Identification of Key Genes and Prognostic Value Analysis in Hepatocellular Carcinoma by Integrated Bioinformatics Analysis by Meng Wang, Licheng Wang, Shusheng Wu, Dongsheng Zhou, Xianming Wang

“…Kaplan-Meier survival curves indicated that high expression of cyclin-dependent kinase (CDK1), cyclin B1 (CCNB1), cyclin B2 (CCNB2), MAD2 mitotic arrest deficient-like 1 (MAD2L1), and topoisomerase IIα (TOP2A) predicted poor overall survival in HCC patients (all log-rank P<0.01). …”
Get full text

Lights and Siren Transport and the Need for Hospital Intervention in Nontrauma Patients: A Prospective Study by Olivier Bertholet, Mathieu Pasquier, Elina Christes, Damien Wirths, Pierre-Nicolas Carron, Olivier Hugli, Fabrice Dami

“…Since 2013, rapid transportation from the field, fast-track, is currently used for patients with acute ST-elevation myocardial infarction, suspicion of acute stroke and out-of-hospital cardiac arrest. The aim of this study was to determine whether the use of LST was associated with the realization of TCHI for nontrauma cases within 15 minutes of hospital arrival, to quantify overtriage (LST without TCHI) and to identify the predictors of TCHI. …”
Get full text

The Proapoptotic Effect of MB-653 Is Associated with the Modulation of Metastasis and Invasiveness-Related Signalling Pathways in Human Colorectal Cancer Cells by Libor Sokoli, Peter Takáč, Mariana Budovská, Radka Michalková, Martin Kello, Natália Nosálová, Ľudmila Balážová, Šimon Salanci, Ján Mojžiš

“…Additionally, MB-653 induces dose-dependent G2/M phase cell cycle arrest, the cause of which could be cyclin B1/CDC2 complex dysfunction and/or a decrease in α-tubulin protein expression. …”
Get full text

A Tale of Two Conditions: Pediatric Brugada Syndrome Unveiled—Navigating the Challenges of Coexisting Arrhythmia and Fever‐Induced ECG Pattern by Hei‐To Leung, Sit‐Yee Kwok, Fong‐Ying Shih, Kin‐Shing Lun, Tak‐Cheung Yung, Sabrina Tsao

“…Fever was present in seven patients at the initial presentation, and two patients experienced aborted cardiac arrest and one had symptomatic ventricular tachycardia. …”
Get full text

Ranibizumab for Visual Impairment due to Diabetic Macular Edema: Real-World Evidence in the Italian Population (PRIDE Study) by Ugo Menchini, Francesco Bandello, Vincenzo De Angelis, Federico Ricci, Luigi Bonavia, Francesco Viola, Elisa Muscianisi, Massimo Nicolò

“…Acute renal failure, lung carcinoma, and cardiac arrest were the causes of death in one unilateral and two bilateral patients. …”
Get full text

Does Baseline Serum Androgen Levels Have an Impact on Ovulation Induction Cycle Outcomes by Using Clomifene Citrate among Infertile Women with Polycystic Ovary Syndrome? A Retrospe... by Serkan Kahyaoglu, Muzeyyen Gulnur Ozaksit, Gozde Karacan Duman, Deniz Ozturk Atan, Inci Kahyaoğlu, Meryem Kuru Pekcan, Ozlem Moraloglu Tekin

“…Hyperandrogenism results in follicular arrest at the antral stage during folliculogenesis. baseline intrinsic hyperandrogenism affects the success of ovulation induction or not. …”
Get full text

PARP‐1 Inhibition Increases Oxidative Stress in Ets‐1‐Expressing MDA‐MB‐231 Breast Cancer Cells by Magalie Hervieu, Arnaud J. Legrand, Emilie Floquet, Thierry Idziorek, Corentin Spriet, Didier Monté, Vincent Villeret, Marc Aumercier, Souhaila Choul‐li

