Dual specific STAT3/5 degraders effectively block acute myeloid leukemia and natural killer/T cell lymphoma by Daniel Pölöske, Helena Sorger, Anna Schönbichler, Elvin D. deAraujo, Heidi A. Neubauer, Anna Orlova, Sanna H. Timonen, Diaaeldin I. Abdallah, Aleksandr Ianevski, Heikki Kuusanmäki, Marta Surbek, Elisabeth Heyes, Thomas Eder, Christina Wagner, Tobias Suske, Martin L. Metzelder, Michael Bergmann, Maik Dahlhoff, Florian Grebien, Roman Fleck, Christine Pirker, Walter Berger, Emir Hadzijusufovic, Wolfgang R. Sperr, Lukas Kenner, Peter Valent, Tero Aittokallio, Marco Herling, Satu Mustjoki, Patrick T. Gunning, Richard Moriggl

“…They induced cell death and growth arrest in both AML/NKCL cell lines and primary AML patient blasts. …”
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Stage-dependent changes in culture medium osmolality promote porcine oocyte maturation in vitro by Lixiang Liu, Lixiang Liu, Yu Tang, Yu Tang, Jing Shao, Jing Shao, Bingfeng Fan, Bingfeng Fan, Yifeng Yang, Yifeng Yang, Ying Zhang, Ying Zhang, Xiangyuan Zhao, Xiangyuan Zhao, Hailong Xue, Hailong Xue, Huimin Sun, Huimin Sun, Xulin Zhang, Xulin Zhang, Yushi Zhang, Yushi Zhang, Baozeng Xu, Baozeng Xu

“…The reduction of medium osmolarity or the supplementation with organic osmolytes can eliminate this arrest. Therefore, cell volume homeostasis is essential for embryonic development in vitro. …”
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DNA hypomethylation-mediated upregulation of GADD45B facilitates airway inflammation and epithelial cell senescence in COPD by Yuan Zhan, Qian Huang, Zhesong Deng, Shanshan Chen, Ruonan Yang, Jiaheng Zhang, Yating Zhang, Maocuo Peng, Jixing Wu, Yiya Gu, Zhilin Zeng, Jungang Xie

“…Accelerated lung aging and inflammation mutually reinforce each other, creating a detrimental cycle that contributes to disease progression. Growth arrest and DNA damage-inducible (GADD45) family has been reported to involve in multiple biological processes, including inflammation and senescence. …”
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Development and validation of a screening tool for sepsis without laboratory results in the emergency department: a machine learning studyResearch in context by Shan Jiang, Shuai Dai, Yulin Li, Xianlong Zhou, Cheng Jiang, Cong Tian, Yana Yuan, Chengwei Li, Yan Zhao

“…Patients who were under 18 years of age, had cardiopulmonary arrest upon arrival at the ED, or had missing and abnormal medical record data were excluded. …”
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A New CYP2E1 Inhibitor, 12-Imidazolyl-1-dodecanol, Represents a Potential Treatment for Hepatocellular Carcinoma by Torsten Diesinger, Alfred Lautwein, Sebastian Bergler, Dominik Buckert, Christian Renz, Radovan Dvorsky, Vyacheslav Buko, Siarhei Kirko, Edith Schneider, Florian Kuchenbauer, Mukesh Kumar, Cagatay Günes, Felicitas Genze, Berthold Büchele, Thomas Simmet, Martin Haslbeck, Kai Masur, Thomas Barth, Dieter Müller-Enoch, Thomas Wirth, Thomas Haehner

“…Cell-cycle analysis showed a complete loss of proliferating cells with a simultaneous increase in S-phase arrest beginning at a threshold dose of 30 μM. I-ol also reduced xenograft tumour growth in nude mice. …”
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Integrating network analysis and experimental validation to reveal the mechanism of Cuscuta chinensis lam. Extract in the treatment of IgA nephropathy by Xianlong Zhang, Mingjie Liang, Ziyang Lin, Minyi Li, Tingting Duan, Yun Han, Lanqing Meng, Mengqiu Li, Guixuan Lin, Tao Xia, Ying Lai, Boen Liang, Bingqiong Li, Minhua Li, Fengxin Kang, Quan Zhu, Zhenghai Li, Junzheng Yang

