Aurora B inhibition induces hyper-polyploidy and loss of long-term proliferative potential in RB and p53 defective cells by Shivam Vora, Saptarshi Chatterjee, Ariel Andrew, Ramyashree Prasanna Kumar, Martina Proctor, Zhen Zeng, Rituparna Bhatt, Deborah Nazareth, Madushan Fernando, Mathew J. K. Jones, Yaowu He, John D. Hooper, Nigel A. J. McMillan, Jelena Urosevic, Jamal Saeh, Jon Travers, Daniela Cimini, Jing Chen, Brian Gabrielli

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Update from Canadian Respirology Program Directors

“…Submitted by Elizabeth Tullis MD FRCPC Associate Professor of Medicine, Respirology Program Director, University of Toronto, Toronto, Ontario The Canadian Organization of Pulmonary Program Directors (COPPD) had their first meeting in Montreal on November 7, 2003, which was sponsored by an unrestricted educational grant from AstraZeneca Canada Inc. This meeting was held in conjunction with the Royal College of Physicians and Surgeons (RCPS) Respirology Subspecialty Committee meeting held on November 6, 2003, and with the first Canadian Division Directors meeting held on November 8, 2003.…”
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Role of macrophage migration inhibitory factor (MIF) in allergic and endotoxin-induced airway inflammation in mice by M. Korsgren, L. Källström, L. Uller, T. Bjerke, F. Sundler, C. G. A. Persson, O. Korsgren

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Real-world treatment patterns and survival outcomes in men with metastatic castration-resistant prostate cancer in Finland: a national, population-based cohort study by Antti Rannikko, Olivia Hölsä, Trude Ågesen, Mattias Ekman, Riikka Mattila

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Patient experience with eosinophilic esophagitis symptoms and impacts on daily life based on in-trial qualitative interviews by Calvin N. Ho, Harald Fjällbrant, Evan S. Dellon, Cecilio Santander, Marc E. Rothenberg, Julie Bailey, Shehan McFadden, Jason Ritchie

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Asthma Control in Canada Remains Suboptimal: The Reality of Asthma Control (TRAC) Study by J Mark FitzGerald, Louis-Philippe Boulet, R Andrew McIvor, Sabrina Zimmerman, Kenneth R Chapman

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Empowering Family Physicians to Impart Proper Inhaler Teaching to Patients with Chronic Obstructive Pulmonary Disease and Asthma by Janice M Leung, Mohit Bhutani, Richard Leigh, Dan Pelletier, Cathy Good, Don D Sin

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Short-acting beta agonist, antibiotics, oral corticosteroid and association with mortality and cardiopulmonary events in patients with COPD: a retrospective cohort study in Alberta... by Mohit Bhutani, Irvin Mayers, Arsh Randhawa, Manisha Talukdar, Suzanne McMullen, Phongsack Manivong, Aaron Gelfand

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IL-33 Mediates Lung Inflammation by the IL-6-Type Cytokine Oncostatin M by Fernando Botelho, Anisha Dubey, Ehab A. Ayaub, Rex Park, Ashley Yip, Allison Humbles, Roland Kolbeck, Carl D. Richards

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A Descriptive-Multivariate Analysis of Community Knowledge, Confidence, and Trust in COVID-19 Clinical Trials among Healthcare Workers in Uganda by Keneth Iceland, Kasozi, Anne, Laudisoit, Lawrence Obado, Osuwat, Gaber El-Saber, Batiha, Naif E. Al, Omairi, Eric, Aigbogun, Herbert Izo, Ninsiima, Ibe Michael, Usman, Lisa M., DeTora, Ewan Thomas, MacLeod, Halima, Nalugo, Francis P., Crawley, Barbara E., Bierer, Daniel Chans, Mwandah, Charles Drago, Kato, Kenedy, Kiyimba, Emmanuel Tiyo, Ayikobua, Linda, Lillian, Kevin, Matama, Shui Ching, Nelly Mak, David, Onanyang, Theophilus, Pius, Linda, Lillian, Kevin, Matama, Shui Ching, Nelly Mak, David, Onanyang, Theophilus, Pius, David Paul, Nalumenya, Robinson, Ssebuufu, Nina Olivia, Rugambwa, Grace Henry, Musoke, Kevin, Bardosh, Juma John, Ochieng, Fred, Ssempijja, Patrick, Kyamanywa, Gabriel, Tumwine, Khalid J., Alzahrani, Susan Christina, Welburn