“…We first demonstrated that PARPi reduced cells growth through G2/M cell cycle arrest. Next, we evaluated PARP‐1 inhibition effect on oxidative DNA damage in Ets‐1‐overexpressing and Ets‐1‐non‐expressing breast cancer cells and we showed that PARPi led only Ets‐1‐overexpressing cells to accumulate it, which triggers the DNA damage response as revealed by the increase in the level of a panel of DNA damage‐related proteins. …”
Get full text

Disorders of esophageal clearance in gastroesophageal reflux disease and option of their treatment by O. A. Storonova, A. S. Trukhmanov, N. L. Dzhahaya, V. T. Ivashkin

“…Decrease of intensity of heartburn and the arrest of retrosternal pain is found in 80 and 72% of patients respectively. …”
Get full text

A new class of natural anthelmintics targeting lipid metabolism by Hala Zahreddine Fahs, Fathima S. Refai, Suma Gopinadhan, Yasmine Moussa, Hin Hark Gan, Yamanappa Hunashal, Gennaro Battaglia, Patricia G. Cipriani, Claire Ciancia, Nabil Rahiman, Stephan Kremb, Xin Xie, Yanthe E. Pearson, Glenn L. Butterfoss, Rick M. Maizels, Gennaro Esposito, Antony P. Page, Kristin C. Gunsalus, Fabio Piano

“…In embryos, AFAs penetrate the eggshell and induce rapid developmental arrest. Genetic and biochemical tests reveal that AFAs inhibit POD-2, encoding an acetyl CoA carboxylase, the rate-limiting enzyme in lipid biosynthesis. …”
Get full text

The PDE4DIP-AKAP9 axis promotes lung cancer growth through modulation of PKA signalling by Yangyang Fu, Shishun Huang, Rulu Pan, Xingan Chen, Ting Liu, Rongzhe Zhang, Fangsheng Zhu, Qiwei Fang, Liyue Wu, Juji Dai, Ouchen Wang, Liting Lu, Xiduan Wei, Liangxing Wang, Xincheng Lu

“…We further demonstrated that PDE4DIP knockdown triggers apoptosis and cell cycle arrest in NSCLC cells by activating the Protein kinase A (PKA) /CREB signalling pathway. …”
Get full text

Heteronemin Suppresses Lymphangiogenesis Through ARF-1 and MMP-9/VE-Cadherin/Vimentin by Hsien-Lin Chen, Yu-Chieh Su, Huang-Chi Chen, Jui-Hsin Su, Chang-Yi Wu, Shih-Wei Wang, In-Pin Lin, Chung-Yi Chen, Chien-Hsing Lee

“…Mechanistically, SP-1 induced the cell cycle arrest of LECs in the G0/G1 phase and reduced the downstream of VEGFR-3, such as phosphorylated MEK/ERK and NF-κB. …”
Get full text

Overexpression of metalloproteinase PAPPA accelerates cancer progression and correlates with immune cell infiltration in gastric cancer: insights from bioinformatics and in vitro i... by Shiya Yu, Shiyao Zheng, Jinwei Qiu, Hongming Lin, Xiaojuan Yu, Huiyan Chen, Junhong Wu, Weihang Wu, Jiong Chen, Yongyuan Chen, Jianwei Chen, Hu Zhao, Yu Wang

“…Cellular experiments have shown that PAPPA promotes cell proliferation, and its deficiency can inhibit the proliferation of GC cells, inducing cell cycle arrest at the G1/S phase. Conclusions The findings of this investigation suggest that PAPPA serves as a crucial modulator of GC, underscoring its potential as a GC treatment target.…”
Get full text

Diisooctyl phthalate (DIOP) exposure leads to cell apoptosis to HUVEC cells and toxicity to Caenorhabditis elegans through increasing the oxidative stress by Siyuan Luo, Junnan Li, Yuqing Zhou, Zihang Zhai, Qiang Li, Zhenglin Huang, Wencan He, Kejun Zhong, Bo Kong, Zanxian Xia, Hang Fai Kwok, Lipeng Zhu

“…Moreover, this cytotoxicity correlates with elevated levels of reactive oxygen species (ROS), causing cell cycle arrest at the G1 phase and the induction of cell apoptosis. …”
Get full text

