Evolution of SARS-CoV-2 spike trimers towards optimized heparan sulfate cross-linking and inter-chain mobility by Jurij Froese, Marco Mandalari, Monica Civera, Stefano Elli, Isabel Pagani, Elisa Vicenzi, Itzel Garcia-Monge, Daniele Di Iorio, Saskia Frank, Antonella Bisio, Dominik Lenhart, Rudolf Gruber, Edwin A. Yates, Ralf P. Richter, Marco Guerrini, Seraphine V. Wegner, Kay Grobe

“…Abstract The heparan sulfate (HS)-rich extracellular matrix (ECM) serves as an initial interaction site for the homotrimeric spike (S) protein of SARS-CoV-2 to facilitate subsequent docking to angiotensin-converting enzyme 2 (ACE2) receptors and cellular infection. …”
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Biomimetic Approach to CO2 Reduction by Ilaria Gamba

“…The determination of these characteristics is of interest both for clarifying aspects of the catalytic cycle of natural enzymes that are still unknown and for developing synthetic molecular catalysts that can readily be applied to artificial photosynthetic devices.…”
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Probiotic active gel promotes diabetic wound healing through continuous local glucose consumption and antioxidant by Yingshuai Wang, Lihua Shi, Junna Lu, Fengyuan Wang, Zihan Zhou, Yuexuan Wang, Xiangyu Du, Di Qin, Fangman Chen, Dan Shao, Yuanyuan Gao, Cheng Gao, Tongyi Sun

“…This study provides an artificial-natural composite hydrogel for cascade therapy on diabetic wound healing, and suggests a complete management approach for diabetic oxidative stress.…”
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Poly (ADP-ribose) (PAR) levels in Peripheral Blood Mononuclear Cells (PBMC) during peri-implantation and early pregnancy in buffalo cows by Giovanna De Matteis, Anna Reale, Michele Zampieri, Emanuela Rossi, Federica Signorelli, Olimpia Barbato, Vittoria Lucia Barile

“… Poly(ADP-ribosyl)ation (PAR) is a reversible post-translational protein modification catalyzed by enzyme  members of the poly(ADP-ribose) polymerases (PARPs) family. …”
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Laying the groundwork: Exploring pesticide exposure and genetic factors in south-eastern Brazilian farmers by Débora Dummer Meira, Victor Nogueira Da Gama Kohls, Matheus Correia Casotti, Luana Santos Louro, Gabriel Mendonça Santana, Thomas Erik Santos Louro, Adriana Madeira Alvares da Silva, Lorena Souza Castro Altoé, Raquel Reis Trabach, Sonia Groisman, Elizeu Fagundes de Carvalho, Jamila Alessandra Perini Machado, Stephanie Seneff, Iúri Drumond Louro

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Canopy humidity and irrigation regimes interactively affect rice physiology, grain filling and yield during grain filling period by Le Chen, Xueyun Deng, Hongxia Duan, Xueming Tan, Xiaobing Xie, Xiaohua Pan, Lin Guo, Tao Luo, Xinbiao Chen, Hui Gao, Haiyan Wei, Hongcheng Zhang, Yongjun Zeng

“…The HH decreased the soil plant analysis development (SPAD) parameter and net photosynthetic rate while leaf surface temperature, antioxidant enzyme activity and malondialdehyde (MDA) level got increased. …”
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Creation of body color mutants by CRISPR/Cas9 gene editing in largemouth bass, Micropterus salmoides by Lina Sun, Tian Gao, Zhiqiang Li, Xiaolong Yang, Zuliang Qin, Mingxiao Ye, Ying Li, Feilong Wang, Deshou Wang

“…The fertilized eggs were obtained through hormonal induction (5 μg/kg LHRH-A3, 600 IU/kg hCG and 2 mg/kg DOM) and artificial insemination, and the tyrb (tyrosinase b) or csf1ra (colony-stimulating factor 1 receptor a) gRNA and Cas9 mRNA were microinjected into the fertilized eggs at the one-cell stage for targeted gene editing. …”
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Polymorphism of the trehalase gene (TREH) in native populations of Siberia by B. A. Malyarchuk, M. V. Derenko

“…Here, in native populations of Siberia, we studied the polymorphism of the TREH gene, which encodes trehalase, an enzyme that cleaves trehalose. The analysis of exome polymorphism showed the presence of seven haplotypes of the TREH gene in the population. …”
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Design, synthesis, and anti-inflammatory activity of 2H-1,4-benzoxazin-3(4H)-one derivatives modified with 1,2,3-triazole in LPS-induced BV-2 cells by Xixi Hou, Xixi Hou, Longfei Mao, Huibin Zhang, Lan Wang, Baoyu He, Jingjing Guo, Jianji Wang

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Diethyldithiocarbamate Delayed Wound-Induced Callus Formation in Potato Tubers by Inhibiting Superoxide Dismutase by CHENG Xinyan, SONG Bingfang, LIU Ning, TIAN Wenmao, YIN Yan, LI Yongcai, BI Yang, WANG Yi