“…Cuscuta chinensis Lam has been shown to nourish the liver and tonify the kidney, consolidate essence, and arrest polyuria, However, whether Cuscuta chinensis Lam has the protective effects on IgA nephropathy and the underlying mechanisms remain unclear. …”
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Protocol and statistical analysis plan for the PREventing cardiovascular collaPse with Administration of fluid REsuscitation during Induction and Intubation (PREPARE II) randomised... by Li Wang, Tamer Hudali, Shekhar Ghamande, Megan Moore, Bruno Pereira, Christopher J Lindsell, Wesley H Self, Todd W Rice, Matthew W Semler, Kate O’Connor, David B Page, Victor E Ortega, Aaron M Joffe, Swati Gulati, G Patel, Heath D White, Muhammad Ali, Jonathan D Casey, David R Janz, Derek W Russell, Derek J Vonderhaar, Kevin M Dischert, William S Stigler, Emily Adams, Kevin W Gibbs, James M Dargin, A M Joffe, Akram Khan, Simanta Dutta, Janna S Landsperger, Sarah W Robison, Itay Bentov, Joanne M Wozniak, Susan Stempek, Olivia F Krol, Matthew E Prekker, Brian E Driver, Joseph M Brewer, Christopher John Lindsell, David Janz, Stephen P Peters, Rita N Bakhru, Scott Bauer, Christina R Bellinger, Amanda M Brown, Blair Brown, Jerri Brown, Caitlin Bumgarner, Wendy Butcher, Megan Caudle, Arjun B Chatterjee, David J Chodos, Gerardo Corcino, Nathan S Cutler, Travis L Dotson, Daniel C Files, Jonathan L Forbes, John P Gaillard, Katherine A Gershner, Shannon Ginty, Kiadrick R Hood, April Hazelwood, Katherine Hendricks, Kelly Jacobus, Jonathan T Jaffe, Stacy Kay, Chad A Kloefkorn, Jennifer Krall, Margo T Lannan, Cornelia Lane, Cynthia Lanning, Jessica Lyons, William I Mariencheck, Chad R Marion, Matthew A Maslonka, Sara McClintock, Nathaniel M Meier, Matthew C Miles, Peter J Miller, Sophia Mitchell, Wendy C Moore, Katherine Moss, Andrew M Namen, Dustin L Norton, Stella B Ogake, Jill A Ohar, Jessica A Palakshappa, Rodolfo M Pascual, Sandi Pascual, Aaron Pickens, Adam R Schertz, Matt Strong, Alexander O Sy, Braghadheeswar Thyagarajan, Amy Townsend, Russell Worthen, Michael Wlodarski, Charles Yarbrough, Caroline York, Bradley Lloyd, James Dargin, Joanne Wozniak, Christopher Adler, Ahmed Agameya, Michael Colancecco, Daniel Fitelson, Joshua Giaccotto, Gena Han, Louise Kane, Ezra Miller, Timothy Noland, Jaqueline Price, Joseph Plourde, Fraser Mackay, Laura Mahoney, Avignat Patel, Michael Plourde, Zena Saadeh, Sara Shadchehr, Sandeep Somalaraju, Eleanor Summerhill, Ryan Webster, Jordan Winnicki, Ekaterina Yavarovich, Sheetal Gandotra, Anna Altz-Stamm, Cristina Bardita, Mary Clay Boone, Joe W Chiles, Kristina Collins, Abby Drescher, Kevin G Dsouza, Janna Dunn, Stacy Ejem, Josh Gautney, Nicole Harris, Savannah Herder, R Chad Wade, Rutwij Joshi, Daniel Kelmenson, Anne Merrill Mason, Scott R Merriman, Takudzwa Mkorombindo, Jada Nowak, D Sheylan, Lisa Sarratt, Tabitha Stewart, Kadambari Vijaykumar, Gina White, Micah R Whitson, Christopher Barnes, Andrew M Walters, Alejandro C Arroliga, Tasnim Lat, Stephanie Nonas, Milad K Jouzestani, Raya Adi, Chandani Anandkat, Hanae Benchbani, Matthew G Drake, Makrina N Kamel, Ramanpreet Randhawa, Jessica L Tsui

“…The primary outcome is cardiovascular collapse, defined as any of: systolic blood pressure <65 mm Hg, new or increased vasopressor administration between induction and 2 min after intubation, or cardiac arrest or death between induction and 1 hour after intubation. …”
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Exploring Medical Students’ Self-Reported Confidence and Willingness Administering Basic Life Support (BLS) Following Peer-Led Training in the Context of COVID-19 by Sarah Allsop