Effect of nursing process-based nursing decision implementation on emergency patients with acute ST-segment elevation myocardial infarction by Tiantian Wan, Caixia Wang, Jingli Shi, Shujian Wu

“…Results Through intervention, the IG suggested visibly shorter rescue time, vein opening time, intervention procedure time, and hospital stay compared to the CG; the probability of heart failure (HF), cardiac arrest, and death in the IG was visibly lower than in the CG; the physical health, mental health, social relationships, and environmental scores in the IG were visibly higher than in the CG. …”
Get full text

Magnolol induces cell death through PI3K/Akt‐mediated epigenetic modifications boosting treatment of BRAF‐ and NRAS‐mutant melanoma by Abdullah Al Emran, Brinda Reddy Chinna Chowdary, Farzana Ahmed, Heinz Hammerlindl, Antje Huefner, Nikolas K. Haass, Wolfgang Schuehly, Helmut Schaider

“…Here, we show that magnolol, a constituent of Magnolia officinalis, induced G1 arrest, apoptosis and cell death in BRAF‐ and NRAS‐mutant melanoma cells at low concentration, with no effect in BRAF‐ and NRAS wild‐type melanoma cells and human keratinocytes. …”
Get full text

Expert-Performed Endotracheal Intubation-Related Complications in Trauma Patients: Incidence, Possible Risk Factors, and Outcomes in the Prehospital Setting and Emergency Departmen... by Yuko Ono, Takeyasu Kakamu, Hiroaki Kikuchi, Yusuke Mori, Yui Watanabe, Kazuaki Shinohara

“…ETI-related complications were defined as hypoxemia, unrecognized esophageal intubation, regurgitation, cardiac arrest, ETI failure rescued by emergency surgical airway, dental trauma, cuff leak, and mainstem bronchus intubation. …”
Get full text

Efficient and Rapid Microfluidics Production of Bio-Inspired Nanoparticles Derived from <i>Bombyx mori</i> Silkworm for Enhanced Breast Cancer Treatment by Muhamad Hawari Mansor, Zijian Gao, Faith Howard, Jordan MacInnes, Xiubo Zhao, Munitta Muthana

“…In vitro studies demonstrated sustained cytotoxic effects, and cell cycle arrest at the G2/M phase in breast cancer cell lines, with minimal toxicity in non-cancerous cells. …”
Get full text

Significant Cytokine mRNA Expression Changes Immediately after Initiation of Cardiopulmonary Resuscitation by Mareen Braunstein, Martina Williamson, Thomas Kusmenkov, Jürgen Landes, Peter Biberthaler, Karl-Georg Kanz, Wolfgang Böcker, Viktoria Bogner

“…The purpose of this study was to evaluate immediate immunological changes following cardiopulmonary resuscitation (CPR). mRNA expression levels of selected immunomodulatory cytokines in out-of-hospital cardiac arrest (OHCA) survivors were detected and correlated to clinical parameter. …”
Get full text

Partial rejuvenation of the spermatogonial stem cell niche after gender-affirming hormone therapy in trans women by Emily Delgouffe, Samuel Madureira Silva, Frédéric Chalmel, Wilfried Cools, Camille Raets, Kelly Tilleman, Guy T'Sjoen, Yoni Baert, Ellen Goossens

“…Besides this, fibrosis was particularly evident in the tubular wall and the lumen was collapsing in most participants. A spermatogenic arrest was also observed in all participants. The transcriptomic profile of transgender tissue confirmed a loss of mature characteristics - a partial rejuvenation - of the spermatogonial stem cell niche and, in addition, detected inflammation processes occurring in the samples. …”
Get full text

Knowledge and Attitude about Basic Life Support and Emergency Medical Services amongst Healthcare Interns in University Hospitals: A Cross-Sectional Study by Shahabe A. Saquib, Hassan M. Al-Harthi, Anas A. Khoshhal, Adel A. Shaher, Abdulsalam B. Al-Shammari, AbdulAhad Khan, Tahani A. Al-Qahtani, Imran Khalid

“…Road traffic accident and sudden cardiac arrest are one of the most leading causes of death in KSA. …”
Get full text