“…We also found a high level of skepticism and possible community resistance to DNA recombinant vaccines, such as the Oxford–AstraZeneca vaccine. Preference for herbal treatments (38/260; 14.6%, 95% CI: 10.7–19.3) currently being promoted by the Ugandan government raises major policy concerns. …”
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COVID-19 Booster Vaccines Administration in Different Countries by Angel Yun-Kuan Thye, Loh Teng-Hern Tan, Jodi Woan Fei Law, Vengadesh Letchumanan

“…This includes COVID-19 vaccines by Pfizer-BioNTech, Moderna, AstraZeneca, Janssen, Sinovac, and Sinopharm. Findings suggested that protection against COVID-19 provided by these vaccines may be waning or that the protection reduces against variants of concern (VOC) or even inadequate protection of the primary vaccination for some risk groups. …”
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Metyrapone for Long-Term Medical Management of Cushing’s Syndrome by Andrea N. Traina, Ashley Farr, Ritu Malik, Robert J. Bingham

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Manifestaciones neurológicas asociadas a la vacuna contra COVID-19 by R. Alonso Castillo, J.C. Martínez Castrillo

“…La mayoría de casos publicados se produjeron en asociación temporal con la vacuna Pfizer (BNT162b2), seguida de la vacuna de AstraZeneca (ChAdOX1 nCoV-19). Conclusiones: Con los datos existentes actualmente no es posible establecer una relación de causalidad entre estos eventos adversos y las vacunas contra la COVID-19, ni calcular la frecuencia de aparición de estos trastornos. …”
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Neurological manifestations associated with COVID-19 vaccine by R. Alonso Castillo, J.C. Martínez Castrillo

“…Most of the published cases occurred in temporal association with the Pfizer vaccine (BNT162b2), followed by the AstraZeneca vaccine (ChAdOX1-S). Conclusions: It is not possible to establish a causal relationship between these adverse events and COVID-19 vaccines with the currently existing data, nor to calculate the frequency of appearance of these disorders. …”
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Highly Synchronized Expression of Lineage-Specific Genes during In Vitro Hepatic Differentiation of Human Pluripotent Stem Cell Lines by Nidal Ghosheh, Björn Olsson, Josefina Edsbagge, Barbara Küppers-Munther, Mariska Van Giezen, Annika Asplund, Tommy B. Andersson, Petter Björquist, Helena Carén, Stina Simonsson, Peter Sartipy, Jane Synnergren

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Association of Self-Reported Weight Change and Quality of Life, and Exercise and Weight Management Behaviors Among Adults with Type 2 Diabetes Mellitus: The SHIELD Study by Susan Grandy, Kathleen M. Fox, Debbra D. Bazata

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Anti-SARS-CoV-2 Antibody Level among Renal Transplant Recipients: A Case Report from Nepal by Kamal Ranabhat, Bhuvan Saud, Saroj Adhikari, Suraj Bhattarai, Rojan Adhikari, Bhoj Raj Luitel, Mahesh Raj Sigdel

“…All three cases had received two doses of Oxford-AstraZeneca COVID-19 vaccine AZD1222 (ChAdOx1). Serological analysis showed protective level of circulating antibodies in the blood of all three cases. …”
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Impact of Regular Exercise and Attempted Weight Loss on Quality of Life among Adults with and without Type 2 Diabetes Mellitus by Andrew J. Green, Kathleen M. Fox, Susan Grandy

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A bad dream come true: ICT patent prosecution against EU competition law by Niccolò Galli

“…Regarding Art. 102 TFEU, the article concludes that the AstraZeneca jurisprudence on abusive patent prosecution is of a limited application for anti-competitive ICT patenting practices that essentially concern blocking patents. …”
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X-Ray Computed Tomography: Semiautomated Volumetric Analysis of Late-Stage Lung Tumors as a Basis for Response Assessments by C. Bendtsen, M. Kietzmann, R. Korn, P. D. Mozley, G. Schmidt, G. Binnig

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