“…Background: Basic life support (BLS) delivery improves prognosis following out-of-hospital cardiac arrest and forms an integral part of undergraduate medical curricula, although limited literature has assessed student confidence in utilizing these skills. …”
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Bailing Out the Protester by Alireza Nourani-Dargiri

“…Protesting on controversial issues, while protected activity, often risks arrests and other interactions with police. Unfortunately, studies show that protesters of color are arrested at higher rates than white protesters. …”
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Addressing Shortcomings in Contingency Standards of Care by Alexander Quan

“…Better Nurse Staffing Is Associated With Survival for Black Patients and Diminishes Racial Disparities in Survival After In-Hospital Cardiac Arrests. Medical Care, 59(2), 169–176. https://doi.org/10.1097/MLR.0000000000001464 [24] Annas, G. …”
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Mechanisms by which Human Cells Bypass Damaged Bases during DNA Replication after Ultraviolet Irradiation by James E. Cleaver

“…The recruitment of recombination components to the arrested forks represents the ultimate failure of replication machinery to relieve the arrested state and bypass the damage. …”
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A novel model of superconducting tape-based hybrid DC circuit breaker for monopolar and bipolar HVDC grid by Mojtaba Roshani Diz, Behrooz Vahidi, Hasan Rastegar

“…Also, the placement of the superconducting coils is such that the current is divided between them, the reactor inductance, and the arrester. Thus, the superconducting tape and the arrester do not experience thermal stress. …”
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Study on the Triggered Discharge Characteristics of Sphere Gaps for Protecting Transformer Neutral Point by Hongyan Nie, Pengfei Wang, Qingguo Chen, Zhen An, Zhixun Li

“…Matching surge arrester with spark sphere gap switches can effectively limit the overvoltage of grounded transformer neutral points and protect the transformer neutral insulation. …”
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Un document: Deziluziile mele în Rusia by Emma Goldman, Cristina Deutsch

“…At the beginning of 1916, she will be arrested again under the accuse of delivering leaflets containing material that has as a subject birth control. …”
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Construire la lutte queer en Iran et dans la diaspora d'Iran. Entretien avec Saghi Ghahraman by Mahdis Sadeghipouya, Sahar Aurore Saeidnia

“…She fled her native Iran after being arrested for working with a communist organization’s women’s branch. …”
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Relationship between Damage Rate of High-Voltage Electrical Equipment and Instrumental Seismic Intensity by Rushan Liu, Mingpan Xiong, Deyuan Tian

“…The second most vulnerable equipment is the circuit breaker, followed by the lightning arrester, transformer, and isolating switch, which share a similar vulnerability curve.…”
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Endothelial calcium firing mediates the extravasation of metastatic tumor cells by Marina Peralta, Amandine Dupas, Annabel Larnicol, Olivier Lefebvre, Ruchi Goswami, Tristan Stemmelen, Anne Molitor, Raphael Carapito, Salvatore Girardo, Naël Osmani, Jacky G. Goetz

“…We have previously demonstrated that endothelial cells (ECs) actively remodel during extravasation by enwrapping arrested tumor cells (TCs) and extruding them from the vascular lumen while maintaining perfusion. …”
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Gardé·es à vue. Domination(s) et reconfigurations des rapports entre manifestant·es et policier·es pendant le hirak (2019-2021) by Lina Benchekor

“…In addition, the class allegiances of those arrested give rise to what appears to be a class struggle between activists and police officers, with those arrested often coming from the upper middle classes. …”
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Numerical modelling of interaction of cemented natural fractures and hydraulic fractures by Haiyang Wang, Peiyao Xiao, Desheng Zhou, Qingqing Wang

“…When the cementation strength ratio is relatively small, the hydraulic fracture is arrested by the CNF, the CNF is opened, generating significant shear fractures. …”
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Bohémiens condamnés aux galères à l’époque du Roi-Soleil (1677 à 1715) by Emmanuel Filhol

“…Those whom the marechaussee (stops) arrests, just because they are Bohemians, follow the routes of the chains of convicts (from Paris, Rennes and Bordeaux) who (that) lead them to Marseille in order to serve on the galleys of the Sun King.…”
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