, Taipei, 11031, Taiwan; 8Taipei Heart Institute, Taipei Medical University, Taipei, 11031, Taiwan; 9Department of Family Medicine, Taipei Medical University Hospital, Taipei, 11031, Taiwan; 10School of Medicine, College of Medicine, Taipei Medical University, Taipei, 11031, Taiwan; 11Clinical Big Data Research Center, Taipei Medical University Hospital, Taipei, 11031, Taiwan*These authors contributed equally to this workCorrespondence: Tzu-Hao Chang; Yu-Da Chen, Email kevinchang@tmu.edu.tw; 153072@h.tmu.edu.twPurpose: As HF progresses into advanced HF, patients experience a poor quality of life, distressing symptoms, intensive care use, social distress, and eventual hospital death. …”
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A Peculiar ICME Event in August 2018 Observed With the Global Muon Detector Network by W. Kihara, K. Munakata, C. Kato, R. Kataoka, A. Kadokura, S. Miyake, M. Kozai, T. Kuwabara, M. Tokumaru, R. R. S. Mendonça, E. Echer, A. Dal Lago, M. Rockenbach, N. J. Schuch, J. V. Bageston, C. R. Braga, H. K. Al Jassar, M. M. Sharma, M. L. Duldig, J. E. Humble, P. Evenson, I. Sabbah, J. Kóta

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Urlinie und Zwölftonreihe als Zeitgenossinnen by Martin Eybl

“…In view of the contrasting positions of their authors, Urlinie and twelve tone row – two concepts that both date to the early 1920s – seem to document the simultaneity of the non-simultaneous rather than contemporaneity. …”
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Arthroplasty registries at a glance: an initiative of the International Society of Arthroplasty Registries (ISAR) to facilitate access, understanding, and reporting of registry dat... by Anne Lübbeke, Lotje A Hoogervorst, Perla J Marang-van de Mheen, Heather A Prentice, Ola Rolfson, Rob G H H Nelissen, Arnd Steinbrück, Gearoid McGauran, Christophe Barea, Kajsa Erikson, Alma B Pedersen, Martyn Porter

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Association of the Triglyceride-Glucose Index and Obesity Indicators with Multiple Chronic Diseases: A Longitudinal Cohort Study Based on CHARLS by Lan Y, Qi G, Li B, Sooranna SR, Chen D, Rao W, Lin Y, Pang Y

“…Yincai Lan,1,* Guangzi Qi,1,* Boya Li,1 Suren Rao Sooranna,2 Dongshun Chen,3 Wenlian Rao,3 Yinxia Lin,1 Yaqin Pang4– 7 1School of Public Health, Youjiang Medical University for Nationalities, Baise, Guangxi, 533000, People’s Republic of China; 2Life science and clinical research center, Youjiang Medical University for Nationalities, Baise 533000, Guangxi, China and Department of metabolism, digestion and reproduction, Imperial College London, Chelsea & Westminster Hospital, London, SW10 9NH, UK; 3School of Basic Medicine, Youjiang Medical University for Nationalities, Baise, Guangxi, 533000, People’s Republic of China; 4School of Medical Laboratory Medicine, Youjiang Medical University for Nationalities, Baise, Guangxi, 533000, People’s Republic of China; 5Key Laboratory of Environmental and Population Health Research, Ecological Aluminum Industrial Base of Guangxi Universities, Baise, Guangxi, 533000, People’s Republic of China; 6Key Laboratory for Environmental Pollution and Health Risk Assessment, Youjiang Medical University for Nationalities, Baise, Guangxi, 533000, People’s Republic of China; 7Modern Industrial College of Biomedicine and Great Health, Youjiang Medical University for Nationalities, Baise, Guangxi, 533000, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yinxia Lin; Yaqin Pang, Email lin1837731@163.com; pangyaqin@126.comObjective: To explore the relationship between triglyceride glucose (TyG) and the obesity combined indexes and the occurrence of multiple chronic diseases (MCD), which will help to provide a basis for the prevention and treatment of this condition.Methods: 3037 participants in the China Health and Retirement Longitudinal Study, which was conducted from 2011 to 2015 were selected for this study. …”
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Leveraging mobility data to analyze persistent SARS-CoV-2 mutations and inform targeted genomic surveillance by Riccardo Spott, Mathias W Pletz, Carolin Fleischmann-Struzek, Aurelia Kimmig, Christiane Hadlich, Matthias Hauert, Mara Lohde, Mateusz Jundzill, Mike Marquet, Petra Dickmann, Ruben Schüchner, Martin Hölzer, Denise Kühnert, Christian Brandt

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Qualitative application of the diffusion of innovation theory to maternity waiting homes in rural Zambia by Jeanette L. Kaiser, Rachel M. Fiorillo, Taryn Vian, Thandiwe Ngoma, Kayla J. Kuhfeldt, Michelle L. Munro-Kramer, Davidson H. Hamer, Misheck Bwalya, Viviane R. Sakanga, Jody R. Lori, Eden Ahmed Mdluli, Peter C. Rockers, Godfrey Biemba, Nancy A. Scott

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Physicians’ Perceptions of the Quality of Palliative Care and of the Importance of Collaboration in Interdisciplinary Teams in Norwegian Nursing Homes by Skomakerstuen Ødbehr L, Hov R, Sanaker H, Sandsdalen T

“…Liv Skomakerstuen Ødbehr,1,* Reidun Hov,2,* Harald Sanaker,3,* Tuva Sandsdalen1,* 1Department of Health and Nursing Sciences, Faculty of Social and Health Sciences, University of Inland Norway, Elverum, Norway; 2Centre for Development of Institutional and Home Care Services Inland (Hedmark) Norway, Hamar Municipality, Norway; 3Municipal Medical Center, Ringsaker Municipality, Brumunddal, Norway*These authors contributed equally to this workCorrespondence: Liv Skomakerstuen Ødbehr, Faculty of Social and Health Sciences, University of Inland Norway, Post Box 400, Elverum, 2418, Norway, Tel +47 959 079 84, Email liv.odbehr@inn.noPurpose: The palliative phase of a patient’s life is often characterized by disease complexity, increasing the need for holistic care, support for the patient’s relatives, and the up-to-date knowledge of a multidisciplinary healthcare team. …”
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Development of Space Weather Reasonable Worst‐Case Scenarios for the UK National Risk Assessment by Mike Hapgood, Matthew J. Angling, Gemma Attrill, Mario Bisi, Paul S. Cannon, Clive Dyer, Jonathan P. Eastwood, Sean Elvidge, Mark Gibbs, Richard A. Harrison, Colin Hord, Richard B. Horne, David R. Jackson, Bryn Jones, Simon Machin, Cathryn N. Mitchell, John Preston, John Rees, Neil C. Rogers, Graham Routledge, Keith Ryden, Rick Tanner, Alan W. P. Thomson, James A. Wild, Mike Willis

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