“…In this study, potato tubers (Solanum tuberosum L.) were artificially damaged and then soaked in 10 mmol/L diethyldithiocarbamate (DDC) solution, an inhibitor of superoxide dismutase (SOD). …”
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Study on the response mechanism of MicroRNA novel-13 and novel-44 to Vibrio parahaemolyticus infection in Pinctada fucata martensii by Chao Jie Li, Qi Yuan Zhang, Bin Zhang, Hai Ying Liang, Li Ning Ma, Muhammad Salman

“…Abstract Pinctada fucata martensii (P. f. martensii) is one of the main pearl oysters cultured in artificial seawater in China. However, it is highly susceptible to pathogen infection under intensive cultivation near the coast. …”
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Resistance-breaking strains of tomato spotted wilt virus hamper photosynthesis and protein synthesis pathways in a virus accumulation-dependent manner in Sw5-carrying tomatoes by Maria Isabella Prigigallo, Ugo Picciotti, Giovanni Bubici

“…This phenomenon was also verified on 15 genes by a quantitative reverse transcription PCR assay on a greenhouse experiment with a different Sw-5b-tomato variety artificially inoculated with another SRB TSWV strain. …”
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Early prediction of long COVID-19 syndrome persistence at 12 months after hospitalisation: a prospective observational study from Ukraine by Dmytro Chumachenko, Tetyana Chumachenko, Oleksii Honchar, Tetiana Ashcheulova

“…Logistic regression and machine learning-based binary classification models have been developed to predict the persistence of LCS symptoms at 12 months after discharge.Conclusions Compared with post-COVID-19 patients who have completely recovered by 12 months after hospital discharge, those who have subsequently developed ‘very long’ COVID were characterised by a variety of more pronounced residual predischarge abnormalities that had mostly subsided by 1 month, except for steady differences in the physical symptoms levels. A simple artificial neural networks-based binary classification model using peak ESR, creatinine, ALT and weight loss during the acute phase, predischarge 6-minute walk distance and complex survey-based symptoms assessment as inputs has shown a 92% accuracy with an area under receiver-operator characteristic curve 0.931 in prediction of LCS symptoms persistence at 12 months.…”
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COFcap2, a recyclable tandem catalysis reactor for nitrogen fixation and conversion to chiral amines by Qianqian Zhu, Peijie Dong, Jiangyue Yu, Zhifang Wang, Ting Wang, Shan Qiao, Jinjin Liu, Shubo Geng, Yunlong Zheng, Peng Cheng, Michael J. Zaworotko, Zhenjie Zhang, Yao Chen

“…Herein we report that co-immobilization of metal nanoparticles and a biocatalytic system within a synthetic covalent organic framework capsule, COFcap-2, functions like an artificial cell in that, whereas the catalysts are trapped within 300-400 nm cavities, substrates/products can ingress/egress through ca. 2 nm windows. …”
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Structure Diversity and Properties of Some Bola-like Natural Products by Valentin A. Stonik, Tatyana N. Makarieva, Larisa K. Shubina, Alla G. Guzii, Natalia V. Ivanchina

“…The promising properties of these metabolites, such as their ability to self-assemble and stabilize biological or artificial membranes, and biological activities, attract additional attention to them.…”
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The Impact of Root Temperature on Photosynthesis and Isoprene Emission in Three Different Plant Species by Mauro Medori, Lucia Michelini, Isabel Nogues, Francesco Loreto, Carlo Calfapietra

“…In this paper, we show the response of three strong isoprene emitter species, namely, Phragmites australis, Populus x euramericana, and Salix phylicifolia exposed to artificial or natural warming of the root system in different conditions. …”
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Impact of Light and Temperature on Growth, Intracellular and Extracellular Pigment, and Lovastatin Yield by Monascus ruber in Synthetic Medium by K. Suganya, A. Usha Raja Nanthini, Jayaraman Narenkumar, Subramani Abilaji, Aruliah Rajasekar, Subpiramaniyam Sivakumar, S. Prasath, Hesham S. Almoallim, Tahani Awad Alahmadi

“…The development of alternate sources for the production of natural pigments has been targeted to overcome the utilization of artificial coloring, which is dangerous to human health and the environment. …”
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Effects of aluminum on metabolism of reactive oxygen species and reactive nitrogen species in root tips of different Eucalyptus species by Zilong Ouyang, Bing Liu, Tangkan Li, Tiandao Bai, Weichao Teng

“…The antioxidant enzymes activities of the root tips of different Eucalyptus species induced by Al stress resulted in different ROS and RNS contents, ultimately resulting in differing degrees of membrane lipid peroxidation. …”
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Molting of laying hens can activate AMPK- lipophagy - lipid metabolism pathway and improve intestinal digestion and absorption by Meiwei Lv, Chenxin Liu, Xiaowen Jiang, Ming Ge, Haibin Wang, Wenhui Yu

“…Poultry molting is a natural phenomenon, and process that improves the physiological function of laying hens. In this study, artificial intervention was used to induced molting (IM) in aged hens and improve their egg- laying performance. …”
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Influence of a lignification and mineralization of leaf tissues on resistance to a brown rust in common wheat plants by A. A. Konovalov, I. K. Shundrina, E. V. Karpova, I. V. Eltsov, E. A. Orlova, N. P. Goncharov

“…On a phytopathologic plot, against artificial infection with spores of a brown rust, two samples of spring bread wheat 3-13-15-4 and 3-4-14-3 were affected 1–5 % and 30 %, respectively. …”
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